CN1706452A - Medicine for treating chronic prostatitis and its prepn process - Google Patents
Medicine for treating chronic prostatitis and its prepn process Download PDFInfo
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Abstract
The present invention discloses one kind of medicine for treating chronic prostatitis and its preparation process, and aims at provides medicine for treating chronic prostatitis and with high curative effect and less side effect. The medicine for treating chronic prostatitis is prepared with red peony root, ground beetle, prepared pangolin scale, peach kernel, Japanese felt fern frond and other six kinds of Chinese medicinal materials. It has the functions of promoting blood circulation to disperse blood clots, clearing away heat, relieving stranguria, etc. and thus can remit the syndromes of prostatitis. It is suitable for treating chronic prostatitis as well as oligospermatism caused by varicocoele and other diseases.
Description
Technical field
The present invention relates to a kind of medicine that is used for the treatment of chronic prostatitis and preparation method thereof.
Background technology
Chronic prostatitis is to influence the adult male commonly encountered diseases of quality of life, and the sickness rate of estimating global man is 9%～14%.Chronic prostatitis is divided into chronic bacterial prostatitis (II class), chronic nonbacterial prostatitis/chronic pelvic pain syndrome and asymptomatic struvite prostatitis (IV class) three classes.The sickness rate of wherein chronic non-antibacterial bacterial prostatitis occupies the majority.The method that is used for the treatment of chronic prostatitis clinically, common has oral drugs internal treatment, vein treatment method, urethra perfusion or medicine external (as demibain) etc. multiple.For chronic bacterial prostatitis, using the Western medicine antibiotic therapy has certain advantage; But, use the antibiotic therapy poor effect, and side effect is big for chronic nonbacterial prostatitis.Can reach the incomparable clinical efficacy of antibiotics and use treatment by Chinese herbs, and not have obvious toxic-side effects.Motherland's medical science thinks, categories such as that chronic prostatitis belongs to is smart turbid, stranguria caused by overstrain and stomachache, and pathomechanism is mainly due to the humid-heat stagnation, and therefore treatment is when with blood circulation promoting and blood stasis dispelling, and inducing diuresis for treating stranguria syndrome is main.And does not have at present the Therapeutic Method of being satisfied with especially clinically yet.
Summary of the invention
Technical problem to be solved by this invention is to overcome the deficiencies in the prior art, and what provide that a kind of therapeutic effect is good, side effect is little is used for the treatment of medicine of chronic prostatitis and preparation method thereof.
The technical solution adopted in the present invention is: the drug main of chronic prostatitis made by following bulk drugs if the present invention is used for the treatment of:
150 parts in 100 parts of Semen Persicaes of 100 parts of Squama Manis preparatas of 150 parts of Eupolyphaga Seu Steleophagas of Radix Paeoniae Rubra
200 parts of 150 parts of Radixs Astragali of 100 parts of Radixs Angelicae Dahuricae of 120 parts of Spica Prunellaes of Folium Pyrrosiae
110 parts of 200 portions of Medulla Tetrapanaciss of 100 parts of Concha Ostreae (calcined)s of Herba Pyrolae
The preparation method that the present invention is used for the treatment of the medicine of chronic prostatitis comprises the following steps:
1, a kind of medicine that is used for the treatment of chronic prostatitis is characterized in that, it is mainly made by following bulk drugs:
150 parts in 100 parts of Semen Persicaes of 100 parts of Squama Manis preparatas of 150 parts of Eupolyphaga Seu Steleophagas of Radix Paeoniae Rubra
200 parts of 150 parts of Radixs Astragali of 100 parts of Radixs Angelicae Dahuricae of 120 parts of Spica Prunellaes of Folium Pyrrosiae
110 parts of 200 portions of Medulla Tetrapanaciss of 100 parts of Concha Ostreae (calcined)s of Herba Pyrolae
2, the described preparation method that is used for the treatment of the medicine of chronic prostatitis of a kind of claim 1 is characterized in that it comprises the following steps:
(1) Squama Manis preparata of described weight proportion, the Concha Ostreae (calcined) of 1/3 described weight proportion are ground into fine powder, the back mixing that sieves, standby;
(2) get the Radix Paeoniae Rubra of described weight proportion,, filter with 75% alcohol heating reflux of 6～10 times of amounts 7～9 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(3) get Eupolyphaga Seu Steleophaga, the Semen Persicae of described weight proportion,, filter with 75% alcohol dipping of 2～4 times of amounts 24 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(4) get the Concha Ostreae (calcined) of Folium Pyrrosiae, Spica Prunellae, the Radix Angelicae Dahuricae, the Radix Astragali, Herba Pyrolae, Medulla Tetrapanacis and 2/3 described weight proportion of described weight proportion and described Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, the Semen Persicae medicinal residues decoct with water secondary, amount of water is 6～10 times, decocted 2 hours for the first time, decocted 1.5 hours for the second time, collecting decoction, and the relative density that is condensed into mensuration in the time of 70 ℃ is 1.04～1.06 clear paste, put cold, add ethanol and make that to contain alcohol amount be 70%, left standstill 24 hours, filter, filtrate is condensed into the relative density of measuring and is about 1.20 clear paste in the time of 70 ℃, standby;
(5) get 60～100 parts of starch and step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste and step (4) gained clear paste mixing, compacting also coating in blocks is made tablet; Or granulate, incapsulate behind dry, the granulate;
Or get 400～700 parts of sucrose, 60～150 parts in dextrin and step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste and step (4) gained clear paste mixing, and granulate, drying, granulate is made granule;
Or get 15～35 parts of refined honeys and step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste and step (4) gained clear paste mixing, make pill.
