CN1681920A - 修饰的admts4分子及其使用方法 - Google Patents

修饰的admts4分子及其使用方法 Download PDF

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Publication number
CN1681920A
CN1681920A CNA038184230A CN03818423A CN1681920A CN 1681920 A CN1681920 A CN 1681920A CN A038184230 A CNA038184230 A CN A038184230A CN 03818423 A CN03818423 A CN 03818423A CN 1681920 A CN1681920 A CN 1681920A
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China
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leu
pro
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ser
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CNA038184230A
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English (en)
Chinese (zh)
Inventor
克里斯托弗·约翰·科科伦
卡尔·R·弗兰纳里
曾维兰
利萨·A·拉塞
托马斯·麦克多纳
贝坦尼·A·弗里曼
凯蒂·E·乔治亚迪斯
爱德华·R·拉瓦利
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Wyeth LLC
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Wyeth LLC
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Publication of CN1681920A publication Critical patent/CN1681920A/zh
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNA038184230A 2002-07-29 2003-07-29 修饰的admts4分子及其使用方法 Withdrawn CN1681920A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39872102P 2002-07-29 2002-07-29
US60/398,721 2002-07-29

Publications (1)

Publication Number Publication Date
CN1681920A true CN1681920A (zh) 2005-10-12

Family

ID=31188463

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038184230A Withdrawn CN1681920A (zh) 2002-07-29 2003-07-29 修饰的admts4分子及其使用方法

Country Status (10)

Country Link
US (2) US7118902B2 (https=)
EP (1) EP1525307A2 (https=)
JP (1) JP2005534308A (https=)
CN (1) CN1681920A (https=)
AU (1) AU2003261269A1 (https=)
BR (1) BR0313083A (https=)
CA (1) CA2492444A1 (https=)
IL (1) IL166535A0 (https=)
MX (1) MXPA05000959A (https=)
WO (1) WO2004011637A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9677829B2 (en) 2001-06-01 2017-06-13 Mitsubishi Paper Mills Limited Total heat exchanging element paper
AU2003215070A1 (en) * 2002-02-05 2003-09-02 Wyeth Truncated aggrecanase molecules
US7118902B2 (en) * 2002-07-29 2006-10-10 Wyeth Modified ADAMTS4 molecules and method of use thereof
US7696307B2 (en) * 2004-04-12 2010-04-13 The Trustees Of The University Of Pennsylvania Function and regulation of ADAMTS-1
EP1737973A1 (en) * 2004-04-16 2007-01-03 Wyeth Truncated adamts molecules
BRPI0616729A2 (pt) * 2005-08-25 2009-11-03 Wyeth Corp estrutura de agrecanase
CN101300345A (zh) 2005-08-25 2008-11-05 惠氏公司 聚集蛋白聚糖酶结构
GB0601976D0 (en) * 2006-02-01 2006-03-15 Merck Sharp & Dohme Proteins
EP2027284A2 (en) * 2006-05-18 2009-02-25 Sanofi-Aventis Use of adamts4 gene and protein polymorphisms
US8263072B2 (en) * 2007-06-22 2012-09-11 Genera Istrazivanja, d.o.o. ADAMTS4 as a blood biomarker and therapeutic target for chronic renal failure
US20110059508A1 (en) * 2007-06-29 2011-03-10 National University Corporation Nagoya University Improving agent for dysfunction due to neuropathy and rho kinase activation inhibitor
EP2420250A1 (en) 2010-08-13 2012-02-22 Universitätsklinikum Münster Anti-Syndecan-4 antibodies
PT3057992T (pt) 2013-10-15 2024-07-10 Univ Keio Anticorpo humano contra espécies de adamts do tipo agrecanase para terapêuticas de doenças relacionadas com agrecanase

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3451575A (en) * 1967-09-15 1969-06-24 Geza Petro Jr Conveyor bucket with hydraulically-operated grille-like lid
US4419446A (en) * 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4522811A (en) * 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4816567A (en) * 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4588684A (en) 1983-04-26 1986-05-13 Chiron Corporation a-Factor and its processing signals
UA39161C2 (uk) 1984-07-06 2001-06-15 Новартіс Аг Рекомбінантний білок gm-csf для збільшення продукції гранулоцитів і макрофагів у пацієнтів, вектор і кднк, що його кодують
EP0177343B1 (en) 1984-10-05 1992-07-22 Genentech, Inc. Dna, cell cultures and methods for the secretion of heterologous proteins and periplasmic protein recovery
US6069229A (en) * 1997-03-07 2000-05-30 Schering Corporation Mammalian proteinases; oxidoreductases; related reagents
EP0998572A2 (en) * 1997-07-25 2000-05-10 Du Pont Pharmaceuticals Company Aggrecan degrading metallo proteases
US6842704B2 (en) * 1998-02-04 2005-01-11 Immunex Corporation Crystalline TNF-α-converting enzyme and uses thereof
AU3622600A (en) * 1999-03-08 2000-09-28 Neurocrine Biosciences, Inc. Metalloproteinases and methods of use therefor
US6391610B1 (en) * 1999-08-06 2002-05-21 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases
EP1136547A3 (en) * 2000-03-22 2002-09-25 Pfizer Products Inc. Adamts polypeptides, nucleic acids encoding them, and uses thereof
US6458552B1 (en) * 2000-06-06 2002-10-01 Ortho-Mcneil Pharmaceutical, Inc. Metalloprotease peptide substrates and methods
US20020151702A1 (en) * 2000-10-18 2002-10-17 Genetics Institute, Inc. Aggrecanase molecules
SE0102298D0 (sv) * 2001-06-27 2001-06-27 Astrazeneca Ab Crystal structure of enzyme and uses thereof
EP1409658A4 (en) * 2001-07-05 2006-08-23 Wyeth Corp Aggrecanase MOLECULES
AU2002336367A1 (en) * 2001-08-16 2003-03-03 The Regents Of The University Of Michigan Adamts13 genes and proteins and variants, and uses thereof
US20030105313A1 (en) * 2001-10-16 2003-06-05 American Home Products Corporation Aggrecanase molecules
CA2474908A1 (en) * 2002-01-31 2003-08-07 Wyeth Aggrecanase molecules
AU2003215070A1 (en) * 2002-02-05 2003-09-02 Wyeth Truncated aggrecanase molecules
US7118902B2 (en) * 2002-07-29 2006-10-10 Wyeth Modified ADAMTS4 molecules and method of use thereof

Also Published As

Publication number Publication date
BR0313083A (pt) 2007-07-17
CA2492444A1 (en) 2004-02-05
WO2004011637A2 (en) 2004-02-05
US7118902B2 (en) 2006-10-10
US20040142863A1 (en) 2004-07-22
AU2003261269A1 (en) 2004-02-16
JP2005534308A (ja) 2005-11-17
IL166535A0 (en) 2006-01-15
WO2004011637A3 (en) 2004-04-08
US20060228354A1 (en) 2006-10-12
MXPA05000959A (es) 2005-05-16
EP1525307A2 (en) 2005-04-27

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WW01 Invention patent application withdrawn after publication