CN100344310C - Medicine for treating tinea containing biological alkaline salt and preparation thereof - Google Patents
Medicine for treating tinea containing biological alkaline salt and preparation thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 208000002474 Tinea Diseases 0.000 title abstract description 33
- 241000130764 Tinea Species 0.000 title abstract description 24
- 229940079593 drug Drugs 0.000 title description 12
- 159000000011 group IA salts Chemical class 0.000 title 1
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- 239000007788 liquid Substances 0.000 claims abstract description 33
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 28
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- 229930013930 alkaloid Natural products 0.000 claims abstract description 12
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- 229960004889 salicylic acid Drugs 0.000 claims abstract description 12
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to medicine containing a biological alkaloid salt for treating tinea and preparation technology thereof. The preparation technology comprises the following steps: lightyellow sophora root, herba artemisiae, etc. are mixed and filled in one filtering bag, and siberian cocklour fruit, puncturevine caltrop fruit, etc. are filled in the other filtering bag; the two filtering bags are immersed, sealed and soaked in alcohol of 450 ml to 560 ml at twice, and medicine liquid of the two times is combined; salicylic acid and benzoic acid are added into the mixed liquid which is stirred and statically placed, and cresol is blended into the supernatant liquid and is sufficiently dissolved; laurocapram is then blended, alcohol or water as the rest is added to the volume of 1000 ml, and the mixed liquid is statically placed and filtered so that the finished product is obtained. The antifungal preparation (tinea killing tincture) has the functions of sterilizing, removing tinea, clearing away heat and toxic material, converging moisture, eliminating slough and promoting granulation, has specially good effects on skin superficial fungi tinea, has the obvious therapeutic effects on bacterial and viral infection dermatopathy proved by theory, toxicology, bacteriostasis experiments and clinical verification, has the total effective rate of higher than 95 %, and has the advantages of obvious effect, short treatment course, few side effects, no recurrence after cure, etc.
Description
Technical field
The present invention relates to treat the medicine of ringworm, specifically is a kind of antipsoric thing and preparation technology thereof who contains alkaloid salt.
Background technology
Because Effect of Environmental such as weather, temperature, humidity, the probability that human body dyes ringworm is very big, and dermatosiss such as skin pruritus, tinea pedis, tinea corporis have become a kind of commonly encountered diseases, frequently-occurring disease, and the obstinate that has has caused misery to the patient.
Present commercially available various antipsoric product, though as beriberi paste, 11 diluted acid tinea liquid, PIYANPING and skin Kang Song etc. certain curative effect is arranged, the course of treatment is long, effect is undesirable, does not antibacterially sterilize, and controls table not effect a permanent cure easy the recurrence.
Summary of the invention
The objective of the invention is to overcome the above-mentioned deficiency of existing antipsoric product, a kind of antipsoric thing (tinea of promptly going out tincture) and preparation technology thereof who contains alkaloid salt is provided.
The antipsoric thing that the present invention contains alkaloid salt is made according to following method with following raw materials according,
Radix Sophorae Flavescentis 10～15 grams, Rhizoma Coptidis 10～15 grams, Cortex Phellodendri 5～15 grams,
Herba Artemisiae Scopariae 10～15 grams, Aloe 5～15 grams, Cortex Dictamni 10～15 grams,
Cortex Pseudolaricis 10～15 grams, Herba Portulacae 10～30 grams, Herba Violae 10～30 grams,
Fructus Xanthii 5～20 grams, Fructus Cnidii 10～15 grams, Fructus Tribuli 5～15 grams,
Fructus Gardeniae 5～20 grams, Scolopendra 2～10 grams, Scorpio 2～10 grams,
Benzoic acid 30～75 grams, salicylic acid 30～75 grams, cresol 10～50ml,
Laurel nitrogen ketone 30～100ml, two parts of 45～75% ethanol, every part of ethanol 450～560ml;
The Chinese medicine filter bag of packing into after the Radix Sophorae Flavescentis of described proportioning, Rhizoma Coptidis, Cortex Phellodendri, Herba Artemisiae Scopariae, Aloe, Cortex Dictamni, Cortex Pseudolaricis, Herba Portulacae and Herba Violae mixed, with another Chinese medicine filter bag of packing into after Fructus Xanthii, Fructus Cnidii, Fructus Tribuli, Fructus Gardeniae, Scolopendra and the Scorpio mixing, with two Chinese medicine filter bags immerse earlier soak in a ethanol the medicinal liquid first, more described two Chinese medicine filter bags are immersed soak in another part ethanol medicinal liquid second; Medicinal liquid first and medicinal liquid second are mixed, filter; The benzoic acid and the salicylic acid that add said ratio in gained filtrate fully dissolve, and filter, and get cresol and Laurel nitrogen ketone that supernatant is blent said ratio, add entry then to 1000ml, and filtration gets product.
