CN1694949A - A composition for disinfecting or washing medical instruments and a process for the preparation thereof - Google Patents

A composition for disinfecting or washing medical instruments and a process for the preparation thereof Download PDF

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CN1694949A
CN1694949A CNA03824750XA CN03824750A CN1694949A CN 1694949 A CN1694949 A CN 1694949A CN A03824750X A CNA03824750X A CN A03824750XA CN 03824750 A CN03824750 A CN 03824750A CN 1694949 A CN1694949 A CN 1694949A
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composition
tensio
cleaning
active agent
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CN1297645C (en
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李镇植
李镇太
金度勋
郑澯浩
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Carida KK
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李镇植
李镇太
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    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66Non-ionic compounds
    • C11D1/722Ethers of polyoxyalkylene glycols having mixed oxyalkylene groups; Polyalkoxylated fatty alcohols or polyalkoxylated alkylaryl alcohols with mixed oxyalkylele groups
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/02Inorganic compounds ; Elemental compounds
    • C11D3/04Water-soluble compounds
    • C11D3/042Acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18Liquid substances or solutions comprising solids or dissolved gases
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/20Organic compounds containing oxygen
    • C11D3/2075Carboxylic acids-salts thereof
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/36Organic compounds containing phosphorus
    • C11D3/361Phosphonates, phosphinates or phosphonites
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16Organic compounds
    • C11D3/37Polymers
    • C11D3/3703Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3707Polyethers, e.g. polyalkyleneoxides
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39Organic or inorganic per-compounds
    • C11D3/3942Inorganic per-compounds
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39Organic or inorganic per-compounds
    • C11D3/3945Organic per-compounds
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/39Organic or inorganic per-compounds
    • C11D3/3947Liquid compositions
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11DDETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Detergent Compositions (AREA)
  • External Artificial Organs (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

A composition for disinfecting or cleaning a medical instrument and a preparation process thereof are provided. The composition includes 1.0 to 1.6% by weight of peracetic acid, 0.1 to 20% by weight of acetic acid, 1 to 6% by weight of hydrogen peroxide, 0.1 to 20% by weight of phosphoric acid, 0.1 to 5% by weight of 1, 1-diphosphonic acid, 0.001 to 10% by weight of a surfactant with alcoholic groups at both terminals, and the remainder of the total composition being distilled water, reverse osmosis water or deionized water.

