CN1672721A - Immunity raising Chinese medicine and its prepn process - Google Patents
Immunity raising Chinese medicine and its prepn process Download PDFInfo
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- CN1672721A CN1672721A CN 200410031358 CN200410031358A CN1672721A CN 1672721 A CN1672721 A CN 1672721A CN 200410031358 CN200410031358 CN 200410031358 CN 200410031358 A CN200410031358 A CN 200410031358A CN 1672721 A CN1672721 A CN 1672721A
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Abstract
The present invention relates to one kind of immunity raising Chinese medicine and its preparation process. The present invention features that the active components of the immunity raising Chinese medicine is prepared through crushing American ginseng into course powder, alcohol soaking and diacolating and recovering alcohol to obtain the first extractum; water soaking white atractylodes rhizome and fleeceflower root, alcohol soaking and recovering alcohol to obtain the second extractum; decocting tuckahoe and wolfberry fruit, merging decoctions, decompression concentrating, alcohol deposition and taking the precipitate as the third extractum; and merging the three kinds of extractum and grinding into the mixture into fine powder.
Description
Technical field
The present invention relates to a kind of human body immunity improving power and have the pure Chinese medicinal preparation of antifatigue effect, and further relate to the preparation method of this Chinese medicine preparation.
Background technology
At present, have the multiple Chinese medicine preparation that can improve immunity on the market, the situation of existing like product sees the following form.
The Chinese medicine preparation of existing raising immunity
| Title | Prescription is formed | Dosage form | Effect | Range of application |
| Bolus of ten powerful tonics | Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, the Radix Astragali, Cortex Cinnamomi | Pill | The temperature compensation QI and blood | Be used for QI and blood deficiency, pale complexion, the cardiopalmus of breathing hard, dizzy spontaneous perspiration, fatigue and asthenia, extremity are not warm |
| GUIPI WAN | Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix Astragali Radix Glycyrrhizae, Poria, Radix Polygalae, Semen Ziziphi Spinosae, Arillus Longan, Radix Angelicae Sinensis, the Radix Aucklandiae, Fructus Jujubae | Pill | Replenishing QI to invigorate the spleen, nourishing blood to tranquillize the mind | Deficiency of both the heart and spleen, the cardiopalmus of breathing hard, insomnia and dreamful sleep, dizzy dizzy, lassitude of the limbs and weakness, inappetence, |
| BUZHONG YIQI WAN | The Radix Astragali, Radix Codonopsis, Radix Glycyrrhizae, the Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, Rhizoma Cimicifugae, Radix Bupleuri, Pericarpium Citri Reticulatae | Pill | Invigorating the spleen and replenishing QI, ascending up spleen-Qi and Yang | Weakness of the spleen and stomach, sinking of QI of middle-JIAO, fatigue and asthenia, lack of appetite abdominal distention, chronic diarrhea |
| Radix Notoginseng powder (ripe) | Radix Notoginseng | Powder | Strongly invigorating QI and blood, strong health | Physical weakness, overtired |
| The light capsule of brain | Radix Rhodiolae, Fructus Schisandrae Chinensis, Folium Ginkgo | Capsule | Resisting fatigue, anoxia enduring, improvement memory | The teenager tired, that memory is bad and the middle-aged and elderly people of hypomnesis |
| Deep-sea dragon capsule | Solenognathus, Hippocampus, Cornu Cervi Pantotrichum, Testis Et penis Caprae seu Ovis, Fructus Cnidii, Herba Epimedii, Herba Cistanches, Fructus Schisandrae Chinensis, Radix Ginseng, the Radix Astragali etc. | Capsule | Warming and recuperating the kidney-YANG, nourishing marrow and benefitting semen | Because of soreness of the waist and knees, aversion to cold and cold limbs, spiritlessness and weakness, dizziness and tinnitus, the palpitation and insomnia due to the insufficiency of kidney-YANG |
| Semifluid extract of ginseng and antler glue | Radix Ginseng, Fructus Lycii, Colla cornus cervi, Colla Plastri Testudinis, Testis Et penis Bovis seu Bubali, the Radix Astragali, Radix Rehmanniae Preparata, Radix Polygoni Multiflori Preparata, Fructus Schisandrae Chinensis etc. | Unguentum | Yin-nourishing and Yang-supporting, benefiting QI and nourishing blood | Treatment QI and blood deficiency, physical fatigue and lassitude of spirit disease |
| Ginseng Siberian cocklebur Rhizoma Atractylodis Macrocephalae capsule | Radix Ginseng, Poria, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, flat, Semen Nelumbinis, Semen Coicis, Fructus Amomi, Radix Platycodonis, Radix Glycyrrhizae in vain | Capsule | Spleen invigorating, QI invigorating | Fatigue and asthenia, anorexia and loose stool |
| The ginseng and fleece-flower root capsule | Radix Ginseng Rubra, Radix Polygoni Multiflori Preparata | Capsule | Invigorating the liver and kidney, replenishing QI and blood | Deficient qi and blood, the beard and hair first from, neurasthenia, forgetful insomnia, inappetence, overfatigue |
The prescription that the product of existing raising immunity has is not comprehensive, can not effectively must play regulating action to body.The flavour of a drug that have are too much, and preparation is inconvenient.Existing like product all adopts traditional Chinese medicinal preparation method to make, and fabricating technology falls behind, and invalid removal of impurity is low, and effective component content is low, and the extractum moisture absorption is strong, and preparation stability is poor.
