CN1411861A - Medicine for curing acute injury of muscle and tendon and its preparation method - Google Patents
Medicine for curing acute injury of muscle and tendon and its preparation method Download PDFInfo
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Abstract
The present invention relates to a Chinese medicine for curing acute injury of the muscle and tendon, and it is made up by using 12 Chinese medicinal materials of notoginseng, dragon's blood, myrrh, frankincense, corydalis tuber, pyrite and others through the processes of pulverizing, decoction, filtering, concentration, drying, granulating and capsulizing to obtain the invented product. Said invented capsule possesses the functions of promoting blood circulation, removing stasis and stopping pain, and its total effective rate is up to 95%.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of the acute injury of tendon and muscle, the invention still further relates to the preparation method of this medicine.
Background technology
Generally the treatment traumatic is a lot of on the market.Old medicine has " ZHONGHUA DIEDA WAN ", " powder for fracture and trauma " etc., and these pharmaceutically dosage forms fall behind, and dose is big, is treated coldly by market gradually.Seven lis of bone-knitting capsules, bone setting tablet, SHEXIANG JIEGU JIAONANG, promoting blood circulation and stopping pain sheet, wound healing spirit etc. were arranged after the eighties, they cure mainly fracture jointly, with callus formation, the promotion union of fracture is therapeutic purposes, and in fact the healing of fracture mainly is the process of self repairing, and has ignored the direct or indirect influence of the damage of muscle arteries and veins, QI and blood, muscle to fracture, and many traumatology medicines also cure mainly rheumatism, rheumatoid, so cure mainly in a jumble, curative effect is very imprecise.Consult Chinese patent literature, the correlation technique of the treatment injury of tendon and muscle has: application number 95111962.1 treatment sprain and fracture prescriptions; Application number 97108298.7 improving appetite diminishing-stagnant of blood 'Tongluowan ' and method for makings thereof.This invention cures mainly injury of tendon and muscle fracture, and medicine is formed 17 flavors, has only 4 kinds of raw materials identical with the present invention, and the two difference is very big.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of the acute injury of tendon and muscle.Another object of the present invention provides the preparation method of this medicine.
Solution of the present invention is on the basis according to hundreds of years secret recipes of use among the people, forms through scientific appraisal, clinical trial screening after Hunan Chinese medicine academy carries out pharmacodynamics, acute and chronic toxicity test again.
The present invention also according in " Yizong Jinjian, bonesetting heart method main idea " and " the Prescriptions for Universal Relief folding is hindered door " about the theory of the treatment injury of tendon and muscle be Therapeutic Principle, traditional Chinese medical science vim and vigour theoretical be the principles of formulating prescriptions, by the capsule formulation that following traditional Chinese medicines material weight proportion is made, trade name: blood stasis dispersing and pain alleviating capsule.
Medicine of the present invention is made by following traditional Chinese medicines material weight proportion:
60～130 parts of 10～50 parts of Myrrhas of 70～120 parts of Sanguis Draxonis of Radix Notoginseng
0～50 part of Olibanum 60～130 parts of Pyritum of 60～130 parts of Rhizoma Corydalis (system)
0～130 part of 40～130 parts of Rhizoma Acori Graminei of 60～130 parts of Flos Carthamis of Semen Persicae
50～120 parts of 0～80 part of Eupolyphaga Seu Steleophagas of 0～130 part of Radix Et Rhizoma Rhei of Herba Taraxaci
Each composition of raw materials preferred weight ratio range of the present invention is:
80～120 parts of 20～40 parts of Myrrhas of 80～100 parts of Sanguis Draxonis of Radix Notoginseng
0～30 part of Olibanum 70～120 parts of Pyritum of 80～120 parts of Rhizoma Corydalis (system)
0～110 part of 40～80 parts of Rhizoma Acori Graminei of 70～110 parts of Flos Carthamis of Semen Persicae
50～90 parts of 50～70 parts of Eupolyphaga Seu Steleophagas of 0～60 part of Radix Et Rhizoma Rhei of Herba Taraxaci
Each raw material optimum weight proportioning of medicine of the present invention is:
100 parts of 30 parts of Myrrhas of 90 parts of Sanguis Draxonis of Radix Notoginseng
30 parts of Olibanum 100 parts of Pyritums of 100 parts of Rhizoma Corydalis (system)
100 parts of 100 parts of Rhizoma Acori Graminei of 100 parts of Flos Carthamis of Semen Persicae
90 parts of 60 parts of Eupolyphaga Seu Steleophagas of 120 parts of Radix Et Rhizoma Rhei of Herba Taraxaci
The preparation method that above-mentioned each raw material is made medicine of the present invention is:
1, take by weighing raw material by the optimum weight proportioning, every part is unit with the gram, becomes fine powder standby Radix Notoginseng, Pyritum (system), Olibanum, Myrrha, Sanguis Draxonis pulverize separately earlier;
2. decoct with water secondary with Flos Carthami, Rhizoma Acori Graminei, Rhizoma Corydalis, Semen Persicae, Radix Et Rhizoma Rhei, Herba Taraxaci, Eupolyphaga Seu Steleophaga, add 10 times of amounts of water at every turn, decocted 1.5 hours, collecting decoction, filtration, filtrate is concentrated into the clear paste that relative density is 1.20 (80 ℃).Drying adds five tastes medical material fine powders such as above-mentioned Radix Notoginseng, and mixing is granulated, and incapsulates, and makes 1000, promptly.
