JP2001072996A - Bactericidal detergent composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a bactericidal detergent composition which exhibits an effective detergency to both inorganic dirt and organic dirt by incorporating peracetic acid, acetic acid, hydrogen peroxide, and a surfactant into the same. SOLUTION: This composition is prepared by dissolving 0.3-1.5 wt.% peracetic acid, 2-20 wt.% acetic acid, 4-12 wt.% hydrogen peroxide, and 1-20 wt.% surfactant. The surfactant is preferably a nonionic surfactant represented by the formula: R1O-(R2-O)n-H, wherein R1 is a hydrocarbon group; R2 is alkylene; and n is 1 or higher. The moiety represented by (R2-O)n in the formula can be formed by the addition polymerization of an alkylene oxide or the like such as ethylene oxide, propylene oxide, butylene oxide, an α-olefin oxide or styrene oxide. In forming the (R2-O)n moiety, R2 is determined by the kind of the alkylene oxide or the like. Preferably, 50-100 mol% of the (R2-O)n moiety is accounted for by oxyethylene units, and the degree of polymerization (n) is 1-20.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a germicidal detergent composition.

[0002]

2. Description of the Related Art An artificial dialysis device for blood is a device for dialyzing blood by bringing a dialysate and blood into contact with each other via a semi-permeable membrane. The dialysate used at this time contains bicarbonate ions or glucose, but by repeating dialysis, inorganic dialysate such as calcium carbonate is formed in the piping of the dialyzer or in a semi-permeable membrane. There is a problem that a system precipitate is deposited and organic dirt such as a protein is deposited. Depending on the dialysis device, pipes and semi-permeable membranes on which dirt is deposited may be discarded for one-time use, but there is also a device that cleans dirt and uses it repeatedly.

Conventionally, a cleaning agent containing a chlorine-based compound such as sodium hypochlorite has been used as a cleaning agent for removing dirt deposited on a pipe or the like of such an artificial dialysis apparatus. The cleaning agent has a possibility of causing chlorine contamination in pipes, semipermeable membranes and the like, and is no longer used. Therefore, recently, a cleaning agent containing a peroxide such as peracetic acid or hydrogen peroxide is being used as a cleaning agent particularly effective for inorganic stains. For example, JP-A-8
JP-A-224299 discloses a method of washing a dialysis device by using an aqueous solution of sodium hypochlorite and an aqueous solution of peracetic acid alternately. Japanese Patent No. 2,599,204 discloses a sanitizing agent for hemodialysis containing hydrogen peroxide, peracetic acid and acetic acid.

[0004]

The cleaning agents containing these peroxides are germicidal and do not attack the object to be cleaned or cause another contamination unlike chlorine-based cleaning agents. Since it is easily decomposable and the substances produced by decomposition are harmless to humans such as water and acetic acid, they are suitable for cleaning medical instruments such as dialysis machines. However, the peroxide component alone was not effective enough for cleaning organic stains such as proteins, apart from inorganic stains. Therefore, the present inventors have studied diligently and have come to develop a germicidal cleaning agent capable of effectively cleaning not only inorganic stains but also organic stains. An object of the present invention is to provide a germicidal detergent composition that exhibits sufficient detergency not only for inorganic stains but also for organic stains.

[0005]

That is, the present invention is a germicidal detergent composition containing peracetic acid, acetic acid, hydrogen peroxide, and a surfactant.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The germicidal detergent composition of the present invention comprises:
Contains peracetic acid, acetic acid, hydrogen peroxide, and a surfactant as essential components. The contents of peracetic acid, acetic acid, and hydrogen peroxide are not particularly limited, but are limited from the viewpoint of the stability of peracetic acid and hydrogen peroxide. The content of these components, as an effective component, peracetic acid is 0.3 to
1.5% by weight is preferred, and acetic acid is 2 to 20% by weight.
Is preferable. Hydrogen peroxide is preferably in the range of 4 to 12% by weight, more preferably in the range of 8 to 12% by weight.

The surfactant used in the present invention is preferably a nonionic surfactant having high stability even in an oxidizing atmosphere. In particular, a polyoxyalkylene type nonionic surfactant represented by the following general formula (1) is preferred. Nonionic surfactants are preferred. ^{R 1 O- (R 2 -O)} n -H (1)

Here, R ¹ represents a hydrocarbon group. Examples of the hydrocarbon group include an alkyl group, an alkenyl group,
Examples thereof include an aryl group, a cycloalkyl group and a cycloalkenyl group. Examples of the alkyl group include methyl,
Ethyl, propyl, isopropyl, butyl, isobutyl, secondary butyl, tertiary butyl, pentyl, isopentyl, secondary pentyl, neopentyl, tertiary pentyl, hexyl, secondary hexyl, heptyl, secondary heptyl, octyl, 2-ethylhexyl, Secondary octyl, nonyl, secondary nonyl, decyl, secondary decyl, undecyl,
Secondary undecyl, dodecyl, secondary dodecyl, tridecyl, isotridecyl, secondary tridecyl, tetradecyl,
Secondary tetradecyl, hexadecyl, secondary hexadecyl,
Stearyl, icosyl, docosyl, tetracosyl, triacontyl, 2-butyloctyl, 2-butyldecyl,
2-hexyloctyl, 2-hexyldecyl, 2-octyldecyl, 2-hexyldecyl, 2-octyldodecyl, 2-decyltetradecyl, 2-dodecylhexadecyl, 2-hexadecyloctadecyl, 2-tetradecyloctadecyl, monomethyl Branched-isostearyl and the like.