Summary of the invention
The object of the present invention is to provide a kind of human body immunity improving power and have the pure Chinese medicinal preparation of antifatigue effect.Said preparation has more specific aim than the compatibility of existing similar prescription, and clinical efficacy is better.
Drug main of the present invention will be made of (weight portion) following bulk drugs:
1～5 part of Radix Panacis Quinquefolii, 2～12 parts of Radix Polygoni Multiflori, 2～12 parts of the Rhizoma Atractylodis Macrocephalaes, 2～12 parts in Poria, 2～12 parts of Fructus Lycii.
The preparation method that the Chinese medicine preparation of immunity is provided of the present invention comprises the steps:
(1) get 1～5 part of Radix Panacis Quinquefolii and be ground into coarse powder, add 40%～80% soak with ethanol more than 72 hours, the reuse ethanol percolation, the percolate decompression recycling ethanol, extractum (1) is standby;
(2) get 2～12 parts of 2～12 parts of the Rhizoma Atractylodis Macrocephalaes and Radix Polygoni Multiflori in addition, add the water logging bubble of 5～10 times of medical material weight, wash with water to very slight color, use ethanol percolation instead, the percolate decompression recycling ethanol, it is standby to get extractum (2);
(3) get 2～12 parts of 2～12 parts in Poria and Fructus Lycii again, the decocting that adds 5～10 times of medical material weight boils secondary, and each 1-2 hour, merge decoction liquor, concentrating under reduced pressure, the ethanol precipitate with ethanol with 60%～90% three times is abandoned supernatant, and taking precipitate gets extractum (3);
(4) above-mentioned three kinds of extractum merge drying, and powder becomes fine powder, has just made the active component of medicine of the present invention.
The active component of medicine of the present invention can be prepared into the medicine or the health product of any peroral dosage form, as capsule, and tablet, granule, oral liquid etc.
The present invention has following advantage:
1. during the present invention writes out a prescription, Radix Panacis Quinquefolii, Radix Polygoni Multiflori Preparata, Poria, Fructus Lycii, Rhizoma Atractylodis Macrocephalae Chinese medicine of the five flavours are tonification class Chinese medicine commonly used.Radix Panacis Quinquefolii QI invigorating tonifying YIN wherein, clearing away heat and promoting production of body fluid, clearing away heat to stop bleeding; The Radix Polygoni Multiflori tonifying liver, kidney tonifying nourishes blood, and dispels the wind; The Poria mind tranquilizing and the heart calming; The Fructus Lycii the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing; Rhizoma Atractylodis Macrocephalae spleen reinforcing, stomach reinforcing, dampness and in.This warm cold of writing out a prescription is helped mutually, and no cold and heat are partially, goes into through taking into account the five internal organs, regulate comprehensively, and to because of the QI and blood damage, the dark consumption in cloudy Tianjin and the multi-organ function imbalance that causes, physiological function disorder, the body vigor pointed regulating action that descends.
2. Chinese medicine preparation of the present invention is compared with other similar products, and flavour of a drug of the present invention are fewer but better, and human body immunity improving power and resisting fatigue are had more specific aim health care and therapeutical effect.
