CN1650911A - Compound gingko chewing gun, lozenge, chewing tablet and its manufacutring method - Google Patents
Compound gingko chewing gun, lozenge, chewing tablet and its manufacutring method Download PDFInfo
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- CN1650911A CN1650911A CN 200410016069 CN200410016069A CN1650911A CN 1650911 A CN1650911 A CN 1650911A CN 200410016069 CN200410016069 CN 200410016069 CN 200410016069 A CN200410016069 A CN 200410016069A CN 1650911 A CN1650911 A CN 1650911A
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Abstract
A health-care food in the form of chewing gum, buccal lozenge, or chewing tablet for softening blood vessel, regulating blood fat, preventing atherosclerosis and cardiovascular and cerebrovascular diseases and delaying senility is prepared from gingko extract, resveratrol, VE, VE, taurine, flavouring, and gum, magnesium stearate plus calcium lactate, or milk powder plus magnesium stearate plus beta-cycodextrin.
Description
The present invention relates to be used for compound ginkgo chewing gum, buccal tablet, chewable tablet of cardiovascular and cerebrovascular disease health care and preparation method thereof.
At present China's aging population are just with annual 3% speed increment, cause the M ﹠ M of all kinds of Senile disease such as coronary heart disease, atherosclerosis, hypertension, apoplexy etc. also to increase year by year, cardiovascular and cerebrovascular disease has become first killer who threatens human life's health thereupon.Along with growth in the living standard, people more and more pay attention to the raising of quality of life, especially have the control of the disease of serious harm to be enhanced considerable position to various.
Ginkgo another name maidenhair tree, Gong Sunshu, duck's foot tree.China is the abundantest country of gingko resource, and its place of production mainly is distributed in ground such as Xingan, Guangxi, Suizhou, Hubei, Pizhou City, Jiangsu and Taixing, Tancheng, Shandong, Anhua, Hunan and Sichuan, and output accounts for 70% of Gross World Product.The Folium Ginkgo main component is terpenoid and flavone compound, and wherein terpenoid is ginkalide A, B, C, M, J (ginkgolide A, B, C, M, J) and bilobalide (bilobalide); Flavone compound is bilobetin (bilobetin), Quercetin (quercetin), isorhamnetin (isohamnotin), Rhizoma Kaempferiae flavin (kaempfreol), Semen Ginkgo foline (ginkgetin) and different Semen Ginkgo foline (isoginkgetin)., promptly on the books in Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica at China's Folium Ginkgo as medicinal existing several thousand history, and recorded by the Pharmacopoeia of the People's Republic of China in 1977 version (an one).The effect of Folium Ginkgo for astringe the lung, relieving asthma, pain relieving, clearing away heat-damp and promoting diuresis, be mainly used in the disease of aspects such as the treatment heart, brain, blood vessel, respiratory tract clinically, evident in efficacy.Dosage forms such as oral liquid, tablet, capsule, electuary and injection have now been developed.In recent years, some countries as Germany, France are also own as medicinal in Europe, then are used for health food in the U.S. and Japan.
Flavone compound in the Folium Ginkgo is to coronary heart disease, anginal good efficacy, with blood fat reducing, improve hemorheology, reduce LPO, to improve the SOD vigor relevant; It can the diastole coronary artery, improve blood circulation, reduce myocardial oxygen consumption, reduce effects such as flow of calcium ions, anticoagulant, reaches the purpose of protection cardiovascular system.The effective ingredient bilobalide of Folium Ginkgo is the natural paf receptor antagonists of clinical practice most worthy so far.PAF is a kind of endogenous phospholipid that is produced by platelet and multiple inflammation tissue secretion, it with the generation of numerous disease, develop closely related.Along with to gingko leaf preparation research progressively deeply and the continuous accumulation of clinical experience, it can be applied even more extensively in the treatment various diseases, be a kind of medicinal plants of very promising and value.China is the main place of production of ginkgo, and we are its resource of digging utilization fully, allows it be that the medicine of China people's health and China goes to the world and makes bigger contribution.
Resveratrol is a kind of phytoalexin that vitis spp produces under ultraviolet radiation, have effects such as antibiotic, antiinflammatory, antioxidation, antimutagenic, and can promote the circulation of blood, reduce the blood vessel wall deposit, platelet function is kept in help, reduce hematoblastic viscosity, make blood, the prevention cardiovascular and cerebrovascular disease is highly profitable smoothly by blood vessel.Also can play the atherosis effect of prevention of arterial by the cholesterol oxidation that prevents low density lipoprotein, LDL in the blood.Current research finds that it also has the effect of very strong anti-curing cancers, and its effect is given extensive concern by international medical facility, and carries out clinical research and experiment.In recent years, people found also that resveratrol has the active effect of the human body SOD of promotion, was proved to be a kind of potential defying age medicinal component.
