CN1663594A - Blood fat-decreasing weight-reducing kaladana capsule - Google Patents

Abstract

The invention provides a blood fat-decreasing weight-reducing kaladana capsule, wherein the capsule is prepared from seven kinds of medicinal herbs including morning glory seeds, senna leaf, cassia seeds through the steps of pulverizing, grilling thick grease and loading capsule.

Description

Blood fat-decreasing weight-reducing kaladana capsule

Affiliated technical field

Blood fat-decreasing weight-reducing kaladana capsule of the present invention belongs to the lowering blood-fat and reducing weight medicine, relates in particular to treatment phlegm-damp obesity and hyperlipemia pure Chinese medicinal preparation and preparation technology thereof.

Background technology

Raising along with people's living standard, obesity and hyperlipidemia crowd enlarge, with 40 years old was the boundary, obesity and hyperlipidemia are with sending out disease among the young and middle-aged patient, because muscle power is healthy and strong, other complication morbidity is light, only influence live and work, but young and middle-aged patient treatment is particularly important, be to avoid obesity and hyperlipidemia, and fail owing to health in the middle-older patient that organ pipe is aging to over-drastic optimal period of person in middle and old age's phase, obesity and hyperlipidemia are to the coronary heart disease of associated, hypertension, cerebrovascular sclerosis, cerebral thrombosis, cerebral ischemia and diabetes development, cause complication to be gathered, have a strong impact on patient's quality of life and quality of life, but at present to the medicine of adolescent patient based on chemicals, as dextro-amphetamine, the stupid propylamine of fluorine etc. are because this class medicine can produce nervousness to the patient, insomnia is uneasy, xerostomia, frequent micturition, side effect such as abdominal discomfort, and Chinese patent medicine is based on the double complication of controlling, the prescription medicine is numerous, and young and middle-aged patient is difficult for accepting.Face obesity and hyperlipidemia crowd market widely, health product such as the diet tea of low curative effect, fat-reducing confection, fat-reducing milk are full of market again, and young and middle-aged patient crowd is growing on and on, development along with domestic aging, young and middle-aged obesity, hyperlipemia become the development source of person in middle and old age's cardiovascular and cerebrovascular disease again, in order to ensure fitness-for-all, domestic drug market is badly in need of that production cost is low, dosage form good, convenient oral, Chinese patent medicine new product that curative effect is outstanding.

Summary of the invention

The objective of the invention is: provide scientific formulation, medication refine, monarch compatibility proper for serious phlegm-damp obesity and hyperlipidemia patient, the pure Chinese medicinal preparation that complementary action significantly, production cost is cheap again, have transforming phlegm and dispersing accumulations, lowering blood-fat and reducing weight effect, can realize fat-reducing and blood fat reducing effectively, the patient is got well.