3. the method for the extraction of Chinese medicine preparation of the present invention and purification has more science, and the dosage form of preparation is advanced modern, taking convenience, and clinical efficacy is good.
Description of drawings
Fig. 1 improves preparation technology's flow chart of the Chinese medicine preparation of immunity for the present invention.
The specific embodiment
Embodiment 1 preparation example
Every day the prescription compatibility of medicines amount
Prescription: Radix Panacis Quinquefolii 2 grams, Radix Polygoni Multiflori 3 grams, the Rhizoma Atractylodis Macrocephalae 10 grams, Poria 3 grams, Fructus Lycii 2 grams
Method for making: get Radix Panacis Quinquefolii powder and be broken into coarse powder, added 40% soak with ethanol 72 hours, the reuse ethanol percolation, the percolate decompression recycling ethanol, extractum (1) is standby.
Other gets the Rhizoma Atractylodis Macrocephalae and Radix Polygoni Multiflori Preparata two flavors, adds the water logging bubble of 5 times of medical material weight, washes with water to very slight color, uses ethanol percolation instead, the percolate decompression recycling ethanol, and it is standby to get extractum (2).
Get Poria and Fructus Lycii two flavors again, the decocting that adds 5 times of medical material weight boils secondary, and each 1 hour, merge decoction liquor, concentrating under reduced pressure, 60% ethanol precipitate with ethanol three times is abandoned supernatant, and taking precipitate gets extractum (3).Above-mentioned three kinds of extractum are merged drying, and powder becomes fine powder, adds adjuvant, makes oral formulations.
Embodiment 2 preparation examples
Every day the prescription compatibility of medicines amount
Prescription: Radix Panacis Quinquefolii 3 grams, Radix Polygoni Multiflori 6 grams, the Rhizoma Atractylodis Macrocephalae 2 grams, Poria 5 grams, Fructus Lycii 10 grams
Method for making: get Radix Panacis Quinquefolii powder and be broken into coarse powder, add 60% soak with ethanol 72 hours, the reuse ethanol percolation, the percolate decompression recycling ethanol, extractum (1) is standby.
Other gets the Rhizoma Atractylodis Macrocephalae and Radix Polygoni Multiflori Preparata two flavors, adds the water logging bubble of 8 times of medical material amounts, washes with water to very slight color, uses ethanol percolation instead, the percolate decompression recycling ethanol, and it is standby to get extractum (2).
Get Poria and Fructus Lycii two flavors again, the decocting that adds 8 times of medical material amounts boils secondary, and each 2 hours, merge decoction liquor, concentrating under reduced pressure, 60%～80% ethanol precipitate with ethanol three times is abandoned supernatant, and taking precipitate gets extractum (3).Above-mentioned extractum merges dry, and powder becomes fine powder, adds a little adjuvant, makes granule.
Embodiment 3 preparation examples
Every day the prescription compatibility of medicines amount
Prescription: Radix Panacis Quinquefolii 5 grams, Radix Polygoni Multiflori 11 grams, the Rhizoma Atractylodis Macrocephalae 5 grams, Poria 2 grams, Fructus Lycii 4 grams
Method for making: get Radix Panacis Quinquefolii powder and be broken into coarse powder, add 70% soak with ethanol 4 days, the reuse ethanol percolation, the percolate decompression recycling ethanol, extractum (1) is standby.
Other gets the Rhizoma Atractylodis Macrocephalae and Radix Polygoni Multiflori Preparata two flavors, adds the water logging bubble of 8 times of medical material amounts, washes with water to very slight color, uses ethanol percolation instead, the percolate decompression recycling ethanol, and it is standby to get extractum (2).
Get Poria and Fructus Lycii two flavors again, the decocting that adds 8 times of medical material amounts boils secondary, merges decoction liquor, concentrating under reduced pressure, and 60%～80% ethanol precipitate with ethanol three times is abandoned supernatant, and taking precipitate gets extractum (3).Above-mentioned extractum merges dry, and powder becomes fine powder, adds a little adjuvant, makes capsule.
