CN1757305A - Chinese herbal feed additive and preparation method thereof - Google Patents
Chinese herbal feed additive and preparation method thereof Download PDFInfo
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- CN1757305A CN1757305A CNA200410011127XA CN200410011127A CN1757305A CN 1757305 A CN1757305 A CN 1757305A CN A200410011127X A CNA200410011127X A CN A200410011127XA CN 200410011127 A CN200410011127 A CN 200410011127A CN 1757305 A CN1757305 A CN 1757305A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention discloses a kind of Chinese herbal feed additive, it is to be made by following materials of weight proportions: coptis extract (30-40), Astragalus Root P.E (20-30), Pericarpium Citri tangerinae micropowder thing (30-40).This feed addictive can effectively substitute the antibiotics additive: compare with the antibiotics additive to have and have no side effect, drug residue free, be of value to the advantage of animal and human's class health; Product reaches traceization, owing to adopt lixiviate, concentrated and spray-dired processing technology, has solved directly to pulverize in the past and has added, the big and unsettled shortcoming of active constituent content of dosage; Use this feed addictive can promote growth of animal, improve feed efficiency, reduce disease incident.
Description
Technical field:
The present invention relates to a kind of feed addictive, relate in particular to a kind of compound Chinese herb feed addictive of forming by Chinese herbal medicines.
The invention still further relates to the preparation method of this Chinese herbal feed additive.
Background technology:
The feed addictive of existing disease-resistant growth-promoting mainly is antibiotic and chemicals additive, also useful Chinese herb feed additives.The shortcoming of antibiotic and chemicals class additive is to use side effect very big for a long time, cause that full pathogenic microorganism develops immunity to drugs on the one hand, reduce the prevention effect of Animal diseases: can in meat, egg, milk and environment, produce medicament residue on the other hand, thus the serious threat health.For this reason, world many countries has been made the regulation of restriction and progressively superseded or forbidding to antibiotic and chemicals Application of Additives.The Chinese herbal medicine immunologic active material can strengthen human body immune function, improve animal anti-stress, resistance against diseases, improve breeding performonce fo animals, have noresidue, be difficult for producing advantage such as drug resistance, be the focus of animal nutrition research in recent years.According to bibliographical information, the Chinese herbal medicine that is used for the feed addictive raw material at present has kind more than 200, some patents of invention also disclose the prescription (CN 1491574A) of various Chinese herbal feed additives, the effect and the cost of various prescriptions are also had nothing in common with each other, and Chinese herbal medicine is directly pulverized interpolation, the big and active constituent content instability of dosage.
Summary of the invention:
The object of the present invention is to provide a kind of alternative antibiotic growth accelerator at present commonly used, have no side effect, pollution-free and Chinese herbal feed additive that production cost is low.
Another object of the present invention is to provide a kind of preparation method of this Chinese herbal feed additive.
Additive formula of the present invention is determined through kind of Chinese herbal medicine different processing methods, fungistatic effect and animal feeding result of the test surplus 20 are summed up.The composition of Chinese herbal medicine is very complicated, therefore also has multifunctionality.The coptis in this prescription not only has direct bacteria resistance function and anti diar rhea function, and can transfer the nonspecific immunity function because of containing alkaloids such as jamaicin, coptisine, worenine, has effects such as anti-inflammatory, analgesic, diuresis, calmness; The Radix Astragali contains 2 ', 4 ' dihydroxy-5,6 dioxy base isoflavones, betaine,, choline, folic acid and several amino acids, lymphatic temperament, bitter principle etc., has the parahormone effect, by exciting non-specific antimicrobial factors, as promoting lysozyme generation, inducement interferon, exciting raising immunity of organisms such as strengthening phagocytic function and body tolerance etc.; Dried orange peel mainly contains citrene, glycosides displayed etc., is the effect of the short digestion of spleen of being good for the stomach.Dried orange peel also has the merit with hundred medicines, then mends as tonic, then rises with hydrargyrum oxydatum crudum, then fall with falling medicine, because of join benefit arranged, rush down, the power of ascending, descending.Therefore, the effect that has disease-resistant growth-promoting.
