CN1179978A - Drug composition for curing osteoporosis - Google Patents
Drug composition for curing osteoporosis Download PDFInfo
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- CN1179978A CN1179978A CN 97116955 CN97116955A CN1179978A CN 1179978 A CN1179978 A CN 1179978A CN 97116955 CN97116955 CN 97116955 CN 97116955 A CN97116955 A CN 97116955A CN 1179978 A CN1179978 A CN 1179978A
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Abstract
The present invention relates to a medicine composition for curing osteoporosis. Said medicine composition consists of American ginseng, cordyceps, cooked rehmannia root, tortoise plastron, Chinese angelica root, red peony root, salvia root, Asiatic elder twig, pyrite, crab, oyster shell, rhubarb, prepared nux vomica, peach kernel and carthamus flower. The above-mentioned medicinal materials can be made into conventional medicine preparation by means of conventional preparation process.
Description
The present invention is a kind of pharmaceutical composition for the treatment of osteoporosis, and the traditional Chinese herbal medicine that consists of China of said composition has favorable effects to the treatment and the prevention of osteoporosis, and the present invention also provides the medicament that is prepared from said composition.Belong to the field of Chinese medicines.
Along with the raising of modern life level, the population life-span increases gradually, and aging population are more and more, and the degeneration physiological decease-primary osteoporosis that brings has thus become one of important diseases of the elder's health.Osteoporosis is a kind of senile disease, commonly encountered diseases, the present domestic specific Chinese medicine preparation that still do not have.The feature of osteoporosis is that the bone amount is low, and the osseous tissue micro structure is degenerated and caused bone fragility to increase, and very easily causes compression fracture of lumbar vertebra, fracture of femoral neck and wrist portion, fracture of radius.These fracture, especially lumbar vertebra fracture often take place under the obvious external force effect not having, and usually show the unexpected back severe pain beginning to be found.Along with the growth in population life-span, the increasing of old number, the harm of this disease is just more and more serious.Therefore, seeking the Chinese medicine of a kind of effective prevention and treatment osteoporosis, is one of important topic of current medical circle.
The present invention seeks to develop a kind of pharmaceutical composition for the treatment of osteoporosis.
According to the theory of the traditional Chinese medical science " kidney governing bones ", it is that disease is basic that patients with osteoporosis is suffered from a deficiency of the kidney.The treatment of disease must aim at its pathogenesis, and suffer from a deficiency of the kidney and the branch of deficiency of the kidney yin, deficiency of the kidney yin is arranged.The utilization differential diagnosis in tcm execute the principle of controlling, according to the whole nation about deficiency of the kidney yin, insufficiency of kidney-YANG diagnostic criteria, to primary disease deficiency of the kidney yin person, tonifying kidney-yin, benefiting QI and nourishing blood, bone strengthening Shujin, promoting blood circulation to disperse blood clots and relieves pain.The inventor by a large amount of case summaries, has developed the medicine of the inclined to one side deficiency of the kidney yin of treatment osteoporosis in clinical practice.
Pharmaceutical composition of the present invention its composition by weight is:
Radix Panacis Quinquefolii 20-80 part
Cordyceps 10-40 part
Radix Rehmanniae Preparata 20-80 part
Carapax et Plastrum Testudinis 30-80 part
Radix Angelicae Sinensis 30-80 part
Radix Paeoniae Rubra 30-80 part
Radix Salviae Miltiorrhizae 30-80 part
Ramulus Sambuci Williamsii 80-120 part
Pyritum 80-120 part
Eriocheir sinensis 80-120 part
Concha Ostreae 80-120 part
Radix Et Rhizoma Rhei 30-80 part
Semen Strychni (processed) 30-80 part
Semen Persicae 30-80 part
Flos Carthami 10-40 part
Its preferred weight proportioning of pharmaceutical composition of the present invention is:
50 parts of Radix Panacis Quinquefoliis
25 parts of Cordyceps
50 parts in Radix Rehmanniae Preparata
50 parts of Carapax et Plastrum Testudiniss
50 parts of Radix Angelicae Sinensis
50 parts of Radix Paeoniae Rubra
50 parts of Radix Salviae Miltiorrhizaes
100 parts of Ramulus Sambuci Williamsii
100 parts of Pyritums
100 parts of Eriocheir sinensiss
100 parts of Concha Ostreaes
50 parts of Radix Et Rhizoma Rhei
50 parts of Semen Strychni (processed)
50 parts in Semen Persicae
15 parts on Flos Carthami
Pharmaceutical composition of the present invention can be prepared into any pharmaceutical dosage form that is suitable for using clinically according to the preparation process of routine.As, pill, tablet, capsule, random notes, syrup, oral liquid, suspensoid, granule etc.
In the above-mentioned pharmaceutical dosage form process of preparation cost invention, can add conventional medicine excipient, for example, disintegrating agent, binding agent, flavoring agent, antiseptic, filler, solubilizing agent, cosolvent, lubricant, pigment etc.