Said medicine also can be made dosage forms such as tablet and powder.
The present invention shows that by clinical test results repeatedly following advantage and curative effect are arranged:
1, the clinical research by the attached First Academy of the Hunan Province college of traditional Chinese medicine, Annex II institute, Changsha four-player people hospital and Shaoyang City central hospital proves, the acute injury of tendon and muscle, soft tissue contusion, fracture, disease is seen diseases such as pain, swelling, hemorrhage and ecchymosis, deformity, dysfunction have unique curative effect.Total effective rate is all more than 95%.Statistical procedures P＞0.05 illustrates that this medicine is safe and effective, taking convenience.
2, this pharmaceutical formulation is reasonable, preparation technology advanced person, and steady quality is taken easy to carryly, without any side effects, can become the choice drug that the acute injury of tendon and muscle is treated by each medical institutions, meets the regulation of state food health legislation.
3, this invention medicine obtains State Drug Administration " the accurate word B20020009 of traditional Chinese medicines " authentication code, trade name: blood stasis dispersing and pain alleviating capsule in June, 2002.
4, owing to be to count, can take reunion of fractured tendons and bones, blood stasis dispelling, external watery wine mediation external application, detumescence, promoting blood circulation and stopping pain orally for secret prescription handed down in the family from generation to generation.Be used for the treatment of various inside and outside contusion, the acute injury of tendon and muscle and swelling pain, the curative effect mystery is described as " refreshing medicine ".
Below the present invention is carried out clinical research No. 1 Hospital Affiliated to Hunan Traditional Chinese Medical College, Annex II institute, the 150 routine acute injury of tendon and muscle patients of Changsha four-player people hospital, now the observational study result is reported as follows:
1, general clinical data:
Treat acute injury of tendon and muscle patient's 100 examples with the present invention,, see table 1 for details with acute injury of tendon and muscle early stage patient 50 examples of " powder for fracture and trauma " contrast treatment.
The general clinical data of table 1
| The example number | Man/woman | Age (big/little) | Mean age X | |
| The treatment group | ????100 | ????67/33 | ???77/6 | ????33.61 |
| Matched group | ????50 | ????36/14 | ???78/5 | ????33.10 |
2, case is selected
2.1 the object of observation: adopt the sick combination of disease to select acute injury of tendon and muscle early stage patient to list the object of observation in.
2.1.1 differentiation of symptoms and signs for classification of syndrome: its canonical reference " Chinese traumatology " (national high medical college teaching material, the 5th edition) in chapters and sections such as " damage classification and etiology and pathogenesis ", " dialectical ", " injury of tendon and muscle ", " method of treatment ", about the acute injury of tendon and muscle dialectical standard in period:
(1) obvious trauma history is arranged;
(2) damage two weeks with interior new wound;
(3) there are pain, tenderness, swelling in the damage part or livid purple ecchymosis is arranged;
(4) hindering limb or part can be with dysfunction and tractive pain;
(5) different parts has special symptom.
2.1.2 Western medicine diagnose: its evaluation criteria is with reference to " normal wind medical diagnosis on disease foundation and curative effect judging standard (surgery) ".The symptom that the diagnostic criteria symptom is diagnosed with the Chinese medical discrimination standard is identical.
