CN1732978A - Externally applied medicine for treating vitiligo and its preparation process - Google Patents
Externally applied medicine for treating vitiligo and its preparation process Download PDFInfo
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- CN1732978A CN1732978A CN 200510093749 CN200510093749A CN1732978A CN 1732978 A CN1732978 A CN 1732978A CN 200510093749 CN200510093749 CN 200510093749 CN 200510093749 A CN200510093749 A CN 200510093749A CN 1732978 A CN1732978 A CN 1732978A
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Abstract
The invention relates to an externally applied medicine for treating vitiligo and its preparation process, wherein the externally used medicament is prepared from acetic acid, 2-hydroxybenzoic acid, bluestone, ferrous sulfate and iron rust through immersion.
Description
Technical field
The present invention relates to treat dermopathic external used medicine, particularly a kind of treatment leucoderma disease external used medicine and manufacture method thereof.
Background technology
Vitiligo is a kind of common skin disease, and is commonplace, and it is wide to distribute, and sickness rate accounts for world population about 7/1000ths, and it is on the rise to fall ill in recent years, is the difficult pertinacious disease of a kind of department of dermatologry of generally acknowledging both at home and abroad.Though current this sick method of treatment and medicine are a lot, can not reach desirable curative effect, for example, Therapeutic Method such as " ultraviolet therapy ", " BAIDIANJING " medicine are weak curative effect, slow, the shortcoming such as the treatment phase is long that takes effect not only, and also has side effect in various degree.
Summary of the invention
The objective of the invention is to overcome above-mentioned the deficiencies in the prior art, provide a kind of and study intensively exploitation and long-term clinical practice for many years and the new prescription that obtains through the inventor, it has, and instant effect, treatment phase are short, effective percentage and cure rate height, easy to use, a kind of treatment leucoderma disease external used medicine (black whirlwind) and the manufacture method thereof that have no side effect.
A kind of treatment leucoderma disease external used medicine provided by the invention (black whirlwind), make with extra care and form through immersion, filtration by the component of following weight portion proportioning:
Acetic acid 4-10 salicylic acid 0.9-4 Chalcanthitum 0.6-4
Ferrous sulfate 0.8-4 rust 0.6-4.
The weight portion proportion optimization of treatment leucoderma disease external used medicine component provided by the invention is:
Acetic acid 4-6 salicylic acid 0.9-1.2 Chalcanthitum 0.9-1.2
Ferrous sulfate 0.9-1.2 rust 0.9-1.2.
The weight portion proportioning of treatment leucoderma disease external used medicine component provided by the invention is more preferably:
Acetic acid 5 salicylic acid 1 Chalcanthitum 1
Ferrous sulfate 1 rust 1.
In leucoderma disease external used medicine provided by the invention, described acetic acid is acetic acid neat liquid or glacial acetic acid, and its consumption is the 4-10 weight portion, is preferably the 4-6 weight portion, more preferably 5 weight portions.Described Chalcanthitum is general popular name, chemistry copper sulfate pentahydrate by name, and its consumption is the 4-10 weight portion, is preferably the 4-6 weight portion.5 weight more preferably.
Described rust be well-known ferrum in natural environment under humid air, producing various subcarbonates through the corrosiveness of complexity is the Main Ingredients and Appearance complex mixture, claims rust, and its consumption is the 0.5-4 weight portion, be preferably the 0.9-1.2 weight portion, more preferably 1.0 weight portions.
In treatment leucoderma disease external used medicine of the present invention:
Chalcanthitum, ferrous sulfate increase melanin, strengthen body immunity.The salicylic acid dredge the meridian passage is changed blood stasis.The rust heat-clearing and toxic substances removing.Acetic acid induces sweat, draw all medicines return through.
Full side's compatibility is reasonable, impels mutually, refinforce each other, and a usefulness each other, thus promote to have improved drug effect.
The manufacture method of treatment leucoderma disease external used medicine provided by the invention comprises the following steps:
(1) soaks extraction
Acetic acid, salicylic acid, Chalcanthitum, ferrous sulfate, rust by the above-mentioned weight portion proportioning mixing in aseptic container such as the glass jar of packing into, after the sealing, were placed ventilating and cooling place 5-20 days, take out medicinal liquid.
(2) filter extraction
Medicinal liquid with above-mentioned (1) obtains is filtered into pure medicinal liquid under gnotobasis.
