CN1733110A - Chinese medicinal composition for clearing heat, dispersing phlegm, ventilating the lung and relieving asthma and process for preparing the same - Google Patents
Chinese medicinal composition for clearing heat, dispersing phlegm, ventilating the lung and relieving asthma and process for preparing the same Download PDFInfo
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- CN1733110A CN1733110A CN 200510012738 CN200510012738A CN1733110A CN 1733110 A CN1733110 A CN 1733110A CN 200510012738 CN200510012738 CN 200510012738 CN 200510012738 A CN200510012738 A CN 200510012738A CN 1733110 A CN1733110 A CN 1733110A
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Abstract
The invention relates to a Chinese medicinal composition for clearing heat, dispersing phlegm, ventilating the lung and relieving asthma and process for preparation, wherein the composition comprises Chinese ephedra, licorice root, bitter apricot seed, radish seeds, lepidium seed, purple perilla seed, baikal skullcap root, mulberry bark, clerodendroa cyrtophyllum, cordate houttuynia and gypsum.
Description
Technical field
The invention belongs to the Chinese herbal and crude drugs preparations technical field, relate in particular to a kind of removing heat-phlegm, the Chinese medicine composition of lung qi dispersing Dingchuan and method for making thereof are applicable to and treat the bronchial asthma of child light outbreak during acute attack clinically that Chinese medical discrimination belongs to cough due to lung-heat person.
Background technology
The full name of asthma is a bronchial asthma, it is bronchial a kind of allergic inflammation, claim chronic inflammatory disease again, cause thus air flue to external world stimulating factor comprise: physical factor such as cold air, strenuous exercise, the abnormal flavour of chemical factor such as flue dust, gasoline and house fitting-up, and the overreaction of viral infection etc., cause the spasm of tracheal smooth muscle, make airway constriction and cause dyspnea symptoms such as asthma, cough, this symptom takes place with the stimulation of extraneous factor, disengage or alleviate through treatment, and outbreak repeatedly, asthma be called.
Asthma is a kind of refractory disease, and protracted course of disease can cause emophysematous generation, produces symptoms such as asthma easily, develop into pulmonary heart disease and respiratory failure at last, be one of respiratory system serious disease, so the early treatment, stoping its development is the key of treatment and prevention.
Use hormone in the western medical treatment, can alleviate clinical symptoms, but one careless slightly, can cause many side effect.Chinese medicine treatment aspect in early days has remarkable advantages, can prevent that as intervening early it from showing effect repeatedly, even not send out for many years.
Summary of the invention
The object of the present invention is to provide a kind of removing heat-phlegm, the lung qi dispersing Dingchuan is used for the treatment of the bronchial asthma of child light outbreak during acute attack, and Chinese medical discrimination belongs to cough due to lung-heat person's Chinese medicine compositions.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
Technical scheme of the present invention is: develop a kind of removing heat-phlegm, the Chinese medicine composition of lung qi dispersing Dingchuan is characterized in that:
(1) by following ten simply medical material form: Herba Ephedrae, Semen Armeniacae Amarum, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, Cortex Mori, Gypsum Fibrosum, Folium Isatidis, Herba Houttuyniae and Radix Glycyrrhizae;
(2) ten simply the part by weight of medical material be:
Each 1.5～9 parts in Herba Ephedrae, Radix Glycyrrhizae; Respectively 2～13 parts of Semen Armeniacae Amarum, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, Cortex Mori; Each 2.5～17 parts of Folium Isatidis, Herba Houttuyniae; 3.5～22 parts in Gypsum Fibrosum.
Above-mentioned removing heat-phlegm, the Chinese medicine composition of lung qi dispersing Dingchuan, it is characterized in that ten simply the part by weight of medical material can also be: each 3～7.5 parts in Herba Ephedrae, Radix Glycyrrhizae; Respectively 4～11 parts of Semen Armeniacae Amarum, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, Cortex Mori; Each 5～15 parts of Folium Isatidis, Herba Houttuyniae; 7～18 parts in Gypsum Fibrosum.
Above-mentioned removing heat-phlegm, the Chinese medicine composition of lung qi dispersing Dingchuan, it is characterized in that ten simply the part by weight of medical material also can be: each 5～7 parts in Herba Ephedrae, Radix Glycyrrhizae; Respectively 7～9.5 parts of Semen Armeniacae Amarum, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, Cortex Mori; Each 9～12 parts of Folium Isatidis, Herba Houttuyniae; 10～15 parts in Gypsum Fibrosum.