Vitamin C and vitamin E all are powerful antioxidants, and fabulous free radical scavenger can be protected biomembrane to avoid free radical and attack; effective anti-senility nutrient, pre-fat cardiovascular diseases, and energy human body immunity improving power; one is water solublity, and one is fat-soluble, and both complement one another.Taurine is a kind of free non-protein amino acid, has to keep myocardial function, improve liver function, reduce cholesterol in the blood, suppress effect such as increased blood pressure, and helps and set up.
So far, China does not see that as yet the food such as the relevant buccal tablet of Semen Ginkgo, chewing gum, chewable tablet of tool cardiovascular and cerebrovascular disease health care appear on the market.
The objective of the invention is to utilize the gingko resource of China's preciousness, develop carry, compound ginkgo chewing gum, buccal tablet and chewable tablet product that taking convenience, through port transmucosal and digestive system absorb, have remarkable cardiovascular health function.
For achieving the above object, the technical scheme taked of the present invention is:
Each goods major ingredient is Semen Ginkgo (leaf) extract, resveratrol, vitamin C, vitamin E, taurine and correctives etc.Major ingredient is added magnesium stearate, calcium lactate etc. make buccal tablet; Major ingredient adds gum base etc. and makes chewing gum; Major ingredient is made chewable tablet with milk powder, magnesium stearate, beta-schardinger dextrin-etc.
The concrete prescription of major ingredient is: Semen Ginkgo (leaf) extract 0.5-50%; resveratrol 0.1-20%; vitamin C 0.2-40%; vitamin E 0.1-20%, taurine 1-50%, oligomeric isomaltose 10-80%; oligofructose 5-50%; citric acid 0.2-0.4%, spice 0.5-1.0%, starch 5-30%.
Add adjuvant magnesium stearate 0.5-1.0%, calcium lactate 5-10% and make the compound ginkgo buccal tablet, add adjuvant gum base 20-30% and make the compound ginkgo chewing gum, add adjuvant milk powder 10-20%, magnesium stearate 0.5-1.0%, beta-schardinger dextrin-5-10% makes the compound ginkgo chewable tablet.
According to the taste needs, the spice in the prescription can be selected fruit type spice and mint type flavor at the same time or separately for use.
Semen Ginkgo (leaf) extract that the present invention is used is with Semen Ginkgo (leaf) extract particles behind Semen Ginkgo (leaf) extract dry of usual method extraction, this Semen Ginkgo extrac content of total flavonol glycosides 〉=24%, and lactone content answers 〉=6%.
Its manufacture method is:
Compound ginkgo buccal tablet: compound ginkgo buccal tablet main ingredient is pulverized; cross 100～200 mesh sieves; adopt the abundant mixing of stepwise dilution method, put into 80 ℃ of baking oven batch (-type) sterilizations, make even granule by granulator; 35～45 ℃ dry down; go up tablet machine again, make the sheet type of regulation, reject irregular type; last packer is finished product after the packing.
The compound ginkgo chewing gum: above-mentioned amount major ingredient is pulverized, crossed 100～200 mesh sieves, adopt the abundant mixing of stepwise dilution method, standby; 60 ℃ of heating of above-mentioned amount gum base were softened in 20～30 minutes, keep 60 ℃, add the mixing major ingredient, stir; Take out the mixing material, bulk is cut in compression moulding under the room temperature, is finished product after the packing.
Compound ginkgo chewable tablet: compound ginkgo chewable tablet main ingredient is pulverized; cross 100～200 mesh sieves; adopt the abundant mixing of stepwise dilution method, put into 80 ℃ of baking oven batch (-type) sterilizations, make even granule by granulator; 35～45 ℃ dry down; go up tablet machine again, make the sheet type of regulation, reject irregular type; last packer is finished product after the packing.
Characteristics of the present invention are functions such as compound ginkgo buccal tablet, chewing gum, chewable tablet all have blood lipid regulation, prevent atherosclerosis, protection cardiovascular and cerebrovascular vessel, and carry, taking convenience, main through port transmucosal absorbs, and is the new type of health leisure food.It is edible to be fit to more than 35 years old middle-aged and elderly people, owing to do not contain sugar, also is suitable for patients with diabetes mellitus.