Or with step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste
And step (4) gained clear paste mixing, make soft capsule.
The invention has the beneficial effects as follows: if drug main of the present invention is by Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, Squama Manis preparata, Semen Persicae, Folium Pyrrosiae, Spica Prunellae, the Radix Angelicae Dahuricae, the Radix Astragali, Herba Pyrolae, Concha Ostreae (calcined), Medulla Tetrapanacis is that crude drug is made, wherein Radix Paeoniae Rubra has removing heat from blood and promoting blood circulation, the function of stasis-dispelling and pain-killing, Semen Persicae, Eupolyphaga Seu Steleophaga has the function of drastically removing blood stasis and resolving static blood, Spica Prunellae, Concha Ostreae has the effect of hard masses softening and resolving, Squama Manis, the Radix Angelicae Dahuricae has the effect of detumescence and apocenosis, the Radix Astragali, Herba Pyrolae has vital energy benefiting and the kidney invigorating, the effect of expelling pus and toxin by strengthening QI, Folium Pyrrosiae, Medulla Tetrapanacis has the effect of relieving stranguria by diuresis, all medicines share, blood stasis must be loose, damp and hot clearly, blood stasis must be arranged.Effects such as pharmacodynamic experiment proves that this medical instrument has anti-subacute inflammation, promotes microcirculation, detumescence, antibacterial, analgesia, anti-fiber, thereby can promote inflammation to absorb, improve the glandular tube drain, reduce sympathetic excitability, alleviate urethral resistance, prostate gland symptoms is alleviated.Because this medicine is a pure Chinese medicinal preparation, has blood circulation promoting and blood stasis dispelling, the effect of clearing heat and freeing strangury, clinical test results shows that this Drug therapy chronic prostatitis is effective, and toxic and side effects is little.The present invention also can be used for treating oligospermia due to the varicocele, azoospermia, and evident in efficacy.
Further set forth beneficial effect of the present invention below by the test example.
Test example one is used the qian lie tong yu jiao nang treatment chronic prostatitis clinical observation that the present invention makes
Test data in this test example is from Dongzhimen Hospital, Beijing Univ of Traditional Chinese Medicine, Xingguang Pharmaceutical Mfg. Co., Ltd., Zhuhai, Song Zhencai, Fuzhou General Hospital of Nanjing Military Command, The First Affiliated Hospital of Guangzhou University of Traditional Chinese Med.
Qian lie tong yu jiao nang has the effect of blood circulation promoting and blood stasis dispelling, clearing heat and freeing strangury, belongs to stagnation of blood stasis the hold concurrently clinical efficacy and the safety of retention of damp-heat in the interior card for investigating its treatment chronic prostatitis, has carried out multicenter, clinical observation at random, is reported as follows:
1 diagnostic criteria
1.1 medical diagnosis on disease standard and syndrome diagnostic criteria medical diagnosis on disease reference literature comprise that clinical symptoms, prostate palpation and massage of prostate liquid (EPS) microscopy WBC 〉=10/aggregative indicatores such as Hp judge.The stagnation of blood stasis retention of damp-heat in the interior card diagnosis reference literature of holding concurrently is drafted: primary symptom: 1 urine urgency-frequency, 2 perineums, lower abdomen or lumbosacral region weigh down the pain that expands, the 3 urine heeltaps not to the utmost, 4 purplish tongue are dim or petechia ecchymosis, stringy and hesitant pulse are arranged, or yellow fur, rolling pulse.Inferior disease: 1 urethra scorching hot pain, 2 dampness of scrotuies, 3 prostate have inflammatory tubercle or tenderness.Wherein 2 primary symptoms add disease 1 time, promptly dialectical establishment.