Above-mentioned removing heat-phlegm, the method for making of the Chinese medicine composition of lung qi dispersing Dingchuan is characterized in that:
(1) Gypsum Fibrosum elder generation decocting boils once, filters the Gypsum Fibrosum filtrate for later use;
(2) Gypsum Fibrosum medicinal residues and all the other ten flavor medical materials merge, and decocting boils once more, and wherein Semen Raphani, Fructus Perillae, Semen Lepidii (Semen Descurainiae) are decocted a drug wrapped, decoct to finish to filter, and the filtrate of merging, relative density is 1.10～1.20 water cooking liquid clear paste when being concentrated into 60 ℃, and is standby;
(3) go up a water cooking liquid clear paste and add ethanol and contain the alcohol amount to total medicinal liquid and reach 60%～80%, staticly settle, get the supernatant decompression recycling ethanol, and relative density is 1.10～1.20 precipitate with ethanol clear paste when being concentrated into 60 ℃, standby;
(4) go up the merging of a precipitate with ethanol clear paste and Gypsum Fibrosum filtrate, add correctives, antiseptic, stir evenly, left standstill 48 hours, filter, filtrate adds water to the preparation total amount, packing, and sterilization promptly gets oral liquid formulations of the present invention.
Above-mentioned removing heat-phlegm, the another kind of method for making of the Chinese medicine composition of lung qi dispersing Dingchuan is:
(1) above ten medical material merging simply, decocting boils, and wherein Semen Raphani, Fructus Perillae, Semen Lepidii (Semen Descurainiae) are decocted a drug wrapped, decoct to finish to filter, merging filtrate, relative density is 1.10～1.20 water cooking liquid clear paste when being concentrated into 60 ℃, and is standby;
(2) go up a water cooking liquid clear paste and add ethanol and contain the alcohol amount to total medicinal liquid and reach 60%～80%, staticly settle, get the supernatant decompression recycling ethanol, relative density is 1.10～1.20 precipitate with ethanol clear paste when being concentrated into 60 ℃, and is standby;
(3) go up a precipitate with ethanol clear paste, add correctives, antiseptic, stir evenly, leave standstill, filter, filtrate adds water to the preparation total amount, packing, and sterilization promptly gets oral liquid formulations of the present invention.
Above-mentioned removing heat-phlegm, the application of the Chinese medicine composition of lung qi dispersing Dingchuan in oral liquid, granule, powder, capsule or the tablet of preparation treatment bronchial asthma of child.
The traditional Chinese medical science is thought asthma be plain body natural endowment too a little less than, volt in the phlegm retention is met the stimulation of factors such as diseases caused by exogenous pathogenic factor again and a kind of rale asthma class illness of taking place.The history in thousands of years of motherland's medical science has accumulated very rich experience on treatment of asthma, have when sending out to control lung, pay attention to saying of tonification lung spleen kidney at ordinary times.Again asthma is divided into asthma of heat type and asthma of cold-type when outbreak, it is a class asthma of main performance that asthma of heat type is meant with expectorant heat, shows as the sticking difficulty of expectorant and goes out, and red complexion is red; Asthma of cold-type is main performance with the cold fluid-retention, and disease sees that the clear Se Baiyi of expectorant goes out, and sees foam more, and complexion is white all of a sudden.People have increased asthma due to stagnation of phlegm and stasis of blood heavy breathing etc. again on this basis in recent years, make the dialectical abundanter of asthma, but total depressed lung-energy dispersing that be unable to do without is gone up in treatment, and Herba Ephedrae is to control the panacea of breathing heavily, and cooperate removing heat-phlegm, the temperature drink etc. that reduces phlegm on this basis.Children's's Dingchuan oral liquid also is highly suitable for the treatment of asthma of heat type in relieving cough and diminishing inflammation.Paracmastic medical treatment is that the traditional Chinese medical science is emphasized always, and in the control asthma attack, the conditioning of paying attention to lung spleen kidney will be with tonification elder generation day after tomorrow, can adopt and build up one's health by taking tonic and the method for tonic, strengthens or the function of conditioning viscera, makes its functional status in order.Pay attention to the protection to the surrounding factor simultaneously, avoid the contact of pungent, the state that makes respiratory tract often be in fresh air also is crucial.
The control of asthma must early will be accomplished early diagnosis in a word, and early treatment, can not wait until that irreversible variation takes place its pulmonary function, and it is very frequent that asthma is shown effect repeatedly, just lost the first chance of treatment like that.
The present invention is with removing heat-phlegm, and the medicine of lung qi dispersing Dingchuan is used for the treatment of the bronchial asthma of child light outbreak during acute attack, and Chinese medical discrimination belongs to cough due to lung-heat person, and trade name is children's's Dingchuan oral liquid.
