CN1709320A - Oral liquid for clearing liver and gallbladder - Google Patents
Oral liquid for clearing liver and gallbladder Download PDFInfo
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- CN1709320A CN1709320A CNA2005100168696A CN200510016869A CN1709320A CN 1709320 A CN1709320 A CN 1709320A CN A2005100168696 A CNA2005100168696 A CN A2005100168696A CN 200510016869 A CN200510016869 A CN 200510016869A CN 1709320 A CN1709320 A CN 1709320A
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Abstract
The present invention relates to a Chinese medicine Gandan Shuangqing oral liquor with the functions of soothing liver, normalizing functioning of gallbladder, nourishing liver, tonifying kidney, strengthening the body resistance to eliminate pathogenic factors for curing chronic hepatitis with obvious therapeutic effect. Said Chinese medicine oral liquor is made up by using 8 Chinese medicinal materials of bear gall powder, moutan root bark, bearded scutellaria, codonopsis root, Chinese angelica root and others through a certain preparation process.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly a kind of Chinese medicine for the treatment of liver, biliary diseases refers to a kind of oral liquid for clearing liver and gallbladder especially.
Background technology
As everyone knows, various hepatopathys, especially hepatitis are higher at China's sickness rate, and the various medicines that are used for the treatment of hepatitis constantly come out, but still lack the health care to liver, the medicine of auxiliary treatment at present.Along with the foundation and the development of every detection technique of hepatitis, to the understanding of this class cause of disease also going deep into progressively.Not only the course of disease is long, treatment is difficult for hepatitis, and the relapse rate after curing is also higher.Therefore, the health medicine of development hepatitis, the recurrence for the curative effect that strengthens medicine, minimizing hepatopathy strengthen the function of liver and the resistance against diseases of body self, thereby the generation of prevention of liver disease and recurrence is very necessary.
Summary of the invention
The object of the present invention is to provide a kind of oral liquid for clearing liver and gallbladder, solved present treatment liver, biliary diseases medicine shortage, grow, take effect and wait problem slowly the course of treatment of treatment.
Theory of Chinese medical science and clinical trial certificate according to motherland, with the Fel Ursi is the main compound Chinese medicinal preparation of forming, not normal from the regulation and control of rectifier body immunity function, recover liver function, improve the angle of hepatic lesions, the hepatopath is played the health care and the effect of prevention of recurrence, therefore, though in the medication to help catharsis, can not be too diffusing; Though set upright, can not cross heap soil or fertilizer over and around the roots, drying can not be too dry; Heat clearing away can not too coldly be the medication purport, thirty years of age regulating liver-QI reason spleen, the method that heat-clearing and toxic substances removing is satisfactory to both parties.The pure Chinese herbal medicine of the selected following all flavors of the present invention is made by traditional Chinese medicine preparation technology.Its concrete prescription following (by ratio of weight and the number of copies):
20～60 parts of 0.5～5 part of Cortex Moutans of Fel Ursi powder
30～70 parts of 20～60 parts of Radix Codonopsis of Herba Scutellariae Barbatae
20～60 parts of 20～60 parts of Fructus Ligustri Lucidi of Radix Angelicae Sinensis
60～100 parts in 15～55 parts of Fructus Hordei Germinatus of Lignum Aquilariae Resinatum
Optimum ratio of the present invention is (by ratio of weight and the number of copies):
40 parts of 1 part of Cortex Moutans of Fel Ursi powder
50 parts of 40 parts of Radix Codonopsis of Herba Scutellariae Barbatae
40 parts of 40 parts of Fructus Ligustri Lucidi of Radix Angelicae Sinensis
60～100 parts in 20 parts of Fructus Hordei Germinatus of Lignum Aquilariae Resinatum
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral formulations.Preferable preparation technique of the present invention is as follows:
More than eight the flavor medicines, Fel Ursi powder is ground into fine powder and is dissolved in water, and makes the Fel Ursi powder aqueous solution; Cortex Moutan, Radix Angelicae Sinensis steam distillation, device is collected distillate in addition; Residue and all the other five kinds of Chinese medicine decoct with water 2 times, add 10 times of amounts for the first time, decoct 1.5 hours, for the second time add 7 times of amounts, decocted collecting decoction 1 hour, filter, it is 1.05～1.40 that filtrate is concentrated into temperature relative density in the time of 30 ℃～70 ℃, adds ethanol and makes and contain the alcohol amount and reach 75%, placed 24 hours, and filtered filtrate recycling ethanol, adding water stirs evenly, place, filter, filtrate concentrates; Other gets 150 parts of Mel, and heating in water bath to 70 ℃～80 ℃ is incubated 1 hour, merges with above-mentioned medicinal liquid, adds distillate and Fel Ursi powder aqueous solution again, adds the alcoholic solution that contains 0.5 part of para hydroxybenzene methyl ethyl ester, adds water, stirs evenly, filter, and fill, promptly.