The preparation technology of above-mentioned antipsoric thing comprises the steps:
A, according to its material component batching, stand-by with being loaded in the Chinese medicine filter bag behind Radix Sophorae Flavescentis, Rhizoma Coptidis, Cortex Phellodendri, Herba Artemisiae Scopariae, Aloe, Cortex Pseudolaricis, Cortex Dictamni, Herba Portulacae and the Herba Violae mix homogeneously, be loaded in another Chinese medicine filter bag Fructus Xanthii, Fructus Cnidii, Fructus Tribuli, Fructus Gardeniae, Scolopendra, Scorpio stand-by;
B, described two Chinese medicine filter bags are immersed in 45～75% the ethanol of 450～560ml in the container first, sealing was soaked 5～8 days, took out two Chinese medicine filter bags, left standstill, must the medicinal liquid first; Described two Chinese medicine filter bags are immersed in 45～75% the ethanol of 450～560ml in the container second, sealing was soaked 5～8 days, took out two Chinese medicine filter bags again, left standstill, must medicinal liquid second; Medicinal liquid first and medicinal liquid second are mixed, filter;
C, adding salicylic acid, benzoic acid are to described admixing medical solutions, stir, it is fully dissolved, leave standstill, filter, get its supernatant, cresol 10～50ml is blent in supernatant, stir, leave standstill, according to quantity Laurel nitrogen ketone 30～100ml is blent into the liquidly, add entry to 1000ml, filtration gets product.
The present invention is Main Ingredients and Appearance according to the rationale of Chinese medicine with Chinese medicine, is aided with chemical raw material, and the Chinese and Western combination is refined into the external antifungal preparation, has the functions such as tinea, heat-clearing and toxic substances removing, dampness convergence, killing parasites for relieving itching, removing the necrotic tissue and promoting granulation of going out that sterilize.
Prove through pharmacology, toxicity and bacteriostatic test and 100 routine clinical verifications, not only the skin superficial mycosis there is specially good effect, and dermatosis bacillary, viral infection also had significant curative effect, clinical experiment report shows that total effective rate reaches more than 95%, can effect a radical cure ringworm and not recur.With similar drug relatively, have advantages such as rapid-action, short treating period, method are easy, few side effects.
The specific embodiment
Below in conjunction with embodiment the present invention is described in detail.
