CN1634263A - Soft capsule for nasosinusitis and its preparation - Google Patents
Soft capsule for nasosinusitis and its preparation Download PDFInfo
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- CN1634263A CN1634263A CN 200410040987 CN200410040987A CN1634263A CN 1634263 A CN1634263 A CN 1634263A CN 200410040987 CN200410040987 CN 200410040987 CN 200410040987 A CN200410040987 A CN 200410040987A CN 1634263 A CN1634263 A CN 1634263A
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- sinusitis
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- cream powder
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Abstract
The invention relates to a soft capsule for treating rhinitis and nasal sinusitis by using plant Chinese medicinal herbs including Xanthium sibiricum, flower bud of lily magnolia, honeysuckle flower, radix rubiae and wild chrysanthemum flower extractive as raw material.
Description
Technical field: the present invention relates to a kind of soft capsule for the treatment of rhinitis and sinusitis, particularly relate to a kind of vegetable Chinese herbal medicine and be the treatment rhinitis that raw material makes and the soft capsule of sinusitis.
Background technology: the nasal sinusitis sheet has heat clearing away poison, clearing the nasal passage effect effect, Main Ingredients and Appearance Fructus Xanthii, Flos Magnoliae have effects such as clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling in the side, the active ingredient of Fructus Xanthii is mainly glycoside, as strumaroside, pharmacological actions such as that these glycoside compositions have is antibiotic, antiinflammatory, dissolubility is higher in water.The active ingredient lignanoids of Flos Magnoliae, magnelin has effects such as antibiotic, antiinflammatory, antiallergic.The effective ingredient volatile oil of Flos Chrysanthemi Indici is one of main active, the resisting pathogenic microbes effect.Effective ingredient of honeysuckle volatile oil monoterpenes and sesquiterpenoids, as: the eugenol antiinflammatory is anticorrosion, and another active ingredient chlorogenic acid is an antibiotic effective ingredient.Another composition Radix Rubiae in the side, its effective ingredient rubican class, as: Rubia schumahhiaha Pritz. have antibacterial action, by above-mentioned Fructus Xanthii, and Flos Magnoliae, Flos Chrysanthemi Indici, Flos Lonicerae and Radix Rubiae are the nasal sinusitis tablet that primary raw material is made, and are mainly used in treatment chronic rhinitis and sinusitis.But tablet exist dose big (the single dose is 6～8), disintegrate slow, absorb and wait deficiency slowly, dosing a patient with makes troubles.The complicated process of preparation of tablet needs through several procedures such as granulation, tabletting, coatings.And from the indication of nasal sinusitis sheet, this medicine is used for the outbreak of sinusitis more, and nose blocks, and needs medicine bring into play the effect of curative effect to play rapidly, be the rapid relief of symptoms of patient, but the nasal sinusitis sheet can not reach the effect of rapid relief of symptoms.
Summary of the invention: the objective of the invention is to the nasal sinusitis tablet is changed system into the nasal sinusitis soft capsule,, can cover the poor taste of medicine because the sealing of soft capsule is better, increase stability of drug, guarantee curative effect, disintegrate is fast, absorption is rapid, can remedy tablet and absorb slow deficiency.Preparation of soft capsule technology is simple, compares with tablet and can reduce production costs.Therefore, we change tablet into soft capsule so that the easier absorption of medicine, and more convenient patient takes, and better guarantees curative effect.The used main medicine of the present invention still is a Fructus Xanthii, Flos Magnoliae, Flos Chrysanthemi Indici, Flos Lonicerae and Radix Rubiae.
The present invention has optimized extraction process, after extracting volatile oil in Flos Magnoliae, Flos Lonicerae, the Flos Chrysanthemi Indici with steam distillation, again with the Fructus Xanthii water boiling and extraction, wherein how main component is soluble in the ethanol, so adopt traditional alcohol precipitating method purification, the active ingredient of Radix Rubiae in the side dissolubility in ethanol is relatively good, and we adopt ethanol percolate extraction.
Concrete extract drugs technology is: Flos Magnoliae, Flos Lonicerae, Flos Chrysanthemi Indici are added 6 times of water gagings, be total to water distillation and extraction, extraction time is 4～8 hours, collect volatile oil, aqueous solution after distillation device is in addition collected, medicinal residues mix with Fructus Xanthii, add 6 times of water gagings, decoct to extract 2.5 hours, so extract secondary, the aqueous solution that merges after secondary decocting liquid, filtration, filtrate and the distillation merges, and is concentrated into relative density 1.15, and adding ethanol, to make pure content be 50% to stir, left standstill precipitate with ethanol 24～72 hours, filter, precipitation is used 50% washing with alcohol, and washing liquid is incorporated in the filtrate.Radix Rubiae is that the leaching of 70% ethanol was carried out percolation after 24 hours with 6～10 times of amount concentration, percolate and above-mentioned filtrate merge, ethanol is reclaimed in distillation, remaining solution heating is condensed into thick paste, after 60～80 ℃ of dryings, be ground into fine powder, cross the dried cream powder that 100 mesh sieves become extract, dried cream powder with the substrate that comprises Semen Maydis oil with comprise that the stabilizing agent of Macrogol 4000～10000 makes the soft capsule content of suspendible shape, is pressed into soft capsule.