The present invention's feed addictive is made by following component: (consumption is a weight portion)
Coptis extract 30-40, Astragalus Root P.E 20-30, Pericarpium Citri tangerinae micropowder 30-40
Described coptis extract preparation technology is for getting coptis impurity elimination, chopping processing; Use the lixiviate of 70%-80% ethanol then, extraction time 2-4 hour, temperature 70-80 ℃, solvent raw material ratio 7-9: 1; Spray-drying concentrates again, with liquid chromatogram the main action component jamaicin in the coptis is measured, and does filling with starch, makes jamaicin account for 10% of extract;
Described Astragalus Root P.E preparation technology is for getting Radix Astragali impurity elimination, chopping processing; Use the lixiviate of 70%-80% ethanol then, extraction time 2-4 hour, temperature 70-80 ℃, solvent raw material ratio 7-9: 1; Spray-drying concentrates again, with liquid chromatogram the main action component jamaicin in the coptis is measured, and makees filler with starch, and the Radix Astragali is made 10: 1 extracts;
Described Pericarpium Citri tangerinae micropowder drying and crushing is to the 80-120 order.
The optimum weight of the present invention's feed addictive (part) proportioning is:
Coptis extract 35
Astragalus Root P.E 25
Pericarpium Citri tangerinae micropowder 35
The preparation method that the present invention's feed adds punishment is:
1, gets coptis impurity elimination, chopping processing earlier; Use the lixiviate of 70%-80% ethanol then, extraction time 2-4 hour, temperature 70-80 ℃, solvent raw material ratio 7-9: 1; Spray-drying concentrates again; With liquid chromatogram the main action component jamaicin in the coptis is measured, done filling, make jamaicin account for 10% of extract with starch;
2, get Radix Astragali impurity elimination, chopping processing; Use the lixiviate of 70%-80% ethanol then, extraction time 2-4 hour, temperature 70-80 ℃, solvent raw material ratio 7-9: 1; Spray-drying concentrates again; Make filler with starch, the Radix Astragali is made 10: 1 extracts;
3, with the dried orange peel drying and crushing to 80-120 order micro mist;
4, above-mentioned 3 steps are obtained raw material coptis extract, Astragalus Root P.E, Pericarpium Citri tangerinae micropowder by weight 30-40: 20-30: 30-40 mix, packing promptly can be made into finished product.
The present invention's feed addictive adds in the feed by the 1-1.5 ‰ of feed weight, is used for nutrition purposes, especially for feeding animals.
Advantage of the present invention is: this feed addictive can effectively substitute the antibiotics additive: compare with the antibiotics additive to have and have no side effect, drug residue free, be of value to the advantage of animal and human's class health; Product reaches traceization, owing to adopt lixiviate, concentrated and spray-dired processing technology, has solved directly to pulverize in the past and has added, the big and unsettled shortcoming of active constituent content of dosage; Use this feed addictive can promote growth of animal, improve feed efficiency, reduce disease incident.
For showing effect of the present invention, provide following test data:
One, different additive is to the check experiment of the influence of growing-finishing pig production performance.
1, experimental design
The design of employing single factor experiment.8 groups are established in test altogether, and each organize 8 pigs, and the identical PIC commodity of test pig hereditary basis are for pig, and each organizes basal diet and base additive (micro-, multivitamin) is identical.Difference is the growth-promoting additive difference, wherein establishes 1 of antibiotic control group, 3 groups of Chinese herb feed additive, and complex enzyme, compound sugar, probiotic, citric acid add each control group of complex enzyme.Concrete experimental design sees Table 1.