(3) fill
The pure medicinal liquid that above-mentioned steps (2) is obtained carries out fill one-tenth as in the 10-100 milliliter bottle with filling apparatus, and the sealing bottleneck places the ventilating and cooling place to preserve.
In the manufacture method according to treatment leucoderma disease external used medicine provided by the invention, described step (1) is soaked and is extracted, be for example soaking of generally adopting of this area with glass jar or ceramic pot or cylinder, its immersion process, also be that the described soak time of known communication method using common does not have strict regulations, but unsuitable long or very little, consider and thoroughly pharmaceutical compositions to be soaked or dissolving extract, general immersion 5-20 days, preferred 15 days.Filter described in the described step (2) (3) and filling apparatus can be with commercially available equipment known in the art, its working procedure also is known conventional method.
The characteristics of treatment leucoderma disease external used medicine provided by the invention are:
1, have consolidate, blood circulation promoting and blood stasis dispelling, the effect of dredge the meridian passage, heat-clearing and toxic substances removing, quick microcirculation improvement, enhancing immunity promotes the skin pigment regeneration function.
2, curative effect is fast, the treatment time limit is short, curative effect is high.Have no side effect, easy to use, the medicine valency is cheap, the practical value height.
(1)
The specific embodiment
The present invention further specifies the present invention with the following example, but protection scope of the present invention is not limited to embodiment.
Embodiment 1
Acetic acid, salicylic acid, Chalcanthitum, ferrous sulfate, rust packed into by weight in the table 1 soaked 15 days in the glass jar, under gnotobasis, " medicinal liquid " that soaks is filtered into " clean pure medicinal liquid " with commercially available filter plant.7.2 kilograms of " the clean pure medicinal liquids " that obtains, fill becomes in 10 milliliters of bottles then, the shady and cool preservation.
Embodiment 2
Embodiment 2 manufacturing steps are identical with the step of embodiment 1, and different is its consumption is shown in (embodiment 2) in the table 1, and " the clean pure medicinal liquid " that wherein obtain is 6.08 kilograms.
Embodiment 3
It is identical with the step of embodiment 1 to implement 3 manufacturing steps, and different is that its consumption is shown in (embodiment 3) in the table 1." the clean pure medicinal liquid " that wherein obtain is 20.8 kilograms.
Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| Acetic acid solution (kilogram) | 5 | 4 | 10 |
| Salicylic acid (kilogram) | 1 | 0.9 | 4 |
| Chalcanthitum (kilogram) | 1 | 0.9 | 4 |
| Ferrous sulfate (kilogram) | 1 | 0.9 | 4 |
| Rust (kilogram) | 1 | 0.9 | 4 |
| The clean pure medicinal liquid (kilogram) that obtains | 7.2 | 6.08 | 20.8 |
Clinical observation result by the curative effect of medication of treatment leucoderma disease external used medicine provided by the invention is as follows:
From year March in March, 2000 to 2005 whole nation the 69 training disease research institute, Hebei province Dingzhou City vitiligo hospital, river shape economize Dingzhou City dermatosis hospital and use treatment leucoderma disease external used medicine provided by the invention (black whirlwind) treatment leucoderma disease clinical observation on the therapeutic effect to be summarized as follows:
Clinical observation on the therapeutic effect
From black whirlwind Drug therapy leucoderma disease 360 examples of three tame large hospital uses in year March in March, 2000 to 2005
| The case history number | Sex | Number | Each age group (year) | Symptom before going to a doctor | Therapeutic effect | Mean age | The mean treatment natural law | |||||
| The initial stage number | Mid-term number | The later stage number | Effective transference cure 36-69% | Produce effects transference cure 70-94% | Cure transference cure 95-99% | Invalid transference cure is below 35% | ||||||
| 72 | The man | 30 | 10-19 | 50 | 12 | 10 | 2 | 4 | 65 | 1 | ||
| The woman | 42 | |||||||||||
| 118 | The man | 50 | 20-29 | 68 | 26 | 24 | 10 | 19 | 86 | 3 | ||
| The woman | 68 | |||||||||||
| 83 | The man | 39 | 30-39 | 33 | 39 | 11 | 12 | 19 | 50 | 2 | ||
| The woman | 44 | |||||||||||
| 38 | The man | 18 | 40-49 | 12 | 10 | 16 | 2 | 8 | 25 | 3 | ||
| The woman | 20 | |||||||||||
| 28 | The man | 12 | 50-59 | 5 | 7 | 16 | 6 | 13 | 6 | 3 | ||
| The woman | 16 | |||||||||||
| 13 | The man | 6 | 60-69 | 1 | 2 | 10 | 3 | 5 | 1 | 4 | ||
| The woman | 7 | |||||||||||
| 8 | The man | 4 | 70-79 | 3 | 5 | 1 | 1 | 6 | ||||
| The woman | 4 | |||||||||||
| The man | 80-89 | |||||||||||
| The woman | ||||||||||||
| Add up to 360 | The man | 159 | 36 | 69 | 233 | 22 | ||||||
| The woman | ||||||||||||
The state of an illness is followed up a case by regular visits to: follow up a case by regular visits to case in 180 days and follow up a case by regular visits to case in 100 360 days and follow up a case by regular visits to case 100 after 160 three years
Curative effect: through the statistical procedures (person in charge of statistics of statistical unit Hebei province Dingzhou City statistics bureau: the king)
Effective percentage is that 93.8% ± 2.6 treatment rate is 26.8 years old 64.7% ± 7.5 mean age mean treatment natural law 389.6 days
Above-listed external used medicine of the present invention the effect evaluation criteria as follows:
(1) effective: transference cure 36-63% is assessed as effectively.