Pharmacodynamics of the present invention and toxicological study show that function of the present invention cures mainly and is that removing heat-phlegm, lung qi dispersing Dingchuan are used for lung-heat cough with asthma rale and breathe hard.Pharmacological experiment study proves, the preparation of the present invention obviously medicine of prolonged guinea pig draws and breathes heavily incubation period, and significant whole antiasthmatic effect is arranged; Isolated tracheal smooth muscle is had direct diastole effect, and tracheal smooth muscle is shunk in histamine antagonism; Tangible phlegm-dispelling functions is arranged; The Cavia porcellus electricity irritation drawn coughed obvious antitussive effect; Mouse ear xenogenesis passive anaphylaxis (PCA) there is the obvious suppression effect; Mice delayed hypersensitive reaction due to the DNCB there is obvious antagonism.Effects such as significantly analgesic and antibiotic are arranged, the relievining asthma of children's's Dingchuan oral liquid, antitussive, eliminate the phlegm, effect such as analgesic, antibacterial obviously is better than MAXINGSHIGAN TANG.
Acute toxicity testing shows that preparation 25g/kg of the present invention does not have overt toxicity to mice, mouse peritoneal LD
50Be 63.98g/kg.One month long term toxicity test of oral administration shows, Canis familiaris L. 100g/kg dosage, rat 200g/kg dosage are to the hematology, and blood biochemical is learned and the histopathology of main organs there is no obvious change.
Prove that preparation of the present invention is that a kind of low toxicity, safety, drug effect are definite, quality standard is easy to control, the stability good medicine of relievining asthma preferably.
Four units of participating in the experiment of family that take the lead with Tianjin College of Traditional Chinese Medicine one attached institute, in June, 1997～1998 between year June to preparation clinical studies show of the present invention, the present invention has the effect of removing heat-phlegm, lung qi dispersing Dingchuan, cures mainly infantile asthma asthma of heat type card.
Statistics collection is with children's's Dingchuan oral liquid treatment person 301 examples (comprising open treatment group 100 examples), with contrast medicine relieving cough, relieving asthma oral liquid treatment person 100 examples altogether.
Clinical effectiveness shows that children's's Dingchuan oral liquid has better curative effect to infantile asthma asthma of heat type card, and it is 83.72% that its control shows rate, apparently higher than matched group (p＜0.01).Light-duty, medium-sized, heavy case is all had better curative effect, but the state of an illness is light more, curative effect is good more; Curative effect to different course of disease infants (P＞0.05) about the same.The efficacy analysis result shows that this medical instrument has preferably the effect of only roaring, relieving asthma, and the treatment group is panted, the complete obiteration time of wheezing symptom all obviously shifts to an earlier date than matched group or be significantly shorter than matched group (P＜0.05 or 0.01).To pant, wheezing, cough up phlegm, unusual pulse condition, and infantile asthma asthma of heat type such as heart rate is fast, three depressions sign are demonstrate,proved the treatment disappearance rate of symptom and sign apparently higher than matched group (P＜0.05～0.001), confirmed the effect of this product removing heat-phlegm, lung qi dispersing Dingchuan, obvious superiority has been arranged than contrast medicine relieving cough, relieving asthma oral liquid.
From treating preceding lab index inspection situation, after the treatment, the SERUM IgE that two groups of infants increase unusually, the unusual and X ray examination of blood leukocytes sum unusually all has clear improvement on every side, in the treatment group, unusual person of total white blood cells and non-unusual person's curative effect there was no significant difference (P＞0.05) illustrates that two medicines all have better curative effect to infective asthma and the allergic asthma that shows as the asthma of heat type card.This medicine also has and improves the pulmonary function effect preferably, after the treatment, and the PaO of the infant of treatment group at random
2, SO
2With the PaCO that adds up to treatment group infant
2, SO
2Treatment before and after difference obviously greater than matched group (P＜0.05～0.001), illustrate that children's's Dingchuan oral liquid all is better than contrasting medicine to the improvement effect of blood gas analysis index.After the treatment, two groups of lung function index PEFR are all than obviously raising before the treatment, and still, after taking medicine first, the treatment group is 82.80% to the total effective rate that peak expiratory flow rate (PEFR) improves, apparently higher than matched group (p＜0.05); PEFR average dynamic change situation in the course of treatment, though two groups of gesture that all are rising gradually after treatment, but the 4th day, the 6th day, the 7th day rising amplitude treatment group greater than matched group (p＜0.05), difference illustrates that also all obviously greater than matched group (p＜0.05) children's's Dingchuan oral liquid has the effect that improves asthma infant respiratory function before and after the treatment of treatment group at random and total treatment group PEFR.301 routine treatment group infants remove 3 example exceptions in the observation process, occurs slight nauseating outside, all do not find poisonous, the side reaction of medicine.Routine blood test, routine urinalysis, stool routine examination, electrocardiogram and hepatic and renal function index detect does not find the abnormal change relevant with medicine yet, tentatively demonstrates the security reliability of this medicine clinical practice.