Table 1. test different disposal group additive is formed (percentage is the weight ratio of additive and feed)
| Group | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
| Number | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 |
| Additive | The present invention 0.1% | Compound sugar 0.2% | The present invention 0.15% | Antibiotic olaquindox 50ppm | Complex enzyme 0.2% | Probiotic 0.2% | The present invention 0.3% | Complex enzyme 0.2% citric acid 0.3% |
2, experimental animal selection, grouping and feeding and management
Test is carried out omnidistance 115 days at academy of agricultural sciences, Jilin Province experiment pig house.Test pig derives from Jilin China and is just planting the pig farm, and kind is that the PIC commodity are for piglet (64).After conventional program vaccinate, expelling parasite, beating overbit and breeding observing, according to the approaching principle of each group average weight, 8 every group, male and female half and half, it is not remarkable that each organizes average weight difference.The test pig house is open colony house, adopts ground flat to support, and raises area for every group and is 10 square metres, the dry powder feeding of feeding, free choice feeding, nipple drinking device drinking-water.
3, mensuration project and method
(1) body weight determination: test starting weight, 60 days (the about 60kg of body weight), test end weigh, and carry out individuality on an empty stomach respectively before early raising and weigh.
(2) food consumption: the feeding coal of weighing every day and each group of record, the clearing feed consumption before this simultaneously of weighing.
(3) diarrhoea and morbidity: every day, diarrhoea and incidence respectively organized in record, statistics diarrhoea and disease incident during off-test.
4, test results and analysis
Each processing of test the results are shown in Table 2.
Table 2, test each processed group production performance statistics
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |
| Starting weight (kg) | 23.8 ±1.85 | 23.2 ±1.95 | 23.4 ±1.56 | 23.3 ±1.81 | 23.2 ±1.34 | 23.2 ±1.39 | 23.2 ±1.89 | 23.15 ±1.41 |
| End heavy (kg) | 98.8 ±8.2 | 101.7 ±7.3 | 104.0 ±7.5 | 104.4 ±7.0 | 108.1 ±7.8 | 102.8 ±9.3 | 113.2 ±9.8 | 109.6 ±9.0 |
| Total augment weight (kg) | 75.0 | 78.4 | 80.6 | 81.1 | 84.9 | 79.5 | 90.0 | 86.5 |
| Omnidistance daily gain (g) | 652.1 | 681.7 | 700.9 | 705.2 | 738.3 | 691.3 | 807.8 | 760.9 |
| Omnidistance material anharmonic ratio | 3.25 | 3.28 | 3.30 | 3.21 | 3.18 | 3.30 | 3.22 | 3.15 |
| Diarrhoea incidence % | 5.2 | 4.3 | 4.0 | 3.5 | 4.3 | 4.6 | 3.6 | 2.8 |
Table 2 result shows that it is not remarkable that each phase material anharmonic ratio difference is respectively organized in test.Disease (mainly being diarrhoea) incidence is minimum with 8 groups of incidences, and 1 group the highest, both phase ratios 46%.The diarrhoea incidence becomes the moderate negative correlation with daily gain.Therefore, prove the disease-resistant growth-promoting additive to a certain extent, reach it by control diarrhoea and promote growth result.
Two, the effect of several disease-resistant growth-promoting feed addictives in the meat chick is produced
1, experimental design
This test has designed 7 groups altogether, and the basal diet and the base additive (trace element, multivitamin, amino acid etc.) of each group are identical.Difference is the disease-resistant growth-promoting additive difference used between each group.Designed five different Antibiotic Additive groups respectively, 1 probiotic enzyme preparation group and this present invention additive group, detailed design sees Table 3.
2, experimental animal
Select healthy 4 age in days Ai Wei mattress commodity for mixing young 1440, be divided into 8 groups at random, 180 every group.1 Japanese instar chickling body weight difference is not remarkable after measured, average weight 36.5 grams/only.
3, test daily ration
The experimental basis daily ration is divided into each stage basal diet composition of 3 stages (4-21,22-42,43-49 age in days) and nutritional labeling sees Table 4.