1.2 state of an illness scalar quantization standard is that draft on the basis with the standards of grading that Japanese city Dai Shi and Xiong Benshi formulate.Paruria score is frequent micturition, urine is urgent, the heeltap not to the utmost, urethra scorching hot pain, dampness of scrotum according to light, in, heavyly count 1,2,3 fen in various degree respectively.Local pain is divided into perineum genital area, lower abdomen suprapubic region and 3 positions of lumbosacral region, the pain degree of each position is divided into gently, in, weigh 3 grades, be respectively 1,2,3 fen, the pain score is each position integration sum.Objective determination score be with prostate tenderness, prostate quality and EPS-WBC counting according to light, in, heavyly count 1,2,3 fen in various degree respectively.Body of the tongue, tongue fur and pulse condition normally respectively are 0 minute, unusually respectively are 1 minute.At last, by above-mentioned every iterated integral what, judge the classification of state of an illness weight: slight≤12 minutes; Moderate 13～20 minutes; Severe＞20 minute.
Meet above-mentioned medical diagnosis on disease standard and syndrome diagnostic criteria 1.3 include the case standard in, check that with EPS WBC 〉=10/Hp person is the main object of observation, and the course of disease is person more than 2 months.
1.4 get rid of the case standard 1. the age at under-18s with more than 55 years old, the allergic constitution person.2. be associated with hyperplasia of prostate, serious neurosis, urethral stricture, tumor of prostate patient.3. be associated with serious primary disease such as cardiovascular, cerebrovascular, Liver and kidney and hemopoietic system, psychotic.4. acute prostatitis patient.5. centrifugal urine WBC＞5/Hp.
1.5 the efficacy assessment standard reference literature is drafted:
1. clinical recent healing: symptom integral reduces more than 90%, and the palpation tenderness disappears, and quality is recovered or near normal, EPS-WBC is normal.2. produce effects: symptom integral reduces 70～89%, and palpation tenderness and quality all have improvement, the more preceding minimizing 1/2 of EPS-WBC value or＜15/HP.3. effective: symptom integral reduces 30%～69%, the more preceding improvement of palpation and EPS.4 is invalid: symptom integral reduces＜30% or no change or increase the weight of, and palpation and EPS also do not have and improve or increase the weight of.
2 physical data
Outpatient service experimenter 410 examples adopt multicenter, random-blind method contrast method to observe, and case is divided into treatment group and matched group, and 304 examples are organized in treatment, matched group 106 examples.
Age distribution: treatment is organized average 32.51 ± 7.13 years old, average 33.29 ± 7.31 years old of matched group, X
2=1.975;
The course of disease distributes: the treatment group is the shortest 2 months, and is the longest 13 years, and matched group is the shortest 2 months, the longest 8 years, X
2=1.185;
The state of an illness distributes: slight 101 examples are organized in treatment, moderate 162 examples, severe 41 examples; 25 examples that matched group is slight, moderate 65 examples, severe 16 examples are through Ridit check, u=1.445.
More than two groups of ordinary circumstances relatively, there are no significant for difference, and comparability is arranged.In addition, two groups of tcm symptom sign tongue arteries and veins distribute and the comparison of EPS-WBC counting, and difference does not also have significance.
3 therapeutic test methods
The treatment group is a qian lie tong yu jiao nang, and huge pharmaceutcal corporation, Ltd provides by Shenzhen.Each 5.Every day 3 times;
Matched group is a QIANLIEXIN JIAONANG, and the pharmaceutical factory of traditional Chinese medicine provides by Jinan, Shandong.Each 5, every day 3 times.
Be 1 month two groups of courses of treatment.Duration of test is forbidden other medicine for the treatment of similar disease and method, prohibits and drinks and strong tea.Note observing untoward reaction.
4 results and analysis
4.1 total effects relatively sees Table 1.
Table 1 total effects relatively
| The example number | Curative effect | Total obvious effective rate % | Total effective rate % | ||||
| Cure | Produce effects | Effectively | Invalid | ||||
| Treatment group matched group | ??304 ??106 | ??58 ??13 | ??98 ??27 | ??114 ??49 | ??34 ??17 | ??51.32 ??37.74 | ??88.82 ??83.96 |
Analyze through Ridit, two groups relatively, u=2.354, P＜0.05.