Description

Be used for composition and method of making the same with medical apparatus sterilizing or washing
Technical field
The present invention relates to be used for peracetic acid (PAA) composition and method of making the same with medical apparatus sterilizing or cleaning, said composition is included in the tensio-active agent that two ends have alcohol radical.
Background technology
Hemodialysis for patients with renal failure was carried out 3-6 hour usually at every turn.Use 2-3 time at one day needs of hospital's haemodialysis equipment, do not have enough timed intervals with equipment disinfection or cleaning, equipment is easy to contaminated.Particularly, the dialyzate that contains glucose along with use increases gradually, and the Pollution risk that is installed in the transmitter in the equipment increases, and the maintenance of equipment is met difficulty.
In order to remove or peel off sedimentary various dirts and microbial film on haemodialysis equipment and the water shoot internal surface thereof, need to use sterilization or cleaning combination.Usually, sterilization or cleaning combination mainly are made up of clorox.Randomly, can also an other week use citric acid, formaldehyde solution or acetate are once or twice.Although clorox and acetate are relative effective aspect sterilization and scale removal, they also have several side effects, comprise because corrosion causes equipment degraded, reduction of service life etc., power consumption or water consumption are because secondary environmental pollution that formaldehyde solution and clorox cause or the like.The effect of removing dirt, microbial film or spore in addition is also unsatisfactory, promptly also be unrealized sterilization fully or cleaning.
Developed the composition that is used to sterilize or cleans medicine equipment, promptly, peracetic acid (PAA) composition that contains peracetic acid, acetate and hydrogen peroxide, as at PCT publication number WO 88/08667, WO93/07909 and WO 94/14321, European patent application EP 596,493, U.S. Patent number 6,168, disclosed in 808 grades.
The conventional PAA composition that is used to sterilize or cleans medicine equipment generally includes peracetic acid, acetate, hydrogen peroxide and purified water, and comprise stablizer such as Phosphoric acid or phosphonic acid in addition, nonionic surface active agent such as sorbitan-monopalmityl ester or polyoxyethylene cetyl ether, amine oxide etc.
Contain in the situation of PAA composition of conventional surfactants in use, can not effectively suppress foamy and produce, make foam stop composition to contact, cause the sterilization and the cleaning efficiency that differ from medicine equipment.
Summary of the invention
Because foam produces the problem that causes, the invention provides a kind of peracetic acid (PAA) composition that is used for medical apparatus sterilizing or cleaning in order to overcome, this PAA composition is included in the tensio-active agent that two ends have alcohol radical.
According to an aspect of of the present present invention, a kind of composition that is used for medical apparatus sterilizing or cleaning is provided, said composition comprises the peracetic acid of 1.0-1.6% weight, the acetate of 0.1-20% weight, the hydrogen peroxide of 1-6% weight, 0.1 phosphoric acid to 20% weight, 1 of 0.1-5% weight, 1-bisphosphate, at least a tensio-active agent of 0.001-10% weight by formula (I) expression, and all the rest part of composition is a distilled water, reverse osmosis water or deionized water:
Figure A0382475000051
L wherein, m, n are the integers of 1-50, the summation of l and n is 2-50.
According to another aspect of the present invention, provide a kind of preparation to be used for method for compositions with medical apparatus sterilizing or cleaning, this method comprises (a) distilled water with 50-55% weight, reverse osmosis water or deionized water, 1 of the phosphoric acid of 0.1-10% weight and 0.1-1.0% weight, the 1-bisphosphate mixes, (b) acetate of 15-25% weight is mixed with the solution that obtains in step (a), (c) hydrogen peroxide of 15-20% weight is mixed the formation peracetic acid with the solution that obtains in step (b), (d) solution that will obtain in step (c) was at 35-45 ℃ of warm 4-7 hour, with its at room temperature aging (maturing) with (e) at least a tensio-active agent by formula (I) expression of 0.001-10% weight is mixed with the solution of acquisition in step (d) then.
Implement best mode of the present invention
Be used for the composition of medical apparatus sterilizing or cleaning is comprised the peracetic acid of 1.0-1.6% weight, the acetate of 0.1-20% weight, the hydrogen peroxide of 1-6% weight, 0.1 phosphoric acid to 20% weight, 1 of 0.1-5% weight, 1-bisphosphate, at least a tensio-active agent of 0.001-10% weight by formula (I) expression, and all the rest part of composition is a distilled water, reverse osmosis water or deionized water:
L wherein, m, n are the integers of 1-50, the summation of l and n is 2-50.
Peracetic acid and hydrogen peroxide directly relate to sterilizing function, and are present in sterilization or the cleaning combination with equilibrium state.
Phosphoric acid and 1, the 1-bisphosphate forms the blended stablizer, and each free following formula is represented:
Phosphatase 11, the 1-bisphosphate
In according to sterilization of the present invention or cleaning combination, the blended stablizer is stablized peracetic acid and hydrogen peroxide.The phosphoric acid that contains in the blended stablizer allows to remove the acidity of dirt (scale), thereby improves the ability of removing dirt, and described dirt is lime carbonate or calcium sulfate for example.In other words, the blended stablizer play a role with stable according to sterilization of the present invention or cleaning combination and its acidity of adjusting in ideal range.
Comprise the tensio-active agent that is expressed from the next according to sterilization of the present invention or cleaning combination:
L wherein, m, n are the integers of 1-50, the summation of l and n, promptly l+n is 2-50.
In tensio-active agent, the summation of l and n corresponding to the amount of ethylene oxide moiety, is preferably about 4 to about 50 moles, and m is preferably about 5 to about 40 moles corresponding to the amount of propylene oxide part.In addition, the molecular-weight average of tensio-active agent is preferably about 1500 to about 3000, and more preferably from about 2,500.The example that is used for tensio-active agent of the present invention comprises the commercially available any tensio-active agent in the above range of definition, comprises polyoxyethylene and oxypropylene block copolymer etc., for example Koremul-PE62 (Hannong Chemicals Inc., Korea).
Because tensio-active agent shows low surface tension and low foaming, it can minimize because the environmental problem that the existence of the defoamer that uses in conventional medicine equipment cleans causes.In other words, produce unlike in the conventional peracetic acid composition defoamer being used to suppress foamy, in with haemodialysis equipment sterilization or cleaning process, cause the infringement of internal toxin filter apparatus, can avoid the problem of damaging according to sterilization of the present invention or cleaning combination.
Be used for the composition of medical apparatus sterilizing or cleaning being used as solvent with water, preferred distilled water, promptly pure basically unpolluted water, more preferably reverse osmosis (RO) water or deionization (DI) water according to the present invention.
The amount of all the components that contains is the amount of the various compositions that contain in the composition of the final acquisition of equilibrium state in sterilization or cleaning combination.Preferably, the sterilization of equilibrium state or cleaning combination comprise the peracetic acid that comprises 1.0-1.6% weight, the acetate of 0.1-20% weight, the hydrogen peroxide of 1-6% weight.Certainly, each amount can depart from above scope according to the definition of sufficiently sterilised or cleaning efficiency a little, however this will be understood that above about scope according to sterilization of the present invention or cleaning combination definition in.
In addition, preferably use phosphoric acid and 1 with the amount of 0.1-20% and 0.1-5% weight respectively, the 1-bisphosphate is as stablizer and dirt remover.Phosphoric acid and 1, the amount of 1-bisphosphate also can depart from above scope according to sufficiently sterilised and scale removal definitions of efficiency a little, however this will be understood that above about scope according to the definition of sterilization of the present invention or cleaning combination in.
Preferably with 0.001-10% weight, more preferably the amount of 0.5-5% weight is used the tensio-active agent by formula (I) expression.
As the distilled water that solvent or thinner according to sterilization of the present invention or cleaning combination provide, RO water or DI water as remainder to 100%, form final composition with other composition with an amount of use.
The medicine equipment that goes for sterilization of the present invention or cleaning combination includes but not limited to, haemodialysis equipment, and peripherals etc.
According to another aspect of the present invention, provide a kind of preparation to be used for method for compositions with medical apparatus sterilizing or cleaning, this method comprises (a) distilled water with 50-55% weight, reverse osmosis water or deionized water, 1 of the phosphoric acid of 0.1-10% weight and 0.1-1.0% weight, the 1-bisphosphate mixes, (b) acetate of 15-20% weight is mixed with the solution that obtains in step (a), (c) hydrogen peroxide of 15-20% weight is mixed the formation peracetic acid with the solution that obtains in step (b), (d) solution that will obtain in step (c) was at 35-45 ℃ of warm 4-7 hour, with its at room temperature aging (maturing) with (e) at least a tensio-active agent by formula (I) expression of 0.001-10% weight is mixed with the solution of acquisition in step (d) then