(ratio is the weight ratio of additive and feed) formed in the disease-resistant growth-promoting agent of each test group of table 3
Table 4, each stage basal diet are formed and nutritional labeling (%, kilojoule)
| Daily ration is formed | The 4-21 age in days | The 22-42 age in days | The 43-49 age in days |
| Corn-soybean meal fish meal Dried meat floss powder albumen powder DDG bone meal calcium monohydrogen phosphate stone flour salt oil additive crude protein metabolizable energy methionine lysine | 59.46 27 3.0 2.0 2.0 1.0 1.0 0.8 1.0 0.24 1.5 1.0 20.9 12.54 0.40 1.0 | 63.27 20 3.0 3.0 3.0 - 1.0 0.8 1.0 0.25 3.5 1.0 19.0 13.02 0.41 0.90 | 65.27 20.0 3.0 1.0 2.0 - 1.0 0.8 1.0 0.25 4.0 1.0 17.5 13.12 0.39 0.88 |
4, feeding and management
Each test group adopts online putting down to support free choice feeding and drinking-water under same raising and management condition.Illumination in 23 hours, the feeding standard control routinely of house temperature, immune programme for children carries out immunity inoculation routinely.
5, test observation index
1. body weight determination: measure respectively and respectively organize 21,28,42,49 age in days whose body weights.
2. the feeding coal of weighing and record each group every day is weighed and is settled accounts feed consumption rate before this simultaneously.
3. quantity is eliminated in the death that every day, detail record was respectively organized chicken.
When 4. the test knot is stated, butcher 4 chickens for every group, test according to safety livestock products standard.
6, use variance analysis method, the different phase body weight is respectively organized in test carried out variance analysis and significance test of difference.Each is formed motility rate carry out the T check.
7, test results and analysis
Each is organized the main production performance of different phase and sees Table 5
Meat chick production performance (gram, only, %) is respectively organized in table 5 test
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | ||
| Each organizes the test chicken number | 180 | 180 | 180 | 180 | 180 | 180 | 180 | 180 | |
| The 0-21 age in days | Feed consumption rate | 1025.6 | 1030.5 | 1029.3 | 1085.1 | 1038.4 | 1062.9 | 1075.7 | 1063.5 |
| Weight | 621.6 ±88.4 | 613.4 ±89.6 | 631.5 ±87.5 | 638.3 ±90.0 | 603.7 ±87.2 | 640.3 ±83.9 | 640.3 ±84.3 | 625.6 ±81.9 | |
| Feedstuff-meat ratio | 1.65∶1 | 1.68∶1 | 1.63∶1 | 1.70∶1 | 1.72∶1 | 1.66∶1 | 1.68∶1 | 1.70∶1 | |
| Survival rate | 97.8 | 97.2 | 98.9 | 98.9 | 98.9 | 98.9 | 96.7 | 96.7 | |
| The 0-28 age in days | Feed consumption rate | 1820.2 | 1657.3 | 1877.9 | 1884.4 | 1748.1 | 1844.6 | 1976.0 | 1810.7 |
| Weight | 1000.1 ± 176.7 | 920.7 ± 168.3 | 1015.1 ± 151.3 | 1013.1 ± 151.1 | 976.6 ± 138.1 | 1030.5 ± 142.7 | 1045.5 ± 139.4 | 973.5 ± 185.3 | |
| Feedstuff-meat ratio | 1.82∶1 | 1.80∶1 | 1.85∶1 | 1.86∶1 | 1.79∶1 | 1.79∶1 | 1.89∶1 | 1.86∶1 | |
| Survival rate | 97.8 | 95.6 | 98.9 | 97.2 | 98.9 | 97.2 | 96.7 | 96.7 | |
| The 0-42 age in days | Feed consumption rate | 4138.8 | 3635.9 | 4101.4 | 3989.2 | 3941.4 | 3999.6 | 3946.2 | 3991.8 |
| Weight | 2155.6 ± 289.5 | 1883.9 ± 297.5 | 2103.3 ± 261.0 | 2056.3 ± 268.5 | 1980.6 ± 251.6 | 2116.2 ± 144.3 | 2055.3 ± 239.0 | 2047.1 ± 240.9 | |
| Feedstuff-meat ratio | 1.92∶1 | 1.93∶1 | 1.95∶1 | 1.94∶1 | 1.99∶1 | 1.89∶1 | 1.92∶1 | 1.95∶1 | |
| Survival rate | 95.6 | 93.3 | 96.7 | 96.7 | 95.6 | 94.5 | 95.6 | 93.3 | |
| The 0-49 age in days | Feed consumption rate | 5350.0 | 5077.0 | 5343.0 | 5404.4 | 5555.2 | 5591.3 | 5656.9 | 5587.4 |