4.2 there are not 86 examples of improvement in the relatively treatment group of doing well,improving degree of urinating after the treatment, improve 1 grade of 168 example, improve 2 grade of 41 example, improve 3 grade of 9 example; Do not have 43 examples of improvement in the matched group, improve 1 grade of 51 example, improve 2 grade of 12 example, improve 3 grade of 0 example.X
2=7.940, P＜0.05, difference has the significance meaning.
4.3 do not have 89 examples of improvement in the relatively treatment group of treatment back local pain doing well,improving degree, improve 1 grade of 152 example, improve 2 grade of 52 example, improve 3 grade of 11 example; Do not have 31 examples of improvement in the matched group, improve 1 grade of 56 example, improve 2 grade of 15 example, improve 3 grade of 4 example.X
2=0.549, P＞0.05, difference does not have significance.
Do not have 44 examples of improvement 4.4 treatment back prostate tenderness is improved relatively treatment group of situation and had in 176 examples of prostate tenderness, improve 1 grade of 22 example, improve 2 grade of 107 example, improve 3 grade of 3 example; Matched group has does not have 28 examples of improvement in 67 examples of prostate tenderness, improve 1 grade of 9 example, improves 2 grade of 30 example, improves 3 grade of 0 example.X
2=8.001, P＜0.05, difference has significance.
Do not have 89 examples of improvement in the 146 unusual examples of prostate quality 4.5 relatively treatment group of treatment back prostate improved texture situation has, improve 1 grade of 6 example, improve 2 grade of 50 example, improve 3 grade of 1 example; Matched group has does not have 40 examples of improvement in the 56 unusual examples of prostate quality, improve 1 grade of 2 example, improves 2 grade of 14 example, improves 3 grade of 0 example.X
2=2.20, P＞0.05, difference does not have significance.
4.6 treatment back relatively treatment group of EPS-WBC counting reduction situation does not have 70 examples of reduction, reduces by 1 grade of 147 example, reduces by 2 grade of 75 example, reduces by 3 grade of 12 example; Matched group does not have 33 examples of reduction, reduces by 1 grade of 52 example, reduces by 2 grade of 19 example, reduces by 3 grade of 2 example.X
2=4.601, P＞0.05, difference does not have significance.
4.7 epigastric discomfort, dull pain occur after having 8 examples to take medicine in the untoward reaction treatment group.Wherein not drug withdrawal of 6 examples changes transference cure behind the one after each meal, does not do special handling.2 examples drug withdrawal voluntarily in addition, stomachache is died away after the drug withdrawal, does not do special handling.Blood, urine and stool routine examination before and after the treatment group is treated, liver, renal function and Electrocardioscopy are all in normal range.
4.8 follow up a case by regular visits to 1 month totally 61 example more than following up a case by regular visits to situation treatment group patient produce effects.Wherein have 4 routine symptoms to change, the slight heeltap that 1 example is left over disappears not to the utmost, and the suprapubic region discomfort appears heavily again in 3 examples.Other case no changes.
The result shows that it is 51.32% that total obvious effective rate is organized in treatment, and total effective rate is 88.82%; The total obvious effective rate of matched group is 37.74%, and total effective rate is 83.96%.Two groups of relatively treatment groups obviously are better than matched group, and have no adverse reaction.
5 discuss
The bonded method of disease is adopted in this research, qian lie tong yu jiao nang has been carried out paired observation, confirmed that this medicine has the effect of blood circulation promoting and blood stasis dispelling, clearing heat and freeing strangury to non-specific chronic prostatitis (stagnation of blood stasis hold concurrently retention of damp-heat in the interior card), improvement to urinate symptom and prostate tenderness is apparent in view, illustrates that the treatment group has stronger eliminating damp-heat effect; Tcm symptom tongue arteries and veins is improved the variation of indexs such as situation, prostate palpation, massage of prostate liquid (EPS) inspection from it, qian lie tong yu jiao nang is this sick active drug of treatment.Safety before and after the treatment of treatment group detects no abnormal variation, illustrates that this medicine is to the heart, liver, the no abnormal influence of renal function.Have the only a few patient slight gastrointestinal reaction to occur in the back of taking medicine, change into one after each meal, symptom is died away, and need not do special handling.
