CN1653068A - 新的二氮杂双环联芳基衍生物 - Google Patents

新的二氮杂双环联芳基衍生物 Download PDF

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Publication number
CN1653068A
CN1653068A CNA03810198XA CN03810198A CN1653068A CN 1653068 A CN1653068 A CN 1653068A CN A03810198X A CNA03810198X A CN A03810198XA CN 03810198 A CN03810198 A CN 03810198A CN 1653068 A CN1653068 A CN 1653068A
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group
alkyl
cycloalkyl
biaryl derivatives
monocyclic heterocycles
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Chinese (zh)
Inventor
D·彼得斯
G·M·奥尔森
E·O·尼尔森
T·D·约金森
P·K·阿林格
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NTG Nordic Transport Group AS
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Neurosearch AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/00—Drugs for immunological or allergic disorders
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    • A—HUMAN NECESSITIES
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    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNA03810198XA 2002-05-07 2003-05-06 新的二氮杂双环联芳基衍生物 Pending CN1653068A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DKPA200200692 2002-05-07
DKPA200200692 2002-05-07
DKPA200201739 2002-11-11
DKPA200201739 2002-11-11

Publications (1)

Publication Number Publication Date
CN1653068A true CN1653068A (zh) 2005-08-10

Family

ID=29421783

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA03810198XA Pending CN1653068A (zh) 2002-05-07 2003-05-06 新的二氮杂双环联芳基衍生物

Country Status (12)

Country Link
US (1) US7300933B2 (https=)
EP (1) EP1506200B1 (https=)
JP (1) JP2005524713A (https=)
CN (1) CN1653068A (https=)
AT (1) ATE348831T1 (https=)
AU (1) AU2003223927B2 (https=)
CA (1) CA2480488A1 (https=)
DE (1) DE60310548T2 (https=)
DK (1) DK1506200T3 (https=)
MX (1) MXPA04010966A (https=)
NZ (1) NZ535642A (https=)
WO (1) WO2003094831A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102648202A (zh) * 2009-12-07 2012-08-22 塔加西普特公司 作为神经元烟碱乙酰胆碱受体配体的3,6-二氮杂双环[3.1.1]庚烷
CN102816165A (zh) * 2005-09-23 2012-12-12 雅培制药有限公司 氨基-氮杂-金刚烷衍生物和使用方法
CN104936955A (zh) * 2013-01-23 2015-09-23 诺华股份有限公司 噻二唑类似物以及治疗与smn缺乏相关的病症的方法

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DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
US20050065178A1 (en) * 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives
US7399765B2 (en) 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
TW200534855A (en) * 2004-01-13 2005-11-01 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
US7582631B2 (en) * 2004-01-14 2009-09-01 Amgen Inc. Substituted heterocyclic compounds and methods of use
US20090253908A1 (en) * 2004-03-11 2009-10-08 Glaxo Group Limited Novel m3 muscarinic acetylchoine receptor antagonists
EP1725238A4 (en) * 2004-03-17 2009-04-01 Glaxo Group Ltd M 3 MUSCARINACETYLCHOLINE RECEPTOR ANTAGONISTS
EA012181B1 (ru) 2004-10-18 2009-08-28 Амген, Инк. Соединения тиадиазола и их применение
WO2006087306A2 (en) * 2005-02-16 2006-08-24 Neurosearch A/S Diazabicyclic aryl derivatives and their use as cholinergic ligands at the nicotinic acetylcholine receptors
DE602006019561D1 (de) 2005-02-16 2011-02-24 Neurosearch As Diazabicyclische arylderivate und ihre verwendung als chinolinergische liganden an nikotin-acetylcholin-rezeptoren
ATE481407T1 (de) 2005-02-16 2010-10-15 Neurosearch As Neue diazabicyclische arylderivate und medizinische verwendung dafür
CA2632642A1 (en) 2005-12-06 2007-06-14 Neurosearch A/S Novel diazabicyclic aryl derivatives and their medical use
JO3019B1 (ar) 2006-04-19 2016-09-05 Janssen Pharmaceutica Nv ثلاثي مستبدل 4،2،1-ثلاثي زولات
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US7897619B2 (en) 2007-07-17 2011-03-01 Amgen Inc. Heterocyclic modulators of PKB
AU2008276512A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of PKB
JP2011500625A (ja) 2007-10-18 2011-01-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ トリ置換された１，２，４−トリアゾール
JO2784B1 (en) * 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
AR070936A1 (es) 2008-03-19 2010-05-12 Janssen Pharmaceutica Nv 1,2,4 -triazoles trisustituidos
JP5486591B2 (ja) 2008-05-09 2014-05-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ アセチルコリン受容体モジュレーターとしての三置換ピラゾール
AR081402A1 (es) 2010-05-17 2012-08-29 Envivo Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato
CN103180321A (zh) 2010-09-23 2013-06-26 Abbvie公司 氮杂金刚烷衍生物的一水合物
CA2872005A1 (en) 2012-05-08 2013-11-14 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
TWI553941B (zh) * 2013-10-29 2016-10-11 Ｌｇ化學股份有限公司 凝膠聚合物電解質以及含有該電解質之鋰二次電池

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
US5478939A (en) 1994-07-20 1995-12-26 American Cyanamid Company (R,R) and (S,S) 2,5-diazabicyclo [2,2,1]heptane derivatives
FR2786769B1 (fr) * 1998-12-04 2002-10-25 Synthelabo Derives de 2,5-diazabicyclo[2.2.1]heptane, leur preparation et leur application en therapeutique
TR200102162T2 (tr) 1999-01-29 2001-12-21 Abbott Laboratories Nikotinik asetilkolin reseptör ligandları olarak diazabisiklik türevler.
JP2003534344A (ja) * 2000-05-25 2003-11-18 ターガセプト，インコーポレイテッド ニコチン性コリン受容体リガンドとしてのヘテロアリールジアザビシクロアルカン

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102816165A (zh) * 2005-09-23 2012-12-12 雅培制药有限公司 氨基-氮杂-金刚烷衍生物和使用方法
CN102648202A (zh) * 2009-12-07 2012-08-22 塔加西普特公司 作为神经元烟碱乙酰胆碱受体配体的3,6-二氮杂双环[3.1.1]庚烷
CN104936955A (zh) * 2013-01-23 2015-09-23 诺华股份有限公司 噻二唑类似物以及治疗与smn缺乏相关的病症的方法
CN104936955B (zh) * 2013-01-23 2018-08-28 诺华股份有限公司 噻二唑类似物以及治疗与smn缺乏相关的病症的方法

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AU2003223927A1 (en) 2003-11-11
WO2003094831A2 (en) 2003-11-20
EP1506200A2 (en) 2005-02-16
AU2003223927B2 (en) 2009-12-17
EP1506200B1 (en) 2006-12-20
US20050131236A1 (en) 2005-06-16
JP2005524713A (ja) 2005-08-18
US7300933B2 (en) 2007-11-27
ATE348831T1 (de) 2007-01-15
DK1506200T3 (da) 2007-04-10
DE60310548D1 (de) 2007-02-01
MXPA04010966A (es) 2005-01-25
WO2003094831A3 (en) 2004-01-15
CA2480488A1 (en) 2003-11-20
DE60310548T2 (de) 2007-05-10
NZ535642A (en) 2006-10-27

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