CN1137696C

CN1137696C - Medicine for treating hepatitis B and rheumatoid diseases

Info

Publication number: CN1137696C
Application number: CNB991096193A
Authority: CN
Inventors: 杰陶; 陶杰
Original assignee: Individual
Current assignee: Individual
Priority date: 1999-07-01
Filing date: 1999-07-01
Publication date: 2004-02-11
Anticipated expiration: 2019-07-01
Also published as: CN1280841A

Abstract

The present invention discloses a medicine for treating hepatitis B and rheumatoid diseases, which is prepared by the following 38 raw materials according to conventional pharmacy methods: silky ants, turtle shells, common prism tubers (prepared with wine), rhubarb (prepared with wine), peach kernels, turtle insects, armadillidium vulgares, herba pyrrosiae, Chinese pink herbs, bignoniad, banxia, bupleurum roots, pilose asiabell roots, astragalus roots, 10 to 40 parts of oldenlandia diffusa, isatis roots, red sage roots, scrophularia roots, white peony roots, rehmannia roots, white atractylodes rhizomes, giant knotweed, toosendan fruits, coptis roots, spica prunellae, angelica roots, nutagrass flatsedge rhizomes, Chinese yams, loranthus parasiticus, orange peel, chicken gizzard-membrane, red peony roots, cortex moutan, safflowers, curcuma roots, zedoary rhizomes, oysters and ginseng. The medicine has obvious therapeutic efficacy.

Description

A kind of treatment hepatitis B and rheumatoid medicine

The present invention relates to a kind of medicine, particularly a kind of treatment hepatitis B and rheumatoid medicine made from raw material of Chinese medicine.

Hepatitis B is caused that by hepatitis B virus (HBV) after HBV entered human body, the invasion and attack hepatocyte was duplicated breeding therein, overflowed then, formed specific virus antigen on the liver plasma membrane surface from hepatocyte.Primed lymphocyte combines with the lip-deep virus antigen of liver plasma membrane, makes the sensitization lymph discharge various humoral factors, and when these humoral factors were killed virus as a result, hepatocyte is sustain damage also, caused necrosis and inflammatory reaction.Human beings'health in the hepatitis B serious threat, and its hazardness has caused the countries in the world great attention, and only in China, the carrier of hepatitis B virus is just more than 100,000,000 2 thousand ten thousand.The treatment hepatitis B still lacks specific medicament and Therapeutic Method at present, and what mainly use is: 1, antiviral drugs; 2, immunomodulator; 3, improve the medicine of hepatocyte function.But above-mentioned all methods all exist deficiency, particularly chronic active hepatitis on the curative effect in, late period, hepatosplenomegaly appears, sclerosis, under the situation of fat water, thorny especially.

Rheumatoid arthritis be a kind of be the chronic systemic autoimmune disease of feature with the articular synovitis, synovitis lastingly repeatedly the outbreak, the destruction that causes intraarticular cartilage and bone, joint function disturbance, it is useless to disable eventually.Rheumatoid arthritis is one and the closely-related diseases of factor such as external environment, antibacterial, virus, heredity, gonadal hormone and the neural mental status, and its cause of disease and pathogeny are clear and definite fully as yet.Rheumatoid arthritis does not still have specific short so far, the main use: 1, based on the general treatement of rest; 2, Drug therapy; 3, physical therapy.But effect is all not good, and particularly Drug therapy also has many toxic and side effects.

The purpose of this invention is to provide a kind ofly all has the medicine of better curative effect by what Chinese medicinal ingredients was formed to hepatitis B and rheumatoid arthritis.

For achieving the above object, the present invention takes following design: a kind of treatment hepatitis B and rheumatoid medicine, and it is by the pharmaceutical methods preparation routinely of the raw material of following portions by weight ratio:

Formica fusca 30-50 Carapax Trionycis 10-25 processed with wine rhizoma sparganic 3-8

Radix et Rhizoma Rhei (processed with wine) 8-15 Semen Persicae 8-23 Eupolyphaga Seu Steleophaga 8-10

Armadillidium 3-8 Folium Pyrrosiae 8-15 Herba Dianthi 8-20

The purple 8-12 Rhizoma Pinelliae 8-12 Radix Bupleuri 5-25 that rivers bend

Radix Codonopsis 5-30 Radix Astragali 10-40 Herba Hedyotidis Diffusae 10-40

Radix Isatidis 10-30 Radix Salviae Miltiorrhizae 10-40 Radix Scrophulariae 10-25

Radix Paeoniae Alba 10-20 Radix Rehmanniae 10-20 Rhizoma Atractylodis Macrocephalae 10-25

