CN1183841C - Anti-fatigue male's health tea its production process - Google Patents
Anti-fatigue male's health tea its production process Download PDFInfo
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Abstract
The present invention discloses a health-care tea for men, which has the effect of fatigue resistance, and a preparation method thereof. The health-care tea is prepared from manyprickle acanthopanax root, glossy ganoderma, epimedium herb, sharpleaf galangal fruit, solomonseal rhizome, Chinese date and green tea according to a certain weight proportion. The health-care tea has the effect for resisting senility, fatigue, hypoxia, radiation, etc., and particularly has the efficacy for resisting fatigue. The health-care tea is suitable for pathological symptoms, comprising physical strength subsidence, tiredness, asthenia, reaction and thinking ability subsidence, etc., caused by chronic fatigue syndromes or a subhealth state.
Description
Technical field
The present invention relates to a kind of male health care tea and preparation method thereof, belong to the Chinese medicine and health food field with antifatigue effect.
Background technology
Chronic fatigue syndrome is the commonly encountered diseases of between twenty and fifty people in the modern society, mainly show as symptoms such as easily tired, weak, insomnia, dizzy, vexed, irritable, anxiety, medically system is referred to as subhealth state, belong to intermediateness healthy and disease, about according to statistics adult of about 50% is in sub-health state.Modern study shows that chronic fatigue syndrome is often followed the changes such as nerve, immunity and endocrine function of body, and if properly handled can transform to health, otherwise then causes the generation of some other disease.
Current society, the male is bearing bigger life and stress, and male's average life is starkly lower than the women.At the chronic fatigue syndrome of above-mentioned serious harm men's health, invention taking convenience and energy antifatigue Chinese medicine health care product are imperative.
Summary of the invention
The purpose of this invention is to provide a kind of taking convenience and energy antifatigue male health care tea.
Another object of the present invention provides a kind of preparation method of resisting fatigue male health care tea.
Male health care tea of the present invention is that the inventor carries out dialectical executing according to theory of Chinese medical science and controls, and develops in conjunction with modern preparation process.
Impairment caused by overstrain vital essence, caused by liver and kidney deficiency are the common main diseases therefore of chronic fatigue syndrome.The present invention is monarch drug with Radix Et Caulis Acanthopanacis Senticosi replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization; Ganoderma nourishes strong, Herba Epimedii warming the kidney to invigorate YANG, strong muscle damp eliminating, and Fructus Alpiniae Oxyphyllae controlling nocturnal emission with astringent drugs warming the spleen, Rhizoma Polygonati nourishing kidney lung moistening, invigorating the spleen and replenishing QI, above-mentioned four flavors are ministerial drug altogether; Assistant is with Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, makes with the green tea clearing heat and relieving fidgetness, refreshment makes eye bright.Each medicine compatibility of above-mentioned integration of edible and medicinal herbs, based on nourishing the liver and kidney, it is auxilliary reposing with relieving restlessness, reaches to mend and oiliness the effect of cutting down clearly and not.
Modern study shows that also Radix Et Caulis Acanthopanacis Senticosi extract has effects such as defying age, resisting fatigue, anoxia enduring, radioprotective, blood fat reducing and raise immunity, and its main effective ingredient is Radix Et Caulis Acanthopanacis Senticosi Saponin and polysaccharide.Ganoderan has enhance immunity, antitumor, defying age, protects the liver dirty effect.Herba Epimedii has sexual function improving, reconciles the effect of hypothalamic pituitary gonadal axis, and Herba Epimedii total flavones and polysaccharide have the effect of enhancing human body immunity function, and can improve the synthetic of " yang deficiency " animal DNA (deoxyribonucleic acid).Fructus Alpiniae Oxyphyllae has the effect of heart tonifying, Fructus Alpiniae Oxyphyllae, and its ethanol extract has vasodilatory function.Rhizoma Polygonati has blood pressure lowering, blood sugar lowering and improves the effect of blood supply of cardiac muscle.Triterpenoid compound in the Fructus Jujubae has antitumor action, and jujube polysaccharide has the adjusting immunologic function, and the ethanol extract of Fructus Jujubae has the effect of tranquillizing and allaying excitement.Said medicine cooperates with the green tea that contains tea polyphenols, tea pigment with antioxidation, refreshment, and daily use will help the chronic fatigue syndrome rehabilitation.
The consumption of health tea crude drug of the present invention is also tested in a large number to grope to sum up through the inventor and is drawn, and the each component consumption is for all to have better curative effect in the following weight parts scope:
Radix Et Caulis Acanthopanacis Senticosi 2.5-7.5 weight portion;
Ganoderma 1-5 weight portion;
Herba Epimedii 1-5 weight portion;
Fructus Alpiniae Oxyphyllae 1-5 weight portion;
Rhizoma Polygonati 1-5 weight portion;
Fructus Jujubae 1-5 weight portion;
Green tea 1-5 weight portion.
The optimum weight proportioning of health tea component of the present invention is:
Radix Et Caulis Acanthopanacis Senticosi 5.25 weight portions;
Ganoderma 3.5 weight portions;
Herba Epimedii 3.5 weight portions;
Fructus Alpiniae Oxyphyllae 3.5 weight portions;
Rhizoma Polygonati 3.5 weight portions;
Fructus Jujubae 3.5 weight portions;
Green tea 3.5 weight portions.
The preparation method of health tea of the present invention is as follows:
(1) take by weighing each crude drug Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and Rhizoma Polygonati, standby;
(2) with Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and the Rhizoma Polygonati of described weight ratio with 60～70% alcohol reflux secondaries, the ethanol that adds for the first time 9～11 times of crude drug weight refluxes, and gets extracting solution 1, the ethanol that adds for the second time 7～9 times of crude drug weight, reflux, get extracting solution 2, merge extractive liquid, 1 and 2, leave standstill, filter, reclaim ethanol, get extracting solution A and residue A1;
(3) Fructus Alpiniae Oxyphyllae of described weight proportion is added the water of 7～9 times of crude drug weight, refluxes, extract volatile oil, aqueous extract B and oil phase extracting solution B1;
(4) Ganoderma and the described residue A1 of step (2) with described weight proportion merges, decoct secondary, the water that adds for the first time 9～11 times of crude drug weight, decocted 1～2 hour, and got extracting solution 3, add the water of 7～9 times of crude drug weight for the second time, decocted 0.5～1.5 hour, get extracting solution 4, merge extractive liquid, 3 and 4 gets extracting solution C;
(5) extracting solution A, oil phase extracting solution B1 and extracting solution C are merged, be condensed into concentrated solution, the Fructus Jujubae that adds described weight proportion, 60～70 ℃ were soaked 9～11 hours down, residual concentrated solution were condensed under 40～60 ℃ the clear paste of relative density 1.22～1.24, get an amount of xanthan gum, moistening and the extracting solution B mix homogeneously of water adds in the clear paste, mixes thoroughly with described Fructus Jujubae, 70～80 ℃ dry down, obtains being soaked with the Fructus Jujubae of medicine components;
(6) take by weighing the green tea of described weight proportion, mix with above-mentioned gained Fructus Jujubae, male health care tea.
The preferred for preparation method of health tea of the present invention is characterized in that: add the ethanol of 10 times of crude drug weight in the described step (2) for the first time, add the ethanol of 8 times of crude drug weight for the second time.
The preferred for preparation method of health tea of the present invention is characterized in that: the water that adds 8 times of crude drug weight in the described step (3).
The preferred for preparation method of health tea of the present invention is characterized in that: add the water of 10 times of crude drug weight when decocting for the first time in the described step (4), decocted 1.5 hours, decoct the water that adds 8 times of crude drug weight for the second time, decocted 1 hour.
The preferred for preparation method of health tea of the present invention is characterized in that: the amount of described adding xanthan gum is 18～22 weight portions, more preferably 20 weight portions.
According to the preparation technique of routine, medicine of the present invention can be prepared into any pharmaceutical preparation that is suitable for clinic trial, for example, and medicinal tea.
The preferred dosage form of health tea of the present invention is a medicinal tea.According to the needs of preparation, can also contain drug excipient commonly used in the pharmaceutics field in the medicine of the present invention, for example, solvent, filler, flavoring agent, disintegrating agent, binding agent, lubricant, wetting agent, pigment, bulking agent, diluent, thickening agent etc.
The instructions of taking of male health care tea of the present invention is daily consumption every day twice, each 1 bag, and every packed 7 grams.
Health tea of the present invention has effects such as defying age, resisting fatigue, anoxia enduring, radioprotective, has anti-fatigue effect especially, is applicable to that the muscle power that chronic fatigue syndrome or sub-health state cause goes down, disease such as spiritlessness and weakness, reaction and ability of thinking go down.
Below further sets forth the beneficial effect of health tea of the present invention by testing example, these are tested routine pharmacodynamics test of health tea of the present invention and the clinical efficacy of having comprised and test.
[test example 1]: health tea of the present invention is to the therapeutical effect of mice.
1. test material:
1.1 animal:
6 age in week Kunming mouse, male, secondary, body weight 18-22 gram (20 ± 2 gram) is available from Chinese Academy of Medical Sciences's animal center.
1.2 test standard:
The blood lactic acid content is measured and is carried out according to 2002 editions 2 the 403rd page of described standards of the Pharmacopoeia of the People's Republic of China; The blood urea nitrogen assay carries out according to 2002 editions 2 the 322nd page of described standards of the Pharmacopoeia of the People's Republic of China.
Male health care tea, every bag 7 gram, after the water concentration contracts before the test, filling stomach dosage preparation on demand.
2. method
2.1 animal grouping and administration:
2.1.1 screening
Laboratory animal adapts to laboratory environment two days later, bears a heavy burden 4%, in 25 ℃ water, swims and carries out screening experiment in 10 minutes, and the rescue survivor uses as formal experiment.
2.1.2 grouping and administration
To screen the back mice weighs after drying and is divided into 4 groups at random, be normal control group (NC, 5% analytical pure alcoholic solution, irritating body of stomach long-pending is 0.4 milliliter/20 gram body weight), low dose group (LD, be equivalent to male health care tea 1.4 gram/kilograms, irritating body of stomach long-pending is 0.4 milliliter/20 gram body weight), middle dosage group (MD is equivalent to male health care tea 2.8 gram/kilograms, and irritating body of stomach long-pending is 0.4 milliliter/20 gram body weight), high dose group (HD, be equivalent to male health care tea 7.4 gram/kilograms, irritating body of stomach long-pending is 0.4 milliliter/20 gram body weight), each is organized to be every day and once gives the above-mentioned thing that tried.Taking dose is equivalent to 5,10,30 times of human body daily intaking amount respectively.
2.2 mice swimming with a load attached to the body experiment
Mice gavages was continuously tried thing 21 days, irritated stomach after 30 minutes in last, 5% (body weight) of bearing a heavy burden swimming, and water temperature is controlled at 25 ± 1 ℃.Note down the time of every mice entry till the death.
2.3 lactic acid content
Mice oral test thing 21 days detects last and irritated behind the stomach 30 minutes, and water temperature is controlled at 25 ± 1 ℃, bears a heavy burden 2% swimming after 60 minutes, plucks eyeball and gets blood, and separation of serum is surveyed lactic acid content.
2.4 blood urea nitrogen content
Experimental technique and get the blood time with 2.3 behind the separation of serum (slurry), utilizes the level of Fearon reaction detection blood urea nitrogen.
2.5 statistical analysis:
Adopt the difference of variance analysis comparative experiments group and matched group,, analyze with the H check as heterogeneity of variance.
3. result:
3.1 male health care tea is to the influence of mice swimming endurance
Experimental result shows, each dosage group of male health care tea is to the effect that all improves of mice swimming endurance, and wherein particularly evident to the potentiation of mice swimming endurance with small dose group, relatively there were significant differences with matched group, and P＜0.05 sees Table 1.
Table 1. male health care tea is to the influence of mice swimming endurance (X ± SD)
Group dosage (the average walk time P of milliliter/number of animals
*
Kilogram) (only) (branch)
NC 0 15 32±22
LD 1.4 15 62±53 ＜0.05
MD 2.8 15 44±48 ＞0.05
HD 7.4 15 40±58 ＞0.05
*P is the significant difference rate.
3.2 male health care tea is to the influence of mice blood lactic acid metabolism.
Experimental result shows that male health care tea small dose group has tangible reduction effect to mice swimming back serum lactate level, and relatively there were significant differences with matched group, P＜0.05; The effect of middle and high dosage group is not obvious, does not relatively have significant difference with matched group, and p＞0.05 sees Table 2.
Table 2. male health care tea is to the influence of mice blood lactate level (X ± SD)
Group dosage (milliliter/number of animals blood lactic acid (milligram/hundred P
Kilogram) (only) rises)
NC 0 15 62±26
LD 1.4 15 40±12 ＜0.05
MD 2.8 15 71±14 ＞0.05
HD 7.4 15 78±18 ＞0.05
3.3 male health care tea is to the influence of mice blood urea nitrogen
Experimental result shows that for motion back mice urea nitrogen levels, each dosage group of male health care tea all is starkly lower than matched group, and credit is analysed by statistics, and significant difference is arranged, P＜0.05,
See Table 3.
Table 3. male health care tea is to the influence of mice blood urea nitrogen content (X ± SD)
Group dosage (milliliter/number of animals blood urea nitrogen (milligram/P
Kilogram) (only) hectolitre)
NC 0 15 9.7±1.0
LD 1.4 15 8.3±1.2 ＜0.05
MD 2.8 15 8.1±1.0 ＜0.05
HD 7.4 15 8.3±1.3 ＜0.05
4. result
This experimental result shows that male health care tea small dose group obviously improves the mice swimming time, obviously reduces motion back mice blood lactate level and blood urea nitrogen level, and middle and high dosage group obviously reduces motion back mice blood urea nitrogen level.Therefore, can think that male health care tea has antifatigue effect.
[test example 2] health tea antifatigue of the present invention clinical trial
1, physical data
Accepting out-patient's totally 30 examples for medical treatment, have following two main standard or add up simple symptom standard more than 8, all is the male, 20～30 years old 7 age example, 31～40 years old 9 example, 41～50 years old 10 example, 4 examples more than 50 years old.Wherein professional cadre 12 people, teacher 7 people, workman 7 people, driver 2 people, peasant, each 1 people of student.
2, diagnostic criteria
(1), main diagnostic criteria
(a) fatigue of outbreak lastingly or repeatedly continues more than 6 months; (b), can get rid of the various organic diseases that cause confirmed fatigue according to medical history, sign or lab testing result.
(2), symptom standard
(a) the overweight fatigue that is difficult for releasing that causes of muscle power or mental workload;
(b) there is not the muscle weakness of clear and definite reason;
(c) insomnia ubiquity, or dreaminess, early awakening are arranged;
(d) feeling of fullness in the head, giddy or headache;
(e) difficult concentrating, hypomnesis;
(f) inappetence;
(g) shoulder back discomfort, chest has constriction, or the myalgia and the arthralgia of lumbago and backache, delocalization is arranged, no clear and definite rheumatism or trauma history;
(h) feel depressed, anxiety or anxiety, fear;
(i) interest goes down or loses;
(g) sexual hypofunction;
(k) low grade fever;
(l) there are constriction in dry pharynx, pharyngalgia or throat.
4, Therapeutic Method
Daily consumption: take twice every day, each 1 bag, packed 7 grams, taking about 10 days is a course of treatment, 3 above courses of treatment of logotype.
5, efficacy assessment standard
Produce effects: symptom all disappears, and observes 3 months no recidivists,
Take a turn for the better: big of symptom disappears or symptom has obvious alleviator.
Invalid: as not reach improvement standard person.
Table 4: therapeutic outcome
| The treatment natural law | Produce effects | Take a turn for the better | Invalid | Total effective rate | |||
| The example number | Obvious effective rate % | The example number | Improvement rate % | The example number | Inefficiency % | ||
| 10 | 0 | 23 | 77 | 7 | 23 | 77 | |
| 20 | 18 | 60 | 9 | 30 | 3 | 10 | 90 |
| 30 | 20 | 67 | 8 | 27 | 2 | 6 | 94 |
With three courses of treatment, treat 30 examples with health tea, produce effects 20 examples as a result, 8 examples that take a turn for the better, invalid 2 examples, obvious effective rate is 67%, and improvement rate is 27%, and total effective rate is 94%.
The specific embodiment
Come further to set forth male health care tea of the present invention and preparation method thereof by the following examples:
(1) with the Rhizoma Polygonatis of the Herba Epimedii of the Radix Et Caulis Acanthopanacis Senticosis of 1300 grams, 870 grams and 870 grams with 70% alcohol reflux secondary, add for the first time 30.4 kilograms of ethanol, refluxed 1.5 hours, for the second time add 24.3 kilograms of ethanol, refluxed merge extractive liquid, 1.0 hours, leave standstill, filter, reclaim ethanol, get (A) liquid and residue (A1);
(2) Fructus Alpiniae Oxyphyllae with 870 grams adds water 6960 grams, refluxes 5 hours, extracts volatile oil, gets (B) liquid and extracting solution (B1);
(3) with the Ganoderma of 870 grams and (A1) merging, decoct secondary, add 8.7 kilograms in water for the first time, decocted 1.5 hours, add entry 6960 grams for the second time, decocted 1.0 hours, merge extractive liquid, gets (C) liquid;
(4) with (A) liquid, (B1) liquid and (C) liquid merging, concentrating under reduced pressure becomes concentrated solution, the Fructus Jujubaes that add 870 grams, 70 ℃ were soaked 10 hours, residual concentrated solution were condensed under 50 ℃ the clear paste of relative density 1.22～1.24, get 5 kilograms of xanthan gum, moistening and (B) the liquid mix homogeneously of water adds in the clear paste, mixes thoroughly with described Fructus Jujubae, 60 ℃ of following drying under reduced pressure 7 hours obtain being soaked with the Fructus Jujubae of medicine components;
(5) take by weighing 870 green tea that restrain, mix, get resisting fatigue male health care tea with above-mentioned made Fructus Jujubae.
Claims (7)
1, a kind of preparation method of resisting fatigue male health care tea, it is characterized in that: its active ingredient is made by following bulk drugs:
Radix Et Caulis Acanthopanacis Senticosi 2.5-7.5 weight portion;
Ganoderma 1-5 weight portion;
Herba Epimedii 1-5 weight portion;
Fructus Alpiniae Oxyphyllae 1-5 weight portion;
Rhizoma Polygonati 1-5 weight portion;
Fructus Jujubae 1-5 weight portion;
Green tea 1-5 weight portion;
Its preparation process is as follows:
(1) take by weighing each crude drug Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and Rhizoma Polygonati, standby;
(2) with Radix Et Caulis Acanthopanacis Senticosi, Herba Epimedii and the Rhizoma Polygonati of described weight ratio with 60～70% alcohol reflux secondaries, the ethanol that adds for the first time 9～11 times of crude drug weight refluxes, and gets extracting solution 1, the ethanol that adds for the second time 7～9 times of crude drug weight, reflux, get extracting solution 2, merge extractive liquid, 1 and 2, leave standstill, filter, reclaim ethanol, get extracting solution A and residue A1;
(3) Fructus Alpiniae Oxyphyllae of described weight proportion is added the water of 7～9 times of crude drug weight, refluxes, extract volatile oil, aqueous extract B and oil phase extracting solution B1;
(4) Ganoderma and the residue obtained A1 of step (2) with described weight proportion merges, decoct secondary, the water that adds for the first time 9～11 times of crude drug weight, decocted 1～2 hour, and got extracting solution 3, add the water of 7～9 times of crude drug weight for the second time, decocted 0.5～1.5 hour, get extracting solution 4, merge extractive liquid, 3 and 4 gets extracting solution C;
(5) described extracting solution A, oil phase extracting solution B1 and extracting solution C are merged, be condensed into concentrated solution, the Fructus Jujubae that adds described weight proportion, 60～70 ℃ were soaked 9～11 hours down, residual concentrated solution were condensed under 40～60 ℃ the clear paste of relative density 1.22～1.24, get an amount of xanthan gum, moistening and the aqueous extract B mix homogeneously of water adds in the clear paste, mixes thoroughly with described Fructus Jujubae, 70～80 ℃ dry down, obtains being soaked with the Fructus Jujubae of medicine components;
(6) take by weighing the green tea of described weight proportion, mix with above-mentioned gained Fructus Jujubae, male health care tea.
2, the preparation method of resisting fatigue male health care tea according to claim 1 is characterized in that: add the ethanol of 10 times of crude drug weight for the first time in described step (2), add the ethanol of 8 times of crude drug weight for the second time.
3, the preparation method of resisting fatigue male health care tea according to claim 2 is characterized in that: the water that the Fructus Alpiniae Oxyphyllae of described weight proportion is added 8 times of crude drug weight in described step (3).
4, the preparation method of resisting fatigue male health care tea according to claim 3, it is characterized in that: the water that adds 10 times of crude drug weight when in described step (4), decocting for the first time, decocted 1.5 hours, and decocted the water that adds 8 times of crude drug weight for the second time, decocted 1 hour.
5, the preparation method of resisting fatigue male health care tea according to claim 4 is characterized in that: the amount that adds xanthan gum in described step (5) is 18～22 weight portions.
6, the preparation method of resisting fatigue male health care tea according to claim 5 is characterized in that: the amount that adds xanthan gum in described step (5) is 20 weight portions.
7, a kind of according among the claim 1-6 each one of the health tea of preparation method preparation of described resisting fatigue male health care tea, it is characterized in that: the active ingredient of described health tea is made by following bulk drugs:
Radix Et Caulis Acanthopanacis Senticosi 5.25 weight portions;
Ganoderma 3.5 weight portions;
Herba Epimedii 3.5 weight portions;
Fructus Alpiniae Oxyphyllae 3.5 weight portions;
Rhizoma Polygonati 3.5 weight portions;
Fructus Jujubae 3.5 weight portions;
Green tea 3.5 weight portions.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN100587682C (en) * | 2002-11-20 | 2010-02-03 | Ipg501健康保健有限公司 | Method and apparatus for secure processing of sensitive data |
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|---|---|---|---|---|
| JP2007306872A (en) * | 2006-05-19 | 2007-11-29 | Suntory Ltd | Proanthocyanidin-containing tea beverage |
| CN103636839B (en) * | 2013-11-26 | 2015-09-23 | 李富玉 | A kind of anti-fatigue tea |
| CN103705562A (en) * | 2013-12-25 | 2014-04-09 | 南京中科药业有限公司 | Traditional Chinese medicine composition for enhancing immunity and preparation method thereof |
| CN106819965A (en) * | 2016-12-22 | 2017-06-13 | 北京康比特体育科技股份有限公司 | A kind of health-care food composition and preparation method and application |
| CN107126390A (en) * | 2017-05-13 | 2017-09-05 | 佛山文森特知识产权服务有限公司 | A kind of man's skin care cosmetic compositions |
| CN110496201A (en) * | 2019-09-24 | 2019-11-26 | 新疆华春生物药业股份有限公司 | A kind of antifatigue compound preparation and preparation method thereof |
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| CN100587682C (en) * | 2002-11-20 | 2010-02-03 | Ipg501健康保健有限公司 | Method and apparatus for secure processing of sensitive data |
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