CN1723965A - Method and use for preparing medicine extracted myrobalan for treating diseases infected by bacteria or virus - Google Patents
Method and use for preparing medicine extracted myrobalan for treating diseases infected by bacteria or virus Download PDFInfo
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- CN1723965A CN1723965A CN 200510042885 CN200510042885A CN1723965A CN 1723965 A CN1723965 A CN 1723965A CN 200510042885 CN200510042885 CN 200510042885 CN 200510042885 A CN200510042885 A CN 200510042885A CN 1723965 A CN1723965 A CN 1723965A
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Abstract
An application of the active extract of the immature fruit of medicine teminalia in preparing the medicine to treat cold and cough is disclosed. Said medicine is prepared from 18 Chinese-medicinal materials including said immature fruit of medicine teminalia. Said active extract is prepared through screening the immature fruit of medicine teminalia, pulverizing and extracting by decocting or other methods.
Description
One technical field:
The present invention relates to the Fructus chebulae immaturus effective site of (perhaps being called FRUCTUS TERMINALIAE IMMATURUS, Tibet Fructus Canarii), and prepare the process of Fructus chebulae immaturus effective site and Fructus chebulae immaturus effective site is controlled antibacterial and disease of viral infection medicine as preparation application (purposes).
Two background technologies:
Sell the medicine of treatment respiratory system, urinary system, intestines and stomach infection and suppurative dermatosis in the market, the chemical drugs symptomatic treatments that adopt more, existing chemical drugs one is synthetic, the 2nd, fermentation gets, side effect is more, and antibacterial easily produces drug resistance, and anaphylaxis, effect are usually undesirable.State Intellectual Property Office has announced a kind of " plant clearing away lung-heat to relieve cough dew " patent application on February 23rd, 2005, the oral liquid that is used for the treatment of flu, cough, the compound preparation of forming by Periostracum Cicadae, the Rhizoma Pinelliae, Fructus chebulae immaturus etc. 16 flavor medicines, advantage is to have good curative effect for itching of the throat, cough, expectoration that flu, pharyngolaryngitis, tracheitis cause, have good curative effect for the caused violent cough patient of pneumonia due to the cureless flu of other method, antibiotic widely, the antibacterial and antiviral of tool, antiinflammatory, anti-allergic effects are wherein arranged in the kinds of traditional Chinese medicines.December was also announced " a kind of Chinese medicine and preparation method (popular name is Yujinwang jieyuliyandan) for the treatment of pharyngitis, globus hystericus " on the 11st in 2002, the Chinese medicine that belongs to treatment pharyngitis, bottleneck throat neurosis (globus hystericus), it comprises following medicine: 41 flavor medicines such as Haematitum, WUHUAFEN, Fructus chebulae immaturus, terminalia flesh, make through technologies such as selected, pulverizing pill, finished product packings.Announced August 16 nineteen ninety-five a kind of " Chinese olive health chewing gum ", by Fructus chebulae immaturus, gum base, Icing Sugar, dextrin, and chlorophyll+cyclamate and Fructus Citri Limoniae oil+Oleum menthae composition, it is to have the astringing intestine to stop diarrhea function of astringing the lung significantly according to Fructus chebulae immaturus, to diseases such as laryngopharynx swelling and pain, chronic cough, chronic diarrhea, chronic dysentery and bleeding not during menses, certain prevention and therapeutical effect are arranged.The unguentum of making of having a dinner joins the glue of making in the chewing gum base of chewing, it is edible to be useful for general adult, child, it not only can play cleaning oral cavity, remove halitosis, control toothache and laryngopharynx swelling and pain, can also play certain health-care effect to intestinal tract disease, be current up-to-date a kind of health chewing gum both at home and abroad.Above-mentioned these all are compound preparations.