The clinical test results of children's's Dingchuan oral liquid shows, children's's Dingchuan oral liquid is 97.01% to the total effective rate of test disease, to roar toot, the extinction time of panting is significantly shorter than matched group, to pant, wheezing, cough up phlegm and the treatment disappearance rate of unusual body of the tongue, tongue fur, pulse condition also apparently higher than matched group, embodied the treatment characteristics of children's's Dingchuan oral liquid, do not had obvious toxic and side effects, met safe and effective principle infantile asthma asthma of heat type card, and mouthfeel is better, taking convenience.
Manufactured goods: the every ml of liquid dosage form is equivalent to medical material 1.005g and (takes 10～20ml) at every turn; Per 4～the 6g of solid dosage forms is equivalent to medical material 10.05g and (takes 4～12g) at every turn; Every weight 0.20～0.35g during tablet, every is equivalent to medical material 3.35g (at every turn taking 3～6).Every capsules weight 0.30～0.40g is equivalent to medical material 3.35g (at every turn taking 3～6) during capsule.
Removing heat-phlegm of the present invention, the application of the Chinese medicinal composition preparation of lung qi dispersing Dingchuan, also comprise can be used as and treat the bronchial asthma of child light outbreak during acute attack clinically, Chinese medical discrimination belongs to cough due to lung-heat person's dosage forms such as oral liquid, granule, powder, capsule or tablet.
The specific embodiment:
Embodiment 1 preparation oral liquid
The used medical material of the present invention is:
Herba Ephedrae (Herba EPhedrae), Radix Glycyrrhizae (Radix Glycyrrhizae), Semen Armeniacae Amarum (SemenArmeniacae Amarum), Semen Raphani (Semen Raphani), Semen Lepidii (Semen Descurainiae) (Semen Lepidii; SemenDescurainiae), Fructus Perillae (Fructus Perillae), Radix Scutellariae (Radix Scutellariae), Cortex Mori (Cortex Mori), Folium Isatidis (Folium Isatidis), Herba Houttuyniae (Herba Houttuyniae), Gypsum Fibrosum (Gypsum Fibrosum).
Medical material proportioning (part by weight):
Herba Ephedrae, each 600g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 850g of Cortex Mori; Folium Isatidis, each 1150g of Herba Houttuyniae; Gypsum Fibrosum 1450g.
Method for making: above ten simply, gets Gypsum Fibrosum and decoct with water 1.5 hours, filters filtrate for later use; Medicinal residues and all the other Herba Ephedraes etc. ten flavor (Semen Raphani wherein, Fructus Perillae, Semen Lepidii (Semen Descurainiae) is decocted a drug wrapped) decoct with water secondary, each 1.5 hours, filter merging filtrate, being concentrated into relative density is the clear paste of 1.10～1.20 (60 ℃), put coldly, add ethanol and make and contain alcohol amount and reach 60%～80%, staticly settle, get the supernatant decompression recycling ethanol, and be concentrated into the precipitate with ethanol clear paste that relative density is 1.10～1.20 (60 ℃), and merge with Gypsum Fibrosum filtrate, add Mel 300g, benzoic acid is received 2g, it is an amount of to add water, stir evenly, leave standstill, filter, filtrate adds water to 1000ml, packing, sterilization promptly gets oral liquid.
This example preparation specification is the oral liquid of 10ml, and every ml is equivalent to medical material 1.005g; Oral, 3 times on the 1st, each 10～20ml.
Embodiment 2 preparation oral liquids
Medical material proportioning (part by weight):
Herba Ephedrae, each 700g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 950g of Cortex Mori; Folium Isatidis, each 1200g of Herba Houttuyniae; Gypsum Fibrosum 1500g; All the other are with embodiment 1.