Substrate except that Semen Maydis oil, also available Oleum Arachidis hypogaeae semen, one of materials such as soybean oil, Oleum Camelliae and PEG400～1000, or both or both above mixture arbitrarily arbitrarily
Stabilizing agent except that Macrogol 4000～10000, also available Cera Flava, insect wax, Macrogol 4000～10000, one of materials such as tween or both or both above mixture arbitrarily.
The weight ratio of dried cream powder and substrate is:
Dried cream powder: substrate=1: 0.5-3;
Preferred proportion is: dried cream powder: substrate=1: 1
The weight of stabilizing agent account for total dried cream powder and substrate weight and 1～5%, preferred proportion is 3%.
Preparation method of the present invention is the dried cream powder with the extract of Fructus Xanthii, Flos Magnoliae, Flos Lonicerae, Radix Rubiae, Flos Chrysanthemi Indici, through pulverizing the 80-200 mesh sieve, substrate and stabilizing agent are mixed in proportion heating, be cooled to room temperature, then the dried cream powder of the extract pulverized is joined in the mixture of the substrate that is cooled to room temperature and stabilizing agent, be stirred into the suspendible shape, add the volatile oil of Flos Magnoliae, Flos Lonicerae, Flos Chrysanthemi Indici extraction, mixing drips makes or is pressed into capsule.
In per 1000 capsules, contain the 1344g Fructus Xanthii, 252g Flos Magnoliae, 84g Flos Lonicerae, 84g Radix Rubiae, the dried cream powder raw material of the extract of 84g Flos Chrysanthemi Indici.
Embodiment 1. gets Flos Magnoliae 252g, Flos Lonicerae 84g, Flos Chrysanthemi Indici 84g, add 2940ml water, water distillation and extraction extracted 4～8 hours altogether, and it is standby to collect volatile oil, aqueous solution after distillation device is in addition collected, medicinal residues mix with the Fructus Xanthii of 1344g, add 6 times of water (10584ml water), decoct leaching 2 hours, so extract 2 times, merge decocting liquid twice, filter, the aqueous solution after the distillation that filtrate is collected with top device in addition merges, be concentrated into relative density 1.15, add ethanol and make that to contain alcohol amount be 50%, precipitate with ethanol 48 hours filters, precipitation is washed for several times with 50% ethanol, and washing liquid is incorporated in the filtrate; In addition with the 84g Radix Rubiae with 70% alcohol dipping of 840ml 24 hours, with percolation percolation slowly, filtrate behind percolate and the above-mentioned precipitate with ethanol merges, ethanol is reclaimed in distillation, remaining solution heating is condensed into thick paste after 60～80 ℃ of dryings, be ground into fine powder, cross 100 mesh sieves, become dried cream powder, must about 100g dried cream powder, get substrate 50g and 1.7g stabilizing agent heating mix homogeneously, put cold rnning and go into the 100g dried cream powder, be stirred into suspension, the volatile oil that the front is standby adds, mixing drips system or is pressed into 1000 of soft capsules, and wherein each composition weight ratio is:
Dried cream powder: 1% of substrate=1: 0.5 stabilizer comprises dried cream powder and substrate total amount.
The technical process of embodiment 2. fronts processing dried cream powder is with embodiment 1.
Get substrate 330g and stabilizing agent 22g heating mix homogeneously, put cold rnning and go into the 100g dried cream powder, be stirred into the suspendible shape, the volatile oil that the front is standby adds, and mixing drips system or is pressed into 1000 of soft capsules, and wherein each composition weight ratio is a dried cream powder: substrate=1: 3
Stabilizer comprises dried cream powder and substrate weight and 5%.
Embodiment 3. preferred versions
The technical process of front processing dried cream powder is with embodiment 1.
Get substrate 110g and stabilizing agent 6.6g heating mix homogeneously, put cold rnning and go into the 100g dried cream powder, be stirred into the suspendible shape, the volatile oil that the front is standby adds, and mixing drips system or is pressed into 1000 of soft capsules, and wherein each composition weight ratio is:
Dried cream powder: substrate=1: 1.
3% of stabilizer comprises dried cream powder and substrate gross weight.
In all embodiments, claimed described substrate is vegetable oil, as Semen Maydis oil, Oleum Arachidis hypogaeae semen, soybean oil, Oleum Camelliae or PEG400～1000, one of them or both mix arbitrarily.Stabilizing agent is oily wax mixture, Cera Flava, insect wax, Macrogol 4000～10000, tween one of them or more than both.