Three summary of the invention:
The objective of the invention is from traditional natural drug Fructus chebulae immaturus, what extract with scientific method is that the salt (being called Fructus chebulae immaturus depside salt or Fructus chebulae immaturus) that liposoluble ingredient that the molecular weight of representative varies in size is made is a class new product of effective site with chebulinic acid, Chebulagic acid, gallic acid, the process of development single Fructus chebulae immaturus effective site, and can be with the application (purposes) of Fructus chebulae immaturus effective site as the medicine of preparation treatment antibacterial and disease of viral infection; Fructus chebulae immaturus depside salt (effective site) is a natural class material, it has extensively and the obvious sterilization effect, and toxic and side effects is low, make various solid forms after deliberation with after a large amount of experiment, the medicine of semi-solid form and liquid form is used for clinical, more effective and be extensive patients treatment antibacterial and disease of viral infection easily, comprise: respiratory system infection disease (pharyngitis, bronchitis etc.), urinary system infection disease (acute urinary tract infection, acute cystitis, acute gonorrhea etc.), suppurative dermatosis (the furuncle of pathogenic infection, carbuncle, erysipelas, paronychia, wound infection, ulcer of the lower limb, cellulitis etc.), the present invention will develop a kind of new single medicinal material product aspect these diseases in treatment, and products thereof preparation technology's method and purposes.
Be the technical solution of the present invention that achieves the above object:
The effective site that a kind of Fructus chebulae immaturus extracts, the feature of this effective site is: with chebulinic acid, Chebulagic acid, gallic acid is that the salt (being called Fructus chebulae immaturus depside salt or Fructus chebulae immaturus) that liposoluble ingredient that the molecular weight of representative varies in size is made is an effective site, contains the phenolic acid salts substances and be a class new product of 80%～100%.
The process 1 of preparation Fructus chebulae immaturus effective site, it is characterized in that: Fructus chebulae immaturus adopts circumfluence method to extract Fructus chebulae immaturus effective site, at normal temperatures and pressures through screening, pulverizing, the Fructus chebulae immaturus of pulverizing is placed in the reflux vessel, add concentration 8～12 times of amounts of 50%～80% ethanol (w/w) solvent, reflux, extract, 3 times, each 2 hours, merge extractive liquid,, filter, filtrate was left standstill 48 hours at 0～10 ℃, filtered with microporous filter membrane; Filtrate adding assistant alkali liquor transfers to PH7.5～8.5,0～10 and ℃ staticly settled 36 hours, and inclining supernatant, filter, and the collecting precipitation thing, vacuum drying promptly get the yellowish-brown powder, the sealing preservation.
The process 2 of preparation Fructus chebulae immaturus effective site is characterized in that: Fructus chebulae immaturus is through screening, pulverizing, and employing decocts extraction method and puies forward Fructus chebulae immaturus effective site, at normal temperatures and pressures, the Fructus chebulae immaturus of pulverizing is placed in the still device, adds pure water submergence medical material, soak after 30 minutes, heated and boiled keeps little and boiled 1 hour, leach decoction liquor, medicinal residues fried again 2 times according to this method are collected the fried liquid of each time, centrifugalize or cold preservation sedimentation, filter, being evaporated to relative density is 1.05～1.20; Add dehydrated alcohol to 2～3 times volume, stir, 0～10 ℃ left standstill 36 hours, filtered, and 0～10 ℃ left standstill 48 hours again, filtered with microporous filter membrane; Filtrate adding assistant alkali liquor transfers to PH7.5～8.5,0～10 and ℃ staticly settled 36 hours, and inclining supernatant, filter, and the collecting precipitation thing, vacuum drying promptly get the yellowish-brown powder, the sealing preservation.
The process 3 of preparation Fructus chebulae immaturus effective site, it is characterized in that: Fructus chebulae immaturus adopts percolation to extract Fructus chebulae immaturus effective site, at normal temperatures and pressures through screening, pulverizing, the Fructus chebulae immaturus of pulverizing is packed in the percolation bucket, add concentration 15～20 times of amounts of 50～90% ethanol (w/w) solvent dipping, percolation speed is 1 milliliter/1 minute, and the percolate total amount is 15～20 times of medical material, percolate merges, filter, filtrate was left standstill 48 hours for 0～10 ℃, filtered with microporous filter membrane; Filtrate adding assistant alkali liquor transferred to PH7.5～8.5,0～10 ℃ precipitation 36 hours, and inclining supernatant, filter, and the collecting precipitation thing, vacuum drying promptly gets the yellowish-brown powder, and sealing is preserved.