Rhizoma Polygoni Cuspidati 10-25 Fructus Toosendan 5-12 Rhizoma Coptidis 10-15

Spica Prunellae 10-20 Radix Angelicae Sinensis 8-15 Rhizoma Cyperi 8-15

Rhizoma Dioscoreae 10-25 Herba Taxilli 15-40 Pericarpium Citri Reticulatae 10-20

Endothelium Corneum Gigeriae Galli 8-15 Radix Paeoniae Rubra 8-15 Cortex Moutan 8-15

Flos Carthami 8-20 Radix Curcumae 8-15 Rhizoma Curcumae 8-15

Concha Ostreae 8-15 Radix Ginseng 8-15

Formica fusca proves after deliberation and contains abundant formic acid and other can improve the material of autoimmunity, with the Formica fusca is primary raw material, the treatment hepatitis B and the rheumatoid medicine that cooperate other Chinese medicine ingredients to make, through clinic trial 200 examples (hepatitis B 150 examples wherein, rheumatoid 50 examples), its effective percentage is 100%, and cure rate is 95%.

The present invention reconciles into the pill of 9 grammes per square metres with Mel, oral every day 3 times, and each 1-3 ball, one month is a course of treatment.

The invention will be further described below in conjunction with specific embodiment.

Embodiment 1: medicine of the present invention is by the pharmaceutical methods preparation routinely of 38 kinds of raw materials of following portions by weight ratio:

Formica fusca 50 Carapax Trionycis 20 processed with wine rhizoma sparganic 5

Radix et Rhizoma Rhei (processed with wine) 15 Semen Persicaes 10 Eupolyphaga Seu Steleophagas 9

Armadillidium 6 Folium Pyrrosiae 12 Herba Dianthis 15

Purple 10 Rhizoma Pinelliaes, 10 Radix Bupleuri 20 of rivering bend

Radix Codonopsis 10 Radixs Astragali 15 Herba Hedyotidis Diffusaes 30

Radix Isatidis 10 Radix Salviae Miltiorrhizaes 25 Radix Scrophulariaes 15

The Radix Paeoniae Alba 15 Radix Rehmanniae 15 Rhizoma Atractylodis Macrocephalaes 15

Rhizoma Polygoni Cuspidati 15 Fructus Toosendans 10 Rhizoma Coptidis 15

Spica Prunellae 12 Radix Angelicae Sinensis 15 Rhizoma Cyperis 15

Rhizoma Dioscoreae 20 Herba Taxillis 20 Pericarpium Citri Reticulataes 15

Endothelium Corneum Gigeriae Galli 15 Radix Paeoniae Rubra 15 Cortex Moutans 15

Flos Carthami 15 Radix Curcumaes 15 Rhizoma Curcumae 10

Concha Ostreae 12 Radix Ginsengs 15

After above-mentioned each component sterilization, powder becomes smalls, adds the proper honey mediation and weighs 9 grams for ball, ball.

Embodiment 2: medicine of the present invention is by the pharmaceutical methods preparation routinely of 38 kinds of raw materials of following portions by weight ratio:

Formica fusca 30 Carapax Trionycis 10 processed with wine rhizoma sparganic 3

Radix et Rhizoma Rhei (processed with wine) 8 Semen Persicaes 8 Eupolyphaga Seu Steleophagas 8

Armadillidium 3 Folium Pyrrosiae 8 Herba Dianthis 8

Purple 8 Rhizoma Pinelliaes, 8 Radix Bupleuri 5 of rivering bend

Radix Codonopsis 5 Radixs Astragali 10 Herba Hedyotidis Diffusaes 10

Radix Isatidis 15 Radix Salviae Miltiorrhizaes 10 Radix Scrophulariaes 10

The Radix Paeoniae Alba 10 Radix Rehmanniae 10 Rhizoma Atractylodis Macrocephalaes 10