| Weight | 2661.7 ± 315.2 | 2417.6 ± 362.3 | 2698.5 ± 309.3 | 2636.3 ± 357.0 | 2583.8 ± 295.0 | 2637.4 ± 305.4 | 2643.4 ± 310.6 | 2673.4 ± 307.0 | |
| Feedstuff-meat ratio | 2.01∶1 | 2.10∶1 | 1.98∶1 | 2.05∶1 | 2.15∶1 | 2.12∶1 | 2.14∶1 | 2.09∶1 | |
| Survival rate | 95.6 | 91.1 | 95.6 | 93.3 | 95.6 | 93.3 | 94.5 | 92.8 | |
From table 5, respectively organize each stage body weight, 3 the week ages and 4 the week age body weight each the group between more approaching, difference is not remarkable.From 6 ages in week and 7 ages in week, the 2nd group (probiotic+enzyme group) significantly is lower than other seven groups, reaches the significance level of difference.And all the other each group differences are not remarkable, prove respectively to organize antibiotic and Chinese herbal medicine all has growth promoting function, and probiotic and enzyme preparation are remarkable not as antibiotic and Chinese herb feed additive effect aspect growth promotion.From each stage body weight standard deviation of table 5, along with age in days increases, each organizes the weight standard difference and the coefficient of variation enlarges markedly, through observation analysis, due to male and female chicken gender differences.Therefore, though the 2nd group of 7 other several class means of weight ratio in age in week low more (mean difference 220 grams) because the difference of male and female chicken in the group has been covered group difference, make significance of difference analysis result not reach the level of signifiance.Each is organized feedstuff-meat ratio and sees, each age in week is all more approaching, no significant difference.From each test group survival results in seven ages in week, second group low slightly, but through difference significance test, difference is not remarkable.Meat detects arsenic, lead, tribute, fluorine, chromium, cadmium, nitrite according to safety livestock products standard, and its result meets safe livestock products standard.As can be seen from the test results, Chinese herb feed additive can substitute Antibiotic Additive.
Three, the Chinese herb feed additive fungistatic effect of different disposal test
This test respectively according to Orthogonal Experiment and Design, has been carried out the bacteriostatic test of 88 treatment combinations to 9 kinds of Chinese herbal medicines, 3 kinds of processing methods, 6 concentration gradients (5 ‰, 3.33 ‰, 2.5 ‰, 1.25 ‰, 0.625 ‰, 0.33 ‰) and 3 kinds of pathogenic bacteria.Coptis root, Herba Andrographitis, the root of large-flowered skullcap, folium isatidis, dandelion, honeysuckle, 7 kinds of Chinese herbal medicines of garlic are carried out the broken back water logging of 100 order micro mists to be handled; Cyrtomium fortunei, the coptis, the Radix Astragali, Herba Andrographitis, Polygonum multiflower knotweed, 6 kinds of medium-height grass liquid medicine of the bark of official magnolia are extracted and handle.Cyrtomium fortunei, folium isatidis, Herba Andrographitis, the coptis, the Radix Astragali, Polygonum multiflower knotweed, dandelion, bark of official magnolia alcohol extract are handled.Research variety classes, different processing methods, variable concentrations Chinese herbal medicine are to Escherichia coli, Staphylococcus aureus and 3 kinds of pathogenic bacterium of Shigella inhibition effect in laboratory, bacteriostatic test adopts cylinder-plate method, 3 repetitions are established in each processing, judge the Chinese herbal medicine fungistatic effect power of different disposal method according to the antibacterial circle diameter size.