[character] this product is dark-brown liquid, is equipped with the easy dispersive precipitation of micro-jog for a long time; Bitter in the mouth.
[specification] every dress 10ml.
[function cures mainly] clearing heat secreting bile, QI and blood regulating.Be used for dampness-heat in the liver and gallbladder, the side of body rib dull pain due to the qi and blood disorder, xerostomia, bitter taste, the auxiliary treatment of symptom such as lack of appetite is weak.
[usage and dosage] is oral.A 10ml, 3 times on the one.
Among the present invention:
Monarch drug in the first-selected Fel Ursi side of being, the Fel Ursi bitter cold, heat-clearing and toxic substances removing, depressed liver-energy dispersing and function of gallbladder promoting moves back subcutaneous ulcer and removes Huang, and speciality is let out the heat of having a surplus clearly.The Herba Scutellariae Barbatae bitter cold, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling is ministerial drug in the side.The sweet suffering of Cortex Moutan, the kind middle latent heat that purifies the blood, source blood and tissue regeneration promoting is ministerial drug in the side, the auxiliary monarch drug Qinghua turbid damp stagnant heat of two flavor ministerial drugs and depressed liver-energy dispersing and function of gallbladder promoting.Radix Codonopsis is sweet flat, invigorating the spleen and replenishing QI, and nourishing blood to promote the production of body fluid is adjuvant drug in the side.The sweet temperature of Radix Angelicae Sinensis, nourshing blood and promoting blood circulation, invigorating middle warmer has, in the row benefit is arranged, and also the panacea in the blood is also; Radix Codonopsis must be joined the Radix Angelicae Sinensis qi and blood tonifying, woodenly must grow honor thereby make, for the recovery of hepatopathy creates favorable conditions.Fructus Ligustri Lucidi is bitter sweet flat, replenishing kidney-YIN, nourishing the liver benefit order.The arduous temperature of Lignum Aquilariae Resinatum, the sending down the abnormal ascending QI warming middle-JIAO, removing expands disappears expires the warming the kidney improving inspiration by invigorating kidney-QI; Fructus Ligustri Lucidi must be joined the Lignum Aquilariae Resinatum Liver and kidney and taken into account, collaborative Radix Codonopsis, Radix Angelicae Sinensis, and the spleen invigorating stomach strengthening, the liver and the kidney tonifying is set upright with eliminating evil.Make with Fructus Hordei Germinatus help digestion and in, depressed liver-energy dispersing and QI regulating has made the usefulness that reaches liver for drawing.
Good effect of the present invention is: medicine is a pure Chinese medicinal preparation, have no side effect, evident in efficacy, all medicines share, and are warm and not dry, cool and not cold, the pathologic basis that meets " damp and hot surplus heresy is residual not to the greatest extent, and Liver and kidney has lost asthenia of qi and blood " of chronic hepatitis prolonged illness is so have thin gallbladder function of gallbladder promoting, the liver and the kidney tonifying is set upright with eliminating evil effect.
For verifying therapeutic effect of the present invention, 113 routine hepatobiliary system disease patients are used the oral liquid for clearing liver and gallbladder treatment, obtained promising result, now be summarized as follows:
One, clinical data
Case is selected: observe among the 113 routine patients, male 61 examples account for 53.98%, and women 52 examples account for 46.02%; Age reckling 7 years old, the maximum 75 years old, 38.8 years old mean age; The course of disease: the shortest person 4 days, elder 12 years, average course of disease is 1.97 years; Occupation: student's 9 examples, account for 7.96%, peasant's 7 examples account for 6.19%, and other 15 examples account for 13.28%.
The disease classification: among the 113 routine patients, the traditional Chinese medical science is examined 68 examples into " hypochondriac pain " person; " gallbladder-distention " person 45 examples; Dialectical genus dampness-heat in the liver and gallbladder person 67 examples; Belong to depression of liver-QI person 19 examples; Belong to deficiecny of liver-YIN person 18 examples; Belong to the blood stasis person of being at a stop 4 examples, other pattern of syndrome person 5 examples.Doctor trained in Western medicine is examined 47 examples into " hepatitis B " person, " hepatitis C " 2 examples, chronic hepatitis 18 examples, cholecystitis, biliary system the infected 45 examples.