Rhizoma Polygoni Cuspidati 10 Fructus Toosendans 5 Rhizoma Coptidis 10

Spica Prunellae 10 Radix Angelicae Sinensis 8 Rhizoma Cyperis 8

Rhizoma Dioscoreae 10 Herba Taxillis 15 Pericarpium Citri Reticulataes 10

Endothelium Corneum Gigeriae Galli 8 Radix Paeoniae Rubra 8 Cortex Moutans 8

Flos Carthami 8 Radix Curcumaes 8 Rhizoma Curcumae 8

Concha Ostreae 8 Radix Ginsengs 8

Embodiment 3: medicine of the present invention is by 38 kinds of raw materials of following portions by weight ratio pharmaceutical methods routinely

Preparation:

Formica fusca 45 Carapax Trionycis 25 processed with wine rhizoma sparganic 8

Radix et Rhizoma Rhei (processed with wine) 10 Semen Persicaes 23 Eupolyphaga Seu Steleophagas 10

Armadillidium 8 Folium Pyrrosiae 15 Herba Dianthis 20

Purple 12 Rhizoma Pinelliaes, 12 Radix Bupleuri 25 of rivering bend

Radix Codonopsis 30 Radixs Astragali 40 Herba Hedyotidis Diffusaes 40

Radix Isatidis 30 Radix Salviae Miltiorrhizaes 40 Radix Scrophulariaes 25

The Radix Paeoniae Alba 20 Radix Rehmanniae 20 Rhizoma Atractylodis Macrocephalaes 25

Rhizoma Polygoni Cuspidati 25 Fructus Toosendans 12 Rhizoma Coptidis 15

Spica Prunellae 20 Radix Angelicae Sinensis 10 Rhizoma Cyperis 10

Rhizoma Dioscoreae 25 Herba Taxillis 40 Pericarpium Citri Reticulataes 20

Endothelium Corneum Gigeriae Galli 10 Radix Paeoniae Rubra 10 Cortex Moutans 10

Flos Carthami 20 Radix Curcumaes 10 Rhizoma Curcumae 15

Concha Ostreae 10 Radix Ginsengs 10

Several routine cases are provided below, sincerely for reference.

1, open * *, woman, 40 years old, in first visit in October, 1986, patient main suit suffers from hepatitis B for many years, and the laboratory is looked into: HBsAg (+) HBeAg (+) resists a HBc (+), abdominal part expands, the blue veins evagination, amine encloses 80cm, and mobile voiced sound is obvious, distension and fullness in the abdomen, side of body painful abdominal mass heating installation, the food of receiving is depressed, thirsty polydipsia, skin is scorching hot, the bitter taste dizziness, and it is weak to sleep less, the little yellow yellowish urine of order is deficient, constipation, lower limb are pitting edema, deep and stringy pulse, the tongue fur white edge has purple tired, this is that liver mistake bar reaches, and gas is to stasis, and meridian stasis hinders, the main clinical manifestation of hepatitis B virus all has, drop into Formica fusca rheumatoid hepatitis B curing ball of the present invention, every day for oral administration 3 times, each 3 balls, medication 3 months was a course of treatment, patient's B ultrasonic after taking 4 courses of treatment of adding medicine to shows: abdominal circumference is reduced to normally, and ascites disappears, and it is normal that the hepatitis B great three positive recovers, continue not see recurrence in 3 years through following up a case by regular visits to for consolidating its curative effect with adding medicine to a course of treatment.

2, permitted * *, the man, 50 years old, the workman, suffer from the hepatitis B great three positive in November, 1996 first visit, look at laboratory: HBsAg (+) HBeAg (ten) resists a HBc (+), clinical manifestation: yellowish urine, yellow sclera, the whole body heating, anorexia, detest oil, abnormal liver function, liver pain, brain gastral cavity feeling of distension and oppression, thready pulse, pale yellow the owing of defecating moistened, palm of the hand slight perspiration and gluing, the soft tenderness of abdomen, there is percussion pain the hepatic region, 3cm under the liver rib, hard in the matter, the edge is sharp, the surface is flat, no tenderness, abnormal liver function, icterus index 30 units, the quantitative 3mg% of bilirubin, turbid 10 units of Moschus moschiferous, glutamate pyruvate transaminase 160 units, alkali phosphatase 85 units, ultrasound wave: the liver upper bound the 5th intercostal, 3.5cm under the rib, 1.5cm under the spleen rib, the intensive small echo in hepatic region is concentrated leading portion, the flat section of visible a plurality of biliary ductulis, clinical diagnosis is: biliary cirrhosis, through with Formica fusca rheumatoid hepatitis B curing ball of the present invention every day 3 times, each 3 balls (3 months is a course of treatment), take 3 courses of treatment after, chemical examination is looked into, B ultrasonic is looked into, and liver function and every index are all normal, hepatitis B two double all normal, obtain clinical cure, for consolidating its curative effect, continue to take the course of treatment of adding medicine to, follow up a case by regular visits to and do not see recurrence so far.

