CN1135904A - Oral liquid of shengxueyin - Google Patents

Abstract

A Chinese-medicinal oral liquid suitable for radiotherapy and chemicotherapy to promote growth of leucocytes and prevent bone marrow inhibition is prepared from 14 Chinese-medicinal materials such as spatholobus stem, astragalus root, lucid ligustrum fruit, lucid ganoderma, pilose asiabell root, etc. through purifying and sterilizing by alcohol, and decoction in aseptic water.

Description

Oral liquid of shengxueyin

The invention belongs to a kind of leukocyte of promotion growth that has, the Chinese herbal medicine oral liquid of control bone marrow depression function.

At present, 60 cobalt radiotherapies and cyclophosphamide (being called for short CTX) chemotherapy are mainly adopted in the treatment of various malignant tumor.These two kinds of therapeutic modalities all destroy the intravital leukocyte of patient to some extent, produce negative interaction.For making smooth the hitting the target the course of treatment of treatment, most hospitals all adopt the leucogen, batyl alcohol, and adenine phosphate, polyactin, medicines such as Colla Corii Asini slurry prevent and treat bone marrow depression, but effect are all not obvious to promote leukocyte growth in patient's body.

The purpose of this invention is to provide a kind of promotion leukocyte growth, prevent and treat the double Chinese herbal medicine oral liquid of protecting the type of building of myelosuppressive treatment.

Oral liquid of shengxueyin is a kind of Chinese herbal medicine oral liquid, and the weight ratio of its drug component is followed successively by:

Caulis Spatholobi 0.15～0.3: the Radix Astragali 0.1～0.2: Fructus Ligustri Lucidi 0.1～0.2:

Ganoderma 0.05～0.1: Radix Codonopsis 0.05～0.1: Radix Angelicae Sinensis 0.05～0.1:

Herba Epimedii 0.01～0.15: Radix Glycyrrhizae 0.1～0.15: Radix Asparagi 0.1～0.15:

Rhizoma Dioscoreae 0.1～0.15: Cortex Cinnamomi 0.05～0.1: Radix Et Caulis Acanthopanacis Senticosi 0.1～0.15:

Radix Rehmanniae Preparata 0.15～0.2: Fructus Rubi 0.1～0.2

Preparation method of the present invention is: above 14 flavor medical herbs are soaked half an hour, decoct then three times, be blended into ethanol after the gained mixed liquor concentrates and purify, make reflow of alcohol after the purification, cooled and filtered, bottling sterilization at last.

The oral liquid of shengxueyin that adopts the said method infusion is a kind of Chinese herbal and crude drugs preparations for the treatment of the health of holding concurrently, because it is soft, be applicable to that the each age group patient takes, particularly to weak and sickly gerontal patient with can not to finish patient's effect of treatment plan to the ability to bear difference of radiotherapy and chemotherapy particularly remarkable.

1993, through the paired observation test that railway hospital in Dalian carries out 1321 routine tumor patients, result of the test proved: the patient who takes oral liquid of shengxueyin finishes and radiocurablely reaches 92.9%.In addition, do experiment effect also clearly with mice:

One, CTX is handled the therapeutic effect of mice

Mice is divided into three groups by the body weight stratified random, makes between group the average weight difference basically less than 1.0 grams.Each is organized first day and irritates stomach CTX once by 100mg/kg.d. dosage, and every day is irritated the stomach oral liquid of shengxueyin in beginning in second day, 20 milliliters/kilogram of high dose group, and 10 milliliters/kilogram of low dose group, matched group is irritated the stomach normal saline once a day, successive administration four days.Got tail vein, and looked into total white blood cells in the 6th day.Obtain the leukocyte rate of rise by following formula:

The results are shown in Table 1. leukogenic effect is arranged.High dose group is compared with matched group, and leukocyte raises 27,5%, P value＜0.02, significant difference.

Table 1. couple CTX handles the therapeutic effect of mice

Group mice body weight (gram) leukocyte count

Experiment back before N P value (milliliter/kilogram) experiment (individual/mm)

20 10 20 18.83 11112±3194 ＜0.02

10 10 19.7 18.4 8977 ± 2442 contrasts 10 19.7 18.8 8717 ± 2835

Two, give the therapeutic effect of CTX after the protection of administration in advance again

Mice is divided into three groups (method is the same) by the body weight stratified random.Each is organized and irritates the stomach oral liquid of shengxueyin every day, 20 milliliters/kilogram of high dose group, 10 milliliters/kilogram of low dose group.Matched group is irritated the stomach normal saline.Once a day, successive administration is eight days.The 5th day each group increases irritates stomach CTX once, and dosage is that 10mg/kg.d. got tail vein on the 9th day, looks into total white blood cells, calculates leukocyte rate of rise (the same).

The results are shown in Table 2. leukogenic effect is arranged.High dose group is compared with matched group, and leukocyte raises 43.8%, P value＜0.005, difference highly significant.

Give therapeutic effect group mice body weight (gram) leukocyte count of CTX after the table 2. administration in advance protection again

Experiment back before N P value (milliliter/kilogram) experiment is (individual/mm) 20 11 19.6 19.5 14327 ± 3761＜0.005 10 11 19.8 18.7 12181 ± 3335 contrasts 12 19.5 19.0 9966 ± 2217

Three, CTX is handled the protection effect of mice

Mice is divided into three groups (method is the same) by the body weight stratified random.Each is organized first day and irritates stomach CTX once by 60mg/kg.d. dosage, begins to irritate the stomach oral liquid of shengxueyin in second day.20 milliliters/kilogram of high dose group, 10 milliliters/kilogram of low dose group, matched group is irritated the stomach normal saline.Once a day, successive administration is three days.Reach administration before the administration and get tail vein after three days, look into total white blood cells.Obtain the protection effect by following formula:

Though the results are shown in Table leukocyte counts of 3. each group, compare all and descend after the administration with before the administration, grand down more obvious of matched group, have only administration preceding 65.1%, P value＜0.05.High dose group then is 86.6% before the administration, and P value＞0.05 presents the protection effect after administration is described.

Table 3. couple CTX handles the protection effect of mice

Group leukocyte count (individual/mm3) (gram)

Administration is after three days before the administration of N protection effect P value (milliliter/kilogram)

8018±2112 6945±2926

20 11 1.33 ＞0.05

(100) (86.6)

9307±2829 6390±1393

10 11 1.05

1100 168.61

10352±4228 6736±2303

Contrast 11＞0.05

(100) (65.1)

Four, 60 cobalts are handled the therapeutic effect of mice

Mice is divided into three groups (method is the same) by the body weight stratified random.Each organizes first day by S=400cm2, and skin is apart from 75cm, the rectangular once irradiating 60 cobalt rays of accumulated dose 100Cry.Began to irritate the stomach oral liquid of shengxueyin in second day, 20 milliliters/kilogram of high dose group, 10 milliliters/kilogram of low dose group.Matched group is irritated the stomach normal saline.Day once, successive administration six days.Got tail vein, and looked into total white blood cells in the 8th day.Calculate leukocyte rate of rise (method is the same).

It is comparatively obvious to the results are shown in Table 4. leukogenic effects.High dose group is compared with matched group, and leukocyte raises 53.8%, P value＜0.005, difference highly significant.

Table 4. pair 60 cobalts are handled the therapeutic effect of mice

Group mice body weight (gram) leukocyte count

Experiment back before N P value (milliliter/kilogram) experiment (individual/mm3)

20 10 19.7 20.1 10505±2601 ＜0.005

10 10 19.7 21.55 8505±3690

Contrast 10 19.85 21.7 6830 ± 2193

Five, shine 60 cobaltic therapeutic effect again after the protection of administration in advance

Mice is divided into two groups (method is the same) by the body weight stratified random.Experimental group is irritated 10 milliliters/kilogram of stomach oral liquid of shengxueyin every day, and matched group is irritated the stomach normal saline.Once a day, successive administration is eight days.Each group press S=400cm in the 4th day, and skin is apart from 75cm, accumulated dose 100Cry, rectangular once irradiating cobalt ray.Get tail vein on the 9th day, and looked into total white blood cells, calculate leukocyte rate of rise (method is the same).

It is comparatively obvious to the results are shown in Table 5. leukogenic effects.Experimental group is compared with matched group, and leukocyte raises 48%, P value＜0.005, difference highly significant.

Shine 60 cobaltic therapeutic effect again after the table 5. administration in advance protection

Group mice body weight (gram) leukocyte count

Experiment back before N P value (milliliter/kilogram) experiment (individual/mm)

10 11 19.8 22.6 10468±2921 ＜0.005

Contrast 12 20 23.8 7070 ± 1797

Oral liquid of shengxueyin of the present invention is achieved by the following technical solution:

1. the present invention's prescription as follows: (unit gram)

Caulis Spatholobi 30; The Radix Astragali 20; Fructus Ligustri Lucidi 20; Ganoderma 10; Radix Codonopsis 10;

Radix Angelicae Sinensis 10; The sheep leaves of pulse plants 15; Radix Glycyrrhizae 15; Radix Asparagi 15; Rhizoma Dioscoreae 15;

Cortex Cinnamomi 10; Radix Et Caulis Acanthopanacis Senticosi 15; Radix Rehmanniae Preparata 20; Fructus Rubi 20.

Above-mentioned 14 flavor medicines are put into jar add after 1000 gram sterilized water soak half an hour, divides three decoction, decocting time is identical, puts into sterilized water 500 during second and third time decoction more respectively and restrains.Three decoction gained medicinal liquid 500 grams that are concentrated into admixed together, the ethanol that adds 1000 grams 97% carries out purification processes, and vaporized alcohol is refluxed, and cooled and stored was used filter paper filtering after 48 hours.Bottle at last and use γShe Xianmiejun.

2. also prescription in the following manner of the present invention: (unit gram)

Caulis Spatholobi 15; The Radix Astragali 10; Fructus Ligustri Lucidi 10; Ganoderma 5; Radix Codonopsis 5; Radix Angelicae Sinensis 5; Herba Epimedii 10; Radix Glycyrrhizae 10; Radix Asparagi 10; Rhizoma Dioscoreae 10; Cortex Cinnamomi 5; Radix Et Caulis Acanthopanacis Senticosi 10; Radix Rehmanniae Preparata 15; Fructus Rubi 10.Concrete preparation method is with 1.

Claims (1)

1. an oral liquid of shengxueyin is to promote the leukocyte growth, prevents and treats myelosuppressive Chinese herbal medicine oral liquid, it is characterized in that the weight ratio that contains drug component is followed successively by:

Caulis Spatholobi 0.15～0.3: the Radix Astragali 0.1～0.2: Fructus Ligustri Lucidi 0.1～0.2:

Ganoderma 0.05～0.1: Radix Codonopsis 0.05～0.1: Radix Angelicae Sinensis 0.05～0.1:

Herba Epimedii 0.01～0.15: Radix Glycyrrhizae 0.1～0.15: Radix Asparagi 0.1～0.15:

Rhizoma Dioscoreae 0.1～0.15: Cortex Cinnamomi 0.05～0.1: Radix Et Caulis Acanthopanacis Senticosi 0.1～0.15:

Radix Rehmanniae Preparata 0.15～0.2: Fructus Rubi 0.1～0.2