Stranguria, turbid card or the asthenia category of the chronic prostatitis ownership traditional Chinese medical science have deficiency and excess two ends.In fact the person many qian lie tong yu jiao nang has blood circulation promoting and blood stasis dispelling, the sensible effect of heat clearing away by due to damp and hot, expectorant is turbid, blood stasis becomes silted up resistance bladder, the key road, the clinical chronic prostatitis that is used for belongs to the stagnation of blood stasis retention of damp-heat in the interior card person that holds concurrently, and is safe and effective.
The observation of curative effect of oligospermia, azoospermia due to the test example two qian lie tong yu jiao nangs treatment varicocele
Varicocele is the commonly encountered diseases of young man, also is the common cause of male infertility.The varicocele differential diagnosis in tcm belongs to the Liver Channel blood stasis, the resistance of the Liver Channel stasis of blood, and the blood walking retardation in children is slow, can not the event of nutrition spermatic cord few smart, azoospermia occur.Qian lie tong yu jiao nang energy blood circulation promoting and blood stasis dispelling, unimpeded Liver Channel, blood work freely, and smart chamber must be supported, thus can improve sperm concentration and energy, thus reach the treatment oligospermia, the purpose of azoospermia.This and medicine are to the sanguimotor improvement of testis, and local pressure alleviates, and local temperature descends relevant.This test example is to carry out clinical treatment with the case that qian lie tong yu jiao nang is accepted for medical treatment Dongguan City, Guangdong Province end of the bridge hospital Urology Surgery, observes oligospermia due to " qian lie tong yu jiao nang " treatment varicocele, azoospermia patient's curative effect.Specifically be reported as follows:
1 diagnostic criteria
1.1 varicocele is according to WHO standard, patient looks with palpation scrotum when orthostatism varicocele is divided into the III level.
1.2 azoospermia stipulates that according to WHO sperm motility is divided into 4 grades.Azoospermia refers to have the sperm (A+B)＜50.0% or A level sperm＜25.0% of propulsion.
1.3 oligospermia is according to WHO standard, sperm concentration is lower than 20 * 10
9Individual/L is an oligospermia.
" the infertile couples standard is checked and diagnosis handbook regulation 1.4 curative effect determinate standard is according to WHO.
2 cases are selected
25～45 years old age met varicocele diagnosis, added in oligospermia or the azoospermia each, or met the varicocele standard, met oligospermia and azoospermia simultaneously and diagnosed patient all can be selected in.
3 physical data
The experimenter is totally 93 examples, and the age is at 20～38 years old, The median age 27.3 years old, and wherein 20～30 years old 55 example accounts for 60.0%;
In 93 routine patients, its midium or long term, the worker of standing accounted for 48%, for a long time worker 15.0% under hot environment.
Meet varicocele+oligospermia+azoospermia person 54 examples among the 93 routine patients; Meet varicocele+azoospermia 39 examples; 58 of varicocele I levels, 32 of II levels, 3 of III levels.
4 Therapeutic Method
The qian lie tong yu jiao nang treatment that all patients all provide with Xingguang Pharmaceutical Mfg. Co., Ltd., Zhuhai, each 5, every day 3 times, 3 months is a course of treatment.
Period in a medicine is withdrawn the medicine that other treatment improves sperm quality, quantity.The inspection seminal fluid is 1 time before taking medicine, and seminal fluid is checked 1 time every month in the back of taking medicine, and checks preceding ascetic 4,5 days, alleviating alcohol addiction, and to get rid of ascetic overlong time, sexual life is too much, excessive drinking etc. influences the factor of sperm check result.
5 results
5.1 curative effect
Judge curative effect according to the forward and backward sperm concentration of treatment, sperm motility, in 93 examples, qian lie tong yu jiao nang is to oligospermia, effective 88 examples of treatment of azoospermia, wherein produce effects 61 examples (65.6%) due to the varicocele, effective 27 examples (30.7%), invalid 5 examples (5.4%).
5.2 spermatozoon activity relatively before and after the treatment
The result shows that qian lie tong yu jiao nang has apparent in view curative effect to oligospermatism, azoospermia due to the varicocele).See Table 2.