3, Lee * *, woman, 52 years old, the peasant examines trouble hepatitis B great three positive in February, 1994, looks into the anti-HBc (+) of HBsAg (+) HBeAg (+), clinical manifestation: become thin, dizzy xerostomia is felt sick, and abdominal distention is obvious, companion's both sides of the chest are attacked to build and are had a pain, and abdominal part expands gradually, abdominal circumference 92cm, lack of appetite, the shank edema, health is heavy, walk with difficulty, sleep unreal night, oliguria with reddish urine, it is dry partially to defecate, deep red tongue, thin fur is restrained less, stringy pulse, 90 times/minute, face is dark and gloomy, and the xerosis cutis lip is dry, 4 of the visible spider angiomas of left cheek and left front breast, clinical diagnosis hepatitis B great three positive causes liver cirrhosis, ascites is taken Formica fusca rheumatoid hepatitis B curing ball of the present invention, every day 3 times, each 3 balls, 3 months is a course of treatment, and after with 4 courses of treatment of adding medicine to, it is normal that chemical examination recovers, for consolidating curative effect, continue the clothes medicine-feeding and obtain healing 2 courses of treatment, followed up a case by regular visits to 4 years, do not see recurrence.

4, Liu * *, man, 43 years old, the peasant seeks medical advice the main suit in January, 1992: suffer from the hepatitis B small three positive, check the anti-HBc (+) of result: HBsAg (+) HBeAg (+), suffered from acute viral hepatitis in 1989, in certain hospitalize half a year, the symptom liver function well then leave hospital, the often hepatalgia of back of leaving hospital, tired postemphasis, in in January, 1992 both sides of the chest pain increase the weight of, myasthenia of limbs, inappetence, big loose stool is thin, chemically examines straight liver function, liver is positioned at the upper bound the 5th intercostal, 2cm under the lower bound midclavicular line costal margin, matter is soft, touches painful, spleen can touch 1cm and slightly touch a tender spot, tongue fur is white, deep-rolling pulse, clinical diagnosis: hepatitis B small three positive, treat oral Formica fusca rheumatoid hepatitis B curing ball of the present invention, every day 3 times, each 3 balls (3 months is a course of treatment), liver function recovery is normal after 2 courses of treatment of medication, for consolidating curative effect, continue one course of treatment of reuse, obtain clinical cure, do not see recurrence in 4 years through following up a case by regular visits to.

5, recklessly * *, woman, 32 years old, the peasant suffers from the hepatitis B small three positive, through checking: the anti-HBc (+) of the anti-HBeAg (+) of HBsAg (+), disease is seen the abdominal part distension, emaciation and sallow complexion, and foot is swollen, indigestion and loss of appetite, big constipation 2-3 day, once sleep owed poor, clinical diagnosis: hepatitis B small three positive, Formica fusca rheumatoid hepatitis B curing ball of the present invention for oral administration, every day 3 times, each 2 balls (2 months is a course of treatment) are after with 2 courses of treatment, and symptom and chemical examination liver function are every all normal, follow up a case by regular visits to and do not see recurrence in 3 years.

6, Wu *, woman, 50 years old, go to a doctor on May 31st, 1994, the main suit: right rib feeling of distension and oppression pain, gastral cavity abdomen feeling of fullness is had a dizzy spell, myasthenia of limbs, muscle hand tremor cardiopalmus is eaten palpitating speed, news oil gas is felt sick, and defecates one for several times, the anti-HBc (+) of HBsAg (+) HBeAg (ten) is looked in chemical examination, hepatomegaly 2 refers to, turbid 9 units of Moschus moschiferous, Moschus moschiferous wadding (10), glutamate pyruvate transaminase 400 units, the former void of patient's taste, deficient and stringy pulse is slow, and pale tongue is fat, clinical diagnosis: hepatitis B small three positive, through with Formica fusca rheumatoid hepatitis B curing ball of the present invention every day 3 times, each 2 balls (three months is a course of treatment), 3 courses of treatment all transference cures, chemical examination is looked into every index such as liver function and has all been recovered normally, follows up a case by regular visits to not see recurrence in 1 year half.