Fructus chebulae immaturus effective site is controlled the application of the medicine of antibacterial and disease of viral infection as preparation, it is characterized in that: with the above-mentioned Fructus chebulae immaturus effective site that obtains---yellowish-brown powder Fructus chebulae immaturus depside salt, mix with organic and/or inorganic solid or liquid excipient, be prepared into solid form, semi-solid form and liquid form with existing mature technology, solid form is tablet, granule, powder, capsule, injectable powder; Semi-solid form is ointment, gel, ointment; Liquid form is injection, suspensoid, syrup, Emulsion; Wherein each preparation unit's effective site content of solid form is 0.01 gram～1.0 grams, each preparation unit's effective site content of semi-solid form is 0.5 gram～5.0 grams, and the percentage concentration of each preparation unit's effective site of liquid form is 0.05%～5.0% (g/ml).
Advantage of the present invention and effect:
1. Chinese medicine Fructus chebulae immaturus, also claim FRUCTUS TERMINALIAE IMMATURUS, Tibet Fructus Canarii, be the dry young fruit of Combretum Racemosum plant Terminaliachebulae Retg, little acid, bitterness, be slightly cold, return intestinal, stomach etc., astringe the lung through being mainly used in, sore-throat relieving, astringing intestine to stop diarrhea stopping leak, be used for diphtheria, laryngitis tonsillitis, bacterium profit etc.This Fructus chebulae immaturus effective site is that salt (being called Fructus chebulae immaturus depside salt or the Fructus chebulae immaturus) content made of liposoluble ingredient that the molecular weight of representative varies in size is more than 80% with chebulinic acid, Chebulagic acid, gallic acid.It is long avette, slightly flat that Fructus chebulae immaturus is, and long 1.5-3 centimetre, diameter 0.5-1.2 centimetre, tool is significantly indulged wrinkle, pitchy, and matter is hard, and colloid sample gloss is arranged, and examines not obviously, generally has hollow." Chinese medicine Ci hai " document record that Chinese medical courses in general publishing house in 1997 publishes: the property of medicine: nature and flavor acid, hardship, puckery, be slightly cold.Return warps such as lung, stomach, effect: clearing away heat and promoting production of body fluid, liyan jiedu has astringing intestine to stop diarrhea to astringe the lung, the pathogenic fire reducing sore-throat relieving.Cure mainly pneumonia, bacillary dysentery, deficiency of YIN diphtheria is used for chronic diarrhea and dysentery, the proctoptosis of having blood in stool, the deficiency of the lung, and cough with asthma is more than, pharyngalgia hoarseness (silent), tonsillitis, chronic pharyngolaryngitis.
2. clinical practice: extract effective ingredient (phenolic acid salt) in the Fructus chebulae immaturus, making oral capsule and externally-applied soft ointment is used for clinical, suppurative dermatosis (comprising furuncle, carbuncle, erysipelas, paronychia, wound infection, ulcer of the lower limb, cellulitis etc.), urinary system infection disease (comprising acute urinary tract infection, acute cystitis, the acute gonorrhea etc.) state of an illness to 84 routine pathogenic infections are light, severe patient, carry out the clinical treatment medication and make observation of curative effect, and compare with Western medicine group 78 examples, the total effective rate of treatment group as a result is 96.43%, and cure rate is 90.47%; The matched group total effective rate is 94.88%, and cure rate is that 78.20%, two group of curative effect comparison cure rate has significant difference: P＞0.05, the curative effect of prompting treatment group obviously is better than matched group, any untoward reaction do not occur.
Selected 169 routine patients of pathogenic infection to treat in addition, man's 76 examples, woman's 93 examples, the course of disease is 3 days-9 months, 169 routine patients are divided into gonorrhea 20 examples, suppurative case 84 examples, genitals 41 examples of festering, acne 24 examples draw pathogenic bacteria by smear staining and mainly contain the positive coccus of leather Lan Shi, leather Lan Shi negative cocci and Oidiomycetes; In treatment, to suppurative inflammation patient by pathogenic infection, do not take and any anti-microbial type medicine of not external, all use Fructus chebulae immaturus effective site---phenolate preparation for treating, wherein gonorrhea 20 example recoveries from illness, the 41 example recoveries from illness of festering of suppurative case 84 example recoveries from illness 71 examples, produce effects 11 examples, invalid 3 examples, genitals, acne 24 example recoveries from illness 20 examples, produce effects 3 examples, invalid 1 examples.Total effective rate reaches 97.64% as a result.