Embodiment 3 preparation oral liquids
Medical material proportioning (part by weight):
Herba Ephedrae, each 500g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 700g of Cortex Mori; Folium Isatidis, each 900g of Herba Houttuyniae; Gypsum Fibrosum 1000g;
Method for making:
More than ten simply medical material merge, decocting boils, wherein Semen Raphani, Fructus Perillae, Semen Lepidii (Semen Descurainiae) are decocted a drug wrapped, decoct to finish to filter, merging filtrate, relative density is 1.10～1.20 water cooking liquid clear paste when being concentrated into 60 ℃, and is standby;
Last water cooking liquid clear paste adds ethanol and contains the alcohol amount to total medicinal liquid and reach 60%～80%, staticly settles, and gets the supernatant decompression recycling ethanol, and relative density is 1.10～1.20 precipitate with ethanol clear paste when being concentrated into 60 ℃, and is standby;
Last precipitate with ethanol clear paste adds correctives, antiseptic, stirs evenly, and leaves standstill, and filters, and filtrate adds water to the preparation total amount, packing, and sterilization promptly gets oral liquid formulations of the present invention.All the other are with embodiment 1.
Embodiment 4 preparation granules
Medical material proportioning (part by weight):
Herba Ephedrae, each 600g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 850g of Cortex Mori; Folium Isatidis, each 1150g of Herba Houttuyniae; Gypsum Fibrosum 1450g.
More than ten simply, get Gypsum Fibrosum and decoct with water 1.5 hours, filter filtrate for later use; Medicinal residues and all the other Herba Ephedraes etc. ten flavor (Semen Raphani wherein, Fructus Perillae, Semen Lepidii (Semen Descurainiae) binds up with gauze with multilamellar) decoct with water secondary, each 1.5 hours, filter, merging filtrate, being concentrated into relative density is the clear paste of 1.10～1.20 (60 ℃), puts cold, adding ethanol makes and contains alcohol amount and reach 60%～80%, staticly settle, get the supernatant decompression recycling ethanol, merge with Gypsum Fibrosum filtrate, and be concentrated into the extractum that relative density is 1.10～1.20 (60 ℃), microwave drying (wavelength 122.5 ± 2.5mm, frequency 2450 ± 50MHz) is ground into fine powder, add excipient (beta-schardinger dextrin-, starch, sorbitol, lactose etc.), mixing granulation, granulate, packing can make sugar-free (sugar is arranged) granule.
Per 4～6g is equivalent to medical material 10.05g; Dose 3 times on the 1st, each 4～12g.
All the other are with embodiment 1.
Embodiment 5 preparation granules
Medical material proportioning (part by weight):
Herba Ephedrae, each 900g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 1300g of Cortex Mori; Folium Isatidis, each 1700g of Herba Houttuyniae; Gypsum Fibrosum 2200g.All the other are with embodiment 4.
Embodiment 6 preparation granules
Herba Ephedrae, each 150g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 200g of Cortex Mori; Folium Isatidis, each 250g of Herba Houttuyniae; Gypsum Fibrosum 350g.
Method for making:
More than ten simply medical material merge, decocting boils, wherein Semen Raphani, Fructus Perillae, Semen Lepidii (Semen Descurainiae) are decocted a drug wrapped, decoct to finish to filter, merging filtrate, relative density is 1.10～1.20 water cooking liquid clear paste when being concentrated into 60 ℃, and is standby;
Last water cooking liquid clear paste adds ethanol and contains the alcohol amount to total medicinal liquid and reach 60%～80%, staticly settles, and gets the supernatant decompression recycling ethanol, and relative density is 1.10～1.20 precipitate with ethanol clear paste when being concentrated into 60 ℃, and is standby;
Last precipitate with ethanol clear paste, and microwave drying (wavelength 122.5 ± 2.5mm, frequency 2450 ± 50MHz) is ground into fine powder, adds excipient (beta-schardinger dextrin-, starch, sorbitol, lactose etc.), mixing granulation, granulate, packing can make sugar-free (sugar is arranged) granule.All the other are with embodiment 4.
Embodiment 7 preparation powders
Medical material proportioning (part by weight):
Herba Ephedrae, each 600g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 850g of Cortex Mori; Folium Isatidis, each 1150g of Herba Houttuyniae; Gypsum Fibrosum 1450g.
More than ten simply, get Gypsum Fibrosum and decoct with water 1.5 hours, filter filtrate for later use; Medicinal residues and all the other Herba Ephedraes etc. ten flavor (Semen Raphani wherein, Fructus Perillae, Semen Lepidii (Semen Descurainiae) is decocted a drug wrapped) decoct with water secondary, each 1.5 hours, filter, merging filtrate, being concentrated into relative density is the clear paste of 1.10～1.20 (60 ℃), puts cold, adding ethanol makes and contains alcohol amount and reach 60%～80%, staticly settle, get the supernatant decompression recycling ethanol, merge with Gypsum Fibrosum filtrate, and be concentrated into the extractum that relative density is 1.10～1.20 (60 ℃), (wavelength 122.5 ± 2.5mm, frequency 2450 ± 50MHz) are ground into 100～200 order fine powders to microwave drying, sieve, mixing, packing, quality inspection, packing.Can make powder.
