CN1943638A - An External use medicine for treating skin pigment reduction and its preparing method - Google Patents
An External use medicine for treating skin pigment reduction and its preparing method Download PDFInfo
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- CN1943638A CN1943638A CN 200610137625 CN200610137625A CN1943638A CN 1943638 A CN1943638 A CN 1943638A CN 200610137625 CN200610137625 CN 200610137625 CN 200610137625 A CN200610137625 A CN 200610137625A CN 1943638 A CN1943638 A CN 1943638A
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- skin pigment
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- pigment reduction
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Abstract
This invention relates to an external use medicine for treating skin pigment reduction and its preparing method. This external use medicine is prepared by using alcohol, radices polygoni multiflori, fructus psoraleae, flos sophorae immaturus, dioxyacetonem through refining. The medicine has the strongpoint of fast effectiveness, high curative effect, innocuity, no side-effect, convenience in use and low price, especially suitable for treatment of vitiligo.
Description
Technical field
The present invention relates to the dermopathic external used medicine of a kind of treatment, particularly relate to treatment skin pigment reduction external used medicine and manufacture method thereof.
Background technology
Skin pigment reduction is a kind of common skin diseases, and is commonplace, and it is wide to distribute, and sickness rate accounts for world population about 7/1000ths, and sickness rate is on the rise in recent years, is a kind of difficult pertinacious disease of generally acknowledging both at home and abroad.Though current this sick method of treatment and medicine are a lot, but can not reach desirable curative effect, for example, Therapeutic Method and medicines such as " ultraviolet therapy ", " BAIDIANJING " medicine, not only weak curative effect, slow, the shortcoming such as the treatment phase is long that takes effect, and also have in various degree side effect.Chinese patent CN1066182A discloses a kind of artificial brown's dihydroxy acetone emulsion composition, only can produce a kind of temporary transient brown on skin, can not treat leucoderma disease.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, study intensively for many years with long-term clinical practice exploitation through the inventor and to provide that a kind of curative effect is fast, the treatment phase is short, effective percentage and cure rate height, easy to use, have no side effect treatment skin pigment reduction external used medicine and manufacture method thereof that practical value is high.
Treatment skin pigment reduction external used medicine provided by the invention (claiming " white king disappears ") is formed through being mixed, filtering by following raw materials according component and weight portion.
Ethanol 80-200 part Radix Polygoni Multiflori 10-30 part Fructus Psoraleae 10-25 part
Flos Sophorae Immaturus 10-30 part dihydroxy acetone 0.1-3 part.
Skin pigment reduction external used medicine preferred feedstock component provided by the invention and weight portion are:
Ethanol 100-150 part Radix Polygoni Multiflori 10-25 part Fructus Psoraleae 10-20 part
Flos Sophorae Immaturus 10-25 part dihydroxy acetone 1-2 part.
Skin pigment reduction external used medicine provided by the invention more preferably raw material components and weight portion is:
10 parts of 10 parts of Fructus Psoraleaes of 100 parts of Radix Polygoni Multiflori of ethanol
1 part of 10 parts of dihydroxy acetone of the Flos Sophorae Immaturus.
In treatment skin pigment reduction external used medicine provided by the invention, described skin pigment reduction such as vitiligo etc., used component is that medicine meets hygienic requirements.
Fructus Psoraleae can improve the pigment cell and generate.Radix Polygoni Multiflori energy kidney-boosting tonic strengthens body immunity, and dihydroxy acetone can make skin be brown.Ethanol can restore menstrual flow and invigorate blood circulation, and promotes the skin metabolism function.The Flos Sophorae Immaturus can dispelling, collateral-activating.
By the said components compositing formula is full side's compatibility, and compatibility is reasonable, impels mutually, refinforce each other, and a usefulness each other, thus promote drug effect to improve, can make skin pigment reduction, particularly vitiligo obtain fast effectively treatment.
The manufacture method of treatment hypopigmentation disease external used medicine provided by the invention comprises the following steps:
(1) is mixed
Ethanol, Radix Polygoni Multiflori, Fructus Psoraleae, the Flos Sophorae Immaturus, dihydroxy acetone in the above-mentioned prescription by described weight portion, in the aseptic container of packing into, behind the lid tightening seal, are seated in the ventilating and cooling place 10 to 20 days, are preferably 15 days, take out medicinal liquid.
