CN1690071A - Method for extraction of ginseng fruit glucoside - Google Patents
Method for extraction of ginseng fruit glucoside Download PDFInfo
- Publication number
- CN1690071A CN1690071A CN 200410034174 CN200410034174A CN1690071A CN 1690071 A CN1690071 A CN 1690071A CN 200410034174 CN200410034174 CN 200410034174 CN 200410034174 A CN200410034174 A CN 200410034174A CN 1690071 A CN1690071 A CN 1690071A
- Authority
- CN
- China
- Prior art keywords
- herba herminii
- described method
- genseng
- glucoside
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 11
- 229930182478 glucoside Natural products 0.000 title claims description 12
- 150000008131 glucosides Chemical class 0.000 title claims description 12
- 241000208340 Araliaceae Species 0.000 title abstract description 12
- 235000008434 ginseng Nutrition 0.000 title abstract description 12
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 title abstract description 11
- 235000003140 Panax quinquefolius Nutrition 0.000 title abstract description 11
- 238000000605 extraction Methods 0.000 title description 4
- 229930182490 saponin Natural products 0.000 claims abstract description 16
- 150000007949 saponins Chemical class 0.000 claims abstract description 16
- 239000000178 monomer Substances 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 5
- 239000000284 extract Substances 0.000 claims description 2
- 239000007791 liquid phase Substances 0.000 claims description 2
- 238000000746 purification Methods 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 238000000825 ultraviolet detection Methods 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 239000012141 concentrate Substances 0.000 claims 2
- 239000002244 precipitate Substances 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 238000007670 refining Methods 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 238000003809 water extraction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 238000001035 drying Methods 0.000 abstract description 2
- 235000017709 saponins Nutrition 0.000 abstract 4
- 238000001816 cooling Methods 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 4
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 208000028399 Critical Illness Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 241001233957 eudicotyledons Species 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides an extracting and refineing method for producing ginseng fruit saponins with the raw material ginseng fruit, by extracting it, concentrating it, cooling it and drying it to make the content of ginseng fruit saponins more than 60 percent, measured the total amount of eight monomers Rg1, Re, Rc, Rg2, Rb1, Rb2, Rb3, Rd by LC. Wherein the content of ginseng fruit saponins sdesmsidic saponins Re is higher than 30 percent.
Description
The present invention relates to the method that Herba Herminii is processed into the genseng pulp, Herba Herminii extracting method, Herba Herminii process for purification.
Genseng is an Araliaceae, belongs to perennial Su Xinggen dicotyledons, first of " northeast Triratna ".It is the rare medicinal herbs that has won fame both at home and abroad.Northeast is that China produces the most famous place of genseng, and really the native place of genseng is on the Changbai Mountain, and the wild ginseng of producing here (being called the mountain ginseng) and the genseng (being called garden ginsent) of cultivation almost account for more than 90% of the whole nation.
The genseng flavor is sweet, warm in nature, is a kind of good medicine that reinforces vital energy.Have tonifying lung, invigorating the spleen, promote the production of body fluid, quench the thirst, calm the nerves, multiple function such as intelligence development.Clinically, be usually used in treating collapse, shock, extreme cold of the limbs, insufficiency of the spleen food less, burnout, pipe power prolapse of the anus and rush down for a long time, insomnia, forgetful, frequent micturition, impotence, seminal emission, spontaneous perspiration, night sweat, the deficiency syndrome of the lung cough breathe heavily, diabetes, hinder disease disease such as Tianjin, particularly when treatment prolonged illness or the critically ill patient of severe, often can give full play to one's remarkable skill.Patients such as being applicable to that vigour will be use up, severe is vomitted, suffering from diarrhoea, sweaing all over, extreme cold of the limbs, pulse are trickle, the traditional Chinese medical science often with genseng as treatment with save urgent patient's good medicine.Why very rare genseng is, very famous and precious, main relevant with its pharmaceutical use.Genseng is splendid to the effect that improves the health, prolongs life, and for thousands of years, genseng all is listed in " top grade " in the herbal medicine.Add that the genseng shape is special, particularly wild old Radix Ginseng often has people's shape, has more produced all mystiques thus, and so-called " panax ginseng extractum ", " genseng doll ", and writing has gone out many moving stories.Because the huge effect of genseng, genseng has become the symbol of Chinese national culture.
Herba Herminii also has the whole effective constituents of genseng, and ginseng monomer saponin Re content exceeds more than 20 times than saponin monomer Re content in the genseng, medical research now proves that the Herba Herminii saponin has good therapeutic action to diabetes, but it is big to extract Herba Herminii saponin's difficulty.
