CN1712036A - Medicine for resisting senility and regulating organismic immune - Google Patents
Medicine for resisting senility and regulating organismic immune Download PDFInfo
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- CN1712036A CN1712036A CN 200410048209 CN200410048209A CN1712036A CN 1712036 A CN1712036 A CN 1712036A CN 200410048209 CN200410048209 CN 200410048209 CN 200410048209 A CN200410048209 A CN 200410048209A CN 1712036 A CN1712036 A CN 1712036A
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- resveratrol
- described medicine
- medicine
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- polygoni cuspidati
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Abstract
A medicine for delaying senility and regulating immunity is prepared from resveratrol and one or mere of the extracts of giant knotweed rhizome, etc. Its preparing process and application are also disclosed.
Description
Technical field the present invention relates to biomedical sector, specifically relate to medicine and the preparation and the application of a kind of defying age and adjusting immunity of organism, the medicine that it is characterized in that defying age and regulate immunity of organism comprises one or more in the extracts such as resveratrol or resveratrol and Rhizoma Polygoni Cuspidati, Fructus Vitis viniferae, can delay the aging of human multiple internal organs, regulate body's immunity, the present invention also provides the preparation and the application of this medicine.
Background technology
The chemical name of resveratrol (Resveratrol) is (E)-5-[2-(4-hydroxyphenyl)-vinyl]-1, the 3-Benzodiazepines.
Studies have shown that resveratrol has the effect of tangible antioxidation, free radical resisting and the aging of delaying human body function, and the pharmacologically active of anticancer significantly, antiinflammatory, sterilization, blood fat reducing, antithrombotic, atherosclerosis, prevention cardiovascular and cerebrovascular disease; Can effectively suppress tumor, prevent and treat coronary heart disease, heart disease, hyperlipidemia.Because resveratrol has positive effect to the treatment and the prevention of cancer and cardiovascular and cerebrovascular disease, its research causes concern day by day with application.Our recent findings resveratrol and composition of medicine thereof can defying age and are kept the kidney normal function.
Resveratrol mainly extracts (content 0.05-0.02%), content higher (reaching as high as 1%) in the Chinese crude drugs such as recent findings Radix Et Rhizoma Rhei, Rhizoma Polygoni Cuspidati the earliest from Pericarpium Vitis viniferae (seed).Resveratrol does not have chiral centre, and structure is simpler, can be manually complete synthesis.We are initiation material with the methyl phenyl ethers anisole with common raw material, all adopt room temperature, synthesis under normal pressure, add a distilling under reduced pressure, have synthesized our desirable monomer.
The people entered after the middle age, and aging is the natural law, and followed old and feeble generation, disease severe impairment such as some frequently-occurring diseases, commonly encountered diseases, Senile disease such as diabetes, cardiovascular and cerebrovascular vessel, tumor, hyperlipidemia middle-aged and elderly people health.To the aging development, China has entered aging society to world population gradually, and the population more than 60 years old surpassed 200,000,000 in 2000, and was increasing with 34% speed.Be localized natural health product with healthy elder at present, mainly lay particular emphasis on replenishing of vitamin and trace element abroad.Domestic is that the product of additive is more with traditional tonic Chinese medicine material, and the effect material is indeterminate, and product quality is uncontrollable.The defying age of our exploitation and the medicine and the combination thereof of adjusting body's immunity, the effect material is clear and definite, and mechanism is clear and definite, and is quality controllable.
Summary of the invention the present invention aim to provide a kind of can defying age and regulate the medicine of immunity of organisms.The result shows that this medicine by reducing copy error, prolongs cell doubling time on cellular level, and the reduction telomere shortens the speed slow down aging, keeps organ function, the conciliation immunity of organism by prolonging the functioning cell life-span on integral level.
This invention provides the composition of this medicine, methods for making and using same:
One, a kind of defying age and the medicine of regulating immunity of organism form the resveratrol list medicine that comprises clinical dosage or with one or more of natural plant extracts such as Fructus Vitis viniferae, Rhizoma Polygoni Cuspidati.Dosage form comprises various oral formulations forms.
Two, to form preparation 1 be initiation material with the methyl phenyl ethers anisole for a kind of defying age and the medicine of regulating immunity of organism, first synthesis of trans-3, and 4 ', 5-trimethoxy stilbene gets resveratrol through demethoxylation then.2 contain the materials such as Rhizoma Polygoni Cuspidati of resveratrol earlier with organic solvent extraction, obtain resveratrol with column chromatography then, can improve the output of resveratrol before the extraction by materials such as fermentation Rhizoma Polygoni Cuspidati.3 are mixed and made into granule with resveratrol and glucose powder, and in the In Aluminium Foil Packing of packing into, the dark-coloured capsule of packing into after perhaps resveratrol and starch or dextrin being mixed perhaps adds resveratrol in the oral liquid.
Three, application process the present invention of the medicine composition of a kind of defying age and adjusting immunity of organism provides the medicine of using above-mentioned defying age and regulating immunity of organisms to form the method for carrying out defying age and regulating immunity of organisms.