(2) filter
The medicinal liquid filter plant that above-mentioned steps (1) is obtained becomes medical filtration pure medicinal liquid under gnotobasis.
(3) fill
With the pure medicinal liquid filling apparatus that above-mentioned steps (2) obtains, in pack under gnotobasis container such as 5-10 milliliter plastic bottle or the vial, the sealing bottleneck is seated in the ventilating and cooling place and preserves.
In the method according to manufacturing provided by the invention treatment skin pigment reduction external used medicine, the described time of being mixed of described step (1) does not have strict regulations, but unsuitable long or very little, 10-20 days usually, is preferably 15 days.Described " filter plant " " filling apparatus " all is commercially available equipment known in the art, and its working procedure also is the known conventional method of regulation.
The specific embodiment
The present invention further specifies the present invention with the following example, but protection scope of the present invention is not limited to the following example.
Embodiment 1
With pharmaceutical grade ethanol, Radix Polygoni Multiflori, Fructus Psoraleae, the Flos Sophorae Immaturus, dihydroxy acetone, to pack into to be mixed in the glass jar by weight listed in the table 1 and placed 15 days, the commercially available filter plant of reuse gets 30 kilograms of clean pure medicinal liquids with medical filtration under gnotobasis.Also fill becomes stand-by in 10 milliliters of plastic bottles again.
Embodiment 2
Embodiment 2 manufacturing steps are identical with the step of embodiment 1, and different is its consumption is shown in (embodiment 2) in the table 1, and the clean pure medicinal liquid that wherein obtains is 65 kilograms.
Embodiment 3
Embodiment 3 manufacturing steps are identical with the step of embodiment 1, and different is its consumption wherein obtains to such an extent that clean pure medicinal liquid is 128 kilograms shown in (embodiment 3) in the table 1.
Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| Ethanol (kilogram) | 60 | 100 | 200 |
| Radix Polygoni Multiflori (kilogram) | 6 | 10 | 25 |
| Fructus Psoraleae (kilogram) | 6 | 10 | 20 |
| The Flos Sophorae Immaturus (kilogram) | 8 | 15 | 25 |
| Dihydroxy acetone (kilogram) | 0.6 | 1 | 2 |
| The clean medicinal liquid (kilogram) that obtains | 30 | 65 | 128 |
The clinical observation result that the invention provides example 3 treatment skin pigment reduction external used medicine curative effects is as shown in following:
Year March in March, 2000 to 2004, the whole nation the 69 training disease research institute, two tame hospitals of Hebei province Dingzhou City vitiligo hospital used external used medicine provided by the invention " white king disappears " treatment skin pigment to reduce the disease clinical observation on the therapeutic effect to be summarized as follows table:
Clinical observation on the therapeutic effect
From year March two in March, 2000 to 2004 tame large hospital use " white king disappears " provided by the invention external medication skin pigment to reduce disease 360 examples
| The case history number | Sex | Number | Each age group (year) | Symptom before going to a doctor | Therapeutic effect | Mean age | The mean treatment natural law | |||||
| The initial stage number | Mid-term number | The later stage number | Effective transference cure 36-69% | Produce effects transference cure 70-94% | Cure transference cure 95-99% | Invalid transference cure 35% | ||||||
| 72 | The man | 30 | 10-19 | 50 | 12 | 10 | 2 | 4 | 65 | 1 | ||
| The woman | 42 | |||||||||||
| 118 | The man | 50 | 20-29 | 68 | 26 | 24 | 10 | 19 | 86 | 3 | ||
| The woman | 68 | |||||||||||
| 83 | The man | 39 | 30-39 | 33 | 39 | 11 | 12 | 19 | 50 | 2 | ||
| The woman | 44 | |||||||||||
| 38 | The man | 18 | 40-49 | 12 | 10 | 16 | 2 | 8 | 25 | 3 | ||
| The woman | 20 | |||||||||||
| 28 | The man | 12 | 50-59 | 5 | 7 | 16 | 6 | 13 | 6 | 3 | ||
| The woman | 16 | |||||||||||
| 13 | The man | 6 | 60-69 | 1 | 2 | 10 | 3 | 5 | 1 | 4 | ||
| The woman | 7 | |||||||||||
| 8 | The man | 4 | 70-79 | 3 | 5 | 1 | 1 | 6 | ||||
| The woman | 4 | |||||||||||
| The man | 80-89 | |||||||||||
| The woman | ||||||||||||
| Add up to 360 | The man | 159 | 36 | 69 | 233 | 22 | 26.8 | 389.6 | ||||
| The woman | 201 | |||||||||||
Curative effect: effective percentage is that 93.8% ± 2.6 cure rate is 26.8 years old 64.7% ± 7.5 mean age mean treatment natural law 389.6 days
The efficacy assessment standard of medicine of the present invention is as follows in the table:
(1) effective: transference cure 36-69% is assessed as effectively.