Examples of the alkenyl group include vinyl, allyl, propenyl, butenyl, isobutenyl, pentenyl, isopentenyl, hexenyl, heptenyl, octenyl, nonenyl, decenyl, undecenyl, dodecenyl, tetradecenyl, oleyl and the like. Examples of the aryl group include phenyl, toluyl, xylyl,
Cumenyl, mesityl, benzyl, phenethyl, styryl, cinnamyl, benzhydryl, trityl, ethylphenyl, propylphenyl, butylphenyl, pentylphenyl, hexylphenyl, heptylphenyl, octylphenyl, nonylphenyl, decylphenyl, undecylphenyl, dodecylphenyl, Examples include phenylphenyl, benzylphenyl, styrenated phenyl, p-cumylphenyl, α-naphthyl and β-naphthyl groups. Examples of the cycloalkyl group and the cycloalkenyl group include, for example, cyclopentyl, cyclohexyl, cycloheptyl, methylcyclopentyl, methylcyclohexyl,
Methylcycloheptyl, cyclopentenyl, cyclohexenyl, cycloheptenyl, methylcyclopentenyl,
Examples thereof include a methylcyclohexenyl group and a methylcycloheptenyl group.

Among them, preferred groups as R ¹ are an alkyl group, an alkenyl group and an aryl group, and have 6 to 2 carbon atoms.
It is more preferably an alkyl group, an alkenyl group or an aryl group of 2, more preferably an alkyl group or an alkenyl group having 6 to 18 carbon atoms.

When R ¹ is an alkyl or alkenyl group having 6 to 18 carbon atoms, R ¹ is usually a residue obtained by removing a hydroxyl group from an aliphatic higher alcohol. Industrially, these alcohols are natural alcohols derived from natural fats and oils, Ziegler alcohols produced through a process of polymerizing ethylene by the Ziegler method (primary linear alcohols), olefins with carbon monoxide. Oxo alcohol (main component is linear primary alcohol, mixed with branched primary alcohol) produced by the oxo method of reacting hydrogen and hydrogen. It is produced by air oxidation of paraffin, and the hydroxyl group is other than the terminal of carbon chain. It is produced as a single or mixed synthetic alcohol, such as a secondary alcohol, which is randomly bonded to any of these alcohols, and any of these alcohols can be used.

R ² represents an alkylene group and has 2 to 2 carbon atoms.
It is preferably an alkylene group of 4, and more preferably an ethylene group. (R ² —O) _{n of the} general formula (1)
Is ethylene oxide, propylene oxide, butylene oxide, α-olefin oxide,
It can be obtained by addition polymerization of an alkylene oxide such as styrene oxide. When the (R ² —O) _n portion is formed by adding an alkylene oxide or the like, R ² is determined by the type of the alkylene oxide or the like to be added.

Polymerization of alkylene oxide or the like to be added
The form is not particularly limited, and one kind of alkylene oxide
Such as homopolymerization, two or more kinds of alkylene oxide
Random copolymer, block copolymer or random / block
Copolymerization or the like. R ^TwoEthylene group is the best
Are also preferred, and R^TwoWhen is a group of two or more,
One is preferably an ethylene group. (R^Two-O)_n
Preferably has 50 to 100 oxyethylene groups.
Mol%, more preferably 60 to 100 mol%.
Lioxyalkylene chains exhibit good detergency
You. The polymerization degree n is a number of 1 or more, preferably 1 to 20.
0, more preferably 2 to 100, still more preferably 2 to 5
0.

The germicidal detergent composition of the present invention comprises the above components, but may contain other additives such as a peroxide stabilizer as other components. The balance is usually water.
Further, the compounding amount of each component of the germicidal detergent composition of the present invention is a compounding amount in the form of an undiluted solution. It is also possible to use it after diluting it about twice.

[0015] The germicidal detergent composition of the present invention can be used for all cleaning applications. The germicidal detergent composition of the present invention has excellent bactericidal activity and excellent detergency against organic stains such as protein stains, and is particularly suitable for washing medical instruments such as artificial dialysis equipment. . In addition, applications requiring sterilization as well as detergency, for example, detergents for automatic dishwashers; so-called residential detergents for cleaning bathrooms, kitchens, walls, floors, walls, etc .; Cleaning agents for sterilizing and cleaning food-filled packages such as bottles, cans, wraps, and food trays; and detergents for cleaning filling and packaging lines in food and beverage factories.