The present invention will be further described below in conjunction with the specific embodiment, all this areas of having done according to the disclosure of invention be equal to replacement, all belong to protection scope of the present invention.
The specific embodiment
Embodiment 1
For example, the resveratrol delaying cell aging is implemented like this:
(a) in the WI-38 cell culture fluid, add 0.2-200 μ M resveratrol or 0.5% dimethyl sulfoxide;
(b) detect resveratrol intervention and cellular control unit doubling time in (a), the terminal joint efficiency of DNA, telomere shortens speed, P21, the expression of P16 and IL-10;
(c) compare (b) resveratrol intervention group and matched group data, find that the former prolongs by cell doubling time, the terminal joint efficiency of DNA increases, and telomere shortening speed reduces, P21, the expression increase of P16 and IL-10;
Embodiment 2
For example, resveratrol and composition of medicine thereof delay the rat aging and improve renal function and implement like this:
(a) senile rat oral 0.2mg resveratrol every day or simulation placebo replace after 28 days, 2 cycles totally; Then
(b) detect kidney of rats glomerular filtration rate in (a), obtain base-line data, data after each treatment cycle; Then
(c) compare resveratrol intervention group and matched group data in (b), find that the former improves the kidney of rats glomerular filtration rate.
Embodiment 3
For example, the resveratrol capsule prepares like this:
(a) with 10mg resveratrol and 0.25g starch or dextrin mixing; Then
(b) mixture in (a) is packed into dark-coloured capsule.
Embodiment 4
For example, resveratrol and composition of medicine thereof improve people's renal function and implement like this:
(a) healthy elder volunteer every day oral 10mg resveratrol or simulation placebo, after 28 days alternately, totally 2 cycles; Then
(b) detect volunteer's glomerular filtration rate in (a), obtain base-line data, all after date data of each medication; Then
(c) compare resveratrol intervention group and matched group data in (b), find that the former improves the middle-aged and elderly people glomerular filtration rate.
Claims (7)
1. a defying age and regulate medicine and the preparation and the application of immunity of organism is characterized in that comprising in the extracts such as resveratrol or resveratrol and Rhizoma Polygoni Cuspidati, Fructus Vitis viniferae one or more, can delay the aging of human multiple internal organs, keeps organ function.
2. described medicine of claim 1 and combination thereof is characterized in that: comprise resveratrol.
3. described medicine of claim 1 and combination thereof is characterized in that: comprise in the extracts such as resveratrol and Rhizoma Polygoni Cuspidati, Fructus Vitis viniferae one or more.
4. described medicine of claim 1 and combination thereof is characterized in that: described medicine is the oral formulations form.
5. described medicine of claim 4 and combination thereof, it is characterized in that: described medicine is a capsule, electuary, tablet, powder, granule, oral formulations forms such as oral liquid.
6. described medicine of claim 1 and combination thereof is characterized in that: resveratrol is initiation material with the methyl phenyl ethers anisole, first synthesis of trans-3, and 4 ', 5-trimethoxy stilbene, demethoxylation obtains then.
7. described medicine of claim 1 and combination thereof is characterized in that: contain the materials such as Rhizoma Polygoni Cuspidati of resveratrol earlier with organic solvent extraction, obtain resveratrol with column chromatography then, can improve the output of resveratrol before the extraction by materials such as fermentation Rhizoma Polygoni Cuspidati.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410048209 CN1712036A (en) | 2004-06-15 | 2004-06-15 | Medicine for resisting senility and regulating organismic immune |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410048209 CN1712036A (en) | 2004-06-15 | 2004-06-15 | Medicine for resisting senility and regulating organismic immune |
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| CN1712036A true CN1712036A (en) | 2005-12-28 |
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| CN 200410048209 Pending CN1712036A (en) | 2004-06-15 | 2004-06-15 | Medicine for resisting senility and regulating organismic immune |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8029830B2 (en) * | 2008-04-18 | 2011-10-04 | Nuvocare Health Services Inc. | Composition and method for promoting internal health and external appearance |
| CN105879015A (en) * | 2014-10-23 | 2016-08-24 | 大连世纪新源技术开发有限公司 | Deuterium depleted water (DDW) oral liquid capable of preventing cancer and aging |
| CN109700023A (en) * | 2017-10-25 | 2019-05-03 | 东莞自然衡健康科技有限公司 | A kind of functional food of anti-aging and preparation method thereof |
-
2004
- 2004-06-15 CN CN 200410048209 patent/CN1712036A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8029830B2 (en) * | 2008-04-18 | 2011-10-04 | Nuvocare Health Services Inc. | Composition and method for promoting internal health and external appearance |
| CN105879015A (en) * | 2014-10-23 | 2016-08-24 | 大连世纪新源技术开发有限公司 | Deuterium depleted water (DDW) oral liquid capable of preventing cancer and aging |
| CN109700023A (en) * | 2017-10-25 | 2019-05-03 | 东莞自然衡健康科技有限公司 | A kind of functional food of anti-aging and preparation method thereof |
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