(2) produce effects: transference cure 70-94% is assessed as produce effects.
(3) cure: transference cure 95-99% is assessed as healing.
(4) invalid: it is invalid that transference cure is assessed as below 36%.
It is as follows that two groups of controlled observation results of leucoderma disease treat year June in June, 2003 to 2004 in Hebei province Dingzhou City vitiligo hospital:
(1) two group of using method and medicine are respectively the treatment group and use the treatment skin pigment reduction medicine for external use that the invention provides example 3, and wipes once every day, at every turn use according to quantity.Matched group uses commercially available BAIDIANJING tincture external used medicine.Wipe once every day, uses according to quantity at every turn.
(2) observe the course of treatment, two groups was to observe 12 courses of treatment continuously a course of treatment with 30 days all.
The treatment group:
Hebei province's Dingzhou City vitiligo hospital uses a present invention's white king's external medication leucoderma disease 21 examples that disappear from year June in June, 2003 to 2004
| The case history number | Sex | Number | Each age group (year) | Symptom before going to a doctor | Therapeutic effect | Mean age | The mean treatment natural law | |||||
| The initial stage number | Mid-term number | The later stage number | Effective transference cure 36-69% | Produce effects transference cure 70-94% | Cure transference cure 95-99% | Invalid transference cure 35% | ||||||
| The man | 10-19 | |||||||||||
| The woman | ||||||||||||
| 21 | The man | 11 | 20-29 | 1 | 3 | 17 | 2 | 4 | 13 | 2 | 26.6 | 386.3 |
| The woman | 10 | |||||||||||
| The man | 30-39 | |||||||||||
| The woman | ||||||||||||
| Add up to | 2 | 4 | 13 | 386.3 | ||||||||
Effective percentage is that 90.5% ± 2.6 cure rate is 26.6 years old 61.9% ± 7.1 mean age mean treatment natural law 386.3 days
Matched group:
Hebei province's Dingzhou City vitiligo hospital uses commercially available BAIDIANJING Drug therapy leucoderma disease 21 examples from year June in June, 2003 to 2004
| The case history number | Sex | Number | Each age group (year) | Symptom before going to a doctor | Therapeutic effect | Mean age | The mean treatment natural law | |||||
| The initial stage number | Mid-term number | The later stage number | Effective transference cure 36-69% | Produce effects transference cure 70-94% | Cure transference cure 95-99% | Invalid transference cure 35% | ||||||
| The man | 10-19 | |||||||||||
| The woman | ||||||||||||
| 21 | The man | 11 | 20-29 | 1 | 3 | 17 | 1 | 3 | 9 | 8 | 26.3 | 568.6 |
| The woman | 10 | |||||||||||
| The man | 30-39 | |||||||||||
| The woman | ||||||||||||
| Add up to | ||||||||||||
Effective percentage is that 61.9% ± 1.8 cure rate is that 42.8% ± 4.9 mean treatment natural law 568.6 is big
It is as follows that Hebei province Dingzhou City vitiligo hospital carries out two groups of comparative results:
Treatment group and matched group are one group of 7 people, 3 groups of each minutes.Case source: successively arrange by patient's prescription on individual diagnosis order, distribute two groups successively.