Embodiment 1:
A, according to its material component batching, stand-by with being loaded in the Chinese medicine filter bag behind Radix Sophorae Flavescentis 10 grams, Rhizoma Coptidis 10 grams, Cortex Phellodendri 5 grams, Herba Artemisiae Scopariae 10 grams, Aloe 10 grams, Cortex Dictamni 10 grams, Cortex Pseudolaricis 11 grams, Herba Portulacae 15 grams and the Herba Violae 15 gram mix homogeneously, be loaded in another Chinese medicine filter bag Fructus Xanthii 10 grams, Fructus Cnidii 10 grams, Fructus Tribuli 8 grams, Fructus Gardeniae 10 grams, Scolopendra 2 grams, Scorpio 2 grams stand-by;
B, described two Chinese medicine filter bags are immersed in 75% the ethanol of 500ml in the container first, sealing was soaked 5 days, stirred every day and took out two Chinese medicine filter bags after twice, five day, left standstill, and got the medicinal liquid first; Described two Chinese medicine filter bags are immersed in 75% the ethanol of 500ml in the container second, sealing was soaked 7 days, stirred every day and took out two Chinese medicine filter bags after twice, seven day, left standstill, and got medicinal liquid second again; Medicinal liquid first and medicinal liquid second are mixed, filter, left standstill two days;
C, adding salicylic acid 40 grams, benzoic acid 45 grams stir to described admixing medical solutions, and it is fully dissolved, left standstill three days, filter, get its supernatant, cresol 20ml is blent in supernatant, stir, left standstill 3 days, and according to quantity Laurel nitrogen ketone 40ml was blent into the liquidly, add surplus ethanol or water to 1000ml, leave standstill and be the brownish red translucent liquid, filtration gets product.
Embodiment 2:
A, get and be loaded in the Chinese medicine filter bag behind Radix Sophorae Flavescentis 15 gram, Rhizoma Coptidis 15 grams, Cortex Phellodendri 15 grams, Herba Artemisiae Scopariae 15 grams, Aloe 15 grams, Cortex Dictamni 15 grams, Cortex Pseudolaricis 15 grams, Herba Portulacae 20 grams and the Herba Violae 20 gram mix homogeneously stand-byly, be loaded in another Chinese medicine filter bag Fructus Xanthii 15 grams, Fructus Cnidii 15 grams, Fructus Tribuli 15 grams, Fructus Gardeniae 15 grams, Scolopendra 5 grams, Scorpio 5 grams stand-by;
B, described two Chinese medicine filter bags are immersed in 65% the ethanol of 560ml in the container first, sealing was soaked 7 days, stirred every day and took out two Chinese medicine filter bags after twice, 7 day, left standstill, and got the medicinal liquid first; Described two Chinese medicine filter bags are immersed in 65% the ethanol of 560ml in the container second, sealing was soaked 7 days, stirred every day and took out two Chinese medicine filter bags after twice, seven day, left standstill, and got medicinal liquid second again; Medicinal liquid first and medicinal liquid second are mixed, filter, left standstill 5 days;
C, adding salicylic acid 45 grams, benzoic acid 50 grams stir to described admixing medical solutions, and it is fully dissolved, left standstill three days, filter, get its supernatant, cresol 30ml is blent in supernatant, stir, left standstill 3 days, and according to quantity Laurel nitrogen ketone 80ml was blent into the liquidly, add surplus ethanol or water to 1000ml, leave standstill, filter and be finished product.
Embodiment 3:
The weight proportion of its each component is: Radix Sophorae Flavescentis 15 grams, Rhizoma Coptidis 12 grams, Cortex Phellodendri 10 grams, Herba Artemisiae Scopariae 12 grams, Aloe 10 grams, Cortex Dictamni 12 grams, Cortex Pseudolaricis 12 grams, Herba Portulacae 30 grams, Herba Violae 30 grams, Fructus Xanthii 20 grams, Fructus Cnidii 12 grams, Fructus Tribuli 10 grams, Fructus Gardeniae 20 grams, Scolopendra 10 grams, Scorpio 10 grams, Laurel nitrogen ketone 60ml, salicylic acid 51 grams, benzoic acid 58 gram and cresol 50ml, wherein preceding nine flavor Chinese medicines and back Six-element Chinese medicine are loaded in the two Chinese medicine filter bags stand-by respectively, solvent is 45% ethanol, consumption of ethanol and concrete preparation technology are not giving unnecessary details with embodiment 1 or embodiment 2.