Show that mainly ginseng juice's shelf time short, have only ten day collection period, and be flow-like, perishable especially.Secondly could produce 1 ton of Herba Herminii glucoside with 400 tons of genseng pulps,, and produce the product saponin monomer and also can change if production technique is not produced the Herba Herminii glucoside to being difficult to.Produce the enterprise that production Herba Herminii glucoside is arranged now, but scale and quality do not reach requirement of the present invention, from the sample survey of universities and colleges and R﹠D institution, saponin monomer changes, and content is lower.The production content height that has, yield rate is low, can not enter production.
Production technique of the present invention is simple, and is molten easy to operate, and the yield rate height can be produced in batch.
The present invention solves the Herba Herminii glucoside and extracts problem, and the content raising, for the exploitation other products creates conditions.Now existing 3 tons of Herba Herminii glucosides, and start selling.
Genseng fruit glucoside extraction process of the present invention:
Getting 1000 kilograms of fresh ginseng mature fruits → clean → mill juice → removal fruit stone → pulp adds the qdx poach 2 times → to boil 1.5 hours for the first time, and boiling 1 hour → extraction supernatant liquor → filtration → concentrated proportion the second time is that Herba Herminii glucoside powder process pulverizer powder becomes 120 orders → chemical examination → packing → finished product → warehouse-in after 1.15-1.18 → 24 hours → extraction of adding 95 degree ethanol ten times of amounts sedimentation supernatant liquor → recovery ethanol → condensed cream lyophilize → drying.
Product proterties of the present invention be canescence to the near-white powder, gas is little, mildly bitter flavor, have draw moist.
Genseng fruit saponin content of the present invention: use ultraviolet detection greater than 75%.The liquid phase look detects eight kinds of saponin monomer total content Rg
1, Re, Rc, Rg
2, R
B1, R
B2, R
B3, R
d, greater than 60%.Wherein saponin monomer Re content is greater than 30%.
Claims (7)
1, a kind of Herba Herminii glucoside extracts process for purification, it is characterized in that this method comprises the following steps:
1), with fresh Herba Herminii defibrination, take out seed;
2), with water extraction Herba Herminii slurry;
3), filtering and concentrating genseng pulp extracting solution;
4), with the refining Herba Herminii concentrated solution of ethanol;
5), lyophilize genseng fruit glucoside;
6), pulverize the Herba Herminii glucoside
2, according to 1 described method, it is characterized in that said is with machine mill, adds clean water and Herba Herminii by than 1: 1 defibrination, removes fruit stone.Collect with clean container.
3, according in 1 2) described method, be to add 1 ton of genseng pulp with the multipotency extractor, added 1 ton of water boil again 1.5 hours, filter, the dregs of a decoction added 1 ton of water boil 1 hour again, filtered.
4, according in 1 3) described method, concentrate the Herba Herminii extracting solution, proportion is standby when 1.15-1.18.
5, according in 1 4) described method, will concentrate the Herba Herminii extracting solution and add 10 times of amount 95% ethanol, precipitate 24 hours, filtering supernatant, precipitation add 10 times of amount 95% ethanol again, precipitate 24 hours, filtering supernatant, standby when concentrating under reduced pressure filtering supernatant proportion is 1.10-1.18.The dregs of a decoction reclaim ethanol, discard the dregs of a decoction.
6, according in 1 5) described method, adopt lyophilize, can guarantee the quality of Herba Herminii.
7, according in 1 6) described method, adopt the Universalpulverizer powder to become the above fine powder of 120 orders.Pack into and seal in the plastics bag.Chemical examination Herba Herminii saponin content: use ultraviolet detection greater than 75%, with eight kinds of saponin monomers of high-efficient liquid phase color detection, Rg
1, Re, Rc, Rg
2, R
B1, R
B2, R
B3, R
d, total content is greater than 60%, and wherein saponin monomer Re content is greater than 30%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100341746A CN100443497C (en) | 2004-04-27 | 2004-04-27 | Method for extraction of ginseng fruit glucoside |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100341746A CN100443497C (en) | 2004-04-27 | 2004-04-27 | Method for extraction of ginseng fruit glucoside |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1690071A true CN1690071A (en) | 2005-11-02 |
| CN100443497C CN100443497C (en) | 2008-12-17 |
Family
ID=35345864
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100341746A Expired - Lifetime CN100443497C (en) | 2004-04-27 | 2004-04-27 | Method for extraction of ginseng fruit glucoside |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100443497C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010528108A (en) * | 2007-05-28 | 2010-08-19 | アモーレパシフィック コーポレイション | Composition for promoting blood circulation, promoting angiogenesis, treating ischemic heart disease, promoting skin beauty, and improving male sexual function, containing ginseng fruit extract |