Carrying out warm is in order to promote the reaction between hydrogen peroxide and the acetate.In solution is aging, the amount of hydrogen peroxide is adjusted to proper level, for example to less than 6% weight.Aging preferably carrying out about 3 days.
In the acceptable scope in this area, for example can suitably dilute sterilization of the present invention or cleaning combination, and can be used for as required with effectively sterilization or cleaning of medicine equipment, as haemodialysis equipment or its peripherals with 1: 10 to 1: 50 ratio.As aqueous solvent, preferably can be with distilled water, RO water is or/and DI water is used as thinner.
With reference now to embodiment, will describe the present invention in more detail, the present invention is confined to this never in any form.
Embodiment 1
With 50g RO water, 10g phosphoric acid and 1g 1, the 1-bisphosphate mixes, and mixes with 20g acetate then, then mixes with the 17g hydrogen peroxide, prepares peracetic acid thus, and it is warm about 7 hours at 35-45 ℃.At room temperature stirring the material that obtains makes it aging, commercially available from Hannong Chemical Inc. to wherein adding 2g with the trade(brand)name of Koremul-PE62, polyoxyethylene-oxypropylene block copolymer of Korea prepares thus according to sterilization of the present invention or cleaning combination.The concentration of contained peracetic acid and hydrogen peroxide is respectively 1.67% and 5.78% in the composition of preparation.
Embodiment 2
Except using 5g phosphoric acid, prepare the composition that is used to sterilize or cleans medicine equipment in the mode identical with embodiment 1.The peracetic acid that contains in the composition that obtains and the concentration of hydrogen peroxide are respectively 1.08% and 5.96%.
Embodiment 3
Except using 5g phosphoric acid and 0.5g 1, beyond the 1-bisphosphate, prepare the composition that is used to sterilize or cleans medicine equipment in the mode identical with embodiment 1.The peracetic acid that contains in the composition that obtains and the concentration of hydrogen peroxide are respectively 1.30% and 5.86%.
Embodiment 4
Except using 15g acetate, prepare the composition that is used to sterilize or cleans medicine equipment in the mode identical with embodiment 1.The peracetic acid that contains in the composition that obtains and the concentration of hydrogen peroxide are respectively 1.01% and 5.86%.
Embodiment 5
Except using 10g acetate, prepare the composition that is used to sterilize or cleans medicine equipment in the mode identical with embodiment 1.The peracetic acid that contains in the composition that obtains and the concentration of hydrogen peroxide are respectively 1.01% and 5.94%.
Embodiment 6: the application of sterilization of the present invention or cleaning combination
Under condition shown in the table 1, use the composition of embodiment 1 preparation to carry out this assessment.Used several dissimilar haemodialysis equipments about 2 months, and comprised Gambro Co., the model AK200Ultra that Sweden sells.
Table 1
Type Thinning ratio The amount of composition therefor (ml) Pre-rinsing (ml) Infusion (minute) Duration of contact (min) Post rinsing (min)
Manufacturers Model
??Gambro ??AK/90 ??/95 ??1/25 ??~1/30 ??80 ??~150 ??10 ??7 ??20 ??30~
??Gambro ??AK100 ??1/35 ??60 ??10 ??3 ??ON ??30~
??Gambro ??AK200 ??Ultra ??1/35 ??60 ??10 ??7 ??ON ??30~
??Gambro ??COBE ??C-3 ??1/9 ??250 ??- ??9~45 ??- ??18~30
??Nikkiso ??DBB22B ??/26B ??- ??60~80 ??30 ??- ??30 ??30
??Nipro ??NIPRO ??1/43 ??~1/45 ??100 ??~110 ??10 ??10~15 ??90 ??30
??Toray ??TR-321 ??/322 ??1/16 ??122~ ??150 ??10 ??5 ??40~90 ??35
??Baxter ??450/550 ??/Median ??1/35 ??255 ??2 ??516 ??~50 ??30 ??6~25
??Baxter ??450/550 ??/Median ??1/16.5 ??170 ??2 ??6~50 Set ??23~30
??Medi-Tech ??NHD-2000 ??1/35 ??250 ??10 ??20 ??20 ??60
??Medi-Tech ??Althin ??- ??220 ??- ??5 ??30~ ??30~
??Medi-Tech ??Touch-M ??1/35 ??150 Set ??7 ??8 ??7
Set: set arbitrarily
ON: spend the night
When sterilization of the present invention or cleaning combination were used under these conditions, the haemodialysis equipment of most of types can sterilize and clean fully, did not produce foam and did not shorten work-ing life of the intracellular toxin filter that is attached in each equipment.
Industrial usability
As mentioned above, sterilization of the present invention or cleaning combination can be advantageously used in the sterilization of haemodialysis equipment and ancillary equipment thereof or clean and do not use defoamer, prevented thus the infringement to equipment, such as the obstruction of combination endotoxin filter place pollutant wherein.

