CN101310760A - Traditional Chinese medicine for preventing and treating metabolism syndrome - Google Patents
Traditional Chinese medicine for preventing and treating metabolism syndrome Download PDFInfo
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- CN101310760A CN101310760A CNA2007100574044A CN200710057404A CN101310760A CN 101310760 A CN101310760 A CN 101310760A CN A2007100574044 A CNA2007100574044 A CN A2007100574044A CN 200710057404 A CN200710057404 A CN 200710057404A CN 101310760 A CN101310760 A CN 101310760A
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Abstract
The invention relates to a traditional Chinese medicine prescription preparation for preventing and treating metabolic syndrome. The traditional Chinese medicine prescription preparation is the traditional Chinese medicine compound preparation which is composed of cortex lycii, golden thread, epimedium herb, cassia bark, kudzuvine root and turmeric. The preparation has the advantages that: 1. the preparation has the effects of clearing heat, moistening dryness, nourishing yin, promoting fluid production, invigorating spleen and kidney yang deficiency, activating blood circulation, removing blood stasis and treating both manifestation and root cause of the disease, thus being used for the metabolic syndrome and significantly improving the symptoms of the metabolic syndrome; 2. the animal experiments show that the preparation can not only have the significant and durable effect on lowering blood sugar, but can also have the significant effect on lowering lipid and regulating liquid, preventing the damages of large blood vessels of diabetic patients and causing the diabetic patients with the early-stage damaged large blood vessels to be reversed; 3. and the animal experiments show that the toxicity is very low and the administration is safe. 4. The extraction process is advanced, the administration amount is small, and the preparation can be made into various formulations, thus facilitating the production, the storage, the transportation, the carrying and the usage.
Description
Technical field:
The invention belongs to a kind of Chinese traditional patent formulation preparation, particularly a kind of Chinese traditional patent formulation preparation of preventing and treating metabolism syndrome.
Background technology:
The file that International Diabetes Federation delivers shows that 20 years global diabeticss increase sharply to 2.3 hundred million by 3,000 ten thousand in the past, in maximum ten countries of global diabetics, has seven to be developing country, and China occupy the umber one.There are 5,000 ten thousand people in China's diabetics at present, and future, in two or three years ill number can double, and World Health Organization's prediction Chinese diabetics in 2015 will be above 100,000,000.
The maximum hazardness of diabetes mainly shows its chronic complicating diseases.Have 96% to suffer from various chronic complicating diseases in various degree in the diabetics.Metabolism syndrome is exactly topmost, the complication of earliest period, sickness rate improves rapidly in recent years, and in the crowd of Chinese city more than 20 years old, average attack rate is 15.7%, the patient who suffers from metabolism syndrome, in following 7 years, its mortality rate is up to 12.5%.World Health Organization's prediction is in 10 years of future, and the whole world will have 3.88 hundred million people to die from diabetes, cardiovascular disease, and wherein 8,000 ten thousand people are in China.Account for 80% by what cardiovascular and cerebrovascular disease caused diabetics death, make the diabetics life expectancy reduce 1/3.The danger of diabetics generation trunk complication is higher 2～4 times than ordinary person, and the sickness rate of diabetics cardiovascular and cerebrovascular disease on average exceeds 4.5 times than ordinary person.The simple average annual medical expense of diabetes patient is 0.37 ten thousand yuan, and the average annual medical expense of the people of diabetes complicated chronic complicating diseases is 1.39 ten thousand yuan, has exceeded nearly 4 times.World Health Organization's prediction, chronic disease will be brought at least 5,500 hundred million dollars economic loss to China in 10 years of future, wherein mainly come from diabetes and complication patient thereof.
Metabolism syndrome is the most common, and the chronic complicating diseases of diabetes that sickness rate is the highest also is the principal element of diabetes complicated macroangiopathy, and untimely treatment will cause macroangiopathy, arteriosclerosis, cardiovascular and cerebrovascular disease.
Verified now, the early intervention metabolism syndrome, Developmental and Metabolic Disorder can obtain correcting, and can disappear, and can reverse.Research and development control metabolism syndrome medicine will have a tremendous social and economic benefits undoubtedly, have much practical value.
Still do not have not only blood sugar lowering in the market but also transfer the Chinese and western drugs of fat, pursuit blood sugar lowering simply makes the matter worse to gradually losing responsive islets of langerhans beyond doubt, quickens insulin resistant, brings out lipid metabolic disorder on the contrary.
The tradition traditional Chinese medical science have the title of " sage's preventive treatment of disease is treating the disease affected not ", and so-called " preventive treatment of disease " comprises prevention of diseae and preventing exacerbation after being taken ill.Chinese medicine melts treatment and anti-complication in a stove, has very big advantage in control on the metabolism syndrome, and has accumulated fruitful experience.The present invention just is being based on this technical background, develops the Chinese traditional patent formulation preparation with clinical practice using value.