3, observational technique and index
3.1 grouping: observe 150 examples altogether, divide three tame hospitals to finish.Hospital of every family 50 examples, wherein No. 1 Hospital Affiliated to Hunan Traditional Chinese Medical College and four-player people hospital set up treatment group (blood stasis dispersing and pain alleviating Capsules group) 34 examples separately, matched group (powder for fracture and trauma group) 16 examples, Annex II institute of Hunan College of Traditional Chinese Medicine sets up treatment group (blood stasis dispersing and pain alleviating Capsules group) 32 examples separately, matched group (powder for fracture and trauma group) 18 examples.The sample randomization.
3.2 method of administration, the course of treatment.
3.2.1 treatment group clothes medicine of the present invention blood stasis dispersing and pain alleviating capsule, one time 5, every day 3 times.
3.2.2 matched group clothes powder for fracture and trauma, one time 10, every day 3 times.
3.3 the course of treatment: be 12 days.
3.4 observation index
Primary symptom weight program classification score: by light (+), in (++), heavy (+++), serious (++ ++) four batch total branches, see the following form 2.Each "+" note 1 minute; Meet dialectical standard picture of the tongue, pulse condition note 1 minute; Transference cure note 0 minute.
Table 2 primary symptom classification score-sheet
| Observation item | Gently (+) | In (++) | Heavy (+++) | Seriously (++ ++) |
| Pain | Mild pain, there is mild tenderness the part, hinder limb and occur the oxycinesia of living when movable significantly, do not have spontaneous pain, routine work is not had obvious influence. | Moderate pain, there is obvious tenderness in the traumatic part, oxycinesia alive, and slight spontaneous pain is arranged, routine work and life there are certain influence. | Severe pain, there is the spontaneous severe pain of continuing in the traumatic part, tenderness, and the restriction limb activity, influence routine work and life. | Serious pain, there is the spontaneous severe pain of continuing in the traumatic part, need the symptomatic drugs treatment, tenderness, serious restriction limb activity can not carry out routine work and life. |
| Swelling | Mild swelling, the part has swelling slightly, or ecchymosis is arranged, bone mark is obvious. | Moderate swelling, local organization swelling is more obvious, ecchymosis is arranged, and bone mark shoals. | Severe swelling, local organization swelling is obvious, the skin anxiety is shinny, and bone mark disappears. | Serious swelling, local organization swelling is serious, the skin anxiety is shinny to be desired to split, bone mark disappears, and needs anti symptom treatment. |
| Dysfunction | Slight obstacle, the traumatic part joint motion is limited slightly, and limb function is not had obvious influence. | The moderate obstacle, active movement part in joint, traumatic part is limited, and limb function is had certain influence. | The severe obstacle, hinder limb the manifest function obstacle is arranged, the joint active movement is limited, or upper limb is not prudent or lower limb can not be walked. | Serious hindrance, hinder limb function serious hindrance, the joint passive activity is limited, or upper limb limitation of activity, or lower limb can not passively be walked the need anti symptom treatment. |
5, curative effect is judged
5.1 the disease disease is in conjunction with criterion of therapeutical effect
To judge the criterion of therapeutical effect of disease, in conjunction with judging sick curative effect (with reference to " Chinese traumatology " and " common disease diagnosis basis and curative effect judging standard (surgery) ")
Clinical recovery: treatment back disease integration reduces more than 90%.
Produce effects: treatment back disease integration reduces 70%～90%.
Effectively: treatment back disease integration reduces 35%～69%.
Invalid: treatment back disease integration reduces below 35%.
5.2 the criterion of therapeutical effect of doctor trained in Western medicine disease
With reference to " common disease diagnosis basis and curative effect judging standard (surgery) ".
Early stage, the swelling pain curative effect determinate standard of the acute injury of tendon and muscle: 1. clinical recovery: transference cure; 2. produce effects: symptom disappears substantially; 3. effective: symptom takes a turn for the better; 4. invalid: symptom does not have improvement.
6, result
6.1 150 routine acute injury of tendon and muscle patients are observed in this test altogether, clinical efficacy sees Table 3.
Table 3 treatment group and matched group clinical efficacy are relatively
| Group | The example number | Cure example (%) | Produce effects example (%) | Effectively routine (%) | Invalid example (%) | Total effective rate |
| The treatment group | ????100 | ????73 ????73％ | ????20 ????20％ | ????5 ????5％ | ????2 ????2％ | ??98％※ |
| Matched group | ????50 | ????28 ????54％ | ????13 ????26％ | ????7 ????14％ | ????2 ????4％ | ??96％※ |
※ and matched group be P＞0.05 relatively.