Per 4～6g is equivalent to medical material 10.05g; Dose 3 times on the 1st, each 4～12g.
All the other are with embodiment 1.
Embodiment 8 preparation powders
Medical material proportioning (part by weight):
Herba Ephedrae, each 750g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 1100g of Cortex Mori; Folium Isatidis, each 150g of Herba Houttuyniae; Gypsum Fibrosum 1800g;
Method for making:
More than ten simply medical material merge, decocting boils, wherein Semen Raphani, Fructus Perillae, Semen Lepidii (Semen Descurainiae) are decocted a drug wrapped, decoct to finish to filter, merging filtrate, relative density is 1.10～1.20 water cooking liquid clear paste when being concentrated into 60 ℃, and is standby;
Last water cooking liquid clear paste adds ethanol and contains the alcohol amount to total medicinal liquid and reach 60%～80%, staticly settles, and gets the supernatant decompression recycling ethanol, and relative density is 1.10～1.20 precipitate with ethanol clear paste when being concentrated into 60 ℃, and is standby;
Last precipitate with ethanol clear paste, (wavelength 122.5 ± 2.5mm, frequency 2450 ± 50MHz) are ground into 100～200 order fine powders to microwave drying, sieve mixing, packing, quality inspection, packing.Can make powder.
All the other are with embodiment 7.
Embodiment 9
Medical material proportioning (part by weight):
Herba Ephedrae, each 300g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, Cortex Mori
Each 400g of skin; Folium Isatidis, each 500g of Herba Houttuyniae; Gypsum Fibrosum 700g; All the other are with embodiment 7.
Embodiment 10 preparation tablets
Medical material proportioning (part by weight):
Herba Ephedrae, each 600g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 850g of Cortex Mori; Folium Isatidis, each 1150g of Herba Houttuyniae; Gypsum Fibrosum 1450g.
Method for making: above ten simply, gets Gypsum Fibrosum and decoct with water 1.5 hours, filters filtrate for later use; Medicinal residues and all the other Herba Ephedraes etc. ten flavor (Semen Raphani wherein, Fructus Perillae, Semen Lepidii (Semen Descurainiae) is decocted a drug wrapped) decoct with water secondary, each 1.5 hours, filter merging filtrate, being concentrated into relative density is the clear paste of 1.10～1.20 (60 ℃), put coldly, add ethanol and make and contain alcohol amount and reach 60%～80%, staticly settle, get the supernatant decompression recycling ethanol, merge with Gypsum Fibrosum filtrate, and be concentrated into the extractum that relative density is 1.10～1.20 (60 ℃), microwave drying (wavelength 122.5 ± 2.5mm, frequency 2450 ± 50MHz), be ground into 100～200 order fine powders,, sieve, granulate after adding excipient, granulate, tabletting can make tablet behind the coating.
Every is equivalent to medical material 3.35g; Dose 3 times on the 1st, each 3～6.All the other are with embodiment 1.
Embodiment 11 preparation tablets
Medical material proportioning (part by weight):
Herba Ephedrae, each 700g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 950g of Cortex Mori; Folium Isatidis, each 1200g of Herba Houttuyniae; Gypsum Fibrosum 1500g;
Method for making:
More than ten simply medical material merge, decocting boils, wherein Semen Raphani, Fructus Perillae, Semen Lepidii (Semen Descurainiae) are decocted a drug wrapped, decoct to finish to filter, merging filtrate, relative density is 1.10～1.20 water cooking liquid clear paste when being concentrated into 60 ℃, and is standby;
Last water cooking liquid clear paste adds ethanol and contains the alcohol amount to total medicinal liquid and reach 60%～80%, staticly settles, and gets the supernatant decompression recycling ethanol, and relative density is 1.10～1.20 precipitate with ethanol clear paste when being concentrated into 60 ℃, and is standby;
Last precipitate with ethanol clear paste, and microwave drying (wavelength 122.5 ± 2.5mm, frequency 2450 ± 50MHz) are ground into 100～200 order fine powders, sieve, granulate behind the adding excipient, and granulate, tabletting can make tablet behind the coating.All the other are with embodiment 10.
