CN1720904A - 用于氧载体的氟化碳乳液 - Google Patents

用于氧载体的氟化碳乳液 Download PDF

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Publication number
CN1720904A
CN1720904A CNA2005100544073A CN200510054407A CN1720904A CN 1720904 A CN1720904 A CN 1720904A CN A2005100544073 A CNA2005100544073 A CN A2005100544073A CN 200510054407 A CN200510054407 A CN 200510054407A CN 1720904 A CN1720904 A CN 1720904A
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CN
China
Prior art keywords
blood
oxygen
perfluorocarbon
patient
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005100544073A
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English (en)
Chinese (zh)
Inventor
N·S·法福尔
P·E·凯佩尔特
D·J·罗思
R·M·霍金斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alliance Pharmaceutical Corp
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Alliance Pharmaceutical Corp
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Filing date
Publication date
Application filed by Alliance Pharmaceutical Corp filed Critical Alliance Pharmaceutical Corp
Publication of CN1720904A publication Critical patent/CN1720904A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/41—Porphyrin- or corrin-ring-containing peptides
    • A61K38/42—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/025—Halogenated hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • External Artificial Organs (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNA2005100544073A 1995-06-07 1996-06-07 用于氧载体的氟化碳乳液 Pending CN1720904A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/484,166 US5865784A (en) 1995-06-07 1995-06-07 Method of hemodilution facilitated by monitoring oxygenation status
US08/484166 1995-06-07

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN96195920A Division CN1192155A (zh) 1995-06-07 1996-06-07 通过监测氧合状态有助血液稀释

Publications (1)

Publication Number Publication Date
CN1720904A true CN1720904A (zh) 2006-01-18

Family

ID=23923030

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA2005100544073A Pending CN1720904A (zh) 1995-06-07 1996-06-07 用于氧载体的氟化碳乳液
CN96195920A Pending CN1192155A (zh) 1995-06-07 1996-06-07 通过监测氧合状态有助血液稀释

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN96195920A Pending CN1192155A (zh) 1995-06-07 1996-06-07 通过监测氧合状态有助血液稀释

Country Status (13)

Country Link
US (3) US5865784A (enExample)
EP (1) EP0831890A1 (enExample)
JP (1) JPH11507378A (enExample)
KR (1) KR19990022355A (enExample)
CN (2) CN1720904A (enExample)
AU (1) AU717317B2 (enExample)
CA (1) CA2222066A1 (enExample)
HU (1) HUP9802266A3 (enExample)
IL (1) IL122239A0 (enExample)
NO (1) NO975318L (enExample)
PL (1) PL323937A1 (enExample)
WO (1) WO1996040222A1 (enExample)
ZA (1) ZA964656B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101448485B (zh) * 2006-05-22 2013-01-09 联合制药公司 用于血液替代品和其他治疗用途的优化的氟碳乳剂
CN116370633A (zh) * 2023-04-21 2023-07-04 中国药科大学 一种包载全氟己烷和抗氧化剂的纳米脂质制剂及其制备方法与制备治疗心肌梗死药物的应用

