CN1662645B - 神经细胞的制备方法 - Google Patents
神经细胞的制备方法 Download PDFInfo
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- CN1662645B CN1662645B CN038149354A CN03814935A CN1662645B CN 1662645 B CN1662645 B CN 1662645B CN 038149354 A CN038149354 A CN 038149354A CN 03814935 A CN03814935 A CN 03814935A CN 1662645 B CN1662645 B CN 1662645B
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/44—Thiols, e.g. mercaptoethanol
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Developmental Biology & Embryology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP182386/2002 | 2002-06-24 | ||
| JP2002182386 | 2002-06-24 | ||
| PCT/JP2003/007906 WO2004007700A1 (ja) | 2002-06-24 | 2003-06-23 | 神経系細胞の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1662645A CN1662645A (zh) | 2005-08-31 |
| CN1662645B true CN1662645B (zh) | 2013-06-12 |
Family
ID=30112242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN038149354A Expired - Fee Related CN1662645B (zh) | 2002-06-24 | 2003-06-23 | 神经细胞的制备方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8492145B2 (https=) |
| EP (1) | EP1516926A4 (https=) |
| JP (1) | JP4439396B2 (https=) |
| KR (1) | KR100846643B1 (https=) |
| CN (1) | CN1662645B (https=) |
| AU (1) | AU2003246176B2 (https=) |
| CA (1) | CA2489206C (https=) |
| IL (2) | IL165772A0 (https=) |
| TW (1) | TW200411058A (https=) |
| WO (1) | WO2004007700A1 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060183221A1 (en) * | 2003-03-31 | 2006-08-17 | Schulz Thomas C | Method for neural differentiation of embryonic stem cells using protease passaging techniques |
| WO2004099395A2 (en) * | 2003-05-08 | 2004-11-18 | Cellartis Ab | A method for the generation of neural progenitor cells |
| US7820439B2 (en) * | 2003-09-03 | 2010-10-26 | Reliance Life Sciences Pvt Ltd. | In vitro generation of GABAergic neurons from pluripotent stem cells |
| JP4481706B2 (ja) * | 2004-03-31 | 2010-06-16 | 独立行政法人科学技術振興機構 | 脳梗塞疾患モデルマウス |
| TW200617165A (en) * | 2004-09-06 | 2006-06-01 | Tanabe Seiyaku Co | Process for preparing a conditioned medium of astrocyte-like cells |
| US7803364B2 (en) | 2005-11-17 | 2010-09-28 | The Cleveland Clinic Foundation | Multipotent neural stem cells |
| JP5279491B2 (ja) * | 2006-05-19 | 2013-09-04 | 愛知県 | 脳損傷改善剤 |
| DE102006060247A1 (de) * | 2006-09-15 | 2008-03-27 | Ossacur Ag | Differenzierung von Stammzellen |
| WO2008066630A2 (en) * | 2006-10-27 | 2008-06-05 | Caritas St. Elizabeth Medical Center Of Boston, Inc. | Methods for reprogramming adult somatic cells and uses thereof |
| US8338176B2 (en) * | 2007-07-30 | 2012-12-25 | The Board Of Trustees Of The Leland Stanford Junior University | Derivation of neural stem cells from embryonic stem cells |
| DE102007036334A1 (de) * | 2007-08-02 | 2009-02-05 | Electrolux Home Products Corporation N.V. | Basiseinheit zum induktiven Aufheizen und Induktionsflüssigkeitserhitzungssystem |
| US20100021437A1 (en) * | 2008-04-07 | 2010-01-28 | The McLean Hospital Corporation Whitehead Institute for Biomedical Research | Neural stem cells derived from induced pluripotent stem cells |
| GB2460552B (en) * | 2008-06-05 | 2011-09-07 | Iti Scotland Ltd | Stem cell culture media and methods |
| JP5734595B2 (ja) * | 2010-08-03 | 2015-06-17 | オリンパス株式会社 | コロニーの特性評価方法 |
| BR112013003031A2 (pt) * | 2010-08-19 | 2016-06-14 | Hoffmann La Roche | método de produção de células hastes neurais (chn), células hastes neurais e seu uso, composição terapêutica e banco biológico de nscs |
| KR101226702B1 (ko) * | 2010-10-08 | 2013-01-25 | 충북대학교 산학협력단 | 인간 콜린 아세틸트랜스퍼라아제를 발현하는 인간 신경줄기세포 및 이의 용도 |
| TWI488641B (zh) * | 2010-12-13 | 2015-06-21 | 生化學工業股份有限公司 | 椎間盤突出治療劑 |
| KR20140121317A (ko) * | 2013-04-06 | 2014-10-15 | 서울대학교산학협력단 | 비신경 세포로부터 유도 신경 줄기 세포의 생산 방법 및 이에 의하여 생산되는 유도 신경 줄기 세포 |
| CN103305466B (zh) * | 2013-06-09 | 2015-02-11 | 吉林省拓华生物科技有限公司 | 一种保持高细胞活率的神经干细胞的培养方法 |
| ES2972541T3 (es) * | 2014-09-08 | 2024-06-13 | Riken | Método para producir tejido progenitor cerebeloso |
| CN104673752A (zh) * | 2015-03-14 | 2015-06-03 | 李�根 | 一种人脑干细胞库构建方法 |
| WO2018107135A1 (en) * | 2016-12-09 | 2018-06-14 | Neoneuron Llc | Method of treating neurological disorders with stem cell therapy |