Effect: the nasal sinusitis soft capsule is the improvement dosage form of nasal sinusitis sheet, has heat clearing away poison, clearing the nasal passage effect, is used for chronic rhinitis and sinusitis.Tablet exist dose big (the single dose is 6～8), disintegrate slow, absorb and wait deficiency slowly, dosing a patient with makes troubles.The complicated process of preparation of tablet needs through several procedures such as granulation, tabletting, coatings.And from the indication of nasal sinusitis sheet, this medicine is used for the outbreak of sinusitis more, and nose blocks, and needs medicine bring into play the effect of curative effect to play rapidly, is the rapid relief of symptoms of patient.The sealing of soft capsule is better, can cover the poor taste of medicine, increases stability of drug, guarantees curative effect, and disintegrate is fast, absorption is rapid, can remedy tablet and absorb slow deficiency.Preparation of soft capsule technology is simple, compares with tablet and can reduce production costs.Therefore, we change tablet into soft capsule so that the easier absorption of medicine, and more convenient patient takes, and better guarantees curative effect.
Claims (7)
1. nasal sinusitis soft capsule for the treatment of rhinitis and sinusitis, utilized the extract of Chinese herbal medicine Fructus Xanthii, Flos Magnoliae Flos Lonicerae, Radix Rubiae, Flos Chrysanthemi Indici to make raw material, it is characterized in that the dried cream powder of extract and the substrate that comprises Semen Maydis oil and comprise that the stabilizing agent of Macrogol 4000～10000 makes the soft capsule content of suspendible shape, be pressed into soft capsule.
2. a kind of nasal sinusitis soft capsule for the treatment of rhinitis and sinusitis according to claim 1 is characterized in that substrate is one of material such as Semen Maydis oil, Oleum Arachidis hypogaeae semen, soybean oil, Oleum Camelliae and PEG400～1000 or both or both above mixture arbitrarily arbitrarily.
3. a kind of nasal sinusitis soft capsule for the treatment of rhinitis and sinusitis according to claim 1 and 2 is characterized in that stabilizing agent is a Cera Flava, one of materials such as insect wax, Macrogol 4000-10000, tween or both or both above mixture arbitrarily arbitrarily.
4. a kind of nasal sinusitis soft capsule for the treatment of rhinitis and sinusitis according to claim 1 and 2 is characterized in that the weight ratio of dried cream powder and substrate is:
Dried cream powder: substrate=1: the 0.5-3 preferred proportion is a dried cream powder: substrate=1: 1
5. according to claim 1 or 3 described a kind of nasal sinusitis soft capsules for the treatment of rhinitis and sinusitis, it is characterized in that stabilizing agent weight account for dried cream powder and substrate weight and 1-5%.
Preferred proportion be the total dried cream powder of stabilizer comprises and substrate weight and 3%.
6. a method for making for the treatment of the nasal sinusitis soft capsule of rhinitis and sinusitis is characterized in that Fructus Xanthii, and the dried cream powder of the extract of Flos Magnoliae, Flos Lonicerae, Radix Rubiae, Flos Chrysanthemi Indici was through pulverizing the 80-200 mesh sieve; Substrate and stabilizing agent are mixed in proportion heating, be cooled to room temperature, then the dried cream powder of the extract pulverized is joined in the mixture of the substrate that is cooled to room temperature and stabilizing agent, be stirred into the suspendible shape, add Flos Magnoliae, Flos Lonicerae, the volatile oil that Flos Chrysanthemi Indici extracts, mixing are dripped and make or be pressed into capsule.
7. a kind of nasal sinusitis soft capsule for the treatment of rhinitis and sinusitis according to claim 1 is characterized in that containing the 1344g Fructus Xanthii in per 1000 capsules 252g Flos Magnoliae, 84g Flos Lonicerae, 84g Radix Rubiae, the dried cream powder raw material of the extract of 84g Flos Chrysanthemi Indici.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410040987 CN1634263A (en) | 2004-11-03 | 2004-11-03 | Soft capsule for nasosinusitis and its preparation |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410040987 CN1634263A (en) | 2004-11-03 | 2004-11-03 | Soft capsule for nasosinusitis and its preparation |
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| CN1634263A true CN1634263A (en) | 2005-07-06 |
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| CN 200410040987 Pending CN1634263A (en) | 2004-11-03 | 2004-11-03 | Soft capsule for nasosinusitis and its preparation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1958003B (en) * | 2005-10-31 | 2011-04-13 | 北京奇源益德药物研究所 | Preparation for treating chronic nasosinusitis, preparation method and quality control method |
| CN101543545B (en) * | 2008-03-28 | 2011-05-25 | 北京亚东生物制药有限公司 | Traditional Chinese medicine preparation for curing rhinitis and quality control method thereof |
| CN103919885A (en) * | 2014-04-25 | 2014-07-16 | 云南云龙制药股份有限公司 | Preparation method and application of nasosinusitis soft capsule |
-
2004
- 2004-11-03 CN CN 200410040987 patent/CN1634263A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1958003B (en) * | 2005-10-31 | 2011-04-13 | 北京奇源益德药物研究所 | Preparation for treating chronic nasosinusitis, preparation method and quality control method |
| CN101543545B (en) * | 2008-03-28 | 2011-05-25 | 北京亚东生物制药有限公司 | Traditional Chinese medicine preparation for curing rhinitis and quality control method thereof |
| CN103919885A (en) * | 2014-04-25 | 2014-07-16 | 云南云龙制药股份有限公司 | Preparation method and application of nasosinusitis soft capsule |
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