| CN102485259A (en) * | 2010-12-03 | 2012-06-06 | 吉林吉春制药有限公司 | Preparation method and application of ginseng fruit medicinal dispersing tablets and buccal tablets |
| US8652542B2 (en) | 2008-11-28 | 2014-02-18 | Amorepacific Corporation | Composition for preventing or treating arteriosclerosis |
| US9314493B2 (en) | 2007-05-28 | 2016-04-19 | Amorepacific Corporation | Method for treating vascular inflammation, improving skin beauty and improving male sexual function using ginseng berry |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031087A (en) * | 1987-07-27 | 1989-02-15 | 昆明医学院 | The extracting method of effective component in saponin-bearing plant |
| CN1033278A (en) * | 1987-11-24 | 1989-06-07 | 白求恩医科大学 | Technology for producing ginsenoside re monomer |
| CN1081922C (en) * | 1998-08-28 | 2002-04-03 | 吉林省集安制药有限公司 | Medicinal composition containing ginsenoside Re, preparation and usage thereof |
-
2004
- 2004-04-27 CN CNB2004100341746A patent/CN100443497C/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010528108A (en) * | 2007-05-28 | 2010-08-19 | アモーレパシフィック コーポレイション | Composition for promoting blood circulation, promoting angiogenesis, treating ischemic heart disease, promoting skin beauty, and improving male sexual function, containing ginseng fruit extract |
| JP2014080444A (en) * | 2007-05-28 | 2014-05-08 | Amorepacific Corp | Composition for improving skin beauty comprising panax ginseng seed extract |
| JP2014129368A (en) * | 2007-05-28 | 2014-07-10 | Amorepacific Corp | Composition containing extract of ginseng for promoting blood circulation, antiaging of blood vessel, and therapy for ischemic heart disease |
| US9314493B2 (en) | 2007-05-28 | 2016-04-19 | Amorepacific Corporation | Method for treating vascular inflammation, improving skin beauty and improving male sexual function using ginseng berry |
| US9597365B2 (en) | 2007-05-28 | 2017-03-21 | Amorepacific Corporation | Method for treating vascular inflammation, improving skin beauty and improving male sexual function using ginseng berry |
| US10086028B2 (en) | 2007-05-28 | 2018-10-02 | Amorepacific Corporation | Method for treating vascular inflammation, improving skin beauty and improving male sexual function using ginseng berry |
| US8652542B2 (en) | 2008-11-28 | 2014-02-18 | Amorepacific Corporation | Composition for preventing or treating arteriosclerosis |
| CN102485259A (en) * | 2010-12-03 | 2012-06-06 | 吉林吉春制药有限公司 | Preparation method and application of ginseng fruit medicinal dispersing tablets and buccal tablets |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100443497C (en) | 2008-12-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101744079B (en) | Beautification and health care lemon tea | |
| CN105767396A (en) | Lipid-lowering ginkgo seed tea | |
| CN102676341B (en) | Method for producing flavone-rich hawthorn wine | |
| CN101606743B (en) | Ganoderma beverage and preparation method thereof | |
| CN107142184B (en) | Wolfberry polysaccharide health wine and preparation method thereof | |
| CN101053407A (en) | Jujube medlar tea and producing technology thereof | |
| CN103609783B (en) | Yunnan olive tea and preparation method thereof | |
| CN103653171A (en) | Preparation method for radix puerariae lactobacillus effervescent tablet | |
| CN103992876A (en) | Extraction method of passionflower seed oil | |
| CN105454963A (en) | All-plant beverage free of edible sugar and chemical additives and production method thereof | |
| CN101692918A (en) | Sessileflower acanthopanax bark fruit vinegar drink and brewing method thereof | |
| CN103952233B (en) | A kind of extracting method of passionflower seed oil | |
| CN103767011B (en) | A kind of plant beverage and preparation method thereof | |
| CN101554242A (en) | Honeysuckle drink and processing technique thereof | |
| CN100443497C (en) | Method for extraction of ginseng fruit glucoside | |
| CN104522244A (en) | Sugar-free momordica grosvenori drink and production method thereof | |
| CN105558194A (en) | Fructus Momordicae and Herba Dendrobii extract mixed tea and preparation method thereof | |
| CN106261409A (en) | The manufacture method of Radix Tinosporae Fructus Crataegi lactic acid beverage | |
| CN102613347A (en) | Gingko black tea and preparation method thereof | |
| CN110074287A (en) | A kind of production technology of And Lycium Chinense Beverage | |
| CN103478823B (en) | Production method for cough and asthma relieving vinegar drink | |
| CN100441592C (en) | Method for extraction of American ginseng fruit glucoside | |
| CN102978091B (en) | Technology for preparing health wine from hippophae rhamnoides and gynostemma pentaphylla | |
| CN114431470A (en) | Astragalus stem and leaf decoction and preparation method thereof | |
| CN106266026A (en) | A kind of curcumin composition of Antialcoholic liver-protecting |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20081217 |
|
| CX01 | Expiry of patent term | ||
| DD01 | Delivery of document by public notice |
Addressee: Wang Xiansheng Document name: Notice of Termination of Patent Rights |
|
| DD01 | Delivery of document by public notice |