| CN106924286A (zh) * | 2017-02-16 | 2017-07-07 | 上海安集协康生物技术股份有限公司 | 一种经鼻腔给药用于帕金森病治疗的神经干细胞制剂 |
| JP2024523361A (ja) | 2021-06-17 | 2024-06-28 | キュー-ステート バイオサイエンシーズ, インコーポレイテッド | 神経細胞を生産するための方法 |
| EP4355862A4 (en) * | 2021-06-18 | 2025-08-06 | Texas A & M Univ Sys | METHODS OF PROCESSING ADULT NEURAL CELLS FROM MAMMALS AND THEIR DOSAGES |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981165A (en) * | 1991-07-08 | 1999-11-09 | Neurospheres Holdings Ltd. | In vitro induction of dopaminergic cells |
| CA2403000C (en) * | 2000-03-14 | 2015-06-23 | Es Cell International Pte Ltd | Embryonic stem cells and neural progenitor cells derived therefrom |
| WO2004081172A2 (en) * | 2003-03-12 | 2004-09-23 | Reliance Life Sciences Pvt. Ltd. | Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells |
-
2003
- 2003-06-23 EP EP03738499A patent/EP1516926A4/en not_active Withdrawn
- 2003-06-23 AU AU2003246176A patent/AU2003246176B2/en not_active Ceased
- 2003-06-23 CN CN038149354A patent/CN1662645B/zh not_active Expired - Fee Related
- 2003-06-23 IL IL16577203A patent/IL165772A0/xx unknown
- 2003-06-23 WO PCT/JP2003/007906 patent/WO2004007700A1/ja not_active Ceased
- 2003-06-23 US US10/518,749 patent/US8492145B2/en not_active Expired - Fee Related
- 2003-06-23 JP JP2004521136A patent/JP4439396B2/ja not_active Expired - Fee Related
- 2003-06-23 CA CA2489206A patent/CA2489206C/en not_active Expired - Fee Related
- 2003-06-23 KR KR1020047021075A patent/KR100846643B1/ko not_active Expired - Fee Related
- 2003-06-24 TW TW092117117A patent/TW200411058A/zh not_active IP Right Cessation
-
2004
- 2004-12-14 IL IL165772A patent/IL165772A/en not_active IP Right Cessation
Non-Patent Citations (10)
| Title |
|---|
| Kawasaki,H.,er al..Induction of midbrain dopaminergic neurons from ES cells bystromal cell-derived inducing activity..Neuron28 1.2000,第31-33页左手栏,第35页-36页. |
| Kawasaki,H.,er al..Induction of midbrain dopaminergic neurons from ES cells bystromal cell-derived inducing activity..Neuron28 1.2000,第31-33页左手栏,第35页-36页. * |
| Pataky,DM,et al..Fibroblast growth factor treatment produces differential effects on survival and neurite outgrowth from identified bulbospinal neurons in vitro..Exp. Neurol.163 2.2000,357-372. |
| Pataky,DM,et al..Fibroblast growth factor treatment produces differential effects on survival and neurite outgrowth from identified bulbospinal neurons in vitro..Exp. Neurol.163 2.2000,357-372. * |
| Rousselet,A, et al..In vitro regulation of neuronal morphogenesis and polarity by astrocyte-derived factors..Dev. Biol.137 1.1990,33-45. |
| Rousselet,A, et al..In vitro regulation of neuronal morphogenesis and polarity by astrocyte-derived factors..Dev. Biol.137 1.1990,33-45. * |
| Yoshida,M.,et al..Neurotrophic effects of conditioned media of astrocytes isolated from different brain regions on hippocampal and cortical neurons..Experientia51 2.1995,133-136. |
| Yoshida,M.,et al..Neurotrophic effects of conditioned media of astrocytes isolated from different brain regions on hippocampal and cortical neurons..Experientia51 2.1995,133-136. * |
| Zhang,SC.,et al..In vitro differentiation of transplantable neural precursors from human embryonic stem cells..Nat. Biotechnol.19 12.2001,第1129-1132页. |
| Zhang,SC.,et al..In vitro differentiation of transplantable neural precursors from human embryonic stem cells..Nat. Biotechnol.19 12.2001,第1129-1132页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| IL165772A (en) | 2012-05-31 |
| TWI309678B (https=) | 2009-05-11 |
| CN1662645A (zh) | 2005-08-31 |
| AU2003246176A1 (en) | 2004-02-02 |
| JPWO2004007700A1 (ja) | 2005-11-10 |
| US8492145B2 (en) | 2013-07-23 |
| WO2004007700A1 (ja) | 2004-01-22 |
| US20050221479A1 (en) | 2005-10-06 |
| TW200411058A (en) | 2004-07-01 |
| CA2489206C (en) | 2012-08-07 |
| KR20050016636A (ko) | 2005-02-21 |
| JP4439396B2 (ja) | 2010-03-24 |
| HK1079812A1 (en) | 2006-04-13 |
| CA2489206A1 (en) | 2004-01-22 |
| EP1516926A4 (en) | 2006-10-11 |
| KR100846643B1 (ko) | 2008-07-16 |
| IL165772A0 (en) | 2006-01-15 |
| EP1516926A1 (en) | 2005-03-23 |
| AU2003246176B2 (en) | 2006-09-07 |
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