CN1733737A - 瑞舒伐他汀及其盐的制备方法 - Google Patents
瑞舒伐他汀及其盐的制备方法 Download PDFInfo
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- CN1733737A CN1733737A CN 200510044286 CN200510044286A CN1733737A CN 1733737 A CN1733737 A CN 1733737A CN 200510044286 CN200510044286 CN 200510044286 CN 200510044286 A CN200510044286 A CN 200510044286A CN 1733737 A CN1733737 A CN 1733737A
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- ether
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Abstract
Description
序号 | I | 还原剂 | 溶剂 | 反应温度/℃ | II、III收率% | II/III |
1. | Ia | NaBH4 | CH3OH | -78 | 89 | 1∶5.4 |
2. | Ia | NaBH4 | CH3OH | -25 | 86 | 1∶5.0 |
3. | Ia | NaBH4 | CH3OH | 0 | 88 | 1∶3.6 |
4. | Ia | NaBH4 | CH3OH | 25 | 94 | 1∶2.8 |
5. | Ic | NaBH4 | CH3OH | -25 | 85 | 1∶3.4 |
6. | Ib | NaBH4 | CH3OH | -25 | 85 | 1∶5.4 |
7. | Id | NaBH4 | CH3OH | -25 | 85 | 1∶3.9 |
8. | Ie | NaBH4 | CH3OH | -25 | 86 | 1∶4.6 |
9. | Ia | BH3:THF | THF | -25 | 80 | 1∶3.5 |
10. | Ia | KBH4 | CH3OH | -25 | 82 | 1∶5.1 |
11. | P=H | NaBH4 | CH3OH | -25 | 88(P=H) | 1.4∶1(P=H) |
Claims (9)
Priority Applications (1)
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CNB2005100442864A CN100436428C (zh) | 2005-08-22 | 2005-08-22 | 瑞舒伐他汀及其盐的制备方法 |
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CNB2005100442864A CN100436428C (zh) | 2005-08-22 | 2005-08-22 | 瑞舒伐他汀及其盐的制备方法 |
Publications (2)
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CN1733737A true CN1733737A (zh) | 2006-02-15 |
CN100436428C CN100436428C (zh) | 2008-11-26 |
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CNB2005100442864A Active CN100436428C (zh) | 2005-08-22 | 2005-08-22 | 瑞舒伐他汀及其盐的制备方法 |
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CN (1) | CN100436428C (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7851624B2 (en) | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
WO2012011129A2 (en) * | 2010-07-22 | 2012-01-26 | Msn Laboratories Limited | Novel polymorph of bis[(e)-7-[4-(4-fluorophenyl)-6-iso-propyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-enoic acid] calcium salt |
CN101490015B (zh) * | 2006-04-13 | 2013-06-12 | 埃吉斯药物股份公开有限公司 | 瑞舒伐他汀锌盐 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2648897B2 (ja) * | 1991-07-01 | 1997-09-03 | 塩野義製薬株式会社 | ピリミジン誘導体 |
GB9903472D0 (en) * | 1999-02-17 | 1999-04-07 | Zeneca Ltd | Chemical process |
EP1585736A2 (en) * | 2002-05-21 | 2005-10-19 | Ranbaxy Laboratories, Ltd. | Process for the preparation of rosuvastatin |
-
2005
- 2005-08-22 CN CNB2005100442864A patent/CN100436428C/zh active Active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7851624B2 (en) | 2003-12-24 | 2010-12-14 | Teva Pharamaceutical Industries Ltd. | Triol form of rosuvastatin and synthesis of rosuvastatin |
CN101490015B (zh) * | 2006-04-13 | 2013-06-12 | 埃吉斯药物股份公开有限公司 | 瑞舒伐他汀锌盐 |
WO2012011129A2 (en) * | 2010-07-22 | 2012-01-26 | Msn Laboratories Limited | Novel polymorph of bis[(e)-7-[4-(4-fluorophenyl)-6-iso-propyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-enoic acid] calcium salt |
WO2012011129A3 (en) * | 2010-07-22 | 2012-03-15 | Msn Laboratories Limited | Novel polymorph of bis[(e)-7-[4-(4-fluorophenyl)-6-iso-propyl-2-[methyl (methylsulfonyl)amino]pyrimidin-5-yl](3r,5s)-3,5-dihydroxyhept-6-enoic acid] calcium salt |
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Publication number | Publication date |
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CN100436428C (zh) | 2008-11-26 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Lunan Beite Pharmaceutical Co., Ltd. Assignor: Lunan Pharmaceutical Group Co., Ltd. Contract record no.: 2010370000513 Denomination of invention: Preparation method of rosuvastain and its salt Granted publication date: 20081126 License type: Exclusive License Open date: 20060215 Record date: 20100909 |
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EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Lunan Beite Pharmaceutical Co., Ltd. Assignor: Lunan Pharmaceutical Group Co., Ltd. Contract record no.: 2010370000513 Date of cancellation: 20131016 |
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LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhang Guimin Inventor after: Zhang Lixing Inventor after: Huang Wenbo Inventor after: Zhao Zhiquan Inventor after: Peng Lizeng Inventor after: Di Fumin Inventor before: Zhao Zhiquan Inventor before: Peng Lizeng Inventor before: Di Fumin |
|
COR | Change of bibliographic data |