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US6180059B1 (en) * 1995-06-05 2001-01-30 Therox, Inc. Method for the preparation and delivery of gas-enriched fluids
US5865784A (en) 1995-06-07 1999-02-02 Alliance Pharmaceutical Corp. Method of hemodilution facilitated by monitoring oxygenation status
WO1999053287A2 (en) * 1998-04-09 1999-10-21 California Institute Of Technology Electronic techniques for analyte detection
GB2343679A (en) * 1998-11-16 2000-05-17 Alison Miriam Davies Autologous transplantation and method for making cells dormant
US6884228B2 (en) 2001-03-06 2005-04-26 Baxter International Inc. Automated system adaptable for use with different fluid circuits
US6706008B2 (en) 2001-03-06 2004-03-16 Baxter International Inc. Automated system and method for withdrawing compounds from blood
US6808503B2 (en) 2001-03-06 2004-10-26 Baxter International Inc. Automated system and method for pre-surgical blood donation and fluid replacement
US6582386B2 (en) 2001-03-06 2003-06-24 Baxter International Inc. Multi-purpose, automated blood and fluid processing systems and methods
US6811778B2 (en) * 2001-09-10 2004-11-02 Biopure Corporation Method for improving oxygen transport by stored red blood cells
US20070160645A1 (en) * 2001-10-25 2007-07-12 Jakob Vinten-Johansen PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs
ATE411058T1 (de) 2001-10-25 2008-10-15 Univ Emory Katheter für modifizierte perfusion
US7241307B2 (en) * 2001-12-31 2007-07-10 Medcool, Inc. Method and apparatus for managing temperature in a patient
JP4773098B2 (ja) * 2003-01-23 2011-09-14 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 呼気を用いる静脈薬剤濃度をモニタするための方法および装置
US20100093873A1 (en) * 2008-10-02 2010-04-15 Goldfischer Sidney L Methods of improving therapy of perfluorocarbons (PFC)
US8636952B2 (en) * 2008-12-04 2014-01-28 Therox, Inc. System for enriching a bodily fluid with a gas having a removable gas-enrichment device with an information recording element
US20100143190A1 (en) * 2008-12-04 2010-06-10 Therox, Inc. System for enriching a bodily fluid with a gas having occlusion detection capabilities
US8192384B2 (en) * 2008-12-04 2012-06-05 Therox, Inc. System for enriching a bodily fluid with a gas having a dual-function power switch mechanism
US8246564B2 (en) * 2008-12-04 2012-08-21 Therox, Inc. System for enriching a bodily fluid with a gas having automated priming capabilities
US20100143192A1 (en) * 2008-12-04 2010-06-10 Therox, Inc. Method and device for combined detection of bubbles and flow rate in a system for enriching a bodily fluid with a gas
US7989593B1 (en) 2010-05-27 2011-08-02 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US8048856B1 (en) 2010-06-23 2011-11-01 Billion King, Ltd. Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
CN108380965B (zh) * 2013-04-04 2021-02-19 米沃奇电动工具公司 电动工具
GB2540724A (en) 2015-03-06 2017-02-01 Spectrum Medical Ltd Blood analysis apparatus and method
FR3097770B1 (fr) * 2019-06-27 2024-03-01 I Sep Système et procédé de traitement de liquide hémorragique pour de l’autotransfusion
CN111135360A (zh) * 2020-01-21 2020-05-12 广州弘大医疗科技有限公司 一种右心辅助装置及其控制方法

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US3958014A (en) 1970-09-05 1976-05-18 The Green Cross Corporation Process for preparing injection-purpose fluorocarbon emulsion capable of carrying oxygen
US3975512A (en) * 1970-12-21 1976-08-17 University Of Illinois Foundation Non-toxic brominated perfluorocarbons radiopaque agents
US4073879A (en) * 1974-08-26 1978-02-14 University Of Illinois Foundation Brominated perfluorocarbon radiopaque agents
DE2754894C2 (de) 1977-12-09 1983-10-13 Fresenius AG, 6380 Bad Homburg Vorrichtung zum Bilanzieren einer einem Patienten entnommenen Flüssigkeit mit einer Ersatzflüssigkeit
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DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
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DE3340592A1 (de) * 1983-11-10 1985-05-23 B. Braun Melsungen Ag, 3508 Melsungen Konjugate makromolekularer verbindungen an haemoglobine, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
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DE3412144A1 (de) * 1984-03-31 1985-10-10 Biotest Pharma GmbH, 6000 Frankfurt Verfahren zur herstellung hochgereinigter, stromafreier, hepatitissicherer human- und tierhaemoglobinloesungen
US4600531A (en) * 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4987154A (en) * 1986-01-14 1991-01-22 Alliance Pharmaceutical Corp. Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
US4927623A (en) 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
US5080885A (en) 1986-01-14 1992-01-14 Alliance Pharmaceutical Corp. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
US4865836A (en) * 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101448485B (zh) * 2006-05-22 2013-01-09 联合制药公司 用于血液替代品和其他治疗用途的优化的氟碳乳剂
CN116370633A (zh) * 2023-04-21 2023-07-04 中国药科大学 一种包载全氟己烷和抗氧化剂的纳米脂质制剂及其制备方法与制备治疗心肌梗死药物的应用

Also Published As

Publication number Publication date
AU717317B2 (en) 2000-03-23
HUP9802266A3 (en) 2001-03-28
AU6271396A (en) 1996-12-30
NO975318D0 (no) 1997-11-19
ZA964656B (en) 1997-02-28
CN1192155A (zh) 1998-09-02
US5865784A (en) 1999-02-02
EP0831890A1 (en) 1998-04-01
HUP9802266A2 (hu) 1999-02-01
JPH11507378A (ja) 1999-06-29
USRE38081E1 (en) 2003-04-15
KR19990022355A (ko) 1999-03-25
IL122239A0 (en) 1998-04-05
NO975318L (no) 1998-01-30
PL323937A1 (en) 1998-04-27
WO1996040222A1 (en) 1996-12-19
CA2222066A1 (en) 1996-12-19
US6007774A (en) 1999-12-28

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C02 Deemed withdrawal of patent application after publication (patent law 2001)
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