The traditional Chinese medical science thinks that the skin ringworm belongs to rheumatism pyretic toxicity discord, corrodes category due to the skin.Prescription of the present invention is a principle with heat-clearing and toxic substances removing, dispeiling pathogenic wind and removing dampness, the sterilization tinea of going out.Radix Sophorae Flavescentis in the prescription, Rhizoma Coptidis, Cortex Phellodendri, Cortex Dictamni bitter in the mouth are cold in nature, have the effect of heat-clearing and toxic substances removing and dispeiling pathogenic wind and removing dampness.Benzoic acid, salicylic acid detoxicating are anticorrosion, and antibacterial anti-tinea is a monarch drug.Fructus Cnidii, Herba Artemisiae Scopariae, Cortex Pseudolaricis, Aloe, Fructus Tribuli acrid in the mouth hardship, be slightly cold, clearing away heat-fire, killing parasites for relieving itching, removing pathogenic heat from blood and toxic substance from the body, expelling wind and removing dampness be ministerial drug.Fructus Xanthii, Scolopendra, Herba Violae, Scorpio, Fructus Gardeniae acrid in the mouth temperature, dispelling wind for relieving itching, remove superfluous analgesia and are adjuvant drug dispersing pathogen accumulation.The Herba Portulacae sour in the mouth is cold in nature, cooling blood for hemostasis, analgesia.Anticorrosion, the granulation promoting of cresol detoxicating.Laurel nitrogen ketone is skin penetrant, can strengthen drug penetration through skin power, and the zest of the side's of mitigation Chinese medicine and strong promotes the through disease of the efficacy of a drug messenger drug of doing.All medicines are common, Chinese and Western in conjunction with, mutually collaborative, having sterilization go out tinea, heat-clearing and toxic substances removing, dampness convergence, killing parasites for relieving itching, remove the effect of superfluous eliminating stagnation, removing the necrotic tissue and promoting granulation.
Chinese crude drugs such as Radix Sophorae Flavescentis, Cortex Phellodendri, Rhizoma Coptidis, Cortex Dictamni mainly contain chemical constituents such as alkaloid in the prescription of the present invention, with material medicine compatibilities such as salicylic acid, benzoic acid, generate the solubility alkaloid salts.
Matrine and salicylism reaction generate the Radix Sophorae Flavescentis Salicylate, and its chemical structural formula is:
Matrine and benzoic acid generate the Radix Sophorae Flavescentis benzoate, and its chemical structural formula is:
Contain solubility Radix Sophorae Flavescentis Salicylate, Radix Sophorae Flavescentis benzoate, matrine and phellodendrine etc. in the antipsoric thing according to the inventive method preparation, solubility alkaloid, salt are as the external skin medicine, directly embrocate various dermatophytosis, can produce extremely strong affinity to focus epidermal tissue immediately, have extremely strong fungus and the virus function killed rapidly and skin keratin albumen strong bonded.This material can not only effectively stop fungus and virus continue to invade skin, refer to or the horny layer of toenail and hair follicle, and can control the focus that has infected, promotes new skin regeneration, strengthens skin antifungal, antiviral immunity, recurs after preventing more.
Fungal culture and bacteriostatic test prove: antipsoric thing of the present invention all has the obvious sterilization effect to Gypsum Fibrosum Westerner pityrosporion ovale, trichophyton gypseum, trichophyton, candida albicans, acrothesium floccosum.
Tongji Medical Univ is as follows to the conclusion of relevant tests such as antipsoric thing of the present invention (tinea of promptly the going out tincture or the tinea king of going out) pharmacodynamics and toxicology:
One, pharmacodynamics test
" tinea of going out king " is outer to wipe, every day three times, and about at every turn 2ml, logotype three days all has significant curative effect to the tinea and tinea pedis two treated animals of suffering from the tinea rabbit.Prove that this medical instrument has the tinea effect of going out that sterilizes.
Two, general pharmacology research
1, mice device central nervous system there is not influence;
2, rats breathing there is not obvious influence;
3, rat blood pressure and electrocardiogram there is not obvious change.
Three, toxicologic study
1, general toxicity: rarely seen movable minimizing after " tinea of going out king " 0.01ml/10g ip in mice, do not see and be poisoned to death.Acute toxicity test to this medicine Main Ingredients and Appearance meets the regulation of " the acute toxicity classification of chemical substance " standard.