Two, diagnostic criteria: the pain over the hypochondriac region distension that every hepatopathy, especially hepatitis that causes owing to a variety of causes and cholecystitis, biliary system infection etc. cause, dry mouth with bitter taste, lack of appetite is indigestion and loss of appetite, malaise, patients such as the abdominal distention of feeling sick are this product object of observation.
Three, Therapeutic Method:
1, adopts Self-control method, promptly, compare observation self medication front and back symptom.
2, allly meet diagnostic criteria person, fill in symptom, sign, liver function, routine blood test, item inspections such as some cases five indexes of hepatitis b by observing requirement; Other stop using during the treatment about medicine, and after finishing the course of treatment, its result carries out statistical procedures.
3, observe medicine and medication: " oral liquid for clearing liver and gallbladder " provided by Jilin Changbaishan Pharmaceutical Group Co., Ltd..Medication: oral, each 1,3 times on the one, serveing on one month is a course of treatment.
4, curative effect determinate standard:
The produce effects standard: clinical symptoms, sign are obviously improved, and it is normal that assay is recovered substantially.
Effective standard: clinical symptoms, sign are more obviously improved or are alleviated, and assay is near recovering normal.
Invalid standard: do not have change before and after clinical symptoms, sign and the assay treatment.
Four, observed result
1,113 routine patient's total effectses see table 1 for details.
Total effects after table 1 " oral liquid for clearing liver and gallbladder " medication
By preventing and treating the hypochondriac pain effective percentage after visible " oral liquid for clearing liver and gallbladder " medication in the table 1 is 95.38%; Control gallbladder-distention effective percentage is 9375%; Its total effective rate is 94.69%.
2, " oral liquid for clearing liver and gallbladder " takes medicine to the situation of liver function recovery influence, sees table 2 for details.
Table 2 " oral liquid for clearing liver and gallbladder " is as follows to the liver function influence situation
By in the table 2 as seen, " oral liquid for clearing liver and gallbladder " back of taking medicine is 68.75% to the liver function recovery total effective rate.
3, to the situation that influences of patient's hepatitis B two and half, see table 3 for details after " oral liquid for clearing liver and gallbladder " takes medicine.
By in the table 3 as seen, and " oral liquid for clearing liver and gallbladder " is 42.85% to its negative conversion rate HBsAg that influences of hepatitis B two half; HBeAg is 50%.Illustrate that this medicine is to the inhibition of hepatitis B virus and certain effect of turning out cloudy.
4, " oral liquid for clearing liver and gallbladder " takes medicine the back to the ultransonic situation that influences of patient's Type B, sees table 4 for details.
Before and after table 4 " oral liquid for clearing liver and gallbladder " medication B ultrasonic is influenced comparable situation
By table 4 as seen, this medicine comprises that to undesired B ultrasonic the hepatic region luminous point is close, intensive, fine and closely woven, the skewness network is unclear after taking medicine, and gallbladder wall is coarse, and it is 60% that wall thickness is owed recovery improvement rate such as smooth.Illustrate that this medicine has the effect of liver heat removing function of gallbladder promoting.
5, " oral liquid for clearing liver and gallbladder " sees table 5 for details to the situation that influences of routine blood test.
Table 5 " oral liquid for clearing liver and gallbladder " is to the situation that influences of routine blood test
By in the table 5 as seen, there is obvious reduction effect the back of taking medicine to WBC in the blood, and Hb, RBC is had relative rising trend.
6, " oral liquid for clearing liver and gallbladder " improves situation to patient's subjective symptoms, sees table 6 for details.
Table 6 " oral liquid for clearing liver and gallbladder " improves situation to patient's subjective symptoms
By table 6 as seen, take that patient's subjective symptoms to be improved situation behind this medicine more obvious, to cardinal symptom improvement rate on average more than 80%.
Four, safety detects
113 routine patients have no adverse effects to blood, routine urinalysis, hepatic and renal function after smelting is treated, and other toxic and side effects do not occur, prove this product safety non-toxic.
Five, conclusion
Take " oral liquid for clearing liver and gallbladder " by 113 routine patients and prevent and treat the observation that various hepatopathys, cholecystitis and biliary system infect, the result shows that this medicine has effects such as liver heat removing function of gallbladder promoting, heat-clearing and toxic substances removing.And Liver and kidney had no adverse effects.It is prevented and treated disease total effective rates such as hepatopathy and biliary system and reaches 94.69%.And do not find any toxic and side effects and untoward reaction therebetween observing.