Embodiment 12 preparation tablets
Medical material proportioning (part by weight):
Herba Ephedrae, each 500g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 700g of Cortex Mori; Folium Isatidis, each 900g of Herba Houttuyniae; Gypsum Fibrosum 1000g; All the other are with embodiment 10.
Embodiment 13 preparation capsules
Medical material proportioning (part by weight):
Herba Ephedrae, each 600g of Radix Glycyrrhizae; Semen Armeniacae Amarum (stir-fry), Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 850g of Cortex Mori; Folium Isatidis, each 1150g of Herba Houttuyniae; Gypsum Fibrosum 1450g.
Method for making:
More than ten simply medical material merge, decoct with water secondary, each 1.5 hours, wherein Semen Raphani, Fructus Perillae, Semen Lepidii (Semen Descurainiae) are decocted a drug wrapped, decoct to finish and filter, merging filtrate, being concentrated into relative density is the clear paste of 1.10～1.20 (60 ℃), put cold, add ethanol and contain the alcohol amount to total medicinal liquid and reach 60%～80%, staticly settle, get the supernatant decompression recycling ethanol, be concentrated into relative density and be the precipitate with ethanol clear paste of 1.10～1.20 (60 ℃), standby;
Last precipitate with ethanol clear paste, and microwave drying (wavelength 122.5 ± 2.5mm, frequency 2450 ± 50MHz) are ground into 100～200 order fine powders, sieve, and mixing, encapsulated, packing.Can make capsule.
Every is equivalent to medical material 3.35g; Dose 3 times on the 1st, each 3～6.
Embodiment 13 preparation capsules
Herba Ephedrae, each 700g of Radix Glycyrrhizae; Semen Armeniacae Amarum, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 950g of Cortex Mori; Folium Isatidis, each 1200g of Herba Houttuyniae; Gypsum Fibrosum 1500g; All the other are with embodiment 12.
Embodiment 14 preparation capsules
Herba Ephedrae, each 500g of Radix Glycyrrhizae; Semen Armeniacae Amarum, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, each 700g of Cortex Mori; Folium Isatidis, each 900g of Herba Houttuyniae; Gypsum Fibrosum 1000g;
Method for making: above ten simply, gets Gypsum Fibrosum and decoct with water 1.5 hours, filters filtrate for later use; Medicinal residues and all the other Herba Ephedraes etc. ten flavor (Semen Raphani wherein, Fructus Perillae, Semen Lepidii (Semen Descurainiae) is decocted a drug wrapped) decoct with water secondary, each 1.5 hours, filter merging filtrate, being concentrated into relative density is the clear paste of 1.10～1.20 (60 ℃), put coldly, add ethanol and make and contain alcohol amount and reach 60%～80%, staticly settle, get the supernatant decompression recycling ethanol, and be concentrated into the precipitate with ethanol clear paste that relative density is 1.10～1.20 (60 ℃), and merge with Gypsum Fibrosum filtrate, add Mel 300g, benzoic acid is received 2g, it is an amount of to add water, stir evenly, leave standstill, filter, filtrate adds water to 1000ml, packing, sterilization promptly gets oral liquid.All the other are with embodiment 13.
Claims (6)
1. removing heat-phlegm, the Chinese medicine composition of lung qi dispersing Dingchuan is characterized in that:
(1) by following ten simply medical material form: Herba Ephedrae, Semen Armeniacae Amarum, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, Cortex Mori, Gypsum Fibrosum, Folium Isatidis, Herba Houttuyniae and Radix Glycyrrhizae;
(2) ten simply the part by weight of medical material be:
Each 1.5～9 parts in Herba Ephedrae, Radix Glycyrrhizae; Respectively 2～13 parts of Semen Armeniacae Amarum, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, Cortex Mori; Each 2.5～17 parts of Folium Isatidis, Herba Houttuyniae; 3.5～22 parts in Gypsum Fibrosum.
2. according to the described removing heat-phlegm of claim 1, the Chinese medicine composition of lung qi dispersing Dingchuan, it is characterized in that ten simply the part by weight of medical material be:
Each 3～7.5 parts in Herba Ephedrae, Radix Glycyrrhizae; Respectively 4～11 parts of Semen Armeniacae Amarum, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, Cortex Mori; Each 5～15 parts of Folium Isatidis, Herba Houttuyniae; 7～18 parts in Gypsum Fibrosum.