Result of the test shows: bigger to the fungistatic effect influence in 4 processing factors with the concentration and the kind of Chinese herbal medicine, and processing method and pathogenic species are less to the result of the test influence.Chinese herbal medicine fungistatic effect and concentration are proportionate, and 5 ‰, 3.33 ‰ and 2.5 ‰ respectively to handle differences not remarkable, and fungistatic effect is better; 1.25 ‰, 0.625 ‰, 0.33 ‰ fungistatic effect weakens gradually; 3 kinds of processing and treating methods relatively slightly are better than water with the alcohol extracting effect and carry and the differential processing, and difference is not remarkable; Water is carried with the differential treatment effect approaching; The Chinese herbal medicine fungistatic effect that micro mist is handled by by force to a little less than be arranged as: the coptis, Herba Andrographitis, folium isatidis, the Radix Astragali, honeysuckle, garlic, dandelion; The Chinese herbal medicine fungistatic effect that water is proposed processing power successively is arranged as: the coptis, Herba Andrographitis, the Radix Astragali, Polygonum multiflower knotweed, the bark of official magnolia, cyrtomium fortunei; The Chinese herbal medicine fungistatic effect power that alcohol extracting is handled is: the coptis, Herba Andrographitis, the bark of official magnolia, the Radix Astragali, folium isatidis, cyrtomium fortunei, Polygonum multiflower knotweed, dandelion; The strong and weak order of the Chinese herbal medicine fungistatic effect of different processing methods is:, the coptis (alcohol extracting, water are carried), Herba Andrographitis (alcohol extracting, water are carried), the bark of official magnolia (alcohol extracting) Radix Astragali (alcohol extracting), the Radix Astragali (water is carried), folium isatidis (alcohol extracting), cyrtomium fortunei (alcohol extracting), Polygonum multiflower knotweed (alcohol extracting), Polygonum multiflower knotweed (water is carried), folium isatidis (micro mist), the bark of official magnolia (water is carried), cyrtomium fortunei (water is carried), honeysuckle (micro mist), dandelion (alcohol extracting), the Radix Astragali (micro mist) dandelion (micro mist), garlic (micro mist); The fungistatic effect power of the selected 10 kinds of Chinese herbal medicines of Comprehensive Assessment is as follows successively: the coptis, Herba Andrographitis, the Radix Astragali, the bark of official magnolia, Polygonum multiflower knotweed, folium isatidis, cyrtomium fortunei, honeysuckle, dandelion, garlic.Conclusion: 4 processing factor action effects are followed successively by in this test: concentration＞kind＞processing method, and the pathogenic bacteria kind does not have influence; Concentration can play better fungistatic effect 5 ‰-2.5 ‰; Selected Chinese herbal medicine all has bacteriostasis, but its fungistatic effect is strong and weak different, is followed successively by: the coptis＞Herba Andrographitis＞Radix Astragali＞bark of official magnolia＞Polygonum multiflower knotweed＞folium isatidis＞cyrtomium fortunei＞honeysuckle＞garlic＞dandelion; 3 kinds of processing and treating methods, the effect of carrying with alcohol extracting, water slightly is better than the effect of micro mist, but different processing methods difference is not remarkable.Water is carried and alcohol extracting Chinese herbal medicine concentration in the test, is to extract preceding bulk drug concentration.
The specific embodiment:
Embodiment 1:
Press column weight amount proportioning and take by weighing raw material (kilogram):
Coptis extract 35
Astragalus Root P.E 25
Pericarpium Citri tangerinae micropowder 35
The preparation method is as follows:
1, gets coptis impurity elimination, chopping processing earlier; Use 70% ethanol lixiviate then, extraction time 3 hours, 75 ℃ of temperature, solvent raw material ratio 8: 1; Spray-drying concentrates again; With liquid chromatogram the main action component jamaicin in the coptis is measured, done filling, make jamaicin account for 10% of extract with starch;
2, get Radix Astragali impurity elimination, chopping processing; Use 70% ethanol lixiviate then, extraction time 3 hours, 75 ℃ of temperature, solvent raw material ratio 8: 1; Spray-drying concentrates again; With liquid chromatogram the main action component jamaicin in the coptis is measured, made filler, the Radix Astragali is made 10: 1 extracts with starch.