Sperm concentration, sperm survival rate are relatively before and after the table 2 93 example treatments
| Spermatozoon activity | Before the treatment | 3 months | 6 months | ??P |
| Sperm concentration (10 9/ L) sperm survival rate (%) A+B level sperm (%) | ??18.54±12.75 ??45.74±13.70 ??22.83±5.13 | ??41.78±14.34 ??61.57±10.84 ??29.91±14.36 | ??54.10±23.49 ??65.26±14.36 ??36.23±6.89 | ??＜0.01 ??＜0.01 ??＜0.01 |
6 discuss
Statistics show, about 24%～39% oligospermia is caused by varicocele, the sickness rate of the male sterility of varicocele is apparently higher than normal population, semen quality improved after the varicocele infertile patients was accepted varicocele ligation, and is unusual with semen quality and testis tissue among the varicocele male.Can influence semen quality from above varicocele as can be seen, because varicocele causes sludging, the local temperature that increases the slow testis pressure of blood circulation rises and causes testis reversibility or irreversibility infringement, and the metabolite that sludging produces testis due to the varicocele is discharged and also caused the spermatogenesis infringement slowly on the other hand.
Qian lie tong yu jiao nang has blood circulation promoting and blood stasis dispelling, the effect of clearing heat and freeing strangury.Clinical therapeutic efficacy is remarkable.
The specific embodiment
Embodiment one:
The tablet of medicine of the present invention or capsular preparation
It is to be made by crude drug Radix Paeoniae Rubra 150g, Eupolyphaga Seu Steleophaga 100g, Squama Manis preparata 100g, Semen Persicae 150g, Folium Pyrrosiae 120g, Spica Prunellae 100g, Radix Angelicae Dahuricae 150g, Radix Astragali 200g, Herba Pyrolae 100g, Concha Ostreae (calcined) 200g, Medulla Tetrapanacis 110g and supplementary product starch 80g, and above-mentioned raw materials can be made into 1000 of 1000 in tablet or capsules.
Preparation method of the present invention comprises the following steps:
(1) get the 100g Squama Manis preparata, the 66.7g Concha Ostreae (calcined) is ground into fine powder, sieve the back mixing, standby;
(2) get 150g Radix Paeoniae Rubra,, filter with 75% alcohol heating reflux of 6～10 times of amounts 7～9 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(3) get 100g Eupolyphaga Seu Steleophaga, 150g Semen Persicae,, filter with 75% alcohol dipping of 2～4 times of amounts 24 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(4) get 120g Folium Pyrrosiae, 100g Spica Prunellae, the 150g Radix Angelicae Dahuricae, the 200g Radix Astragali, 100g Herba Pyrolae, 110g Medulla Tetrapanacis and 133.3g Concha Ostreae (calcined) and described Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, the Semen Persicae medicinal residues decoct with water secondary, amount of water is 6～10 times, decocted 2 hours for the first time, decocted 1.5 hours for the second time, collecting decoction and to be condensed in the time of 70 ℃ the relative density of measuring be 1.04～1.06 clear paste, add ethanol and make that to contain alcohol amount be 70%, left standstill 24 hours, filter, filtrate is condensed into the relative density of measuring and is about 1.20 clear paste in the time of 70 ℃, standby;
(5) get 80g starch and step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste and step (4) gained clear paste mixing, compacting is in blocks, and coating is made tablet; Or granulate, incapsulate behind dry, the granulate;
Embodiment two:
The preparation of the granule of medicine of the present invention
It is to be made by crude drug Radix Paeoniae Rubra 150g, Eupolyphaga Seu Steleophaga 100g, Squama Manis preparata 100g, Semen Persicae 150g, Folium Pyrrosiae 120g, Spica Prunellae 100g, Radix Angelicae Dahuricae 150g, Radix Astragali 200g, Herba Pyrolae 100g, Concha Ostreae (calcined) 200g, Medulla Tetrapanacis 110g and adjuvant sucrose 500g, dextrin 100g.