[0016]

The present invention will be described more specifically with reference to the following examples. In the following examples,% is based on weight unless otherwise specified. EO is an abbreviation for oxyethylene group, and PO is an abbreviation for oxypropylene group.

The surfactants used in the test are as follows. (Surfactant _{A) C 12 H 25 O- (} EO) 8 - (PO) 5 -H ( block-like polymer) (surfactant _{B) C 14 H 29 O- (} EO) 10 / (PO) 3 - H (random polymerization) (Surfactant C) C ₁₂ H ₂₅ O- (EO) ₉ -H

A bactericidal detergent composition of the present invention using the above surfactant and having the composition shown in Table 1 below, and a comparative product having the composition shown in Table 1 without using the surfactant. Each of the germicidal detergent compositions was prepared and used in the following tests. In addition, the compounding amount of each component is a ratio to the total amount of the composition, and the balance is water.

[0019]

[Table 1]

Example 1 2 g of raw egg white was collected in a polystyrene petri dish, heated to 70 ° C. and dried to obtain a model stain. To this petri dish, the detergent composition of the present invention or the comparative product was diluted 50-fold or 100-fold with water and added in 5 mL portions. The plate was allowed to stand for 3 hours, and then the washing liquid was removed, and the dish was washed with water. The state of the model stain adhering to the dish was observed and evaluated according to the following criteria. A: There was no adhesion of dirt, and the cleanability was extremely good. ：: Some stains remained, but cleanability was good. Δ: Most of the stains remained, and the cleanability was poor. X: Almost no dirt was peeled off, and the cleanability was extremely poor. Table 2 shows the results of these detergency tests.

Example 2: Bovine serum was applied to a silicon plate,
It was dried by heating at 80 ° C. This operation was repeated several times to prepare a silicon plate on which bovine serum was dried and fixed, and this was used as a model stain. The cleaning composition of the present invention or the comparative product was diluted 70-fold with water and added to the silicon plate in 10 mL portions. Let stand for 2 hours, then
The petri dish was washed with water after removing the washing liquid, and the state of the model stain attached to the petri dish was observed, and evaluated according to the same criteria as in Example 1. Table 2 shows the results of these detergency tests.

[0022]

[Table 2]

From the above results, it can be seen that the germicidal detergent composition of the present invention has excellent detergency for organic stains such as proteins.

Example 3 Staphylococcus aur was cultured at 37 ° C. for 24 hours using SCD agar slant medium (manufactured by Eiken Chemical Co., Ltd.) as a medium.
eus) or E. coli (Escherichia col)
i) was suspended in 9 mL of sterile physiological saline,
L was cultured in SCD broth (manufactured by Eiken Chemical) at 37 ° C. for 24 hours to prepare an inoculum. Using this bacterial solution, a bactericidal test was performed according to the minimum bactericidal concentration (MBC) measurement method. First, 10 mL of the detergent solution of the present invention diluted 50-fold or 100-fold with sterile purified water was added to the inoculated bacterial solution 10 described above.
0 μL was added and allowed to act for 10 minutes. Then, 0.1 mL of this was used for SCDLP broth (Eiken Chemical) 10
The mixture was cultured at 37 ° C. for 48 hours, and the presence or absence of turbidity of the medium was visually determined. +: The medium is turbid. -: The medium is not turbid. Table 3 shows the results of these bactericidal tests.

[0025]

[Table 3]

From the above results, it can be seen that all the germicidal detergents of the present invention have excellent germicidal activity.

[0027]

The effect of the present invention is to provide a germicidal detergent composition which exerts sufficient detergency on not only inorganic stains but also organic stains.

 ──────────────────────────────────────────────────の Continued on the front page F term (reference) 4C058 AA02 AA06 AA07 AA12 AA17 AA23 AA24 AA25 CC06 JJ07 JJ08 4H003 AC08 AC11 AC23 BA12 DA05 DA12 DA17 DA19 DA20 DB01 EB07 ED02 EE04 EE06 FA34

Claims (5)

[Claims] 1. A germicidal detergent composition comprising peracetic acid, acetic acid, hydrogen peroxide, and a surfactant. 2. The surfactant is represented by the following general formula (1): R ¹ O— (R ² —O) _n —H (1) (wherein, R ¹ represents a hydrocarbon group, and R ² represents an alkylene) The germicidal detergent composition according to claim 1, which is a nonionic surfactant represented by the following formula: wherein n represents a number of 1 or more. 3. Peracetic acid is added in an amount of from 0.3 to 3 parts by weight based on the total amount of the composition.
1.5% by weight, 2 to 20% by weight of acetic acid, 4% of hydrogen peroxide
The germicidal detergent composition according to claim 1, which contains about 12% by weight. 4. The germicidal detergent composition according to claim 1, wherein the content of the surfactant is 1 to 20% by weight based on the total amount of the composition. 5. A cleaning composition for an artificial dialysis device, comprising the germicidal cleaning composition according to any one of claims 1 to 4.