3, with dried orange peel drying and crushing to 100 order micro mist.
4, above-mentioned 3 kinds of raw material mixing, sealing, packing are got product.
Embodiment 2:
Press column weight amount proportioning and take by weighing raw material (kilogram):
Coptis extract 30
Astragalus Root P.E 30
Pericarpium Citri tangerinae micropowder 40
The preparation method is as follows:
1, gets coptis impurity elimination, chopping processing earlier; Use 80% ethanol lixiviate then, extraction time 4 hours, 70 ℃ of temperature, solvent raw material ratio 9: 1; Spray-drying concentrates again; With liquid chromatogram the main action component jamaicin in the coptis is measured, done filling, make jamaicin account for 10% of extract with starch;
2, get Radix Astragali impurity elimination, chopping processing; Use 80% ethanol lixiviate then, extraction time 4 hours, 70 ℃ of temperature, solvent raw material ratio 9: 1; Spray-drying concentrates again; Make filler with starch, the Radix Astragali is made 10: 1 extracts.
3, with dried orange peel drying and crushing to 120 order micro mist.
4, above-mentioned 3 kinds of raw material mixing, sealing, packing are got product.
Embodiment 3:
1, gets coptis impurity elimination, chopping processing earlier; Use 80% ethanol lixiviate then, extraction time 4 hours, 70 ℃ of temperature, solvent raw material ratio 9: 1; Spray-drying concentrates again; With liquid chromatogram the main action component jamaicin in the coptis is measured, done filling, make jamaicin account for 10% of extract with starch;
2, get Radix Astragali impurity elimination, chopping processing; Use 80% ethanol lixiviate then, extraction time 4 hours, 70 ℃ of temperature, solvent raw material ratio 9: 1; Spray-drying concentrates again; Make filler with starch, the Radix Astragali is made 10: 1 extracts.
3, with dried orange peel drying and crushing to 120 order micro mist.
4, mixing in 35: 25: 35, packing promptly can be made into finished product by weight above-mentioned 3 steps to be obtained raw material coptis extract, Astragalus Root P.E, Pericarpium Citri tangerinae micropowder.
Embodiment 4:
1, gets coptis impurity elimination, chopping processing earlier; Use 80% ethanol lixiviate then, extraction time 4 hours, 70 ℃ of temperature, solvent raw material ratio 7: 1; Spray-drying concentrates again; With liquid chromatogram the main action component jamaicin in the coptis is measured, done filling, make jamaicin account for 10% of extract with starch;
2, get Radix Astragali impurity elimination, chopping processing; Use 80% ethanol lixiviate then, extraction time 4 hours, 70 ℃ of temperature, solvent raw material ratio 7: 1; Spray-drying concentrates again; Make filler with starch, the Radix Astragali is made 10: 1 extracts.
3, with dried orange peel drying and crushing to 120 order micro mist.
4, mixing in 40: 30: 40, packing promptly can be made into finished product by weight above-mentioned 3 steps to be obtained raw material coptis extract, Astragalus Root P.E, Pericarpium Citri tangerinae micropowder.
Claims (5)
1, a kind of Chinese herbal feed additive is characterized in that it is to be made by following materials of weight proportions:
Coptis extract 30-40, Astragalus Root P.E 20-30, Pericarpium Citri tangerinae micropowder 30-40
Described coptis extract preparation technology is for getting coptis impurity elimination, chopping processing; Use the lixiviate of 70%-80% ethanol then, extraction time 2-4 hour, temperature 70-80 ℃, solvent raw material ratio 7-9: 1; Spray-drying concentrates again, with liquid chromatogram the main action component jamaicin in the coptis is measured, and does filling with starch, makes jamaicin account for 10% of extract;
Described Astragalus Root P.E preparation technology is for getting Radix Astragali impurity elimination, chopping processing; Use the lixiviate of 70%-80% ethanol then, extraction time 2-4 hour, temperature 70-80 ℃, solvent raw material ratio 7-9: 1; Spray-drying concentrates again, makees filler with starch, and the Radix Astragali is made 10: 1 extracts;
Described Pericarpium Citri tangerinae micropowder drying and crushing is to the 80-120 order.