Claims (5)

1. composition that is used for medical apparatus sterilizing or cleaning, said composition comprises the peracetic acid of 1.0-1.6% weight, the acetate of 0.1-20% weight, the hydrogen peroxide of 1-6% weight, the phosphoric acid of 0.1 to 20% weight, 1 of 0.1-5% weight, the 1-bisphosphate, at least a tensio-active agent of 0.001-10% weight by formula (I) expression, and all the rest part of composition is a distilled water, reverse osmosis water or deionized water:
Figure A038247500002C1
L wherein, m, n are the integers of 1-50, the summation of l and n is 2-50.
2. the composition of claim 1, the molecular-weight average of wherein said tensio-active agent is about 1500 to about 3000.
3. the composition of claim 2, the molecular-weight average of wherein said tensio-active agent is about 2,500.
4. the composition of claim 2, wherein said medicine equipment is haemodialysis equipment or its peripherals.
5. one kind prepares the method for compositions that is used for medical apparatus sterilizing or cleaning, and this method comprises
(a) with distilled water, reverse osmosis water or the deionized water of 50-55% weight, 1 of the phosphoric acid of 0.1-10% weight and 0.1-1.0% weight, the 1-bisphosphate mixes;
(b) acetate of 15-25% weight is mixed with the solution that obtains in step (a);
(c) hydrogen peroxide of 15-20% weight is mixed the formation peracetic acid with the solution that obtains in step (b);
(d) solution that will obtain in step (c) at room temperature wore out it then at 35-45 ℃ of warm 4-7 hour; With
(e) at least a tensio-active agent by formula (I) expression with 0.001-10% weight mixes with the solution that obtains in step (d):
L wherein, m, n are the integers of 1-50, the summation of l and n is 2-50.
CNB03824750XA 2002-08-28 2003-08-28 A composition for disinfecting or washing medical instruments and a process for the preparation thereof Expired - Fee Related CN1297645C (en)

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KR10-2002-0051155A KR100515929B1 (en) 2002-08-28 2002-08-28 A composition for disinfecting and washing medical instruments comprising a surfactant having alcohol groups at the both terminals and a process for the preparation thereof 2
KR1020020051155 2002-08-28

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CN104981158A (en) * 2012-12-14 2015-10-14 萨班企业私人有限公司 Disinfectant
CN109705986A (en) * 2019-01-25 2019-05-03 石华英 A kind of no enzyme multipurpose medical instrument cleaning agent, preparation method and application

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US7226897B1 (en) 2006-07-26 2007-06-05 Innovation Services, Inc. Water soluble barrier film conformal coating composition
US7198680B1 (en) 2006-07-26 2007-04-03 Innovation Services, Inc. Process for cleaning surfaces of medical equipment

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CN104981158A (en) * 2012-12-14 2015-10-14 萨班企业私人有限公司 Disinfectant
CN104981158B (en) * 2012-12-14 2017-12-22 萨班企业私人有限公司 Disinfectant
CN104041511A (en) * 2014-06-18 2014-09-17 海南朗腾医疗设备有限公司 Solution for sterilizing and cleaning hemodialysis machine and preparation method of solution
CN104041511B (en) * 2014-06-18 2016-06-29 海南朗腾医疗设备有限公司 A kind of solution for haemodialysis control unit sterilization and cleaning and preparation method thereof
CN109705986A (en) * 2019-01-25 2019-05-03 石华英 A kind of no enzyme multipurpose medical instrument cleaning agent, preparation method and application

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CN1297645C (en) 2007-01-31
AU2003253480A1 (en) 2004-03-19

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