(2) produce effects: transference cure 70-94% is assessed as produce effects.
(3) cure: transference cure 95-99% is assessed as healing.
(4) invalid: it is invalid that transference cure is assessed as below 36%.
Two groups of therapeutic effect observations in Hebei province Dingzhou City vitiligo hospital year June in June, 2003 to 2004 and other results are as follows:
(1) two group of using method and medicine are respectively the treatment group and use " black whirlwind " external used medicine.Wipe once every day, uses according to quantity at every turn.Matched group uses " BAIDIANJING " tincture external used medicine.Wipe once every day, uses according to quantity at every turn.
(2) observe the course of treatment, two groups was to observe 12 courses of treatment continuously a course of treatment with 30 days all.
The clinical efficacy controlled observation
The treatment group:
From day to 2004 in June, 2003 year black whirlwind Drug therapy leucoderma disease 21 examples of Hebei province's Dingzhou City vitiligo hospital use in June
| The case history number | Sex | Number | Each age group (year) | Symptom before going to a doctor | Therapeutic effect | Mean age | The mean treatment natural law | |||||
| The initial stage number | Mid-term number | The later stage number | Effective transference cure 36-69% | Produce effects transference cure 70-94% | Cure transference cure 95-99% | Invalid transference cure is below 35% | ||||||
| The man | 10-19 | |||||||||||
| The woman | ||||||||||||
| 21 | The man | 11 | 20-29 | 1 | 3 | 17 | 2 | 4 | 13 | 2 | 26.6 | 386.3 |
| The woman | 10 | |||||||||||
| The man | 30- 39 | |||||||||||
| The woman | ||||||||||||
| Add up to | 2 | 4 | 13 | 3863 | ||||||||
Effective percentage is that 90.5% ± 2.6 treatment rate is 26.6 years old 61.9% ± 7.1 mean age mean treatment natural law 386.3 days.
Matched group:
From day to 2004 in June, 2003 year Hebei province's Dingzhou City vitiligo hospital use in June BAIDIANJING Drug therapy leucoderma disease 21 examples
| The case history number | Sex | Number | Each age group (year) | Symptom before going to a doctor | Therapeutic effect | Mean age | The mean treatment natural law | |||||
| The initial stage number | Mid-term number | The later stage number | Effective transference cure 36-69% | Produce effects transference cure 70-94% | Cure transference cure 95-99% | Invalid transference cure is below 35% | ||||||
| The man | 10-19 | |||||||||||
| The woman | ||||||||||||
| 21 | The man | 11 | 20-29 | 1 | 3 | 17 | 1 | 3 | 9 | 8 | 26.3 | 568.6 |
| The woman | 10 | |||||||||||
| The man | 30- 39 | |||||||||||
| The woman | ||||||||||||
| Add up to | ||||||||||||
Effective percentage is that 61.9% ± 1.8 treatment rate is 26.3 years old 42.8% ± 4.9 mean age mean treatment natural law 568.6 days.
It is as follows that Hebei province Dingzhou City vitiligo hospital carries out two groups of comparative results:
Treatment group and matched group are one group of 7 people, 3 groups of each minutes.Case source: successively arrange by patient's prescription on individual diagnosis order, distribute two groups successively.
(1) treatment group: effective percentage is that 90.5% ± 2.6 treatment rate is 26.6 years old 61.9% ± 7.1 mean age mean treatment natural law 386.3 days.