By table 3 as seen, the treatment group is taken medicine of the present invention blood stasis dispersing and pain alleviating capsule for treating 100 routine acute injury of tendon and muscle early stage patients, and clinical cure 73 examples account for 73%, and produce effects 20 examples account for 20%, and effective 5 examples account for 5%, and total effective rate is 98%; Matched group is taken powder for fracture and trauma and is treated 50 routine acute injury of tendon and muscle patients, and wherein clinical cure 28 examples account for 54%, and produce effects 13 examples account for 26%, and effective 7 examples account for 14%, and total effective rate is 96%.Learn by statistics and handle treatment group and matched group curative effect there was no significant difference (P＞0.05).
6.2 this test, 100 routine acute injury of tendon and muscle early stage patients are taken the blood stasis dispersing and pain alleviating capsule, there is no toxicity.
7, Drug therapy evaluation of effect of the present invention.
By using this product 100 routine acute injury of tendon and muscle early stage patients, the result shows:
7.1 capsule for treating acute injury of tendon and muscle early stage patient in blood stasis dispersing and pain alleviating can be obtained significant curative effect.And compare with the contrast powder for fracture and trauma, cure rate is also slightly advanced.
7.2 this product was taken 12 days through observing 100 routine patients, there is no toxicity, showed this product safety.
7.3 taking convenience, patient is convenient to accept.
In view of above some observed result: we think that the blood stasis dispersing and pain alleviating capsule is a kind of medicine of safe, effective, the simple and easy to do acute injury of tendon and muscle early stage patient of treatment, is worth using widely and promoting.
Description of drawings
Fig. 1 is a process chart of the present invention.
The specific embodiment
Embodiment 1, takes by weighing raw material by following weight proportion:
Radix Notoginseng 90g Sanguis Draxonis 30g Myrrha 100g
Olibanum 100g Rhizoma Corydalis 100g Pyritum (system) 30g
Semen Persicae 100g Flos Carthami 100g Rhizoma Acori Graminei 100g
Herba Taraxaci 120g Radix Et Rhizoma Rhei 60g Eupolyphaga Seu Steleophaga 90g
Preparation technology is as shown in Figure 1:
Become fine powder standby Radix Notoginseng, Pyritum (system), Olibanum, Myrrha, Sanguis Draxonis pulverize separately; Flos Carthami, Rhizoma Acori Graminei, Rhizoma Corydalis, Semen Persicae, Radix Et Rhizoma Rhei, Herba Taraxaci, Eupolyphaga Seu Steleophaga are decocted with water secondary, add 10 times of amounts of water at every turn, decocted 1.5 hours, collecting decoction, filtration, filtrate is concentrated into the clear paste that relative density is 1.20 (80 ℃).Drying adds above-mentioned Radix Notoginseng, Pyritum (system), Olibanum, Myrrha, Resina Draconis-drug fine powder, and mixing is granulated, and drying incapsulates, and makes 1000, promptly.
Embodiment 2, press column weight amount proportioning and take by weighing raw material:
Radix Notoginseng 80g Sanguis Draxonis 40g Myrrha 80g
Olibanum 80g Rhizoma Corydalis 80g Semen Persicae 80g
Flos Carthami 80g Eupolyphaga Seu Steleophaga 100g
Preparation technology is as follows:
Become fine powder standby Radix Notoginseng, Olibanum, Myrrha, Sanguis Draxonis pulverize separately; Flos Carthami, Rhizoma Corydalis, Semen Persicae, Eupolyphaga Seu Steleophaga are decocted with water secondary, add 10 times of amounts of water at every turn, decocted 1.5 hours, collecting decoction, filtration, filtrate is concentrated into the clear paste that relative density is 1.20 (80 ℃).Drying adds above-mentioned Radix Notoginseng, Olibanum, Myrrha, Resina Draconis-drug fine powder, mixing, and drying incapsulates, and makes 1000, promptly.
The present invention is a capsule, and content is tan granule or powder, gas perfume (or spice), bitter in the mouth.