To achieve these goals, the technical solution adopted in the present invention is: blood fat-decreasing weight-reducing kaladana capsule is according to the main etiology and pathogenesis of phlegm-damp obesity and hyperlipemia, with transforming phlegm and dispersing accumulations, lowering blood-fat and reducing weight is principle of treatment, the crude drug total amount is 740 grams in the prescription, is made up of Semen Pharbitidis 120 grams, Folium Sennae 100 grams, Rhizoma Alismatis 100 grams, the Rhizoma Atractylodis Macrocephalae 100 grams, Semen Cassiae 100 grams, Fructus Crataegi 110 grams, Radix Polygoni Multiflori 110 grams.The preparation technology of blood fat-decreasing weight-reducing kaladana capsule is divided into 2 flavor Chinese crude drug powder process, 5 flavor Chinese crude drugs decoct, mixing and grain-making dress capsule three road technologies, getting Semen Pharbitidis and Semen Cassiae earlier dries below 80 ℃ and pulverized 80 mesh sieves and become the fine powder medicine standby, get Rhizoma Alismatis again, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi, Radix Polygoni Multiflori four flavor Chinese crude drugs add 8 times of water gagings and decocted 1.5 hours, filter, medicinal residues and Folium Sennae are added 6 times of water gagings decoctions 1 hour again, filter the back and merge twice filtrate, being evaporated to relative density is the thick paste of 1.25-1.30 (80 ℃ of surveys), at last thick paste and standby fine powder medicine are mixed thoroughly and made soft material, crossing 14 mesh sieves granulates, below 80 ℃ the oven dry, the capsule of packing into No. 1, every capsules pack into 0.3 restrain patent medicine.Chinese medicine thinks that obesity claims obesity again, be because due to the body fat mass in human body overheap, clinical manifestation is stopped up the long-pending the most common pattern of syndrome that is with phlegm-damp, hyperlipemia claims hyperlipoproteinemia again, at aspects such as etiology and pathogenesis and clinical manifestations, closely related with obesity, reciprocal causation, Chinese medical discrimination belongs to " phlegm-damp ", " turbid resistance " more, and it also is main pathogenesis of hyperlipemia and modal pattern of syndrome that phlegm-damp is stopped up long-pending.In blood fat-decreasing weight-reducing kaladana capsule, the relieving constipation of Semen Pharbitidis diuretic, eliminate the phlegm by drink, eliminating stagnated food and killing intestinal worms, cure mainly expectorant stop up breath with cough, edema, ascites, constipation, dyspepsia malnutrition due to parasitic infestation; Folium Sennae profit intestinal internal organs, logical stool, removing food stagnancy food cure mainly bloated, the dryness of the intestine constipation of the fertile breast of body; The Rhizoma Alismatis promoting diuresis to eliminate damp pathogen, expel the heat-evil treating strangurialy, cure mainly dysuria, edema distension, dizziness due to fluid-retention; Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, dampness diuretic cure mainly deficiency-weakness of spleen-QI, spiritlessness and weakness, lack of appetite abdominal distention, secret, the dizziness due to fluid-retention in big loose stool; Semen Cassiae liver heat removing kidney tonifying, diuretic relieving constipation cure mainly dysuria, habitual constipation; Radix Polygoni Multiflori nourishing the blood and yin, loosening bowel to relieve constipation cure mainly blood deficiency Light-headedness, dryness of the intestine constipation.In prescription, the Semen Pharbitidis removing food stagnancy that eliminates the phlegm is a monarch drug, Folium Sennae Li Changfu, logical stool, assistance Semen Pharbitidis removing food stagnancy are ministerial drug, Rhizoma Alismatis, Semen Cassiae, Antilipemic haw is lost weight is adjuvant drug, Rhizoma Atractylodis Macrocephalae spleen invigorating, Radix Polygoni Multiflori kidney tonifying are messenger drug altogether, the merit that the many medicines of rate are played transforming phlegm and dispersing accumulations, lowering blood-fat and reducing weight altogether, effectively treatment of obesity and hyperlipidemia.Modern Chinese medicine research confirms: the contained pharbitin of Semen Pharbitidis has intensive discharge function, pharbitin meets bile in intestinal and intestinal juice decomposites the Semen Pharbitidis element, can stimulate intestinal, promotes wriggling, causes rushing down down, can quicken inulin and in kidney, discharge, diuresis is arranged; Alkaloid has the effect that stimulating intestine and stomach strengthens gastric secretion and enterokinesia in the Folium Sennae, can strengthen the excretion of cholesterol in the liver sausage circulation, reduces the synthetic of body inner cholesterol and triglyceride; The Rhizoma Alismatis water decoction has antiobesity action, can reduce fat index and serum triglycerides content around the Lee exponential quantity of obese rat and uterus and the testis; The merit of Rhizoma Atractylodis Macrocephalae dehumidifying has antiperspirant then to end for winning, and losslessly then sends out, and the deficiency-phlegm that can disappear has function of gallbladder promoting, diuresis; Semen Cassiae is high density lipoprotein increasing content obviously, improves the distribution situation of body inner cholesterol, has the function that reduces total egg sterin and triglyceride, has blood fat reducing, cathartic and diuresis; Fructus Crataegi extract is oral to make lecithin ratio raising in the atherosis blood of animal, and cholesterol and the lipid deposition on organ pipe is reduced, and has remarkable effect for reducing fat and diuresis; Radix Polygoni Multiflori can make the hypercholesterolemia in the blood be dropped rapidly to normal level, has the effect that suppresses endarterium speckle formation and lipidosis, prevents atherosclerosis generation and development, can prevent and treat hyperlipemia from multipaths such as the absorption of cholesterol, metabolism, many each effective ingredient complementations of medicine, treatment of obesity and hyperlipidemia effectively improve quality of life of patient.Blood fat-decreasing weight-reducing kaladana capsule preparation technology only adds many medicine thick pastes by the fine powder medicine and directly mixes soft material granulation dress capsule, and preparation technology is easy, low production cost.