(2) matched group: effective percentage is that 61.9% ± 1.8 treatment rate is 26.3 years old 42.8% ± 4.9 mean age mean treatment natural law 568.6 days.
Treatment is organized in 21 cases: male's 11 examples wherein, and women's 10 examples, the age is at 20-29 between year, 26.6 years old mean age.In matched group 21 cases: male's 11 examples wherein, women's 10 examples, the age is at 20-29 between year, 26.3 years old mean age.
According to male, women and the two groups of mean aves before above two groups of treatments, average period of disease, average disease symptom, by these four analyses before going to a doctor, difference does not have the significance meaning between two groups, and it is more reasonable, balanced to illustrate that grouping is controlled in this examination, has neat same comparability.
Two groups of data contrast efficacy analysis:
The effective percentage of treatment group, cure rate are apparently higher than matched group, and the treatment group treatment phase is short, effect is fast.Two groups of differences all have the significance meaning.Clinical observation shows: treatment group effective percentage is higher than matched group 28.6, and treatment group cure rate is higher than matched group 19.1.The treatment group mean treatment phase was lower than matched group 182.3 days, and the treatment group does not have the side effect of appearance, and matched group has 3 examples side effect to occur.
The result shows: observe through three tame hospital clinicals and sum up, " black whirlwind " external medication leucoderma disease has and consolidates, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, the effect of heat-clearing and toxic substances removing, microcirculation improvement fast, enhancing immunity.Promote the skin pigment regeneration function.Its advantage: curative effect is fast, the treatment phase is short, curative effect is high.Have no side effect, easy to use, the medicine valency is cheap, the practical value height.
Claims (4)
1, a kind of treatment leucoderma disease external used medicine is characterized in that being formed through soaking, filter to make with extra care by following component weight portion proportioning:
Acetic acid 4-10 salicylic acid 0.9-4 Chalcanthitum 0.6-4
Ferrous sulfate 0.8-4 rust 0.5-4.
2,, it is characterized in that described component weight portion proportioning is according to the treatment leucoderma disease external used medicine of claim 1
Acetic acid 4-6 salicylic acid 0.9-1.2 Chalcanthitum 0.9-1.2
Ferrous sulfate 0.9-1.2 rust 0.9-1.2.
3,, it is characterized in that described component weight portion proportioning is according to the treatment leucoderma disease external used medicine of claim 1
Acetic acid 5 salicylic acid 1 Chalcanthitum 1
Ferrous sulfate 1 rust 1.
4, according to the manufacture method of arbitrary treatment leucoderma disease external used medicine of claim 1-3, comprise the following steps:
(1) soaks extraction
Acetic acid, salicylic acid, Chalcanthitum, ferrous sulfate, rust by its weight portion mixing in the aseptic container of packing into, after the sealing, were placed ventilating and cooling place 5-20 days, take out medicinal liquid;
(2) filter extraction
Medicinal liquid with above-mentioned (1) obtains is filtered into pure medicinal liquid under gnotobasis;
(3) fill
The pure medicinal liquid that above-mentioned steps (2) is obtained carries out fill under aseptic, and In Shade preservation.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100937496A CN1327847C (en) | 2005-08-29 | 2005-08-29 | Externally applied medicine for treating vitiligo and its preparation process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100937496A CN1327847C (en) | 2005-08-29 | 2005-08-29 | Externally applied medicine for treating vitiligo and its preparation process |
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| Publication Number | Publication Date |
|---|---|
| CN1732978A true CN1732978A (en) | 2006-02-15 |
| CN1327847C CN1327847C (en) | 2007-07-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100937496A Expired - Fee Related CN1327847C (en) | 2005-08-29 | 2005-08-29 | Externally applied medicine for treating vitiligo and its preparation process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITLI20110006A1 (en) * | 2011-07-04 | 2013-01-05 | Ivo Pera | COMPOSITION FOR THE CARE OF VITILIGINE |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121870C (en) * | 2001-10-10 | 2003-09-24 | 成中田 | Exterior-applied medicine 'Xiaobaiwang' for treating leukoderma and its preparing process |
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- 2005-08-29 CN CNB2005100937496A patent/CN1327847C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITLI20110006A1 (en) * | 2011-07-04 | 2013-01-05 | Ivo Pera | COMPOSITION FOR THE CARE OF VITILIGINE |
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| CN1327847C (en) | 2007-07-25 |
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Granted publication date: 20070725 Termination date: 20120829 |