Claims (5)
- One kind the treatment the acute injury of tendon and muscle medicine, it is characterized in that: it is made by the following weight proportioning:60～130 parts of 10～50 parts of Myrrhas of 70～120 parts of Sanguis Draxonis of Radix Notoginseng0～50 part of Olibanum 60～130 parts of Pyritum of 60～130 parts of Rhizoma Corydalis (system)0～130 part of 40～130 parts of Rhizoma Acori Graminei of 60～130 parts of Flos Carthamis of Semen Persicae50～120 parts of 0～80 part of Eupolyphaga Seu Steleophagas of 0～130 part of Radix Et Rhizoma Rhei of Herba Taraxaci
- 2. the medicine of the acute injury of tendon and muscle of treatment according to claim 1, wherein each composition of raw materials preferred weight ratio range is:80～120 parts of 20～40 parts of Myrrhas of 80～100 parts of Sanguis Draxonis of Radix Notoginseng0～30 part of Olibanum 70～120 parts of Pyritum of 80～120 parts of Rhizoma Corydalis (system)0～110 part of 40～80 parts of Rhizoma Acori Graminei of Semen Persicae 70～1 10 part Flos Carthami50～90 parts of 50～70 parts of Eupolyphaga Seu Steleophagas of 0～60 part of Radix Et Rhizoma Rhei of Herba Taraxaci
- 3. medicine according to claim 2, wherein each raw material optimum weight proportioning is:100 parts of 30 parts of Myrrhas of 90 parts of Sanguis Draxonis of Radix Notoginseng30 parts of Olibanum 100 parts of Pyritums of 100 parts of Rhizoma Corydalis (system)100 parts of 100 parts of Rhizoma Acori Graminei of 100 parts of Flos Carthamis of Semen Persicae90 parts of 60 parts of Eupolyphaga Seu Steleophagas of 120 parts of Radix Et Rhizoma Rhei of Herba Taraxaci
- 4. the medicine of the acute injury of tendon and muscle of treatment according to claim 1 and 2 is characterized in that said medicament is a said dosage form on any pharmaceutics, and the present invention adopts capsule formulation.
- 5. the preparation method of the medicine of the acute injury of tendon and muscle of treatment according to claim 1 is characterized in that: will become fine powder standby with Radix Notoginseng, Pyritum (system), Olibanum, Myrrha, the Sanguis Draxonis pulverize separately in 12 flavors; Decoct with water secondary with Flos Carthami, Rhizoma Acori Graminei, Rhizoma Corydalis, Semen Persicae, Radix Et Rhizoma Rhei, Herba Taraxaci, Eupolyphaga Seu Steleophaga, add 10 times of amounts of water at every turn, decocted 1.5 hours, collecting decoction, filtration, filtrate is concentrated into the clear paste that relative density is 1.20 (80 ℃); Drying adds above-mentioned Radix Notoginseng, Pyritum (system), Olibanum, Myrrha, Resina Draconis-drug fine powder, and mixing is granulated, and incapsulates, and makes 1000, promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 02139616 CN1186067C (en) | 2002-09-13 | 2002-09-13 | Medicine for curing acute injury of muscle and tendon and its preparation method |
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| CN 02139616 CN1186067C (en) | 2002-09-13 | 2002-09-13 | Medicine for curing acute injury of muscle and tendon and its preparation method |
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| CN1411861A true CN1411861A (en) | 2003-04-23 |
| CN1186067C CN1186067C (en) | 2005-01-26 |
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| CN108686083A (en) * | 2018-08-13 | 2018-10-23 | 庞栋升 | External Miao medicine liquid for treating pain and preparation method thereof |
| CN108785492A (en) * | 2018-06-12 | 2018-11-13 | 孙彩春 | A kind of imperial plaster of wood and preparation method thereof |
| CN113230238A (en) * | 2021-05-21 | 2021-08-10 | 李井田 | Externally applied plaster |
-
2002
- 2002-09-13 CN CN 02139616 patent/CN1186067C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101972378A (en) * | 2010-09-27 | 2011-02-16 | 陈树亮 | Traditional Chinese medicine for treating gout |
| CN101972378B (en) * | 2010-09-27 | 2011-11-09 | 陈树亮 | Traditional Chinese medicine for treating gout |
| CN106074993A (en) * | 2016-07-14 | 2016-11-09 | 李连波 | One is invigorated blood circulation bone-setting pain stopping plaster |
| CN106074993B (en) * | 2016-07-14 | 2019-11-05 | 李连波 | A kind of promoting blood circulation bone-setting pain stopping plaster |
| CN108785492A (en) * | 2018-06-12 | 2018-11-13 | 孙彩春 | A kind of imperial plaster of wood and preparation method thereof |
| CN108686083A (en) * | 2018-08-13 | 2018-10-23 | 庞栋升 | External Miao medicine liquid for treating pain and preparation method thereof |
| CN113230238A (en) * | 2021-05-21 | 2021-08-10 | 李井田 | Externally applied plaster |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1186067C (en) | 2005-01-26 |
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