2, feed addictive according to claim 1, wherein the weight proportion of each raw material is:
Coptis extract 35
Astragalus Root P.E 25
Pericarpium Citri tangerinae micropowder 35
3, the preparation method of claim 1 or 2 described feed addictives is characterized in that:
A, get coptis impurity elimination earlier, chopping is handled; Use the lixiviate of 70%-80% ethanol then, extraction time 2-4 hour, temperature 70-80 ℃, solvent raw material ratio 7-9: 1; Spray-drying concentrates again, with liquid chromatogram the main action component jamaicin in the coptis is measured, and does filling with starch, makes jamaicin account for 10% of extract;
B, get Radix Astragali impurity elimination, chopping is handled; Use the lixiviate of 70%-80% ethanol then, extraction time 2-4 hour, temperature 70-80 ℃, solvent raw material ratio 7-9: 1; Spray-drying concentrates again, with liquid chromatogram the main action component jamaicin in the coptis is measured, and makees filler with starch, and the Radix Astragali is made 10: 1 extracts;
C, with the dried orange peel drying and crushing to 80-120 order micro mist;
D, with above-mentioned 3 steps obtain raw material coptis extract, Astragalus Root P.E, Pericarpium Citri tangerinae micropowder by weight 30-40: 20-30: 30-40 mix, packing promptly can be made into finished product.
4, the preparation method of the described feed addictive of claim 3, wherein the lixiviate concentration of alcohol 70%, extraction time 3 hours, 75 ℃ of temperature, solvent raw material ratio 8: 1; Dried orange peel drying and crushing to 100 order micro mist; Coptis extract, Astragalus Root P.E, Pericarpium Citri tangerinae micropowder were by weight 35: 25: 35.
5, feed addictive according to claim 1 and 2 is characterized in that using method is that 1-1.5 ‰ by feed weight adds in the feed, is used for nutrition purposes, especially for feeding animals.
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| CNA200410011127XA CN1757305A (en) | 2004-10-10 | 2004-10-10 | Chinese herbal feed additive and preparation method thereof |
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| CN1757305A true CN1757305A (en) | 2006-04-12 |
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| CN101233898B (en) * | 2007-12-11 | 2010-12-29 | 吉林省农业科学院 | Compound plant extract feed additive and preparation thereof |
| CN102475193A (en) * | 2010-12-29 | 2012-05-30 | 吉林省农业科学院 | Heat stress resistant plant extractive feed additive and preparation method thereof |
| CN102813064A (en) * | 2012-09-16 | 2012-12-12 | 北京翰赛柯生物科技有限公司 | Plant extract feed additive for piglets |
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| CN101233898B (en) * | 2007-12-11 | 2010-12-29 | 吉林省农业科学院 | Compound plant extract feed additive and preparation thereof |
| CN101961067B (en) * | 2009-07-22 | 2013-01-16 | 吉林农业大学 | Novel feed additive for broilers |
| CN102475193A (en) * | 2010-12-29 | 2012-05-30 | 吉林省农业科学院 | Heat stress resistant plant extractive feed additive and preparation method thereof |
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| CN103494913B (en) * | 2012-06-30 | 2015-04-22 | 四川德润通生物科技有限公司 | Preparation method of compound radix astragali immune activation injection |
| CN102813064A (en) * | 2012-09-16 | 2012-12-12 | 北京翰赛柯生物科技有限公司 | Plant extract feed additive for piglets |
| CN102813064B (en) * | 2012-09-16 | 2013-12-11 | 北京翰赛柯生物科技有限公司 | Plant extract feed additive for piglets |
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| CN102987107B (en) * | 2012-09-29 | 2013-12-11 | 凤台县瑞普农业发展有限公司 | Chick feed |
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