Blood fat-decreasing weight-reducing kaladana capsule cures mainly relevant Pharmacodynamic test of active extract with function and confirms in preclinical study: blood fat-decreasing weight-reducing kaladana capsule can obviously suppress rat body weight and increase, obviously influence the obese degree of fat model, and certain dose dependent is arranged, the whole blood viscosity of hyperlipemia fat disease rat is had significant down regulation; Recommend clinical medication every day 1.8-3.0 gram; Oral; 6 weeks were a course of treatment.

The invention has the beneficial effects as follows: prescription thinking novelty, the refining of prescription YAOJING, monarch compatibility science, preparation technology is easy, and low production cost is by the effective ingredient complementation, can bring into play transforming phlegm and dispersing accumulations, functions of lowering blood-fat and reducing weight, effectively treatment of obesity and hyperlipidemia.

Specific embodiments

1, blood fat-decreasing weight-reducing kaladana capsule is made up of seven flavor Chinese herbal medicine, wherein Semen Pharbitidis 120 restrains, Folium Sennae 100 restrains, Rhizoma Alismatis 100 restrains, the Rhizoma Atractylodis Macrocephalae 100 restrains, Semen Cassiae 100 restrains, Fructus Crataegi 110 restrains, Radix Polygoni Multiflori 110 restrains, get crude drug respectively by existing tcm and herbal slice standard before the preparation, the weighing of remove impurity well sifted is standby.

2, blood fat-decreasing weight-reducing kaladana capsule preparation technology: get Semen Pharbitidis and Semen Cassiae and dry below 80 ℃ and pulverized 80 mesh sieves and become the fine powder medicine standby, get Rhizoma Alismatis, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi, Radix Polygoni Multiflori 5 flavor Chinese crude drugs add 8 times of water gagings and decocted 1.5 hours, the cooling after-filtration, get filtrate for later use, again filtering residue and Folium Sennae are added 6 times of water gagings decoctions cooling in 1 hour after-filtration, merge twice decocting liquid and be evaporated to the thick paste of relative density 1.25-1.30 (80 ℃ of surveys), thick paste and fine powder medicine fully mixed thoroughly make soft material, crossing 14 mesh sieves granulates, oven dry below 80 ℃, 1000 capsules of packing into (0.3 gram) promptly get patent medicine.

Claims (2)

1, a kind of blood fat-decreasing weight-reducing kaladana capsule, spring feature are that the crude drug total amount is 740 grams in the original formulation, are made up of Semen Pharbitidis 120 grams, Folium Sennae 100 grams, Rhizoma Alismatis 100 grams, the Rhizoma Atractylodis Macrocephalae 100 grams, Semen Cassiae 100 grams, Fructus Crataegi 110 grams, Radix Polygoni Multiflori 110 grams.

2, the preparation technology of blood fat-decreasing weight-reducing kaladana capsule according to claim 1, it is characterized in that: get Semen Pharbitidis and Semen Cassiae earlier and dry below 80 ℃ and pulverized 80 mesh sieves and become the fine powder medicine standby, get Rhizoma Alismatis again, the Rhizoma Atractylodis Macrocephalae, Fructus Crataegi, Radix Polygoni Multiflori four flavor Chinese crude drugs add 8 times of water gagings and decocted 1.5 hours, filter, medicinal residues and Folium Sennae are added 6 times of water gagings decoctions 1 hour again, filter the back and merge twice filtrate, being evaporated to relative density is the thick paste of 1.25-1.30 (80 ℃ of surveys), at last thick paste and standby fine powder medicine are mixed thoroughly and made soft material, crossing 14 mesh sieves granulates, below 80 ℃ the oven dry, the capsule of packing into No. 1, every capsules pack into 0.3 restrain patent medicine.