Embodiment 4 preparation examples
Every day the prescription compatibility of medicines amount
Prescription: Radix Panacis Quinquefolii 2 grams, Radix Polygoni Multiflori 4 grams, the Rhizoma Atractylodis Macrocephalae 5 grams, Poria 12 grams, Fructus Lycii 4 grams
Method for making: get Radix Panacis Quinquefolii powder and be broken into coarse powder, add 80% soak with ethanol 72 hours, the reuse ethanol percolation, the percolate decompression recycling ethanol, extractum (1) is standby.
Other gets the Rhizoma Atractylodis Macrocephalae and Radix Polygoni Multiflori Preparata two flavors, adds the water logging bubble of 10 times of medical material amounts, washes with water to very slight color, uses ethanol percolation instead, the percolate decompression recycling ethanol, and it is standby to get extractum (2).
Get Poria and Fructus Lycii two flavors again, the decocting that adds 10 times of medical material amounts boils secondary, merges decoction liquor, concentrating under reduced pressure, and 90% ethanol precipitate with ethanol three times is abandoned supernatant, and taking precipitate gets extractum (3).Above-mentioned three kinds of extractum merge dry, and powder becomes fine powder, adds a little adjuvant, and compacting in flakes.
Embodiment 5 pilot processes
Get the medical material of 500 times of embodiment recipe quantities 1 every day
The above five tastes are got Radix Panacis Quinquefolii powder and are broken into coarse powder, add 60% soak with ethanol 72 hours, the reuse ethanol percolation, the percolate decompression recycling ethanol, extractum (1) is standby.Other gets the Rhizoma Atractylodis Macrocephalae and Radix Polygoni Multiflori Preparata two flavors, adds the water logging bubble of 8 times of medical material amounts, washes with water to very slight color, uses ethanol percolation instead, the percolate decompression recycling ethanol, and it is standby to get extractum (2).Get Poria and Fructus Lycii two flavors again, the decocting that adds 8 times of medical material amounts boils secondary, merges decoction liquor, concentrating under reduced pressure, and 60%～80% ethanol precipitate with ethanol three times is abandoned supernatant, and taking precipitate gets extractum (3).Above-mentioned extractum merges dry, and powder becomes fine powder, adds appropriate amount of auxiliary materials, and mix homogeneously is made oral formulations (granule, capsule, tablet etc.), promptly.
Produce 3 batches according to above preparation technology, the result is as follows:
| Lot number | Inventory (kg) | Extractum amount (kg) | Total saponin content % | Crude polysaccharides content (g) |
| ?20021121 | ????65 | ????3.25 | ????10.6 | ????2.2 |
| ?20021122 | ????65 | ????3.32 | ????9.8 | ????2.0 |
| ?20021123 | ????65 | ????3.21 | ????11.2 | ????2.3 |
Carry out pilot scale according to above preparation technology, the extractum yield is about 5%, and total saponin content (in the ginsenoside Re) is not less than 8%, and crude polysaccharides (in glucosan) is not less than 2%.
Embodiment 6-9 is the pharmacological research experimental example of medicine of the present invention
Sample: the fine powder that the embodiment of the invention 5 makes.
Experimental animal: 220 of secondary Male Kunming strain mice, body weight 18-22g, available from Nat'l Pharmaceutical ﹠ Biological Products Control Institute's Experimental Animal Center, the quality certification number: No. the 017th, the moving word of doctor.
Sample dose; Giving the dosage that mice tried thing is respectively: middle dosage is that 0.13g/kg.bw, high dose are that 0.40g/kg.bw, low dosage are 0.03g/kg.bw, and high, medium and low dosage is equivalent to people's 30 times, 10 times and 2 times of recommendation per kilogram of body weight daily intaking amounts respectively.
The sample dose compound method: it is an amount of to take by weighing fine drug powder of the present invention, with the sample solution of 0.25% sodium carboxymethyl cellulose (CMC) solution preparation high dose group, the sample solution of middle dosage group and low dose group is then made with the 0.25%CMC solution dilution in proportion by the sample solution of high dose group.
Irritate the sample solution of each dosage group of stomach this product for the continuous per os of each experimental mice, normal control group mice gives 0.25%CMC solution.