2, to " tinea of going out king " 0.2ml/10g ip mice postmortem till death, naked eyes are not seen parenchymatous organ's pathological change.
3, local toxicity: after " tinea of going out king " was used for the healthy application on human skin of volunteer, visible local skin was red slightly, and not having burns and steep rash occurs, and illustrates that this medicine zest is little; After complete and damaged skin is applied medicinal lotion or ointment to rabbit, there is no the whole body specific response.
4, sensitization test (STT):, do not see sensitization phenomenon to Cavia porcellus intradermal injection " tinea of going out king " 0.1ml.
Four, preliminarily stabilised test
Deposit trimestral preliminarily stabilised test and illumination, intensification accelerated stability test under " tinea of going out king " three batch sample room temperatures, investigate by total quality, think that this product stability is better, at room temperature should keep in Dark Place, effect duration drafted 2 years, health examination standard up to specification.
Five, the examination and test of products is qualified, and meeting the Ministry of Public Health pharmacopeia can Chinese Pharmacopoeia and medicine sanitary standard, and the project demand of defined such as drug standard draft.
Antipsoric thing of the present invention (tinea of promptly the going out tincture or the tinea king of going out) is through three tame hospital clinical tests such as Hainan People's Hospital, Hainan Medicine Institute, Affiliated Hospital and Hainan Province institute of traditional Chinese medicine, and the sick clinical verification comprehensive report of external curing superficial skin fungus conclusion is as follows:
General curative effect: 100 routine patients, 60 examples of fully recovering, produce effects 15 examples, effective 20 examples, invalid 5 examples, total effective rate 95.00%.
Each sick efficacy analysis of planting sees Table 1:
The curative effect (table 1) of 100 routine different superficial mycosis
| The sick kind | The example number | Recovery from illness | Produce effects | Effectively | Invalid | Effective percentage |
| Tinea manus and pedis | 52 | 28(53.85％) | 7(13.46％) | 13(25.00％) | 4(7.69％) | 92.31％ |
| Tinea cruris | 24 | 15(62.50％) | 4(16.67％) | 4(16.67％) | 1(4.16％) | 95.83％ |
| Tinea corporis | 13 | 9(69.23％) | 2(15.38％) | 2(15.38％) | 0 | 100％ |
| Tinea versicolor | 11 | 8(72.72％) | 2(18.18％) | 1(9.09％) | 0 | 100％ |
This medicine Main Ingredients and Appearance is Cortex Pseudolaricis, Radix Sophorae Flavescentis etc.Major function is: tinea, heat-clearing and toxic substances removing, dampness removing to stop itchin, the convergence granulation promoting of going out sterilizes.100 routine tinea corporis, tinea cruris, the tinea manuum, tinea pedis, tinea versicolor patient have been observed in outpatient service, find that this medicine has better curative effect to various superficial skin fungus diseases, total effective rate reaches 95.00%, and have advantages such as rapid-action, short treating period, method are easy, few side effects, be worth applying clinically.
