TWI324070B - Nucleic acids, polypeptides, and methods for modulating apoptosis - Google Patents

Nucleic acids, polypeptides, and methods for modulating apoptosis Download PDF

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Publication number
TWI324070B
TWI324070B TW092129428A TW92129428A TWI324070B TW I324070 B TWI324070 B TW I324070B TW 092129428 A TW092129428 A TW 092129428A TW 92129428 A TW92129428 A TW 92129428A TW I324070 B TWI324070 B TW I324070B
Authority
TW
Taiwan
Prior art keywords
apoptosis
eif
cells
specific
cell
Prior art date
Application number
TW092129428A
Other languages
English (en)
Chinese (zh)
Other versions
TW200501988A (en
Inventor
E Thompson John
Taylor Catherine
Cliche Dominic
Dinarello Charles
Reznikov Leonid
Pomerantz Benjamin
Original Assignee
Senesco Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senesco Technologies Inc filed Critical Senesco Technologies Inc
Publication of TW200501988A publication Critical patent/TW200501988A/zh
Application granted granted Critical
Publication of TWI324070B publication Critical patent/TWI324070B/zh

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747Apoptosis related proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
TW092129428A 2002-10-23 2003-10-23 Nucleic acids, polypeptides, and methods for modulating apoptosis TWI324070B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/277,969 US7217517B2 (en) 2001-07-23 2002-10-23 Nucleic acids, polypeptides, and methods for modulating apoptosis

Publications (2)

Publication Number Publication Date
TW200501988A TW200501988A (en) 2005-01-16
TWI324070B true TWI324070B (en) 2010-05-01

Family

ID=32174556

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092129428A TWI324070B (en) 2002-10-23 2003-10-23 Nucleic acids, polypeptides, and methods for modulating apoptosis

Country Status (12)

Country Link
US (1) US7217517B2 (enExample)
EP (1) EP1578452B1 (enExample)
JP (1) JP4890763B2 (enExample)
KR (1) KR20050046015A (enExample)
CN (1) CN1732018B (enExample)
AT (1) ATE384740T1 (enExample)
AU (1) AU2003301585B2 (enExample)
CA (1) CA2503442C (enExample)
DE (1) DE60318900D1 (enExample)
NZ (1) NZ540105A (enExample)
TW (1) TWI324070B (enExample)
WO (1) WO2004037984A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7166467B2 (en) * 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
NZ542665A (en) * 2003-03-05 2008-05-30 Senesco Technologies Inc Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1
US20140371299A1 (en) * 2004-06-07 2014-12-18 Senesco Technologies, Inc. Use of Apoptosis-Specific elF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis
AR049999A1 (es) * 2004-07-20 2006-09-20 Senesco Technologies Inc Uso de siarn de eif-5a y polinucleotidos antisentido especificos de la apoptosis para inhibir/suprimir una respuesta inflamatoria.
EP1959010A3 (en) * 2004-12-03 2009-02-25 Senesco Technologies, Inc. Apoptosis-specific eif-5A and polynucleotides encoding same
JP5205058B2 (ja) * 2004-12-03 2013-06-05 セネスコ テクノロジーズ,インコーポレイティド 種子の収量を増大させる方法
WO2009144933A1 (ja) * 2008-05-27 2009-12-03 国立大学法人東京大学 アポトーシス誘導薬
JP6639408B2 (ja) 2014-11-07 2020-02-05 藤倉化成株式会社 デオキシハイプシン・シンターゼ遺伝子を指標として用いる動脈硬化及びがんの検出方法
JP2021526837A (ja) * 2018-06-12 2021-10-11 アンジーエックス・インコーポレーテッド 抗体−オリゴヌクレオチドコンジュゲート
CN114231551B (zh) * 2021-12-24 2023-09-29 云南大学 蛋白在促进昆虫淋巴细胞凋亡和/或防治害虫中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5344846A (en) 1992-12-30 1994-09-06 The United States Of America As Represented By The Department Of Health And Human Services Compositions and methods for inhibiting deoxyhypusine synthase and the growth of cells
CZ255397A3 (cs) * 1995-02-13 1998-02-18 Novartis Ag Mutantní proteiny, způsob jejich přípravy, farmaceutické prostředky, které je obsahují, a jejich použití
US5849587A (en) 1995-06-09 1998-12-15 Cornell Research Foundation, Inc. Method of inhibiting viral replication in eukaryotic cells and of inducing apoptosis of virally-infected cells
WO1999001551A2 (en) 1997-06-30 1999-01-14 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Novel inhibitor of cellular proliferation
US6538182B1 (en) 1999-07-06 2003-03-25 Senesco, Inc. DNA encoding a plant deoxyhypusine synthase, a plant eukaryotic initiation factor 5A, transgenic plants and a method for controlling senescence programmed and cell death in plants
WO2001010906A1 (en) 1999-08-06 2001-02-15 Pharmacia & Upjohn Company Crystallization and structure determination of staphylococcus aureus elongation factor p
US7166467B2 (en) 2001-07-23 2007-01-23 Senesco Technologies, Inc. Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis

Also Published As

Publication number Publication date
CA2503442C (en) 2014-02-18
EP1578452A4 (en) 2006-01-11
TW200501988A (en) 2005-01-16
AU2003301585B2 (en) 2009-08-20
WO2004037984A3 (en) 2005-04-14
CN1732018A (zh) 2006-02-08
EP1578452A2 (en) 2005-09-28
CN1732018B (zh) 2014-09-10
US20030144238A1 (en) 2003-07-31
CA2503442A1 (en) 2004-05-06
NZ540105A (en) 2006-10-27
ATE384740T1 (de) 2008-02-15
DE60318900D1 (de) 2008-03-13
US7217517B2 (en) 2007-05-15
EP1578452B1 (en) 2008-01-23
AU2003301585A1 (en) 2004-05-13
JP4890763B2 (ja) 2012-03-07
KR20050046015A (ko) 2005-05-17
JP2006507816A (ja) 2006-03-09
WO2004037984A2 (en) 2004-05-06

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