3. the inventor is once to the test of 329 kinds of Chinese herbal medicine vitro antibacterial activities, and the Fructus chebulae immaturus effective site of extraction (phenolic acid salt) is the strongest to staphylococcus aureus, bacillus pyocyaneus, escherichia coli, shigella flexneri effect; Once 124 kinds of Chinese herbal medicine are carried out antibacterial potency again and measure, the result learns that Fructus chebulae immaturus is the highest to the antibacterial potency of common pathogen, can deserve to be called the hat of hundred medicines in the Chinese herbal medicine.Adopting modern scientific method therefrom to extract effective antimicrobial component, carry out above-mentioned antibacterial tests, prove the antibacterial potency height of this effective site than crude drug, is the antibiotic effective site of a kind of new plant amedica.
4. extracting with scientific method in the Fructus chebulae immaturus is that the salt (being called Fructus chebulae immaturus depside salt or Fructus chebulae immaturus) that liposoluble ingredient that the molecular weight of representative varies in size is made is a class new product of effective site with chebulinic acid, Chebulagic acid, gallic acid, extraction process has circumfluence method, decocts extraction method, percolation extraction method, but the effective site sharp separation.This Fructus chebulae immaturus depside salt effective site, stable in properties, high temperature resistant, antioxidation, stable in properties, method with this effective site with medicament, can make the various medicament forms that adapt to clinical use, mix with organic and/or inorganic solid or liquid excipient, be prepared into solid form with existing mature technology, semi-solid form and liquid form, solid form is a tablet, granule, powder, capsule, injectable powder, semi-solid form is an ointment, gel, ointment, liquid form is an injection, suspensoid, syrup, Emulsion, each preparation unit's effective site content of solid form is 0.01 gram～1.0 grams, each preparation unit's effective site content of semi-solid form is 0.5 gram～5.0 grams, and the percentage concentration of each preparation unit's effective site of liquid form is 0.05%～5.0%.The medicament forms that this effective site obtains, main interaction energy killing bacteria is applicable to antibacterial and disease of viral infection.
Four, specific embodiment:
Implement 1: adopt circumfluence method to extract Fructus chebulae immaturus effective site, Fructus chebulae immaturus is through screening, mechanical activation comminution, at normal temperatures and pressures, the Fructus chebulae immaturus of pulverizing is placed in the return channel, adds 8～12 times of amounts of concentration 50%～80% ethanol solvent, reflux, extract, 3 times, each 2 hours, merge extractive liquid, filtered, filtrate was left standstill 48 hours for 0～10 ℃, filtered with microporous filter membrane (aperture is 0.5～0.8 micron); Filtrate adding assistant alkali liquor (as?, these auxiliary agent alkali liquor) transfer to PH7.5～8.5,0～10 and ℃ left standstill 36 hours, inclining supernatant, filter, the collecting precipitation thing, vacuum drying promptly get the yellowish-brown powder, and the sealing preservation is stand-by.With stand-by Fructus chebulae immaturus effective site yellowish-brown powder---Fructus chebulae immaturus depside salt, mix with organic and/or inorganic solid or liquid excipient, be prepared into solid form with existing mature technology, semi-solid form and liquid form, solid form is a tablet, granule, powder, capsule, injectable powder, semi-solid form is an ointment, gel, ointment, liquid form is an injection, suspensoid, syrup, Emulsion, each preparation unit's effective site content of solid form is 0.01 gram～1.0 grams, each preparation unit's effective site content of semi-solid form is 0.5 gram～5.0 grams, and the percentage concentration of each preparation unit's effective site of liquid form is 0.05%～5.0%.For example each dosage form of solid form is divided into ten groups: be respectively 0.01,0.02 gram, 0.04 gram, 0.08 gram, 0.16 gram, 0.32 gram, 0.64 gram, 0.8 gram, 0.9 gram and 1.0 grams are respectively applied for treatment urinary system infection disease with these medicines, including acute urinary tract infection, acute cystitis, acute gonorrhea, genitals festers etc., oral, each 3 (1/3 granule bag, 1/3 bag of powder, 3 capsules), every day 3 times, 7～10 is a course of treatment, according to the state of an illness oral 1～3 course of treatment, weight person patient cooperates other drug simultaneously, but both produce effects or recoveries from illness.