Embodiment 1:
A kind of compound ginkgo buccal tablet; the disposable 100kg that feeds intake; wherein: commercially available Folium Ginkgo extract 6kg; resveratrol 0.6kg; microcapsule vitamin C 3kg; microcapsule vitamin E 2kg; taurine 15kg; oligomeric isomaltose 40kg; oligofructose 14kg; citric acid 0.2kg; fruit type spice 0.3kg; mint type flavor 0.2kg; starch 10kg; magnesium stearate 0.7kg; calcium lactate 8kg; above-mentioned material is pulverized; cross 80 mesh sieves; adopt the abundant mixing of stepwise dilution method; put into 80 ℃ of baking oven batch (-type) sterilizations; make even granule by granulator; 35～45 ℃ dry down; go up tablet machine again; make the sheet type of regulation; reject irregular type, last packer is finished product after the packing.Go out 19.9 ten thousand of finished products altogether, every 0.5g.Every contains Semen Ginkgo total flavones 〉=7.2mg, resveratrol 3mg, vitamin C 15mg, vitamin E 10mg, taurine 75mg.
Embodiment 2:
A kind of compound ginkgo chewing gum, the disposable 100kg that feeds intake, wherein: commercially available Folium Ginkgo extract 1kg, resveratrol 0.1kg, microcapsule vitamin C 0.5kg, microcapsule vitamin E 0.3kg, taurine 3kg, oligomeric isomaltose 40kg, oligofructose 10kg, citric acid 0.2kg, fruit type spice 0.3kg, mint type flavor 0.1kg, starch 20kg, above-mentioned material is pulverized, cross 150 mesh sieves, adopt the abundant mixing of stepwise dilution method; 60 ℃ of heating of 25kg gum base were softened in 20～30 minutes, keep 60 ℃, add the mixing material, stir; Take out the mixing material, bulk is cut in compression moulding under the room temperature, is finished product after the packing.Go out 3.1 ten thousand of finished products altogether, every 3g.Every contains Semen Ginkgo total flavones 〉=7.2mg, resveratrol 3mg, vitamin C 15mg, vitamin E 9mg, taurine 90mg.
Embodiment 3:
A kind of compound ginkgo chewable tablet; the disposable 100kg that feeds intake; wherein: commercially available Folium Ginkgo extract 3kg; resveratrol 0.3kg; microcapsule vitamin C 1.5kg; microcapsule vitamin E 1kg; taurine 7.5kg; oligomeric isomaltose 40kg; oligofructose 10kg; citric acid 0.2kg; fruit type spice 0.3kg; mint type flavor 0.2kg; starch 17kg; milk powder 10kg; magnesium stearate 0.7kg; beta-schardinger dextrin-8kg; above-mentioned material is pulverized; cross 80 mesh sieves; adopt the abundant mixing of stepwise dilution method; put into 80 ℃ of baking oven batch (-type) sterilizations; make even granule by granulator; 35～45 ℃ dry down; go up tablet machine again; make the sheet type of regulation; reject irregular type, last packer is finished product after the packing.Go out 9.9 ten thousand of finished products altogether, every 1g.Every contains Semen Ginkgo total flavones 〉=7.2mg, resveratrol 3mg, vitamin C 15mg, vitamin E 10mg, taurine 75mg.
Claims (9)
1. compound ginkgo buccal tablet is characterized in that in the buccal tablet that each composition and consumption (weight portion) thereof are as follows:
Major ingredient: Semen Ginkgo (leaf) extract 0.5-50%
Resveratrol 0.1-20%
Vitamin C 0.2-40%
Vitamin E 0.1-20%
Taurine 1-50%
Oligomeric isomaltose 10-80%
Oligofructose 5-50%
Citric acid 0.2-0.4%
Spice 0.5-1.0%
Starch 5-30%
Adjuvant: magnesium stearate 0.5-1.0%
Calcium lactate 5-10%
2. compound ginkgo buccal tablet according to claim 1; the manufacture method that it is characterized in that it is: above-mentioned amount main ingredient is pulverized, crossed 100～200 mesh sieves, adopt the abundant mixing of stepwise dilution method; put into 80 ℃ of baking oven batch (-type) sterilizations; make even granule by granulator, 35～45 ℃ dry down, goes up tablet machine again; make the sheet type of regulation; reject irregular type, last packer is finished product after the packing.
3. according to claim 1 and 2 described compound ginkgo buccal tablets, it is characterized in that: the spice in its prescription can adopt fruit type spice and mint type flavor.