(1) treatment group: effective percentage is that 90.5% ± 2.6 treatment rate is 26.6 years old 61.9% ± 7.1 mean age mean treatment natural law 386.3 days
(2) matched group: effective percentage is that 61.9% ± 1.8 treatment rate is 26.3 years old 42.8% ± 4.9 mean age mean treatment natural law 568.6 days
Treatment is organized in 21 cases: male's 11 examples wherein, and women's 10 examples, the age is at 20-29 between year, 26.6 years old mean age.In matched group 21 cases: male's 11 examples wherein, women's 10 examples, the age is at 20-29 between year, 26.3 years old mean age.
According to male, women and the two groups of mean aves before above two groups of treatments, average period of disease, average disease symptom, by these four analyses before going to a doctor, difference does not have the significance meaning between two groups, and it is more reasonable, balanced to illustrate that grouping is controlled in this examination, has neat same comparability.Two groups of contrast efficacy analysis: the effective percentage of treatment group, cure rate are apparently higher than matched group, and the treatment group treatment phase is short.
The effective percentage of treatment group, cure rate are apparently higher than matched group, and the treatment group treatment phase is short, effect is fast.Two groups of differences all have the significance meaning.Clinical observation shows: treatment group effective percentage is higher than matched group 28.6, and treatment group cure rate is higher than matched group 19.1.The treatment group mean treatment phase was lower than matched group 182.3 days, and the treatment group does not have the side effect of appearance, and matched group has 3 examples side effect to occur.
Therefore, observe summary through two tame hospitals, " white king disappears " provided by the invention external medication leucoderma disease has kidney-boosting tonic, blood circulation promoting and blood stasis dispelling, dredge the meridian passage, the effect of heat-clearing and toxic substances removing, energy is microcirculation improvement fast, and enhancing immunity promotes the skin pigment regeneration function.Its advantage: curative effect is fast, the treatment phase is short, curative effect is high, effective percentage 93.8%, cure rate 64.7%.Nontoxic, have no side effect, easy to use, the medicine valency is cheap, the practical value height.
Claims (4)
1, a kind of treatment skin pigment reduction external used medicine is characterized in that being made through being mixed, filtering by following raw materials according component and weight portion
Ethanol 80-200 part Radix Polygoni Multiflori 10-30 part Fructus Psoraleae 10-25 part
Flos Sophorae Immaturus 10-30 part dihydroxy acetone 0.1-3 part.
2, according to the external used medicine of the treatment skin pigment reduction of claim 1, it is characterized in that described raw material components and weight portion are:
Ethanol 100-150 part Radix Polygoni Multiflori 10-25 part Fructus Psoraleae 10-20 part
Flos Sophorae Immaturus 10-25 part dihydroxy acetone 1-2 part.
3, according to the external used medicine of the treatment skin pigment reduction of claim 1, it is characterized in that described raw material components and weight portion are:
10 parts of 10 parts of Fructus Psoraleaes of 100 parts of Radix Polygoni Multiflori of ethanol
1 part of 10 parts of dihydroxy acetone of the Flos Sophorae Immaturus.
4, the manufacture method of the arbitrary treatment skin pigment reduction of a kind of claim 1-3 external used medicine comprises the following steps:
(1) is mixed
Ethanol, Radix Polygoni Multiflori, Fructus Psoraleae, the Flos Sophorae Immaturus, dihydroxy acetone by described weight portion, in the aseptic container of packing into, behind the lid tightening seal, are seated in ventilating and cooling place 10-20 days, take out medicinal liquid;
(2) filter
The medicinal liquid filter plant that above-mentioned steps (1) is obtained becomes medical filtration pure medicinal liquid under gnotobasis;
(3) fill
The pure medicinal liquid that above-mentioned steps (2) is obtained is filled in the container under gnotobasis, and sealing is seated in the ventilating and cooling place and preserves.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610137625 CN1943638A (en) | 2006-10-31 | 2006-10-31 | An External use medicine for treating skin pigment reduction and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610137625 CN1943638A (en) | 2006-10-31 | 2006-10-31 | An External use medicine for treating skin pigment reduction and its preparing method |
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| CN1943638A true CN1943638A (en) | 2007-04-11 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110339257A (en) * | 2019-08-20 | 2019-10-18 | 江苏博润医疗集团有限公司 | It is a kind of for treating the external drug of leucoderma |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110339257A (en) * | 2019-08-20 | 2019-10-18 | 江苏博润医疗集团有限公司 | It is a kind of for treating the external drug of leucoderma |
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Open date: 20070411 |