Instrument and reagent: instrument: YSI 1500 lactic acid analysers (U.S.), Hitachi's 7060 automatic clinical chemistry analyzers (Japan), Fisher M-300 DR electronic balance (Germany), TP-1000 animal balance (Hunan Yi Tianpingyiqichang), TGL-16G centrifuge (Anting Scientific Instrument Factory, Shanghai), LD5-2A centrifuge (Beijing Medical Centrifugal Machine Factory), 721 spectrophotometers (Shanghai the 3rd analytical tool factory), timer, 120L swim the bucket, sheet lead, the quantitative blood taking tube of 20 μ l, 0.5ml and 1.5ml centrifuge tube.
Reagent: lactic acid is measured hemolytic agent, enzyme membrane, 5mmol/L lactic acid titer, buffer (U.S. YSI Inc.) determination of urea nitrogen test kit (giving birth to biotechnology company in Beijing), 5% trichloroacetic acid (TCA), glucose titer (100mg/dL), 72% sulphuric acid, the anthrone reagent (containing 0.05% anthrone and 1% thiourea, with the preparation of 72% sulphuric acid) of usefulness.
Test method:
Screening: after mice entered laboratory and adapts to 2 days, the sheet lead of 4% body weight of the bearing a heavy burden screening test of swimming was taken out the survivor after 10 minutes.
Animal grouping: 60 mices after the screening of will swim are dried, and weigh and by the body weight random packet, enter swimming with a load attached to the body and test; 120 mices of not screening are pressed the body weight random packet, carry out the biochemical measurement test.Every experiment is divided into 4 groups, i.e. normal control group, low dose group, middle dosage group and high dose group.
Tried the approach and the time of thing: irritated the corresponding sample solution of stomach 28 days for the continuous per os of each dosage experiments group mice, irritate stomach every day once, every mouse stomach amount 0.5ml weighs weekly, is tried substrate concentration with adjustment.
Embodiment 6 mice swimmings with a load attached to the body test
Irritate stomach for the continuous per os of mice and tried thing 28 days, weigh, last was irritated stomach after 0.5 hour, at the bear a heavy burden sheet lead of 5% body weight of the root of the tail portion of decimal, put in the swimming bucket of depth of water 30cm, temperature 25 degree and swam.Record mice entry to power exhausts the swimming time when dead, as the swimming time of mice.
Medicine is to the influence (adopting the SigmaStat statistical procedure to carry out the relatively difference between each variable of variance analysis, if homogeneity of variance or normality can not satisfy the requirement of variance analysis then carry out after data transaction) of mice swimming endurance.
Table 1 is the influence of fine drug powder of the present invention to endurance group mice body weight.Compare body weight there was no significant difference before the actual swimming of the grouping of each dosage group mice, p＞0.05 with the normal control group.
Table 1. fine drug powder is to the influence of endurance group mice body weight
| Group | Dosage (g/kg.bw) | Body weight during grouping (g) 1，2 | Body weight (g) before the swimming 1，3 |
| Dosage group high dose group in the normal control group low dose group | ?- ?0.03 ?0.13 ?0.40 | 18.6±2.0(15) 18.8±1.9(15) 18.8±2.0(15) 18.6±1.9(15) | 34.3±28.7(15) 37.2±2.6(15) 37.7±2.2(15) 37.0±2.6(15) |
1In X ± SD bracket is number of animals
2Variance analysis: F=0.044, P=0.99
3Variance analysis: F=0.58, P=0.63
Table 2 is the influence of fine drug powder of the present invention to heavy burden mice swimming endurance.Compare the swimming time significant prolongation of high dose group mice, p＜0.05 with the normal control group.