Implement 2: adopt to decoct extraction method extraction Fructus chebulae immaturus effective site, Fructus chebulae immaturus is pulverized through screening, at normal temperatures and pressures, the Fructus chebulae immaturus of pulverizing is placed in the still device, adds pure water to the submergence medical material, soak after 30 minutes, heated and boiled keeps little and boiled 1 hour, leach decoction liquor, medicinal residues fried again 2 times according to this method are collected the fried liquid of each time, centrifugalize or cold preservation sedimentation, filter, cryoconcentration to relative density is 1.05～1.20; Add dehydrated alcohol to 2～3 times volume, stir, 0～10 ℃ left standstill 36 hours, filtered, and 0～10 ℃ left standstill 48 hours, and filtered with microporous filter membrane; Filtrate adding assistant alkali liquor transferred to PH7.5～8.5,0～10 ℃ precipitation 36 hours, and inclining supernatant, filter, and the collecting precipitation thing, vacuum drying promptly gets yellowish-brown powder Fructus chebulae immaturus depside salt, and sealing is preserved, and is stand-by.With above-mentioned stand-by Fructus chebulae immaturus effective site Fructus chebulae immaturus depside salt yellowish-brown powder, mix with organic and inorganic liquid excipient, be prepared into solid form with existing mature technology, semi-solid form and liquid form, solid form is a tablet, granule, powder, capsule, injectable powder, semi-solid form is an ointment, gel, ointment, liquid form is an injection, suspensoid, syrup, Emulsion, each preparation unit's effective site content of solid form is 0.01 gram～1.0 grams, each preparation unit's effective site content of semi-solid form is 0.5 gram～5.0 grams, and the percentage concentration of each preparation unit's effective site of liquid form is 0.05%～5.0%.For example semi-solid form is divided into 42 groups, 0.5,0.6,0.7,0.8,0.9,1.0,1.1,1.2,1.3,1.4,1.5,1.6,1.7,1.8,1.9,2.0,2.1,2.2,2.3,2.4,2.5,2.6,2.7,2.8,2.9,3.0,3.1,3.2,3.3,3.4,3.5,3.6,3.7,3.8,3.9,4.0,4.1,4.2,4.3,4.4,4.5,4.6,4.7,4.8,4.9 the disease of suppurative skin infection aspect is treated: the suppuration sexually transmitted disease (STD) by 5.0 (units for gram), the seat skin ulcer, genitals festers, and first debridement face is with ointment, gel, ointment, or liniment is applied to or puts on the skin in wound face, reuse gauze or the wrapping of aseptic sliver, and every day 1 time, 5～7 days was 1 course of treatment, connect and applied for 1～3 course of treatment,, come off recovery from illness voluntarily to wound face formation crust.
Implement 3: adopt the percolation extraction method to extract Fructus chebulae immaturus effective site, Fructus chebulae immaturus is through screening, pulverizing, at normal temperatures and pressures, the Fructus chebulae immaturus of pulverizing is packed in the percolation bucket, add 15～20 times of amounts of concentration 50～80% ethanol solvent dipping, percolation speed is 1 milliliter/1 minute, the percolate total amount is 15～20 times of medical material, and percolate merges, and filters, filtrate was left standstill 48 hours for 0～10 ℃, filtered with microporous filter membrane; Filtrate adding assistant alkali liquor transferred to PH7.5～8.5,0～10 ℃ precipitation 36 hours, and inclining supernatant, filter, and the collecting precipitation thing, vacuum drying promptly gets yellowish-brown powder Fructus chebulae immaturus depside salt, and sealing is preserved, and is stand-by.With above-mentioned stand-by Fructus chebulae immaturus effective site Fructus chebulae immaturus depside salt yellowish-brown powder, mix with organic and/or inorganic solid or liquid excipient, be prepared into solid form with existing mature technology, semi-solid form and liquid form, solid form are tablet, granule, powder, capsule, injectable powder, semi-solid form is an ointment, gel, ointment, liquid form is an injection, suspensoid, syrup, Emulsion, each preparation unit's effective site content of solid form are 0.01 gram～1.0 grams, and each preparation unit's effective site content of semi-solid form is 0.5 gram～5.0 grams, the percentage concentration of each preparation unit's effective site of liquid form is 0.05%～5.0% (g/ml), concentration is respectively 0.05%, 0.1%, and 0.2%, 0.4%, 0.8%, 1.6%, 2.4%, 3.2%, 4.0%,, 5.0%, 0.08%, 0.09%, 0.15%, 0.18%, 0.25%, 0.30%, 0.35%, 0.38%, 0.45%, 0.47%, 0.12%, 0.17%, 0.24%, 0.26%, 0.28%, 0.33%, 0.37%, 0.44%, 0.49%, for example liquid form is divided into 29 groups.Treat the disease of respiratory system aspect, for example injections such as pharyngitis, bronchitis, pneumonia are 2～100 milliliters, every day 2 times; Oral each 10～20 milliliters of other dosage forms, every day 3 times, serveing on 7～10 days is a course of treatment, according to the state of an illness oral 1～3 course of treatment, weight person patient cooperates other drug simultaneously, but both produce effects or recoveries from illness.Perhaps treat the disease of suppurative skin infection aspect: suppuration sexually transmitted disease (STD), seat skin ulcer, genitals fester, elder generation's debridement face, also available liquid medicine directly drips medicine-feeding with gauze or aseptic sliver band, with the fixing wrapping of adhesive tape affected part, drip medicine every day 5～7 times, make wound face form crust, come off voluntarily after 7 days, but both produce effects or recoveries from illness.