Preparation method of the present invention comprises the following steps:
(1) get the 100g Squama Manis preparata, the 66.7g Concha Ostreae (calcined) is ground into fine powder, sieve the back mixing, standby;
(2) get 150g Radix Paeoniae Rubra,, filter with 75% alcohol heating reflux of 6～10 times of amounts 8 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(3) get 100g Eupolyphaga Seu Steleophaga, 150g Semen Persicae,, filter with 75% alcohol dipping of 2～4 times of amounts 24 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(4) get 120g Folium Pyrrosiae, 100g Spica Prunellae, the 150g Radix Angelicae Dahuricae, the 200g Radix Astragali, 100g Herba Pyrolae, 110g Medulla Tetrapanacis and 133.3g Concha Ostreae (calcined) and described Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, the Semen Persicae medicinal residues decoct with water secondary, amount of water is 6～10 times, decocted 2 hours for the first time, decocted 1.5 hours for the second time, collecting decoction and to be condensed in the time of 70 ℃ the relative density of measuring be 1.04～1.06 clear paste, add ethanol and make that to contain alcohol amount be 70%, left standstill 24 hours, filter, filtrate is condensed into the relative density of measuring and is about 1.20 clear paste in the time of 70 ℃, standby;
(5) get 500g sucrose, 100g dextrin and step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste and step (4) gained clear paste mixing, granulation, drying, granulate are made granule;
Embodiment three:
The preparation of the pill of medicine of the present invention
It is to be made by crude drug Radix Paeoniae Rubra 150g, Eupolyphaga Seu Steleophaga 100g, Squama Manis preparata 100g, Semen Persicae 150g, Folium Pyrrosiae 120g, Spica Prunellae 100g, Radix Angelicae Dahuricae 150g, Radix Astragali 200g, Herba Pyrolae 100g, Concha Ostreae (calcined) 200g, Medulla Tetrapanacis 110g and adjuvant refined honey 25g.
Preparation method of the present invention comprises the following steps:
(1) get the 100g Squama Manis preparata, the 66.7g Concha Ostreae (calcined) is ground into fine powder, sieve the back mixing, standby;
(2) get 150g Radix Paeoniae Rubra,, filter with 75% alcohol heating reflux of 6～10 times of amounts 8 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(3) get 100g Eupolyphaga Seu Steleophaga, 150g Semen Persicae,, filter with 75% alcohol dipping of 2～4 times of amounts 24 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(4) get 120g Folium Pyrrosiae, 100g Spica Prunellae, the 150g Radix Angelicae Dahuricae, the 200g Radix Astragali, 100g Herba Pyrolae, 110g Medulla Tetrapanacis and 133.3g Concha Ostreae (calcined) and described Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, the Semen Persicae medicinal residues decoct with water secondary, amount of water is 6～10 times, decocted 2 hours for the first time, decocted 1.5 hours for the second time, collecting decoction and to be condensed in the time of 70 ℃ the relative density of measuring be 1.04～1.06 clear paste, add ethanol and make that to contain alcohol amount be 70%, left standstill 24 hours, filter, filtrate is condensed into the relative density of measuring and is about 1.20 clear paste in the time of 70 ℃, standby;
(5) get 25g refined honey and step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste and step (4) and get the clear paste mixing, make pill, dry, polishing gets final product.
Embodiment four:
The preparation of the soft capsule of medicine of the present invention
It is to be made by crude drug Radix Paeoniae Rubra 150g, Eupolyphaga Seu Steleophaga 100g, Squama Manis preparata 100g, Semen Persicae 150g, Folium Pyrrosiae 120g, Spica Prunellae 100g, Radix Angelicae Dahuricae 150g, Radix Astragali 200g, Herba Pyrolae 100g, Concha Ostreae (calcined) 200g, Medulla Tetrapanacis 110g.
Preparation method of the present invention comprises the following steps:
(1) get the 100g Squama Manis preparata, the 66.7g Concha Ostreae (calcined) is ground into fine powder, sieve the back mixing, standby;
(2) get 150g Radix Paeoniae Rubra,, filter with 75% alcohol heating reflux of 6～10 times of amounts 8 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(3) get 100g Eupolyphaga Seu Steleophaga, 150g Semen Persicae,, filter with 75% alcohol dipping of 2～4 times of amounts 24 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(4) get 120g Folium Pyrrosiae, 100g Spica Prunellae, the 150g Radix Angelicae Dahuricae, the 200g Radix Astragali, 100g Herba Pyrolae, 110g Medulla Tetrapanacis and 133.3g Concha Ostreae (calcined) and described Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, the Semen Persicae medicinal residues decoct with water secondary, amount of water is 6～10 times, decocted 2 hours for the first time, decocted 1.5 hours for the second time, collecting decoction and to be condensed in the time of 70 ℃ the relative density of measuring be 1.04～1.06 clear paste, add ethanol and make that to contain alcohol amount be 70%, left standstill 24 hours, filter, filtrate is condensed into the relative density of measuring and is about 1.20 clear paste in the time of 70 ℃, standby;
(5) get step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste and step (4) and get the clear paste mixing, make soft capsule, get final product.