Table 2. fine drug powder is to the influence of mice swimming time
| Group | Dosage (g/kg.bw) | Number of animals (only) | Swimming time (min) 1，2 |
| Dosage group high dose group in the normal control group low dose group | ?- ?0.03 ?0.13 ?0.40 | ?15 ?15 ?15 ?15 | 34.3±28.7 56.6±40.4 65.5±43.6 73.3±37.3 * |
1X ± SD;
2Variance analysis: F=3.00, P=0.038;
*Compare P＜0.05 with matched group
Embodiment 7 blood lactic acid contents (mmol/L)
Irritate stomach for the continuous per os of mice and tried thing 28 days, weigh, last was irritated stomach after 0.5 hour, take a blood sample with the quantitative blood taking tube of 20 μ l by eye socket, the blood sample of gathering quantitatively is transferred in the centrifuge tube that contains 40 μ l enzymolysis inhibitor mixed liquid (hemolytic agent), mixing, and inferior is blood lactic acid under the mice rest state.Then mice was put in the swimming bucket of depth of water 30cm, temperature 30 degree swimming 10 minutes, take out mice, take a blood sample with the quantitative blood taking tube of 20 μ l by eye socket immediately, the blood sample of gathering quantitatively is transferred in the centrifuge tube that contains 40 μ l enzymolysis inhibitor mixed liquid (hemolytic agent), mixing, this is the blood lactic acid behind the mouse movement; Mice is swum or recovered 20 minutes, is taken a blood sample with the quantitative blood taking tube of 20 μ l by eye socket once more, and the blood sample of collection quantitatively is transferred in the centrifuge tube that contains 40 μ l enzymolysis inhibitor mixed liquid (hemolytic agent), mixing, and this is the convalescent blood lactic acid in mice swimming back.
Table 3 is the influence of fine drug powder of the present invention to lactic acid group mice body weight.Compare body weight there was no significant difference before the actual swimming of the grouping of each dosage group mice, p＞0.05 with the normal control group.
Table 3. medicine is to the influence of lactic acid group mice body weight
| Group | Dosage (g/kg.bw) | Body weight during grouping (g) 1，2 | Body weight (g) before the swimming 1，3 |
| Dosage group high dose group in the normal control group low dose group | ?- ?0.03 ?0.13 ?0.40 | 19.9±1.8(15) 19.8±1.6(15) 20.0±1.2(15) 19.7±1.4(15) | 39.7±2.9(15) 38.6±2.6(15) 39.0±2.4(15) 39.4±3.2(15) |
1X±SD
2Variance analysis: F=0.060, P=0.98
3Variance analysis: F=0.040, P=0.75
Table 4. is the influence of medicine to mice blood lactate level.Compare the blood lactate level there was no significant difference of each dosage experiments group mice of swimming, p＞0.05 with the normal control group; At once, the blood lactate level of high dose group mice significantly reduces, p＜0.05 after the swimming; Swim back 20 minutes the time blood lactate level there was no significant difference of each dosage group mice, p＞0.05.
Table 4. medicine is to the influence of mice blood lactate level
| Group | Dosage (g/kg.bw) | Blood lactic acid content (mmol/L) before the swimming 1，2 | Swimming bleeding from anus lactic acid content (mmol/L) 1，3 | 20min bleeding from anus lactic acid content (mmol/L) 1，4 |
| Dosage group high dose group in the normal control group low dose group | ??- ??0.03 ??0.13 ??0.40 | ?2.03±0.56 ?2.03±0.35 ?1.90±0.46 ?1.92±0.42 | ?5.60±1.78 ?45.26±1.57 ?4.72±0.72 ?3.95±0.69 * | ?3.05±1.21 ?2.60±0.62 ?2.78±0.55 ?2.30±0.50 |
1X±SD
2Variance analysis (average root conversion): F=0.35, P=0.79
3Variance analysis: F=4.13, P=0.011,
*Compare p＜0.05 with the normal control group
4Variance analysis (allowing to number conversion certainly): F=1.84, P=0.15
The influence that table 5 increases and eliminates mice blood lactic acid for fine drug powder of the present invention.Compare with the normal control group, after the swimming, the blood lactic acid of high dose group mice increases significantly and reduces, p＜0.05; The blood lactic acid of each dosage group mice of swimming back 20 minutes the time is eliminated no significant difference, p＞0.05.
The influence that table 5. medicine increases and eliminates mice blood lactic acid
| Group | Dosage (g/kg.bw) | Blood lactic acid content (mmol/L) before the swimming 1，2 | Swimming bleeding from anus lactic acid content (mmol/L) 1，3 |
| Dosage group high dose group in the normal control group low dose group | ?- ?0.03 ?0.13 ?0.40 | ?3.57±1.87 ?3.22±1.54 ?28.2±0.79 ?2.03±0.88 * | ?2.55±1.33 ?2.66±1.58 ?1.94±0.78 ?1.65±0.84 |
1X±SD
2Variance analysis: F=3.25, P=0.029,
*Compare p＜0.05 with the normal control group
3Variance analysis (square root conversion): F=1.64, P=0.19
Embodiment 8 blood urea nitrogen content (mmol/L)
Irritate stomach for the continuous per os of mice and tried thing 28 days, weigh, last was irritated stomach after 0.5 hour, mice was put in the swimming bucket of depth of water 30cm, temperature 30 degree swimming 90 minutes, took out mice.After 1 hour, pluck the eyeball blood sampling, centrifugal preparation serum.Measure the serum urea nitrogen content.
Table 6 is the influence of fine drug powder of the present invention to blood urea nitrogen group mice body weight.Body weight there was no significant difference during with the grouping of each dosage group mice of normal control group and before the swimming, p＞0.05.
Table 6. fine drug powder of the present invention is to the influence of blood urea nitrogen body weight
| Group | Dosage (g/kg.bw) | Body weight during grouping (g) 1，2 | Body weight (g) before the swimming 1，3 |
| Dosage group high dose group in the normal control group low dose group | ?- ?0.03 ?0.13 ?0.40 | 19.8±1.4(15) 20.0±1.5(15) 19.9±1.7(15) 19.5±1.4(15) | 40.5±2.4(15) 39.6±2.6(15) 40.2±3.9(15) 38.5±2.6(15) |
1X±SD
2Variance analysis: F=0.29, P=0.83
3Variance analysis (square root conversion): F=1.40, P=0.25
Table 7 is the influence of fine drug powder of the present invention to mice swimming back serum urea nitrogen content.Compare with the normal control group, after the swimming, the blood urea nitrogen significance of each dosage group mice reduces, p＜0.05.
Table 7. fine drug powder of the present invention is to the influence of mice serum urea nitrogen content
| Group | Dosage (g/kg.bw) | Number of animals (only) | Serum urea nitrogen content (mmol/L) 1，2 |
| Dosage group high dose group in the normal control group low dose group | ?- ?0.03 ?0.13 ?0.40 | ?14 ?14 ?14 ?14 | 10.09±1.00 8.12±0.98 *8.08±0.68 *8.38±1.80 * |
1X±SD
2Variance analysis: F=9.73, P＜0.0001,
*Compare p＜0.05 with the normal control group
Embodiment 9 liver glycogen content (mg/00g)-anthrone methods
The above-mentioned mice that carries out blood lactic acid mensuration continues to irritate stomach 3 days, and last was irritated stomach 0.5 hour, and sacrificed by decapitation is got liver 200mg, carries out the liver glycogen assay by anthrone method.
Table 8 is the influence of fine drug powder of the present invention to mice glycogen content.Compare with the normal control group, the glycogen content of high dose group mice significantly increases, p＜0.05.
Table 8 fine drug powder of the present invention is to the influence of mice glycogen content
| Group | Dosage (g/kg.bw) | Number of animals (only) | Hepatic glycogen content (mg/100g) 1，2 |
| Dosage group high dose group in the normal control group low dose group | ?- ?0.03 ?0.13 ?0.40 | ?14 ?14 ?14 ?14 | 2284.4±1052.7 2376.9±877.5 2581.1±1171.6 4294.8±676.6 * |
1X±SD
2Variance analysis: F=12.7, P＜0.0001,
*Compare p＜0.05 with the normal control group
This experimental result shows: irritates stomach fine drug powder of the present invention after 28 days for the continuous per os of mice, compares with the normal control group, and after the swimming, the swimming time significant prolongation of high dose group mice (p＜0.05); At once, the lactate level significance of being permitted of high dose group mice reduces (p＜0.05), and the blood lactic acid of this dosage group mice increases significantly less (p＜0.05) (before the swimming, each organizes the blood lactate level there was no significant difference of mice) after the swimming; After the swimming, the serum urea nitrogen level significance of each dosage group mice lowers (p＜0.05); The liver glycogen content of high dose group mice significantly increases, p＜0.05.According to the criterion in " the function assessment assessment process and the method for inspection of health food ", heat has antifatigue effect for fine drug powder of the present invention to mice.
Claims (3)
1. Chinese medicine that improves immunity, mainly make by following bulk drugs:
1～5 part of Radix Panacis Quinquefolii, 2～12 parts of Radix Polygoni Multiflori, 2～12 parts of the Rhizoma Atractylodis Macrocephalaes, 2～12 parts in Poria, 2～12 parts of Fructus Lycii.