Claims (5)
1, a kind of effective site of Fructus chebulae immaturus extraction, the feature of this effective site is: with chebulinic acid, Chebulagic acid, gallic acid is that the salt (being called Fructus chebulae immaturus depside salt or Fructus chebulae immaturus) that liposoluble ingredient that the molecular weight of representative varies in size is made is an effective site, contains the phenolic acid salts substances and be a class new product of 80%～100%.
2, the process of preparation Fructus chebulae immaturus effective site, it is characterized in that: Fructus chebulae immaturus adopts circumfluence method to extract Fructus chebulae immaturus effective site, at normal temperatures and pressures through screening, pulverizing, the Fructus chebulae immaturus of pulverizing is placed in the return channel, add concentration 8～12 times of amounts of 50%～80% ethanol (w/w) solvent, reflux, extract, 3 times, each 2 hours, merge extractive liquid,, filter, filtrate was left standstill 48 hours at 0～10 ℃, filtered with microporous filter membrane; Filtrate adding assistant alkali liquor transfers to PH7.5～8.5,0～10 and ℃ staticly settled 36 hours, and inclining supernatant, filter, and the collecting precipitation thing, vacuum drying promptly get the yellowish-brown powder, the sealing preservation.
The process of 3 preparation Fructus chebulae immaturus effective sites is characterized in that: Fructus chebulae immaturus is through screening, pulverizing, and employing decocts extraction method and puies forward Fructus chebulae immaturus effective site, at normal temperatures and pressures, the Fructus chebulae immaturus of pulverizing is placed in the still device, adds pure water submergence medical material, soak after 30 minutes, heated and boiled keeps little and boiled 1 hour, leach decoction liquor, medicinal residues fried again 2 times according to this method are collected the fried liquid of each time, centrifugalize or cold preservation sedimentation, filter, being evaporated to relative density is 1.05～1.20; Add dehydrated alcohol to 2～3 times volume, stir, 0～10 ℃ left standstill 36 hours, filtered, and 0～10 ℃ left standstill 48 hours again, filtered with microporous filter membrane; Filtrate adding assistant alkali liquor transfers to PH7.5～8.5,0～10 and ℃ staticly settled 36 hours, and inclining supernatant, filter, and the collecting precipitation thing, vacuum drying promptly get the yellowish-brown powder, the sealing preservation.
4, the process of preparation Fructus chebulae immaturus effective site, it is characterized in that: Fructus chebulae immaturus adopts percolation to extract Fructus chebulae immaturus effective site, at normal temperatures and pressures through screening, pulverizing, the Fructus chebulae immaturus of pulverizing is packed in the percolation bucket, add concentration 15～20 times of amounts of 50～90% ethanol (w/w) solvent dipping, percolation speed is 1 milliliter/1 minute, and the percolate total amount is 15～20 times of medical material, percolate merges, filter, filtrate was left standstill 48 hours for 0～10 ℃, filtered with microporous filter membrane; Filtrate adding assistant alkali liquor transferred to PH7.5～8.5,0～10 ℃ precipitation 36 hours, and inclining supernatant, filter, and the collecting precipitation thing, vacuum drying promptly gets the yellowish-brown powder, and sealing is preserved.