Claims (4)
1, a kind of antipsoric thing that contains alkaloid salt is characterized in that: it adopts following raw materials according to make according to following method,
Radix Sophorae Flavescentis 10～15 grams, Rhizoma Coptidis 10～15 grams, Cortex Phellodendri 5～15 grams,
Herba Artemisiae Scopariae 10～15 grams, Aloe 5～15 grams, Cortex Dictamni 10～15 grams,
Cortex Pseudolaricis 10～15 grams, Herba Portulacae 10～30 grams, Herba Violae 10～30 grams,
Fructus Xanthii 5～20 grams, Fructus Cnidii 10～15 grams, Fructus Tribuli 5～15 grams,
Fructus Gardeniae 5～20 grams, Scolopendra 2～10 grams, Scorpio 2～10 grams,
Benzoic acid 30～75 grams, salicylic acid 30～75 grams, cresol 10～50ml,
Laurel nitrogen ketone 30～100ml, two parts of 45～75% ethanol, every part of ethanol 450～560ml;
The Chinese medicine filter bag of packing into after the Radix Sophorae Flavescentis of described proportioning, Rhizoma Coptidis, Cortex Phellodendri, Herba Artemisiae Scopariae, Aloe, Cortex Dictamni, Cortex Pseudolaricis, Herba Portulacae and Herba Violae mixed, with another Chinese medicine filter bag of packing into after Fructus Xanthii, Fructus Cnidii, Fructus Tribuli, Fructus Gardeniae, Scolopendra and the Scorpio mixing, with two Chinese medicine filter bags immerse earlier soak in a ethanol the medicinal liquid first, more described two Chinese medicine filter bags are immersed soak in another part ethanol medicinal liquid second; Medicinal liquid first and medicinal liquid second are mixed, filter; The benzoic acid and the salicylic acid that add said ratio in gained filtrate fully dissolve, and filter, and get cresol and Laurel nitrogen ketone that supernatant is blent said ratio, add entry then to 1000ml, and filtration gets product.
2, contain the preparation technology of the antipsoric thing of alkaloid salt according to claim 1, it is characterized in that comprising the steps:
A, according to its feed proportioning, stand-by with being loaded in the Chinese medicine filter bag behind Radix Sophorae Flavescentis, Rhizoma Coptidis, Cortex Phellodendri, Herba Artemisiae Scopariae, Aloe, Cortex Pseudolaricis, Cortex Dictamni, Herba Portulacae and the Herba Violae mix homogeneously, be loaded in another Chinese medicine filter bag Fructus Xanthii, Fructus Cnidii, Fructus Tribuli, Fructus Gardeniae, Scolopendra, Scorpio stand-by;
B, described two Chinese medicine filter bags are immersed in 45～75% the ethanol of 450～560ml in the container first, sealing was soaked 5～8 days, took out two Chinese medicine filter bags, left standstill, must the medicinal liquid first; Described two Chinese medicine filter bags are immersed in 45～75% the ethanol of 450～560ml in the container second, sealing was soaked 5～8 days, took out two Chinese medicine filter bags again, left standstill, must medicinal liquid second; Medicinal liquid first and medicinal liquid second are mixed, filter;
C, adding salicylic acid, benzoic acid stir to described admixing medical solutions, and it is fully dissolved, and leave standstill, filter, get its supernatant, cresol 10～50ml is blent in supernatant, stir, leave standstill, Laurel nitrogen ketone 30～100ml is blent into the liquid, add entry to 1000ml, filtration gets product.
3, as containing the preparation technology of the antipsoric thing of alkaloid salt as described in the claim 2, it is characterized in that: described Chinese medicine filter bag between soak period, stirs twice in container first or container second every day.
4, as containing the preparation technology of the antipsoric thing of alkaloid salt as described in the claim 2, it is characterized in that: the admixing medical solutions of described medicinal liquid first and medicinal liquid second left standstill 2～5 days after filtering.
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| CN101972408B (en) * | 2010-10-19 | 2013-04-17 | 赵自裕 | Tinea washing traditional Chinese medicinal preparation and preparation method thereof |
| CN102362844B (en) * | 2011-11-07 | 2013-12-11 | 金华职业技术学院 | Aromatic plant bacteriostatic skin-care foot washing liquid and preparation method thereof |
| CN102552522A (en) * | 2011-12-15 | 2012-07-11 | 李秀香 | Chinese medicine composition for treating dandruff |
| US9375457B2 (en) | 2013-06-13 | 2016-06-28 | Hong Kong Baptist University | Composition comprising Rhizoma coptidis, Cortex phellodendri and Fructus gardeniae and for treating neurodegenerative diseases |
| CN104971125A (en) * | 2014-04-14 | 2015-10-14 | 黄冠华 | Alkaloid salt-type medicine for treating psoriasis and preparation method thereof |
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| Title |
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| 中药外用治疗皮肤病 王玉英，河北中医杂志，第18卷第123期 1996 * |
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