CN1732018B - 核酸、多肽和调节细胞凋亡的方法 - Google Patents

核酸、多肽和调节细胞凋亡的方法 Download PDF

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Publication number
CN1732018B
CN1732018B CN200380107399.3A CN200380107399A CN1732018B CN 1732018 B CN1732018 B CN 1732018B CN 200380107399 A CN200380107399 A CN 200380107399A CN 1732018 B CN1732018 B CN 1732018B
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apoptosis
eif
cells
gly
ala
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Chinese (zh)
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CN1732018A (zh
Inventor
J·E·汤普逊
C·泰勒
D·克利彻
C·迪纳雷洛
L·雷兹尼科夫
B·波梅兰茨
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Eloxx Pharmaceuticals Inc
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Senesco Technologies Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
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  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN200380107399.3A 2002-10-23 2003-10-22 核酸、多肽和调节细胞凋亡的方法 Expired - Fee Related CN1732018B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/277,969 2002-10-23
US10/277,969 US7217517B2 (en) 2001-07-23 2002-10-23 Nucleic acids, polypeptides, and methods for modulating apoptosis
PCT/US2003/033463 WO2004037984A2 (en) 2002-10-23 2003-10-22 Nucleic acids, polypeptides, and methods for modulating apoptosis

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CN1732018A CN1732018A (zh) 2006-02-08
CN1732018B true CN1732018B (zh) 2014-09-10

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CN200380107399.3A Expired - Fee Related CN1732018B (zh) 2002-10-23 2003-10-22 核酸、多肽和调节细胞凋亡的方法

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Country Link
US (1) US7217517B2 (enExample)
EP (1) EP1578452B1 (enExample)
JP (1) JP4890763B2 (enExample)
KR (1) KR20050046015A (enExample)
CN (1) CN1732018B (enExample)
AT (1) ATE384740T1 (enExample)
AU (1) AU2003301585B2 (enExample)
CA (1) CA2503442C (enExample)
DE (1) DE60318900D1 (enExample)
NZ (1) NZ540105A (enExample)
TW (1) TWI324070B (enExample)
WO (1) WO2004037984A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166467B2 (en) * 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
NZ542665A (en) * 2003-03-05 2008-05-30 Senesco Technologies Inc Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1
US20140371299A1 (en) * 2004-06-07 2014-12-18 Senesco Technologies, Inc. Use of Apoptosis-Specific elF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis
AR049999A1 (es) * 2004-07-20 2006-09-20 Senesco Technologies Inc Uso de siarn de eif-5a y polinucleotidos antisentido especificos de la apoptosis para inhibir/suprimir una respuesta inflamatoria.
EP1959010A3 (en) * 2004-12-03 2009-02-25 Senesco Technologies, Inc. Apoptosis-specific eif-5A and polynucleotides encoding same
JP5205058B2 (ja) * 2004-12-03 2013-06-05 セネスコ テクノロジーズ，インコーポレイティド 種子の収量を増大させる方法
WO2009144933A1 (ja) * 2008-05-27 2009-12-03 国立大学法人東京大学 アポトーシス誘導薬
JP6639408B2 (ja) 2014-11-07 2020-02-05 藤倉化成株式会社 デオキシハイプシン・シンターゼ遺伝子を指標として用いる動脈硬化及びがんの検出方法
JP2021526837A (ja) * 2018-06-12 2021-10-11 アンジーエックス・インコーポレーテッド 抗体−オリゴヌクレオチドコンジュゲート
CN114231551B (zh) * 2021-12-24 2023-09-29 云南大学 蛋白在促进昆虫淋巴细胞凋亡和/或防治害虫中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1173897A (zh) * 1995-02-13 1998-02-18 诺瓦蒂斯有限公司 真核起始因子5A(eIF－5A)突变体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5344846A (en) 1992-12-30 1994-09-06 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for inhibiting deoxyhypusine synthase and the growth of cells
US5849587A (en) 1995-06-09 1998-12-15 Cornell Research Foundation, Inc. Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells
WO1999001551A2 (en) 1997-06-30 1999-01-14 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Novel inhibitor of cellular proliferation
US6538182B1 (en) 1999-07-06 2003-03-25 Senesco, Inc. DNA encoding a plant deoxyhypusine synthase, a plant eukaryotic initiation factor 5A, transgenic plants and a method for controlling senescence programmed and cell death in plants
WO2001010906A1 (en) 1999-08-06 2001-02-15 Pharmacia & Upjohn Company Crystallization and structure determination of staphylococcus aureus elongation factor p
US7166467B2 (en) 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1173897A (zh) * 1995-02-13 1998-02-18 诺瓦蒂斯有限公司 真核起始因子5A(eIF－5A)突变体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JENKINS A.等人.Human EIF5A2 on Chromosome 3q25–q27 IsaPhylogeneticallyConserved Vertebrate Variant of EukaryoticTranslationInitiation Factor 5A with Tissue-Specific Expression.Genomics71.2001,71101-109. *

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Publication number Publication date
CA2503442C (en) 2014-02-18
EP1578452A4 (en) 2006-01-11
TW200501988A (en) 2005-01-16
AU2003301585B2 (en) 2009-08-20
WO2004037984A3 (en) 2005-04-14
CN1732018A (zh) 2006-02-08
EP1578452A2 (en) 2005-09-28
US20030144238A1 (en) 2003-07-31
CA2503442A1 (en) 2004-05-06
NZ540105A (en) 2006-10-27
ATE384740T1 (de) 2008-02-15
DE60318900D1 (de) 2008-03-13
US7217517B2 (en) 2007-05-15
EP1578452B1 (en) 2008-01-23
AU2003301585A1 (en) 2004-05-13
JP4890763B2 (ja) 2012-03-07
KR20050046015A (ko) 2005-05-17
TWI324070B (en) 2010-05-01
JP2006507816A (ja) 2006-03-09
WO2004037984A2 (en) 2004-05-06

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