5, Fructus chebulae immaturus effective site is controlled the application of the medicine of antibacterial and disease of viral infection as preparation, it is characterized in that: with the above-mentioned Fructus chebulae immaturus effective site that obtains---yellowish-brown powder Fructus chebulae immaturus depside salt, mix with organic and/or inorganic solid or liquid excipient, be prepared into solid form, semi-solid form and liquid form with existing mature technology, solid form is tablet, granule, powder, capsule, injectable powder; Semi-solid form is ointment, gel, ointment; Liquid form is injection, suspensoid, syrup, Emulsion; Wherein each preparation unit's effective site content of solid form is 0.01 gram～1.0 grams, each preparation unit's effective site content of semi-solid form is 0.5 gram～5.0 grams, and the percentage concentration of each preparation unit's effective site of liquid form is 0.05%～5.0% (g/ml).
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| CNB2005100428852A CN100502894C (en) | 2005-07-01 | 2005-07-01 | Method for preparing medicine of effective parts extracted from myrobalan for treating diseases infected by bacteria or virus |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101532245B (en) * | 2009-04-09 | 2010-12-01 | 浙江理工大学 | Method for extracting, from myrobalan, finishing agent having a function of removing formaldehyde, and applications thereof |
| CN102764282A (en) * | 2012-08-06 | 2012-11-07 | 中国人民解放军第三军医大学第一附属医院 | Method for extracting and separating tannins components of immature fruits of medicine terminalia |
| CN106841462A (en) * | 2016-12-20 | 2017-06-13 | 宁夏多维药业有限公司 | The detection method of gallic acid in a kind of FRUCTUS TERMINALIAE IMMATURUS |
| CN108467417A (en) * | 2018-04-23 | 2018-08-31 | 中国科学院成都生物研究所 | FRUCTUS TERMINALIAE IMMATURUS extract, FRUCTUS TERMINALIAE IMMATURUS extract monomeric compound and its application in inhibiting monoamine oxidase B activity |
| CN109806205A (en) * | 2019-01-07 | 2019-05-28 | 惠州绵俪生物科技有限公司 | A kind of FRUCTUS TERMINALIAE IMMATURUS extract and its antibacterial application |
| CN115381877A (en) * | 2022-09-30 | 2022-11-25 | 西安航天基地美托邦医疗美容有限公司 | A topical skin preparation for treating acne, and its preparation method |
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2005
- 2005-07-01 CN CNB2005100428852A patent/CN100502894C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101532245B (en) * | 2009-04-09 | 2010-12-01 | 浙江理工大学 | Method for extracting, from myrobalan, finishing agent having a function of removing formaldehyde, and applications thereof |
| CN102764282A (en) * | 2012-08-06 | 2012-11-07 | 中国人民解放军第三军医大学第一附属医院 | Method for extracting and separating tannins components of immature fruits of medicine terminalia |
| CN106841462A (en) * | 2016-12-20 | 2017-06-13 | 宁夏多维药业有限公司 | The detection method of gallic acid in a kind of FRUCTUS TERMINALIAE IMMATURUS |
| CN108467417A (en) * | 2018-04-23 | 2018-08-31 | 中国科学院成都生物研究所 | FRUCTUS TERMINALIAE IMMATURUS extract, FRUCTUS TERMINALIAE IMMATURUS extract monomeric compound and its application in inhibiting monoamine oxidase B activity |
| CN108467417B (en) * | 2018-04-23 | 2021-07-06 | 中国科学院成都生物研究所 | Fructus chebulae immaturus extract, fructus chebulae immaturus extract monomer compound and application of fructus chebulae immaturus extract monomer compound in inhibition of monoamine oxidase B activity |
| CN109806205A (en) * | 2019-01-07 | 2019-05-28 | 惠州绵俪生物科技有限公司 | A kind of FRUCTUS TERMINALIAE IMMATURUS extract and its antibacterial application |
| CN109806205B (en) * | 2019-01-07 | 2022-07-01 | 惠州绵俪生物科技有限公司 | Fructus chebulae immaturus extract and antibacterial application thereof |
| CN115381877A (en) * | 2022-09-30 | 2022-11-25 | 西安航天基地美托邦医疗美容有限公司 | A topical skin preparation for treating acne, and its preparation method |
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