The preparation method of bolus of drug of the present invention (commodity are called brave bone pellet) is:
With Radix Panacis Quinquefolii, Cordyceps, Eriocheir sinensis accelerated freeze-drying, be the end, keep biological activity.Pyritum, Concha Ostreae, Carapax et Plastrum Testudinis, Radix Et Rhizoma Rhei, Semen Strychni (processed) grind to the powder, and remaining all medicines are made clear paste by official preparation general rule regulation, mix with above-mentioned medicated powder then, and making pellets by mixing medical powder with honey, every ball weigh 6 grams.
The effect of medicine of the present invention is: tonifying kidney-yin, benefiting QI and nourishing blood, bone strengthening Shujin, blood circulation promoting and blood stasis dispelling.
Cure mainly: deficiency of the kidney yin type osteoporosis.
Clinical practice: osteoporosis, aching pain in waist and back, two knees soreness, fracture pain be double sees dizziness and blurred vision, hectic fever night sweat, dry mouth and throat, the few tongue of red tongue, thready and rapid pulse person, each clothes one ball, every day three times, sweetened vinegar is converted water for 25 milliliters and is taken in right amount after meal, and 30 days is a course of treatment.
From nineteen ninety-five to 1997 year, use Drug therapy osteoporosis patient 30 examples of the present invention.30 routine patient's bone X line plain films show: thoracic vertebra, hipbone all have bone density reduction in various degree.Wherein, 6 routine compression fracture of lumbar vertebra, 4 routine fracture of femoral neck, 1 routine fracture of radius, 1 routine hip fracture.30 routine patients all have lumbar and back pain medical history, knee joint and hip pain medical history in various degree.
Efficacy assessment standard to therapeutic outcome is:
Produce effects is pain complete obiteration after the medication, and movable function is significantly promoted;
Effectively be pain relief after the medication, movable function improves;
Invalid for pain after the medication does not alleviate, still need take other drug.
By above-mentioned therapeutic evaluation standard, therapeutic outcome such as following table:
| Curative effect | The example number | ????％ | The woman | The man | ||
| The example number | ????％ | The example number | ????％ | |||
| Produce effects | ??13 | ????43 | ????10 | ??33.3 | ????3 | ????10 |
| Effectively | ??15 | ????50 | ????10 | ??33.3 | ????5 | ??16.8 |
| Invalid | ???2 | ????7 | ?????1 | ??3.3 | ????1 | ??3.3 |
Medicine composite for curing osteoporosis total effective rate 93% of the present invention.
Embodiment 1
Radix Panacis Quinquefolii 50 gram Cordyceps 25 gram Radix Rehmanniaes Preparata 50 gram Carapax et Plastrum Testudiniss 50 grams
Radix Angelicae Sinensis 50 gram Radix Paeoniae Rubra 50 gram Radix Salviae Miltiorrhizaes 50 gram Ramulus Sambuci Williamsii 100 grams
Pyritum 100 gram Eriocheir sinensiss 100 gram Concha Ostreaes 100 gram Radix Et Rhizoma Rhei 50 grams
Semen Strychni (processed) 50 gram Semen Persicaes 50 gram Flos Carthamis 15 grams
Measure Radix Panacis Quinquefolii, Cordyceps, Eriocheir sinensis accelerated freeze-drying according to prescription, be the end, keep biological activity.Pyritum, Concha Ostreae, Carapax et Plastrum Testudinis, Radix Et Rhizoma Rhei, Semen Strychni (processed) are ground to the powder, and remaining all medicines are made clear paste by official preparation general rule regulation, mix with last medicated powder then, and making pellets by mixing medical powder with honey is made 100 balls, and every ball weighs 6 grams.
Embodiment 2
Radix Panacis Quinquefolii 60 gram Cordyceps 30 gram Radix Rehmanniaes Preparata 40 gram Carapax et Plastrum Testudiniss 40 grams
Radix Angelicae Sinensis 70 gram Radix Paeoniae Rubra 30 gram Radix Salviae Miltiorrhizaes 40 gram Ramulus Sambuci Williamsii 80 grams
Pyritum 90 gram Eriocheir sinensiss 90 gram Concha Ostreaes 90 gram Radix Et Rhizoma Rhei 40 grams
Semen Strychni (processed) 50 gram Semen Persicaes 60 gram Flos Carthamis 25 grams
Measure Radix Panacis Quinquefolii, Cordyceps, Eriocheir sinensis accelerated freeze-drying according to prescription, be the end, keep biological activity.Pyritum, Concha Ostreae, Carapax et Plastrum Testudinis, Radix Et Rhizoma Rhei, Semen Strychni (processed) grind to the powder, and remaining all medicines are made clear paste by official preparation general rule regulation, mix with last medicated powder then, and making pellets by mixing medical powder with honey, every ball weigh 6 grams.