7, Zhai Guoxia, woman, 52 years old, Nangong north is office recklessly, main suit, whole body arthritis, bitterly, 3-4 is surplus, takes multiple antalgica for a long time, is not also taking antalgica when examining, look into rheumatoid factor (ten) through chemical examination, erythrocyte sedimentation rate speeds, and anti-" 0 " is normal, and deadlock was greater than 1 hour in morning in the morning, clinical diagnosis: rheumatoid arthritis, deep 30 bags that loose of wind, quick-acting health ball 27 boxes of Formica fusca rheumatoid hepatitis B of the present invention for oral administration, every day 3 times are compeled in external, each 3 balls (one month is a course of treatment), after with a course of treatment, effect is very remarkable, continues to take orally, and external combines to treat and checks 3 courses of treatment again again: rheumatoid factor and every index, all recover normal, follow up a case by regular visits to and see recurrence the year ends 2.

8, Shi Guirong, woman 59 years old, people from Linxi County, the peasant, go to a doctor March nineteen ninety-five, the main suit: the 8-9 that falls ill is surplus, and repeatedly therapeutic effect is not good through various big hospital, disease is seen, the both feet arthroncus, pain, the swelling of both hands wrist, pain, and occur together hot 37.5 ℃-39.50 ℃, rheumatoid factor (ten) is looked in chemical examination, anti-" 0 " is normal, erythrocyte sedimentation rate 80mm/ hour, it was difficult to meet rheumatoid diagnosis mark, clinical diagnosis: rheumatoid arthritis, for oral administration Formica fusca rheumatoid hepatitis B curing ball of the present invention every day 3 times, each 3 balls, external chase after the wind speed bone and loose (one month was 1 course of treatment), take for 1 course of treatment, clinical assay is every all normal, follows up a case by regular visits to and does not see recurrence in 3 years.

9; Xiao * *; the woman; 60 years old; the peasant, people from Julu County went to a doctor on February 24th, 1996; main suit: double-legged neck swelling; pain; the right gonalgia; swelling; left side knee joint is light less; both hands wrist swelling pain; fall ill 25 years surplus, take hormone and some other analgesic such as a large amount of DIMI prednisones for a long time, with controlling symptoms always; face as a result; edema appears in both legs; stomach discomfort appetite is not good enough; the ochriasis palpitation and insomnia, limbs fatigue was looked into (RE) 1: 85 through chemical examination; (ESR) 20-40mm; (AS0) 1: 700, Huaihe River, clinical diagnosis rheumatoid arthritis were marked in the diagnosis that meets rheumatoid arthritis; treatment Formica fusca rheumatoid hepatitis B curing ball of the present invention for oral administration every day 3 times; each 2 balls, external air intake bone diffusing (month is a course of treatment) treatment is chemically examined every index after 4 courses of treatment and is all normally obtained clinical cure, follows up a case by regular visits to and sees recurrence the year ends 2.

10, Liu *, man 31 years old, people from Nanhe County, patient are in JIUYUE, 1996 prescription on individual diagnosis main suit: the swelling of right crus of diaphragm neck, two knee joint pain, the swelling of both hands wrist, the swelling of both hands middle finger, pain, distortion, other equal pain of each from head to foot, both shoulders, duplex, double knee joint feels cold, be afraid of cold at ordinary times, meet rainy weather and increase the weight of, activity is limited slightly, ill 6-7 is surplus, not good through curing in many ways, chemical examination is looked into: rheumatoid factor (RF) (ten), erythrocyte sedimentation rate (ESR) 20-402mm/ hour, antistreptolysin " 0 " (ASO) 1: 600, clinical diagnosis: rheumatoid arthritis, for oral administration Formica fusca rheumatoid hepatitis B curing ball of the present invention every day 3 times, each 2 balls, external chases after wind and looses thoroughly, treat 5 courses of treatment (one month is a course of treatment), it is all normal to check every index, obtains clinical cure, tracking is followed up a case by regular visits to and seen recurrence the year ends 2, and is complete.

Claims

1, a kind of treatment hepatitis B and rheumatoid medicine is characterized in that: it is by the pharmaceutical methods preparation routinely of the raw material of following portions by weight ratio: