CN1736445A - Kidney-tonifying brain-invigorating medicine and preparation process thereof - Google Patents
Kidney-tonifying brain-invigorating medicine and preparation process thereof Download PDFInfo
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Abstract
Disclosed is a kidney-tonifying brain-invigorating medicine and preparation process, which consists of grilling barrenwort with water, filtering the grilling liquid, decompression concentrating the filtrate, charging ethanol to make the alcohol content reach 60-70%, homogenizing, stewing to precipitate, filtering the supernatant fluid, disintegrating Cinnamomum cassia into coarse powder, abstracting volatile oil, collecting the aqueous solution after distillation with another container, merging medicament slag with ten Chinese herbs including doddor seed, grilling with water, filtering the grilling liquid, concentrating the filtrate, charging ethanol to make the alcohol content reach 60-70%, homogenizing, stewing to precipitate, filtering the supernatant fluid, merging the filtrates, reclaiming the ethanol, charging Cinnamomum cassia volatile oil and aqueous solution after distillation, charging bee honey, sorbic acid, homogenizing, freezing and filtering, making 1000ml package, finally loading and sterilizing.
Description
Technical field
The present invention relates to a kind of Chinese medicine health-care class medicine, nourishing kidney cerebral tonic and preparation technology thereof.
Background technology
Chinese medicine is thought: " kidney governing bones is got the essence of five ZANG-organs and six FU-organs and is hidden it." " kidney storing essence, the smart marrow of giving birth to, marrow nourishing bone, bone is hidden marrow, poly-marrow is a brain ", " the brain being the reservoir of the marrow ".Therefore on physiology, the relation of kidney and brain is very close, and the normal activity of brain must depend on supplementing nutrition of kidney.Tcm theory is also emphasized " grow Miao Zhebi and irrigate its root, cutting down down the person must be short of money on it ", so title kidney behaviour the congenital foundation, nourishing kidney health preserving is most important.The hypokinetic people that suffers from a deficiency of the kidney can cause multiple pathological changes, and is poor, easy to catch cold etc. as dizziness, insomnia, dizzy, tinnitus, sore waist and aching in the waist and the back, foot skelasthenia, sexual hypofunction, loss of hairs face wrinkle, resistance.Simultaneously, the tcm health preserving theory is thought: " kind support the person, must precious its essence, essence is full of then arrogant, and arrogant then god is extremely." essence is supported in this explanation could be arrogant, brain-strengthening just can be calmed the nerves, and just can reach to consolidate Baconic, postpones the health preserving purpose of brain aging.
Along with the development of society and the raising of living standards of the people, keep the abundant energy and the thinking of clear agility, the demand of relevant this respect health care medicine, growing.Though the product of a lot of nourishing kidneys is arranged on the market, can nourishing kidney again can brain-strengthening product seldom, can reach the fewer of nourishing kidney brain invigorating liquid curative effect in the like product.
Summary of the invention
Purpose of the present invention aims to provide a kind of good effect, has nourishing the liver and kidney, a kind of nourishing kidney cerebral tonic and the preparation technology thereof of the effect of invigorating brain and relieving mental uneasiness.
The objective of the invention is to realize by following manner:
Component of the present invention comprises (following all by weight)
100～150 parts of 100～150 parts of Fructus Lycii of 100～150 parts of Semen Cuscutae of Fructus Rubi
120～180 parts of 100～150 parts of Radixs Astragali of 100～150 parts of Fructus Ligustri Lucidi of Fructus Rosae Laevigatae
120～180 parts of Radix Salviae Miltiorrhizae 100～150 parts of Radix Polygoni Multiflori of 100～150 portions of Radix Paeoniae Albas (system)
5～20 parts of 200～280 portions of Cortex Cinnamomis of Herba Epimedii.
Component of the present invention also comprises 30～60 parts in Radix Glycyrrhizae (processed with honey), 150～300 parts of Mel.
The preferred raw material weight proportioning of the present invention is:
110～130 parts of 110～130 parts of Fructus Lycii of 110～130 parts of Semen Cuscutae of Fructus Rubi
130～160 parts of 110～130 parts of Radixs Astragali of 110～130 parts of Fructus Ligustri Lucidi of Fructus Rosae Laevigatae
130～160 parts of Radix Salviae Miltiorrhizae 110～130 parts of Radix Polygoni Multiflori of 110～130 portions of Radix Paeoniae Albas (system)
40～55 parts in Herba Epimedii 10～15 portions of Radix Glycyrrhizaes of 230～260 portions of Cortex Cinnamomis (processed with honey), 180～250 parts of Mel.
The present invention can be any peroral dosage form on the pharmaceutics.
Oral liquid of the present invention consists of:
Fructus Rubi 100～150 gram Semen Cuscutae 100～150 gram Fructus Lycii 100～150 grams
Fructus Rosae Laevigatae 100～150 gram Fructus Ligustri Lucidi 100～150 gram Radixs Astragali 120～180 grams
Radix Salviae Miltiorrhizae 100～150 gram Radix Paeoniae Albas 100～150 gram Radix Polygoni Multiflori (system) 120～180 grams
Herba Epimedii 200～280 gram Mel 150～300 grams
Radix Glycyrrhizae (processed with honey) 30～60 gram Cortex Cinnamomis 5～20 gram sorbic acid 1～4 gram
Make 1000ml.
Technical process of the present invention is: (1) is got Herba Epimedii and is decocted with water three times, adds 9-16 times of water gaging the 1st time, adds 10-14 times of water gaging the 2nd time, add 8-12 times of water gaging the 3rd time, each 0.5-1.5 hour, collecting decoction filtered, filtrate decompression concentrates, add ethanol and make and contain alcohol amount and reach 60-70%, stir evenly, leave standstill and make precipitation, get supernatant and filter filtrate for later use;
(2) Cortex Cinnamomi powder is broken into coarse powder, extracts volatile oil, and is standby; Aqueous solution after the Cortex Cinnamomi distillation, standby
(3) Cortex Cinnamomi medicinal residues and Fructus Rubi, Semen Cuscutae, Fructus Lycii, Fructus Rosae Laevigatae, Fructus Ligustri Lucidi, the Radix Astragali, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Radix Glycyrrhizae ten flavor merges, and decocts with water three times, adds 6-10 times of water gaging the 1st time, the 2nd, add 4-9 times of water gaging for 3 times, each 0.5-1.5 hour, collecting decoction, filter, filtrate concentrates, and adds ethanol and makes and contain the alcohol amount and reach 60-70%, stir evenly, leave standstill and make precipitation, get supernatant and filter, the filtrate during filtrate goes on foot with (1) merges, reclaim ethanol, aqueous solution after adding Cortex Cinnamomi volatile oil and the distillation adds Mel, sorbic acid stirs evenly, cold preservation, filter, make 1000ml, fill, sterilization, promptly.
Described (1) step filtrate decompression is concentrated into every 1ml and is equivalent to crude drug 1g; Filtrate is concentrated into relative density and is about 1.25 (80 ℃) in described (3) step
The technical process of the best of the present invention is:
Get Herba Epimedii and decoct with water three times, add 14 times of water gagings the 1st time, add 12 times of water gagings the 2nd time, add 10 times of water gagings the 3rd time, each 1 hour, collecting decoction filtered, filtrate decompression is concentrated into every 1ml and is equivalent to crude drug 1g, add ethanol and make and contain alcohol amount and reach 65%, stir evenly, leave standstill and make precipitation, get supernatant and filter filtrate for later use; Cortex Cinnamomi powder is broken into coarse powder, extracts volatile oil, and is standby; Aqueous solution after distillation device is in addition collected, and ten flavors such as medicinal residues and all the other Semen Cuscutae merge, and decoct with water three times, add 8 times of water gagings the 1st time, add 6 times of water gagings, each 1 hour the 2nd, 3 time, collecting decoction filters, and filtrate is concentrated into relative density and is about 1.25 (80 ℃), add ethanol and make and contain alcohol amount and reach 65%, stir evenly, leave standstill and make precipitation, getting supernatant filters, filtrate and above-mentioned filtrate merge, and reclaim ethanol, the aqueous solution after adding Cortex Cinnamomi volatile oil and the distillation, add Mel, sorbic acid, stir evenly, cold preservation filters, make 1000ml, fill, sterilization, promptly.
This prescription is the famous old docter of TCM LiuBing Fan researcher in Hunan Inst of Traditional Chinese Medicine according to the mechanism of " marrow nourishing bone, bone store essential substances, poly-marrow are brain for kidney storing essence, the smart marrow of giving birth to ", the well-designed one-tenth in conjunction with the clinical rich experiences in oneself in year surplus 60.
Aminoacid, vitamin and trace element are rich in the present invention, the energy nourishing the liver and kidney, invigorating brain and relieving mental uneasiness is applicable to the disease of caused by liver and kidney deficiency, and it is evident in efficacy that dizziness and dim eyesight, soreness of the waist and knees, kidney encephalasthenia, dizziness and tinnitus, amnesia and melancholy, insomnia and dreamful sleep, impotence and seminal emission, nocturia such as are made frequently at symptom.The Radix Astragali, Radix Salviae Miltiorrhizae tonifying QI to promote blood circulation in the side; Semen Cuscutae, Fructus Lycii, Fructus Rubi, Fructus Rosae Laevigatae, Fructus Ligustri Lucidi, Radix Polygoni Multiflori enriching kidney essence; Mel, Cortex Cinnamomi, the Radix Paeoniae Alba, Radix Glycyrrhizae Preparata transfer liver to please spleen; The Herba Epimedii YANG invigorating is supporing yang, and strong kidney machine has nourishing the liver and kidney, the effect of invigorating brain and relieving mental uneasiness.
Unique distinction of the present invention is: 1, the present invention is a pure Chinese medicinal preparation, does not contain any chemical addition agent, takes safe and reliablely, has no side effect.
2, prescription science of the present invention, determined curative effect, have human body immunity improving power, promote effects such as body fatigue resistance, anoxia enduring, the clinical observation checking of carrying out through how tame hospital shows: the present invention has more significantly effect to doing well,improvings such as dizziness, tinnitus, insomnia, nocturia.
3, quality standard height of the present invention, production technology advanced person, the medicine height concentrates, oral liquid gas perfume (or spice) of the present invention, it is sweet to distinguish the flavor of, little hardship, mouthfeel is good, be easy to take, and dose is few, oral one time 10 milliliters, service once sooner or later and get final product every day.
4, oral liquid formulation of the present invention, the bioavailability height, it is rapid to improve symptom, instant effect, general patient can improve symptom in oral 2 ~ 3 days.
The pharmacological action of nourishing kidney brain invigorating liquid
One. the pharmacodynamic experiment research summary
The animal pharmacodynamics experimental result of non-preclinical study shows: the nourishing kidney brain invigorating liquid has following drug action:
1. the present invention can increase the life span under the mice cold conditions, can strengthen the anti-hypobaric hypoxia ability of mice.Specifically see the following form:
Table 1 brain invigorating liquid is to the influence of white mice tolerance to cold:
| Group | Number of animals | Dosage | Mean survival time (branch) |
| HUANJINGJIAN group nourishing kidney brain invigorating liquid group nourishing kidney brain invigorating liquid group normal saline group | 12 12 12 12 | 2ml/kg 4.0g/kg 10g/kg | 17.3±7.2** 16.7±6.3** 19.6±8.3** |
* and normal saline contrast P＜0.05
Can strengthen life span under the white mice cold conditions from the visible brain invigorating liquid of The above results, significant difference relatively be arranged with the normal saline matched group.
Table 2 nourishing kidney brain invigorating liquid is to the influence of white mice hypoxia-bearing capability
| Group | Number of animals (N) | Dosage | Mean survival time (branch) |
| HUANJINGJIAN group nourishing kidney brain invigorating liquid group nourishing kidney brain invigorating liquid group normal saline group | 12 12 12 12 | 2ml/kg 4.0g/kg 10g/kg | 6.5±2.2** 6.8±2.4** 7.4±2.6** 4.6±2.3 |
* and normal saline contrast P＜0.05
As can be seen from Table 2, the nourishing kidney brain invigorating liquid can strengthen the mice hypoxia-bearing capability, compares with matched group, and the statistics notable difference is arranged.
2. the present invention can reduce the trend that big mice collagen content reduced with the age, and slow down aging can significantly strengthen the old and feeble ability of rat anti.Specifically see the following form:
Table 3 nourishing kidney brain invigorating liquid is to the influence of rat skin hydroxyproline content:
| Group | Number of animals | Dosage | Hydroxyproline (ug/g) |
| HUANJINGJIAN group nourishing kidney brain invigorating liquid group nourishing kidney brain invigorating liquid group normal saline group | 10 10 10 10 | 2ml/kg 4.0g/kg 10g/kg | 115.3±9.9*** 99.4±10.5** 114.5±12.3*** 85.6±12.6 |
* * and normal saline be P＜0.01 relatively
* and normal saline be P＜0.05 relatively
From The above results as can be seen: the nourishing kidney brain invigorating liquid can make rat skin hydroxyproline content obviously improve.(hydroxyproline is the distinctive aminoacid ingredient of collagen protein (do not have in its hetero-organization or content few), accounts for the 12-14% of collagen protein, so the lifting of hydroxyproline content and collagen protein are synchronous.The content of collagen protein increases and reduces with the age, crosses practice already and confirms that above-mentioned experimental result shows that the nourishing kidney brain invigorating liquid can improve the content of rat skin hydroxyproline, also can improve their collagen content.This prompting nourishing kidney brain invigorating liquid has the effect of certain defying age life-saving.)
3. the present invention can increase big mouse brain active substance.
Table 4: the nourishing kidney brain invigorating liquid is to the influence of white mice liver, brain MAO-B vigor
| Group | Dosage | Hepatic tissue (active unit/mg albumen) | Cerebral tissue (active unit/mg albumen) |
| The blank group | 0.41 | 0.18 | |
| The HUANJINGJIAN group | 2ml/kg | 0.39 -5％ | 0.16 -11％ |
| Nourishing kidney brain invigorating liquid group | 0.8g/kg | 0.39 -5％ | 0.16 -11％ |
| Nourishing kidney brain invigorating liquid group | 4.0g/kg | 0.385 -5％ | 0.155 -14％ |
As can be known from the results of Table 4: the nourishing kidney brain invigorating liquid is the same with HUANJINGJIAN to suppress cerebral tissue MAO-B, but hepatic tissue MAO-B is suppressed less.Since 1970's, many scholars find that MAO-B and aging course and some Senile disease are closely related, Renedetti etc. (1980) have studied the active variation of young and old rat brain MAO-B, find that the MAO-B activity rises with age growth, the biochemical lesion that is caused by it is one of old and feeble reason.We show that the nourishing kidney brain invigorating liquid can make the activity of white mice cerebral tissue MAO-B be inhibited at experiment, and the brain invigorating liquid of nourishing kidney simultaneously is little to the metabolic activity influence of white mice MAO-B, so the nourishing kidney brain invigorating liquid is of value to anti-ageing life-prolonging.
4. the present invention can make the immunity of normal rat and Aged Mice significantly strengthen.
The influence (N=12) of table 5 pair immune organ weight
| Group | Thymus heavy (mg/10g body weight) | Spleen heavy (mg/10g body weight) |
| Normal saline group levamisole group low dose group high dose group cyclophosphamide group | 32.2±8.9 41.4±12.3** 56.2±26.5*** 28.5±12.6* 14.1±4.7*** | 34.5±7.5 47.6±14.8** 70.9±22.6*** 44.7±17.9* 27.2±9.2** |
| A left side+ring group is low+ring group height+ring group | 24.9±6.1ΔΔΔ 25.6±5.7ΔΔΔ 24.9±6.1ΔΔΔ | 48.3±14.4ΔΔΔ 68.4±18.9ΔΔΔ 48.3±14.4ΔΔΔ |
Compare * P＞0.05 with normal saline, * * P＜0.05, Δ Δ Δ P＜0.01 is compared with cyclophosphamide in * * * P＜0.01
Experiment showed, that after ontogeny, maturation body's immunological function is promptly followed and gone down, multiple disease takes place in the old people, and cancer and autoimmune disease particularly take place, and changes closely related therewith.In recent years, old and feeble relation with immunity causes people's attention day by day, bibliographical information, and old people T cell transformation rate all descends, and humoral immune function obviously goes down, and macrophage function also weakens etc.Therefore, preventing or delay the process that goes down that immune function undergoes senescence with increases age, is the major issue of anti-ageing life-prolonging.
Modern medicine studies have shown that many Chinese medicines such as the Radix Astragali, Fructus Ligustri Lucidi, Herba Epimedii, Fructus Lycii, Mel all have the effect of obvious raise immunity.The Radix Paeoniae Alba has report to think that it has dual regulation.This experimental result is consistent with most reports, shows that with these medicines be the main nourishing kidney brain invigorating liquid of forming, and can bring into play the whole immunoregulation effect of Chinese medicine preferably.Prompting nourishing kidney brain invigorating liquid is extraordinary to regulating old people's immunologic function, benefits for a long time and takes.
Pharmacological toxicology experiment conclusion of the present invention:
1, life test, the result shows that the nourishing kidney brain invigorating liquid can the significant prolongation housefly life-span.
2, irritability test, the result shows that the nourishing kidney brain invigorating liquid can strengthen anti-hypobaric hypoxia ability, and can increase the life span of mice under cold conditions.
3, collagen content determination test, the result shows that the nourishing kidney brain invigorating liquid can make rat skin hydroxyproline content improve 8%, makes the hydroxyproline content of large and small Mus tail tendon improve 6%, can improve their collagen content, prove that the nourishing kidney brain invigorating liquid has certain anti-ageing life-prolonging effect.
4, aging relevant enzyme test, the result shows that the nourishing kidney brain invigorating liquid is inhibited the activity of white mice cerebral tissue MAO-B, simultaneously not too to the metabolic activity influence of white mice hepatic tissue MAO-B, so the nourishing kidney brain invigorating liquid anti-ageing life-prolonging of intending.
5, immunity test, the result shows that the nourishing kidney brain invigorating liquid can make normal rat and Aged Mice serum hemolysin and Ea-RFC that remarkable potentiation is arranged; And can show immune rising effect to immunocompromised mice due to the cycli phosphate amide.
6, lipid peroxide contents and superoxide dismutase activity determination test, the result shows that the nourishing kidney brain invigorating liquid can significantly reduce the rat liver lipid peroxide contents and can significantly improve the rat superoxide dismutase activity.
7, the part threpsology detects test, and the result shows that the nourishing kidney brain invigorating liquid is rich in aminoacid, vitamin and trace element.
8, general pharmacology test, the result shows that the nourishing kidney brain invigorating liquid does not all have obviously influence to anesthesia Cor Canitis electricity, heart rate and breathing etc.
9, toxicological test, acute subacute test shows, do not see obvious acute subacute toxicity reaction, its toxicity is very little: long term toxicity test shows that each dosage body weight, hemogram, liver, renal function etc. are all normal, and the heart, liver, spleen, lung, kidney the five internal organs pathology slice probing Non Apparent Abnormality change.Its no overt toxicity is described, safety is big.
In sum, the nourishing kidney brain invigorating liquid to kidney encephalasthenia, dizzy tinnitus, dizzyly deal with, the patient of old and feeble all diseases such as the forgetful heart is swollen, insomnia and dreamful sleep, impotence and seminal emission, soreness of the waist and knees, nocturia are frequent is can be useful, and is and as safe as a house when using.
Two, clinical research data
Carried out clinical verification in three hospitals such as No. 1 Hospital Affiliated to Hunan Traditional Chinese Medical College, Annex II institute, Affiliated Hospital No. 1, Hunan Medical College before the present invention is gone on the market, existing Clinical results with three hospitals is summarized as follows:
1. general material
Several 158 examples of total example, male's 110 examples, women's 48 examples.Cerebral arteriosclerosis 101 examples, hyperplasia of prostate 57 examples; 108 examples are organized in treatment, man/woman: 75/33, and cerebral arteriosclerosis 70 examples, hyperplasia of prostate 38 examples; Matched group 50 examples, man/woman: 35/15, cerebral arteriosclerosis 31 examples, hyperplasia of prostate 19 examples.
2. therapeutic scheme
1) treatment group clothes nourishing kidney brain invigorating liquid, each 10 milliliters, every day secondary, early morning and sleep before take.Matched group is taken contrast medicine---HUANJINGJIAN, each 10 milliliters, early morning and sleep before take.
2) two groups of courses of treatment be 60 days.
3) strict control variable factor guarantees to take separately trial drug.
3. conclusion
1) ill effect is not seen in clinical observation, and safe in utilization, taking convenience.
2) three tame hospital clinical checkings show: the nourishing kidney brain invigorating liquid has obvious curative effects to the hepatic and renal YIN deficiency, kidney encephalasthenia disease, and medicine---it is suitable substantially that HUANJINGJIAN is compared the total effective rate curative effect with contrast.But the nourishing kidney brain invigorating liquid obviously is better than the HUANJINGJIAN group to the curative effect of dizzy, forgetful, nocturia, sexual impotence, premature ejaculation, insomnia, alopecia symptom.Illustrate that this medicine is the nourishing medicine of the ideal treatment hepatic and renal YIN deficiency, kidney encephalasthenia disease.
Description of drawings
Accompanying drawing is a process chart of the present invention
The specific embodiment
Embodiment 1
(1) gets Herba Epimedii .200 gram and decoct with water three times, add 9 times of water gagings the 1st time, add 10 times of water gagings the 2nd time, add 8 times of water gagings the 3rd time, each 0.5 hour, collecting decoction filtered, filtrate decompression is concentrated into every 1ml and is equivalent to crude drug 1g, add ethanol and make and contain alcohol amount and reach 60%, stir evenly, leave standstill and make precipitation, get supernatant and filter filtrate for later use;
(2) Cortex Cinnamomi 5 grams are ground into coarse powder, extract volatile oil, and are standby; Aqueous solution after the Cortex Cinnamomi distillation, standby.
(3) with Cortex Cinnamomi medicinal residues and Fructus Rubi 100 grams, Semen Cuscutae 100 grams, Fructus Lycii 100 grams, Fructus Rosae Laevigatae 100 grams, Fructus Ligustri Lucidi 100 grams, the Radix Astragali 120 grams, Radix Salviae Miltiorrhizae 100 grams, the Radix Paeoniae Alba 100 grams, Radix Polygoni Multiflori (system) 120 grams, Radix Glycyrrhizae (processed with honey) 30 grams ten flavors merge, decoct with water three times, add 6 times of water gagings, the 2nd the 1st time, add 4 times of water gagings for 3 times, each 0.5 hour, collecting decoction, filter, filtrate is concentrated into relative density and is about 1.25 (80 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, stir evenly, leave standstill and make precipitation, get supernatant and filter, the filtrate during filtrate goes on foot with (1) merges, reclaim ethanol, aqueous solution after adding Cortex Cinnamomi volatile oil and the distillation adds Mel 150 grams, sorbic acid 1 gram stirs evenly, cold preservation, filter, make 1000ml, fill, sterilization, promptly.
Embodiment 2
(1) gets Herba Epimedii 240 gram and decoct with water three times, add 14 times of water gagings the 1st time, add 12 times of water gagings the 2nd time, add 10 times of water gagings the 3rd time, each 1 hour, collecting decoction filtered, filtrate decompression is concentrated into every 1ml and is equivalent to crude drug 1g, add ethanol and make and contain alcohol amount and reach 65%, stir evenly, leave standstill and make precipitation, get supernatant and filter filtrate for later use;
(2) Cortex Cinnamomi 15 grams are ground into coarse powder, extract volatile oil, and are standby; Aqueous solution after the Cortex Cinnamomi distillation, standby.
(3) with Cortex Cinnamomi medicinal residues and Fructus Rubi 125 grams, Semen Cuscutae 125 grams, Fructus Lycii 125 grams, Fructus Rosae Laevigatae 125 grams, Fructus Ligustri Lucidi 125 grams, the Radix Astragali 140 grams, Radix Salviae Miltiorrhizae 125 grams, the Radix Paeoniae Alba 125 grams, Radix Polygoni Multiflori (system) 140 grams, Radix Glycyrrhizae (processed with honey) 45 grams ten flavors merge, decoct with water three times, add 8 times of water gagings, the 2nd the 1st time, add 6 times of water gagings for 3 times, each 1 hour, collecting decoction, filter, filtrate is concentrated into relative density and is about 1.25 (80 ℃), adds ethanol and makes and contain the alcohol amount and reach 65%, stir evenly, leave standstill and make precipitation, get supernatant and filter, the filtrate during filtrate goes on foot with (1) merges, reclaim ethanol, aqueous solution after adding Cortex Cinnamomi volatile oil and the distillation adds Mel 200 grams, sorbic acid 2 grams stir evenly, cold preservation, filter, make 1000ml, fill, sterilization, promptly.
Embodiment 3
(1) gets Herba Epimedii 280 gram and decoct with water three times, add 16 times of water gagings the 1st time, add 14 times of water gagings the 2nd time, add 12 times of water gagings the 3rd time, each 1.5 hours, collecting decoction filtered, filtrate decompression is concentrated into every 1ml and is equivalent to crude drug 1g, add ethanol and make and contain alcohol amount and reach 70%, stir evenly, leave standstill and make precipitation, get supernatant and filter filtrate for later use;
(2) Cortex Cinnamomi 20 grams are ground into coarse powder, extract volatile oil, and are standby; Aqueous solution after the Cortex Cinnamomi distillation, standby.
(3) with Cortex Cinnamomi medicinal residues and Fructus Rubi 150 grams, Semen Cuscutae 150 grams, Fructus Lycii 150 grams, Fructus Rosae Laevigatae 150 grams, Fructus Ligustri Lucidi 150 grams, the Radix Astragali 180 grams, Radix Salviae Miltiorrhizae 150 grams, the Radix Paeoniae Alba 150 grams, Radix Polygoni Multiflori (system) 180 grams, Radix Glycyrrhizae (processed with honey) 60 grams ten flavors merge, decoct with water three times, add 10 times of water gagings, the 2nd the 1st time, add 9 times of water gagings for 3 times, each 1 hour, collecting decoction, filter, filtrate is concentrated into relative density and is about 1.25 (80 ℃), adds ethanol and makes and contain the alcohol amount and reach 70%, stir evenly, leave standstill and make precipitation, get supernatant and filter, the filtrate during filtrate goes on foot with (1) merges, reclaim ethanol, aqueous solution after adding Cortex Cinnamomi volatile oil and the distillation adds Mel 300 grams, sorbic acid 4 grams stir evenly, cold preservation, filter, make 1000ml, fill, sterilization, promptly.
Embodiment 4
Take by weighing raw material by following proportioning:
Fructus Rubi 110 gram Semen Cuscutae 110 gram Fructus Lycii 110 grams
The Fructus Rosae Laevigatae 110 gram Fructus Ligustri Lucidi 110 gram Radixs Astragali 130 grams
The Radix Salviae Miltiorrhizae 110 gram Radix Paeoniae Albas 110 gram Radix Polygoni Multiflori (system) 130 grams
Herba Epimedii 230 gram Cortex Cinnamomis 10 gram Radix Glycyrrhizaes (processed with honey) 40 grams, Mel 180 grams.Preparation technology is with embodiment 2.
Embodiment 5
Take by weighing raw material by following proportioning:
Fructus Rubi 130 gram Semen Cuscutae 130 gram Fructus Lycii 130 grams
The Fructus Rosae Laevigatae 130 gram Fructus Ligustri Lucidi 130 gram Radixs Astragali 160 grams
The Radix Salviae Miltiorrhizae 130 gram Radix Paeoniae Albas 130 gram Radix Polygoni Multiflori (system) 160 grams
Herba Epimedii 260 gram Cortex Cinnamomis 15 gram Radix Glycyrrhizaes (processed with honey) 55 grams, Mel 250 grams.Preparation technology is with embodiment 2.
Claims (8)
1, a kind of nourishing kidney cerebral tonic, the medicament by following weight proportioning raw material components is made comprises
100～150 parts of 100～150 parts of Fructus Lycii of 100～150 parts of Semen Cuscutae of Fructus Rubi
120～180 parts of 100～150 parts of Radixs Astragali of 100～150 parts of Fructus Ligustri Lucidi of Fructus Rosae Laevigatae
120～180 parts of Radix Salviae Miltiorrhizae 100～150 parts of Radix Polygoni Multiflori of 100～150 portions of Radix Paeoniae Albas (system)
5～20 parts of 200～280 portions of Cortex Cinnamomis of Herba Epimedii.
2, a kind of its raw material components of nourishing kidney cerebral tonic according to claim 1 also comprises 30～60 parts in Radix Glycyrrhizae (processed with honey), 150～300 parts of Mel.
3, a kind of nourishing kidney cerebral tonic according to claim 1 and 2, the raw material weight proportioning is:
110～130 parts of 110～130 parts of Fructus Lycii of 110～130 parts of Semen Cuscutae of Fructus Rubi
130～160 parts of 110～130 parts of Radixs Astragali of 110～130 parts of Fructus Ligustri Lucidi of Fructus Rosae Laevigatae
130～160 parts of Radix Salviae Miltiorrhizae 110～130 parts of Radix Polygoni Multiflori of 110～130 portions of Radix Paeoniae Albas (system)
40～55 parts in Herba Epimedii 10～15 portions of Radix Glycyrrhizaes of 230～260 portions of Cortex Cinnamomis (processed with honey), 180～250 parts of Mel.
4, a kind of nourishing kidney cerebral tonic according to claim 1 and 2 can be any peroral dosage form on the pharmaceutics.
5, a kind of nourishing kidney cerebral tonic according to claim 1 and 2, its oral liquid raw material consists of:
Fructus Rubi 100～150 gram Semen Cuscutae 100～150 gram Fructus Lycii 100～150 grams
Fructus Rosae Laevigatae 100～150 gram Fructus Ligustri Lucidi 100～150 gram Radixs Astragali 120～180 grams
Radix Salviae Miltiorrhizae 100～150 gram Radix Paeoniae Albas 100～150 gram Radix Polygoni Multiflori (system) 120～180 grams
Herba Epimedii 200～280 gram Mel 150～300 grams
Radix Glycyrrhizae (processed with honey) 30～60 gram Cortex Cinnamomis 5～20 gram sorbic acid 1～4 gram
Make 1000ml.
6, the technology of preparation claim 1 described a kind of nourishing kidney cerebral tonic is: (1) is got Herba Epimedii and is decocted with water three times, adds 9-16 times of water gaging the 1st time, adds 10-14 times of water gaging the 2nd time, add 8-12 times of water gaging the 3rd time, each 0.5-1.5 hour, collecting decoction filtered, filtrate decompression concentrates, add ethanol and make and contain alcohol amount and reach 60-70%, stir evenly, leave standstill and make precipitation, get supernatant and filter filtrate for later use;
(2) Cortex Cinnamomi powder is broken into coarse powder, extracts volatile oil, and is standby; Aqueous solution after the Cortex Cinnamomi distillation, standby
(3) Cortex Cinnamomi medicinal residues and Fructus Rubi, Semen Cuscutae, Fructus Lycii, Fructus Rosae Laevigatae, Fructus Ligustri Lucidi, the Radix Astragali, Radix Salviae Miltiorrhizae, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Radix Glycyrrhizae ten flavor merges, and decocts with water three times, adds 6-10 times of water gaging the 1st time, the 2nd, add 4-9 times of water gaging for 3 times, each 0.5-1.5 hour, collecting decoction, filter, filtrate concentrates, and adds ethanol and makes and contain the alcohol amount and reach 60-70%, stir evenly, leave standstill and make precipitation, get supernatant and filter, the filtrate during filtrate goes on foot with (1) merges, reclaim ethanol, aqueous solution after adding Cortex Cinnamomi volatile oil and the distillation adds Mel, sorbic acid stirs evenly, cold preservation, filter, make 1000ml, fill, sterilization, promptly.
7 a kind of its preparation technologies of nourishing kidney cerebral tonic according to claim 6, described (1) step filtrate decompression is concentrated into every 1ml and is equivalent to crude drug 1g; Filtrate is concentrated into relative density and is about 1.25 (80 ℃) in described (3) step
8, a kind of its preparation technology of nourishing kidney cerebral tonic according to claim 6 is: get Herba Epimedii and decoct with water three times, add 14 times of water gagings the 1st time, add 12 times of water gagings the 2nd time, add 10 times of water gagings the 3rd time, each 1 hour, collecting decoction filtered, filtrate decompression is concentrated into every 1ml and is equivalent to crude drug 1g, add ethanol and make and contain alcohol amount and reach 65%, stir evenly, leave standstill and make precipitation, get supernatant and filter filtrate for later use; Cortex Cinnamomi powder is broken into coarse powder, extracts volatile oil, and is standby; Aqueous solution after distillation device is in addition collected, and ten flavors such as medicinal residues and all the other Semen Cuscutae merge, and decoct with water three times, add 8 times of water gagings the 1st time, add 6 times of water gagings, each 1 hour the 2nd, 3 time, collecting decoction filters, and filtrate is concentrated into relative density and is about 1.25 (80 ℃), add ethanol and make and contain alcohol amount and reach 65%, stir evenly, leave standstill and make precipitation, getting supernatant filters, filtrate and above-mentioned filtrate merge, and reclaim ethanol, the aqueous solution after adding Cortex Cinnamomi volatile oil and the distillation, add Mel, sorbic acid, stir evenly, cold preservation filters, make 1000ml, fill, sterilization, promptly.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012635A (en) * | 2015-08-06 | 2015-11-04 | 苏州神林堂中医药研究所 | Medicinal preparation for treating insomnia |
| CN108066494A (en) * | 2018-02-02 | 2018-05-25 | 湖南新汇制药股份有限公司 | A kind of enuresis nocturna frequency effect liquid and preparation method thereof |
| CN112245550A (en) * | 2020-10-22 | 2021-01-22 | 王建军 | A Chinese medicinal composition with effect in regulating emotion, and its preparation method |
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| CN1216621C (en) * | 2002-12-02 | 2005-08-31 | 张治文 | Medication for nourishing yin and strengthening yang and preparation method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012635A (en) * | 2015-08-06 | 2015-11-04 | 苏州神林堂中医药研究所 | Medicinal preparation for treating insomnia |
| CN108066494A (en) * | 2018-02-02 | 2018-05-25 | 湖南新汇制药股份有限公司 | A kind of enuresis nocturna frequency effect liquid and preparation method thereof |
| CN108066494B (en) * | 2018-02-02 | 2020-05-08 | 湖南新汇制药股份有限公司 | Liquid medicine with frequent nocturia and preparation method thereof |
| CN112245550A (en) * | 2020-10-22 | 2021-01-22 | 王建军 | A Chinese medicinal composition with effect in regulating emotion, and its preparation method |
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