Embodiment 3
Radix Panacis Quinquefolii 80 gram Cordyceps 10 gram Radix Rehmanniaes Preparata 80 gram Carapax et Plastrum Testudiniss 80 grams
Radix Angelicae Sinensis 40 gram Radix Paeoniae Rubra 50 gram Radix Salviae Miltiorrhizaes 80 gram Ramulus Sambuci Williamsii 120 grams
Pyritum 90 gram Eriocheir sinensiss 100 gram Concha Ostreaes 100 gram Radix Et Rhizoma Rhei 30 grams
Semen Strychni (processed) 40 gram Semen Persicaes 30 gram Flos Carthamis 20 grams
Measure Radix Panacis Quinquefolii, Cordyceps, Eriocheir sinensis accelerated freeze-drying according to prescription, be the end, keep biological activity.Pyritum, Concha Ostreae, Carapax et Plastrum Testudinis, Radix Et Rhizoma Rhei, Semen Strychni (processed) grind to the powder, and remaining all medicines are made clear paste by official preparation general rule regulation, mix with last medicated powder then, and making pellets by mixing medical powder with honey is made 100 balls, and every ball weighs 6 grams.
Claims (4)
1, a kind of pharmaceutical composition for the treatment of osteoporosis is characterized in that the composition of said composition is by weight:
Radix Panacis Quinquefolii 20-80 part
Cordyceps 10-40 part
Radix Rehmanniae Preparata 20-80 part
Carapax et Plastrum Testudinis 30-80 part
Radix Angelicae Sinensis 30-80 part
Radix Paeoniae Rubra 30-80 part
Radix Salviae Miltiorrhizae 30-80 part
Ramulus Sambuci Williamsii 80-120 part
Pyritum 80-120 part
Eriocheir sinensis 80-120 part
Concha Ostreae 80-120 part
Radix Et Rhizoma Rhei 30-80 part
Semen Strychni (processed) 30-80 part
Semen Persicae 30-80 part
Flos Carthami 10-40 part
2, the pharmaceutical composition above-mentioned according to claim 1 is characterized in that the weight ratio of described each component is:
50 parts of Radix Panacis Quinquefoliis
25 parts of Cordyceps
Ripe 50 parts
50 parts of Carapax et Plastrum Testudiniss
50 parts of Radix Angelicae Sinensis
50 parts of Radix Paeoniae Rubra
50 parts of Radix Salviae Miltiorrhizaes
100 parts of Ramulus Sambuci Williamsii
100 parts of Pyritums
100 parts of Eriocheir sinensiss
100 parts of Concha Ostreaes
50 parts of Radix Et Rhizoma Rhei
50 parts of Semen Strychni (processed)
50 parts in Semen Persicae
15 parts on Flos Carthami
3, a kind of pharmaceutical preparation is characterized in that with the described pharmaceutical composition of claim 1 be material component.
4, pharmaceutical preparation according to claim 3 is characterized in that also containing in the said preparation excipient.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97116955A CN1051471C (en) | 1997-09-29 | 1997-09-29 | Drug composition for curing osteoporosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97116955A CN1051471C (en) | 1997-09-29 | 1997-09-29 | Drug composition for curing osteoporosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1179978A true CN1179978A (en) | 1998-04-29 |
| CN1051471C CN1051471C (en) | 2000-04-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97116955A Expired - Fee Related CN1051471C (en) | 1997-09-29 | 1997-09-29 | Drug composition for curing osteoporosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1051471C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100391497C (en) * | 2004-02-11 | 2008-06-04 | 辽宁中医学院 | Nanometer Chinese traditional medicine for treating osteoporosis |
| CN101138597B (en) * | 2007-08-31 | 2010-06-23 | 澳门科技大学 | Traditional Chinese medicine preparation for preventing and controlling osteoporosis and method of preparing the same |
| CN102614339A (en) * | 2011-06-07 | 2012-08-01 | 李学朋 | Preparation method of Chinese patent medicine used for treating osteoporosis |
| CN104367629A (en) * | 2014-11-06 | 2015-02-25 | 成都果睿医药科技有限公司 | Pharmaceutical composition for treating osteoporosis |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004315454A (en) | 2003-04-17 | 2004-11-11 | Yamato Scient Co Ltd | Therapeutic agent for osteoporosis and osteoclastogenesis inhibitor |
| CN103349123A (en) * | 2013-07-22 | 2013-10-16 | 北京绿源求证科技发展有限责任公司 | Food health preserving tea electuary for preventing osteoporosis |
-
1997
- 1997-09-29 CN CN97116955A patent/CN1051471C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100391497C (en) * | 2004-02-11 | 2008-06-04 | 辽宁中医学院 | Nanometer Chinese traditional medicine for treating osteoporosis |
| CN101138597B (en) * | 2007-08-31 | 2010-06-23 | 澳门科技大学 | Traditional Chinese medicine preparation for preventing and controlling osteoporosis and method of preparing the same |
| CN102614339A (en) * | 2011-06-07 | 2012-08-01 | 李学朋 | Preparation method of Chinese patent medicine used for treating osteoporosis |
| CN104367629A (en) * | 2014-11-06 | 2015-02-25 | 成都果睿医药科技有限公司 | Pharmaceutical composition for treating osteoporosis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1051471C (en) | 2000-04-19 |
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