Claims (2)
1, a kind of medicine that is used for the treatment of chronic prostatitis is characterized in that, it is mainly made by following bulk drugs:
150 parts in 100 parts of Semen Persicaes of 100 parts of Squama Manis preparatas of 150 parts of Eupolyphaga Seu Steleophagas of Radix Paeoniae Rubra
200 parts of 150 parts of Radixs Astragali of 100 parts of Radixs Angelicae Dahuricae of 120 parts of Spica Prunellaes of Folium Pyrrosiae
110 parts of 200 portions of Medulla Tetrapanaciss of 100 parts of Concha Ostreae (calcined)s of Herba Pyrolae
2, the described preparation method that is used for the treatment of the medicine of chronic prostatitis of a kind of claim 1 is characterized in that it comprises the following steps:
(1) Squama Manis preparata of described weight proportion, the Concha Ostreae (calcined) of 1/3 described weight proportion are ground into fine powder, the back mixing that sieves, standby;
(2) get the Radix Paeoniae Rubra of described weight proportion,, filter with 75% alcohol heating reflux of 6～10 times of amounts 7～9 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(3) get Eupolyphaga Seu Steleophaga, the Semen Persicae of described weight proportion,, filter with 75% alcohol dipping of 2～4 times of amounts 24 hours, filtrate recycling ethanol, it is standby to be condensed into thick paste, and medicinal residues device are in addition collected standby;
(4) get the Concha Ostreae (calcined) of Folium Pyrrosiae, Spica Prunellae, the Radix Angelicae Dahuricae, the Radix Astragali, Herba Pyrolae, Medulla Tetrapanacis and 2/3 described weight proportion of described weight proportion and described Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, the Semen Persicae medicinal residues decoct with water secondary, amount of water is 6～10 times, decocted 2 hours for the first time, decocted 1.5 hours for the second time, collecting decoction, and the relative density that is condensed into mensuration in the time of 70 ℃ is 1.04～1.06 clear paste, put cold, add ethanol and make that to contain alcohol amount be 70%, left standstill 24 hours, filter, filtrate is condensed into the relative density of measuring and is about 1.20 clear paste in the time of 70 ℃, standby;
(5) get 60～100 parts of starch and step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste and step (4) gained clear paste mixing, compacting also coating in blocks is made tablet; Or granulate, incapsulate behind dry, the granulate;
Or get 400～700 parts of sucrose, 60～150 parts in dextrin and step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste and step (4) gained clear paste mixing, and granulate, drying, granulate is made granule;
Or get 15～35 parts of refined honeys and step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste and step (4) gained clear paste mixing, make pill.
Or, make soft capsule with step (1) gained fine powder, step (2) gained thick paste, step (3) gained thick paste and step (4) gained clear paste mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510034444 CN1706452A (en) | 2005-04-30 | 2005-04-30 | Medicine for treating chronic prostatitis and its prepn process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510034444 CN1706452A (en) | 2005-04-30 | 2005-04-30 | Medicine for treating chronic prostatitis and its prepn process |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823979B (en) * | 2005-12-31 | 2010-05-05 | 北京因科瑞斯生物制品研究所 | Medicinal tablet for treating prostate disease and its preparation method |
| CN102258597A (en) * | 2011-07-18 | 2011-11-30 | 西安大唐制药集团有限公司 | Preparation technique of tablets for removing prostate stagnation |
| CN103816269A (en) * | 2014-02-05 | 2014-05-28 | 刘斌胜 | Traditional Chinese medicine for treating chronic prostatitis |
| CN104857114A (en) * | 2015-06-01 | 2015-08-26 | 孙伟 | Traditional Chinese medicine for treating chronic prostatitis |
-
2005
- 2005-04-30 CN CN 200510034444 patent/CN1706452A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1823979B (en) * | 2005-12-31 | 2010-05-05 | 北京因科瑞斯生物制品研究所 | Medicinal tablet for treating prostate disease and its preparation method |
| CN102258597A (en) * | 2011-07-18 | 2011-11-30 | 西安大唐制药集团有限公司 | Preparation technique of tablets for removing prostate stagnation |
| CN102258597B (en) * | 2011-07-18 | 2012-12-26 | 西安大唐制药集团有限公司 | Preparation technique of tablets for removing prostate stagnation |
| CN103816269A (en) * | 2014-02-05 | 2014-05-28 | 刘斌胜 | Traditional Chinese medicine for treating chronic prostatitis |
| CN103816269B (en) * | 2014-02-05 | 2016-06-01 | 刘斌胜 | A kind of Chinese medicine being used for the treatment of chronic prostatitis |
| CN104857114A (en) * | 2015-06-01 | 2015-08-26 | 孙伟 | Traditional Chinese medicine for treating chronic prostatitis |
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