4. compound ginkgo chewing gum is characterized in that in the chewing gum that each composition and consumption (weight portion) thereof are as follows:
Major ingredient: Semen Ginkgo (leaf) extract 0.5-50%
Resveratrol 0.1-20%
Vitamin C 0.2-40%
Vitamin E 0.1-20%
Taurine 1-50%
Oligomeric isomaltose 10-80%
Oligofructose 5-50%
Citric acid 0.2-0.4%
Spice 0.5-1.0%
Starch 5-30%
Adjuvant: gum base 20-30%
5. compound ginkgo chewing gum according to claim 4 is characterized in that its manufacture method is: above-mentioned amount major ingredient pulverized, crossed 100～200 mesh sieves, adopt the abundant mixing of stepwise dilution method, and standby; 60 ℃ of heating of above-mentioned amount gum base were softened in 20～30 minutes, keep 60 ℃, add the mixing major ingredient, stir; Take out the mixing material, bulk is cut in compression moulding under the room temperature, is finished product after the packing.
6. according to claim 4 and 5 described compound ginkgo chewing gum, it is characterized in that: the spice in its prescription can adopt fruit type spice and mint type flavor.
7. compound ginkgo chewable tablet is characterized in that in the chewable tablet that each composition and consumption (weight portion) thereof are as follows:
Major ingredient: Semen Ginkgo (leaf) extract 0.5-50%
Resveratrol 0.1-20%
Vitamin C 0.2-40%
Vitamin E 0.1-20%
Taurine 1-50%
Oligomeric isomaltose 10-80%
Oligofructose 5-50%
Citric acid 0.2-0.4%
Spice 0.5-1.0%
Starch 5-30%
Adjuvant: milk powder 10-20%
Magnesium stearate 0.5-1.0%
Beta-schardinger dextrin-5-10%
8. compound ginkgo chewable tablet according to claim 7; the manufacture method that it is characterized in that it is: above-mentioned amount main ingredient is pulverized, crossed 100～200 mesh sieves, adopt the abundant mixing of stepwise dilution method; put into 80 ℃ of baking oven batch (-type) sterilizations; make even granule by granulator, 35～45 ℃ dry down, goes up tablet machine again; make the sheet type of regulation; reject irregular type, last packer is finished product after the packing.
9. according to claim 7 and 8 described compound ginkgo chewable tablet, it is characterized in that: the spice in its prescription can adopt fruit type spice and mint type flavor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410016069 CN1650911A (en) | 2004-02-03 | 2004-02-03 | Compound gingko chewing gun, lozenge, chewing tablet and its manufacutring method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410016069 CN1650911A (en) | 2004-02-03 | 2004-02-03 | Compound gingko chewing gun, lozenge, chewing tablet and its manufacutring method |
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| CN1650911A true CN1650911A (en) | 2005-08-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200410016069 Pending CN1650911A (en) | 2004-02-03 | 2004-02-03 | Compound gingko chewing gun, lozenge, chewing tablet and its manufacutring method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101214014B (en) * | 2008-01-02 | 2011-08-10 | 南京农业大学 | Production technology of barley seedling powder and product thereof |
| CN102754729A (en) * | 2012-08-01 | 2012-10-31 | 徐州绿之野生物食品有限公司 | Chewing gum with black gingko kernel |
| CN105594972A (en) * | 2015-12-30 | 2016-05-25 | 重庆市科学技术研究院 | Gum capable of controllably releasing resveratrol and preparing method thereof |
| CN109662980A (en) * | 2018-11-29 | 2019-04-23 | 青川县农村产业技术服务中心 | The preparation method of ginkgo oral buccal tablet |
-
2004
- 2004-02-03 CN CN 200410016069 patent/CN1650911A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101214014B (en) * | 2008-01-02 | 2011-08-10 | 南京农业大学 | Production technology of barley seedling powder and product thereof |
| CN102754729A (en) * | 2012-08-01 | 2012-10-31 | 徐州绿之野生物食品有限公司 | Chewing gum with black gingko kernel |
| CN102754729B (en) * | 2012-08-01 | 2013-05-01 | 徐州绿之野生物食品有限公司 | Chewing gum with black gingko kernel |
| CN105594972A (en) * | 2015-12-30 | 2016-05-25 | 重庆市科学技术研究院 | Gum capable of controllably releasing resveratrol and preparing method thereof |
| CN109662980A (en) * | 2018-11-29 | 2019-04-23 | 青川县农村产业技术服务中心 | The preparation method of ginkgo oral buccal tablet |
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