3. according to the described removing heat-phlegm of claim 1, the Chinese medicine composition of lung qi dispersing Dingchuan, it is characterized in that ten simply the part by weight of medical material be:
Each 5～7 parts in Herba Ephedrae, Radix Glycyrrhizae; Respectively 7～9.5 parts of Semen Armeniacae Amarum, Semen Raphani, Semen Lepidii (Semen Descurainiae), Fructus Perillae, Radix Scutellariae, Cortex Mori; Each 9～12 parts of Folium Isatidis, Herba Houttuyniae; 10～15 parts in Gypsum Fibrosum.
4. according to claim 1,2 or 3 described removing heat-phlegm, the method for making of the Chinese medicine composition of lung qi dispersing Dingchuan is characterized in that:
(1) Gypsum Fibrosum elder generation decocting boils once, filters the Gypsum Fibrosum filtrate for later use;
(2) Gypsum Fibrosum medicinal residues and all the other ten flavor medical materials merge, and decocting boils once more, and wherein Semen Raphani, Fructus Perillae, Semen Lepidii (Semen Descurainiae) are decocted a drug wrapped, decoct to finish to filter, and merging filtrate, relative density is 1.10～1.20 water cooking liquid clear paste when being concentrated into 60 ℃, and is standby;
(3) go up a water cooking liquid clear paste and add ethanol and contain the alcohol amount to total medicinal liquid and reach 60%～80%, staticly settle, get the supernatant decompression recycling ethanol, and relative density is 1.10～1.20 precipitate with ethanol clear paste when being concentrated into 60 ℃, standby;
(4) go up the merging of a precipitate with ethanol clear paste and Gypsum Fibrosum filtrate, add correctives, antiseptic, stir evenly, leave standstill, filter, filtrate adds water to the preparation total amount, packing, and sterilization promptly gets oral liquid formulations of the present invention.
5. according to claim 1,2 or 3 described removing heat-phlegm, the method for making of the Chinese medicine composition of lung qi dispersing Dingchuan is characterized in that:
(1) above ten medical material merging simply, decocting boils, and wherein Semen Raphani, Fructus Perillae, Semen Lepidii (Semen Descurainiae) are decocted a drug wrapped, decoct to finish to filter, merging filtrate, relative density is 1.10～1.20 water cooking liquid clear paste when being concentrated into 60 ℃, and is standby;
(2) go up a water cooking liquid clear paste and add ethanol and contain the alcohol amount to total medicinal liquid and reach 60%～80%, staticly settle, get the supernatant decompression recycling ethanol, relative density is 1.10～1.20 precipitate with ethanol clear paste when being concentrated into 60 ℃, and is standby;
(3) go up a precipitate with ethanol clear paste, add correctives, antiseptic, stir evenly, leave standstill, filter, filtrate adds water to the preparation total amount, packing, and sterilization promptly gets oral liquid formulations of the present invention.
6. according to claim 1,2 or 3 described removing heat-phlegm, the application of the Chinese medicine composition of lung qi dispersing Dingchuan in oral liquid, granule, powder, capsule or the tablet of preparation treatment bronchial asthma of child.
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| CNB2005100127380A CN1320902C (en) | 2005-08-12 | 2005-08-12 | Chinese medicinal composition for clearing heat, dispersing phlegm, ventilating the lung and relieving asthma and process for preparing the same |
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| CNB2005100127380A CN1320902C (en) | 2005-08-12 | 2005-08-12 | Chinese medicinal composition for clearing heat, dispersing phlegm, ventilating the lung and relieving asthma and process for preparing the same |
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| CN103585499A (en) * | 2013-10-23 | 2014-02-19 | 北京博爱旺康医药科技有限公司 | Chinese medicinal composition for clearing lung and eliminating phlegm as well as preparation method and application thereof |
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| CN104721388B (en) * | 2014-12-02 | 2019-04-05 | 首都医科大学附属北京地坛医院 | The Chinese medicine composition and its preparation method and application for treating people at highest risk's influenza severe |
| CN104771621B (en) * | 2015-03-24 | 2018-07-13 | 首都医科大学附属北京友谊医院 | A kind of Chinese prescription that treating cough and asthma, preparation method and applications |
| CN104771621A (en) * | 2015-03-24 | 2015-07-15 | 首都医科大学附属北京友谊医院 | Chinese medicinal prescription for treating cough and asthma, preparation method and application thereof |
| CN113876854A (en) * | 2021-10-25 | 2022-01-04 | 荣昌制药(淄博)有限公司 | Application of Chinese medicinal composition for ventilating lung and relieving asthma in preparation of HIV (human immunodeficiency virus) inhibiting medicament |
| CN115487265A (en) * | 2022-11-01 | 2022-12-20 | 王雪峰 | Traditional Chinese medicine composition for treating children community acquired pneumonia and particle preparation method |
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