The specific embodiment:
The following example is intended to further describe for example the present invention, rather than limits the present invention by any way.Under the prerequisite that does not deviate from the spirit and principles in the present invention, any change or change that this area common skill wooden man person that the present invention did is realized easily all will fall in the claim scope of the present invention.
Embodiment 1:
Take by weighing each medicine by following weight ratio, Fel Ursi powder 0.5g, Cortex Moutan 20g, Herba Scutellariae Barbatae 20g, Radix Codonopsis 30g, Radix Angelicae Sinensis 20g, Fructus Ligustri Lucidi 20g, Lignum Aquilariae Resinatum 15g, Fructus Hordei Germinatus 60g are standby;
More than eight the flavor medicines, Fel Ursi powder is ground into fine powder and is dissolved in water, and makes the Fel Ursi powder aqueous solution; Cortex Moutan, Radix Angelicae Sinensis steam distillation, device is collected distillate in addition; Residue and all the other five kinds of Chinese medicine decoct with water 2 times, add 10 times of amounts for the first time, decoct 1.5 hours, for the second time add 7 times of amounts, decocted collecting decoction 1 hour, filter, it is 1.40 that filtrate is concentrated into temperature relative density in the time of 30 ℃, adds ethanol and makes and contain the alcohol amount and reach 75%, placed 24 hours, and filtered filtrate recycling ethanol, adding water stirs evenly, place, filter, filtrate concentrates; Other gets 150 parts of Mel, and heating in water bath to 70 ℃ is incubated 1 hour, merges with above-mentioned medicinal liquid, adds distillate and Fel Ursi powder again
Aqueous solution adds the alcoholic solution that contains 0.5 part of para hydroxybenzene methyl ethyl ester, adds water, stirs evenly, filter, and fill, promptly.
Embodiment 2:
Take by weighing each medicine by following weight ratio, Fel Ursi powder 1g, Cortex Moutan 40g, Herba Scutellariae Barbatae 40g, Radix Codonopsis 50g, Radix Angelicae Sinensis 40g, Fructus Ligustri Lucidi 40g, Lignum Aquilariae Resinatum 20g, Fructus Hordei Germinatus 80g are standby;
More than eight the flavor medicines, Fel Ursi powder is ground into fine powder and is dissolved in water, and makes the Fel Ursi powder aqueous solution; Cortex Moutan, Radix Angelicae Sinensis steam distillation, device is collected distillate in addition; Residue and all the other five kinds of Chinese medicine decoct with water 2 times, add 10 times of amounts for the first time, decoct 1.5 hours, for the second time add 7 times of amounts, decocted collecting decoction 1 hour, filter, it is 1.10 that filtrate is concentrated into temperature relative density in the time of 50 ℃, adds ethanol and makes and contain the alcohol amount and reach 75%, placed 24 hours, and filtered filtrate recycling ethanol, adding water stirs evenly, place, filter, filtrate concentrates; Other gets 150 parts of Mel, and heating in water bath to 75 ℃ is incubated 1 hour, merges with above-mentioned medicinal liquid, adds distillate and Fel Ursi powder aqueous solution again, adds the alcoholic solution that contains 0.5 part of para hydroxybenzene methyl ethyl ester, adds water, stirs evenly, filter, and fill, promptly.
Embodiment 3:
Take by weighing each medicine by following weight ratio, Fel Ursi powder 5g, Cortex Moutan 60g, Herba Scutellariae Barbatae 60g, Radix Codonopsis 70g, Radix Angelicae Sinensis 60g, Fructus Ligustri Lucidi 60g, Lignum Aquilariae Resinatum 60g, Fructus Hordei Germinatus 100g are standby;
More than eight the flavor medicines, Fel Ursi powder is ground into fine powder and is dissolved in water, and makes the Fel Ursi powder aqueous solution; Cortex Moutan, Radix Angelicae Sinensis steam distillation, device is collected distillate in addition; Residue and all the other five kinds of Chinese medicine decoct with water 2 times, add 10 times of amounts for the first time, decoct 1.5 hours, for the second time add 7 times of amounts, decocted collecting decoction 1 hour, filter, it is 1.05 that filtrate is concentrated into temperature relative density in the time of 70 ℃, adds ethanol and makes and contain the alcohol amount and reach 75%, placed 24 hours, and filtered filtrate recycling ethanol, adding water stirs evenly, place, filter, filtrate concentrates; Other gets 150 parts of Mel, and heating in water bath to 80 ℃ is incubated 1 hour, merges with above-mentioned medicinal liquid, adds distillate and Fel Ursi powder aqueous solution again, adds the alcoholic solution that contains 0.5 part of para hydroxybenzene methyl ethyl ester, adds water, stirs evenly, filter, and fill, promptly.