2. the Chinese medicine of the described raising immunity of claim 1 is characterized in that, this medicine is a peroral dosage form.
3. the preparation method of Chinese medicine of the described raising immunity of claim 1 comprises the steps:
(1) get 1～5 part of Radix Panacis Quinquefolii and be ground into coarse powder, add 40%～80% soak with ethanol more than 72 hours, the reuse ethanol percolation, the percolate decompression recycling ethanol, extractum (1) is standby;
(2) get 2～12 parts of 2～12 parts of the Rhizoma Atractylodis Macrocephalaes and Radix Polygoni Multiflori in addition, add the water logging bubble of 5～10 times of medical material weight, wash with water to very slight color, use ethanol percolation instead, the percolate decompression recycling ethanol gets extractum
(2) standby;
(3) get 2～12 parts of 2～12 parts in Poria and Fructus Lycii again, the decocting that adds 5～10 times of medical material weight boils secondary, and each 1-2 hour, merge decoction liquor, concentrating under reduced pressure, the ethanol precipitate with ethanol with 60%～90% three times is abandoned supernatant, and taking precipitate gets extractum (3);
(4) above-mentioned three kinds of extractum merge drying, and powder becomes fine powder, has just made the active component of medicine of the present invention.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100387272C (en) * | 2005-10-08 | 2008-05-14 | 曲声波 | Anti-fatigue anti-senility, sexual function improving Chinese medicinal composition and its preparation method |
| CN101229320B (en) * | 2008-01-14 | 2011-06-15 | 张�成 | Glutathione ammoniacum compounds and processing method thereof |
| CN103006904A (en) * | 2012-12-22 | 2013-04-03 | 北华大学 | Healthcare product with function of strengthening immunity |
| CN103798773A (en) * | 2012-11-12 | 2014-05-21 | 苏州市洋海电子有限公司 | Health-care product |
| CN105010862A (en) * | 2015-07-20 | 2015-11-04 | 句容市郭庄镇南河农庄 | Chinese herbal medicine feed additive capable of enhancing immunity of Chinese softshell turtles, as well as preparation method and application of Chinese herbal medicine feed additive |
| CN106509892A (en) * | 2016-10-28 | 2017-03-22 | 芜湖市诺康生物科技有限公司 | Health product for alleviating human body fatigue and preparation method thereof |
| CN108066384A (en) * | 2016-11-08 | 2018-05-25 | 郑州桂仁医药科技有限公司 | A kind of Chinese medicine preparation with strengthen immunity and preparation method thereof |
| CN112999286A (en) * | 2021-04-23 | 2021-06-22 | 江苏金维氨生物工程有限公司 | Granules capable of relieving fatigue and preparation method thereof |
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2004
- 2004-03-25 CN CN 200410031358 patent/CN1289115C/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100387272C (en) * | 2005-10-08 | 2008-05-14 | 曲声波 | Anti-fatigue anti-senility, sexual function improving Chinese medicinal composition and its preparation method |
| CN101229320B (en) * | 2008-01-14 | 2011-06-15 | 张�成 | Glutathione ammoniacum compounds and processing method thereof |
| CN103798773A (en) * | 2012-11-12 | 2014-05-21 | 苏州市洋海电子有限公司 | Health-care product |
| CN103006904A (en) * | 2012-12-22 | 2013-04-03 | 北华大学 | Healthcare product with function of strengthening immunity |
| CN105010862A (en) * | 2015-07-20 | 2015-11-04 | 句容市郭庄镇南河农庄 | Chinese herbal medicine feed additive capable of enhancing immunity of Chinese softshell turtles, as well as preparation method and application of Chinese herbal medicine feed additive |
| CN106509892A (en) * | 2016-10-28 | 2017-03-22 | 芜湖市诺康生物科技有限公司 | Health product for alleviating human body fatigue and preparation method thereof |
| CN108066384A (en) * | 2016-11-08 | 2018-05-25 | 郑州桂仁医药科技有限公司 | A kind of Chinese medicine preparation with strengthen immunity and preparation method thereof |
| CN112999286A (en) * | 2021-04-23 | 2021-06-22 | 江苏金维氨生物工程有限公司 | Granules capable of relieving fatigue and preparation method thereof |
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