Claims (3)
1, a kind of oral liquid for clearing liver and gallbladder is characterized in that: be to be made by the crude drug of following portions by weight ratio:
20～60 parts of 0.5～5 part of Cortex Moutans of Fel Ursi powder
30～70 parts of 20～60 parts of Radix Codonopsis of Herba Scutellariae Barbatae
20～60 parts of 20～60 parts of Fructus Ligustri Lucidi of Radix Angelicae Sinensis
60～100 parts in 15～55 parts of Fructus Hordei Germinatus of Lignum Aquilariae Resinatum
2, a kind of bear gall eyesight-improving tablet according to claim 1, it is characterized in that: wherein the consumption of each crude drug is:
40 parts of 1 part of Cortex Moutans of Fel Ursi powder
50 parts of 40 parts of Radix Codonopsis of Herba Scutellariae Barbatae
40 parts of 40 parts of Fructus Ligustri Lucidi of Radix Angelicae Sinensis
80 parts in 20 parts of Fructus Hordei Germinatus of Lignum Aquilariae Resinatum
3, medicine according to claim 1 and 2, its concrete preparation technology is as follows:
More than eight the flavor medicines, Fel Ursi powder is ground into fine powder and is dissolved in water, and makes the Fel Ursi powder aqueous solution; Cortex Moutan, Radix Angelicae Sinensis steam distillation, device is collected distillate in addition; Residue and all the other five kinds of Chinese medicine decoct with water 2 times, add 10 times of amounts for the first time, decoct 1.5 hours, for the second time add 7 times of amounts, decocted collecting decoction 1 hour, filter, it is 1.05～1.40 that filtrate is concentrated into temperature relative density in the time of 30 ℃～70 ℃, adds ethanol and makes and contain the alcohol amount and reach 75%, placed 24 hours, and filtered filtrate recycling ethanol, adding water stirs evenly, place, filter, filtrate concentrates; Other gets 150 parts of Mel, and heating in water bath to 70 ℃～80 ℃ is incubated 1 hour, merges with above-mentioned medicinal liquid, adds distillate and Fel Ursi powder aqueous solution again, adds the alcoholic solution that contains 0.5 part of para hydroxybenzene methyl ethyl ester, adds water, stirs evenly, filter, and fill, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100168696A CN1325105C (en) | 2005-06-14 | 2005-06-14 | Oral liquid for clearing liver and gallbladder |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100168696A CN1325105C (en) | 2005-06-14 | 2005-06-14 | Oral liquid for clearing liver and gallbladder |
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| Publication Number | Publication Date |
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| CN1709320A true CN1709320A (en) | 2005-12-21 |
| CN1325105C CN1325105C (en) | 2007-07-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100168696A Active CN1325105C (en) | 2005-06-14 | 2005-06-14 | Oral liquid for clearing liver and gallbladder |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110118841A (en) * | 2019-06-10 | 2019-08-13 | 吉林修正药业新药开发有限公司 | A kind of construction method of the HPLC characteristic spectrum of oral liquid for clearing liver and gallbladder |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1137696C (en) * | 1999-07-01 | 2004-02-11 | 陶杰 | Medicine for treating hepatitis B and rheumatoid diseases |
| CN1101687C (en) * | 2000-01-25 | 2003-02-19 | 邓云飞 | Liver-invigorating detoxication pill for treating hepatitis B |
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2005
- 2005-06-14 CN CNB2005100168696A patent/CN1325105C/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110118841A (en) * | 2019-06-10 | 2019-08-13 | 吉林修正药业新药开发有限公司 | A kind of construction method of the HPLC characteristic spectrum of oral liquid for clearing liver and gallbladder |
| CN110118841B (en) * | 2019-06-10 | 2021-06-04 | 吉林修正药业新药开发有限公司 | Method for constructing HPLC (high Performance liquid chromatography) characteristic spectrum of liver and gallbladder clearing oral liquid |
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| Publication number | Publication date |
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| CN1325105C (en) | 2007-07-11 |
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