Summary of the invention:
The object of the present invention is to provide a kind of Chinese traditional patent formulation preparation of preventing and treating metabolism syndrome, this Chinese medicine preparation can effective, persistent blood sugar lowering, again can blood lipid regulation, bring high blood pressure down, and prevent and treat atherosclerosis, thus the control cardiovascular and cerebrovascular disease.
Technical scheme of the present invention is: a kind of control is for penetrating syndromic Chinese traditional patent formulation preparation.It is characterized in that: use traditional Chinese medicine theory and clinical practice experience and determined its prescription Cortex Lycii 6-30, Rhizoma Coptidis 0.5-5, Herba Epimedii 1.5-8, Cortex Cinnamomi 1.5-8, Radix Puerariae 5-30, Rhizoma Curcumae Longae 3-15.(daily dose, unit are gram)
Above-mentioned side's medicine takes distinct methods to extract, and obtains extract, makes the different preparations that differ from one another with this extract:
The medicinal 3-10 of the above-mentioned side of extracting method (1) times water gaging, heating and refluxing extraction 2-5 time was extracted 1-3 hour at every turn, extracting liquid filtering, concentrating under reduced pressure gets extractum, and is standby.
The above-mentioned side's medicine of extracting method (2), Rhizoma Curcumae Longae, Rhizoma Coptidis, Cortex Cinnamomi is doubly measured alcohol heating reflux with 3-6 and extracts 2-5 time, extracts 1-3 hour at every turn, its extracting solution decompression recycling ethanol, concentrated standby, its medicinal residues add Herba Epimedii, Cortex Lycii, Radix Puerariae three medicines are with 3-10 times of water heating and refluxing extraction 2-5 time, each 1-3 hour, extracting solution is evaporated to relative density 1.01-1.15 (60 ℃), after cooling, adds ethanol, make and contain alcohol amount 40%-80%, leave standstill, get supernatant, decompression recycling ethanol is to there not being the alcohol flavor, mix with above-mentioned alcohol extraction concentrated solution, continue concentrating under reduced pressure, get extractum, standby.
Extracting method (3), above-mentioned side's medicine, Cortex Lycii, Rhizoma Curcumae Longae, Cortex Cinnamomi are extracted 3-5 time with 3-6 times of alcohol heating reflux, and each 1-3 hour, the extracting solution decompression recycling ethanol concentrated to such an extent that extractum I is standby; Recipe quantity Rhizoma Coptidis coarse powder, with acid soak 8-14 hour of 0.5%-3%, use sulphuric acid percolation, percolation speed 10-40ml/ branch with concentration, to percolate inanimate object alkali reaction, the percolate that 3-6 doubly measures before collecting is transferred PH6-7 with lime cream, places 8-14 hour for 0-8 ℃, filter, filtrate is transferred PH1-2 with hydrochloric acid, places 8-14 hour for 0-8 ℃, filters, the precipitation cold wash, filter is done, and vacuum drying gets the crocus powder, and is standby, Herba Epimedii, Cortex Lycii after Radix Puerariae and the alcohol extraction, Rhizoma Curcumae Longae, Cortex Cinnamomi is doubly measured the 30-80% alcohol heating reflux with 3-6 and extracts 3-5 time, and each 1-3 hour, the extracting solution decompression recycling ethanol was to there not being the alcohol flavor, merging continuation with above-mentioned extractum I concentrates, with the crocus powder mixes, get extractum, standby.
Extracting method (4), above-mentioned side's medicine, Cortex Lycii, Rhizoma Curcumae Longae, the same method of the processing of Cortex Cinnamomi, Rhizoma Coptidis (3) gets extractum I and crocus powder respectively; Herba Epimedii, the Cortex Lycii after Radix Puerariae and the alcohol extraction, Rhizoma Curcumae Longae, Cortex Cinnamomi and method (3) extract phase does not separate post with, reclaim under reduced pressure to there being the post of having handled on the alcohol flavor back
Adsorbent is a kind of in polyamide, silica gel, ion exchange resin, the macroporous adsorbent resin, uses the 20-70% alcohol desorption, and the concentrating under reduced pressure stripping liquid is with extractum I orange colour powder mixes, standby.
The same method of processing (3) of extracting method (5) Rhizoma Coptidis gets the orange colour powder, the same method of the processing of Herba Epimedii, Radix Puerariae (4), and Cortex Lycii, Rhizoma Curcumae Longae, Cortex Cinnamomi powder become coarse powder, use CO
2Supercritical extraction, pressure are 10-30Mpa, temperature 30-50 ℃.Flow is 200-300Kg/h, and the extraction time is 1-4 hour, gets extract and mixes with all the other extracts, gets extractum, and is standby.
Use above-mentioned extract, can make differ from one another dosage form.Comprising tablet, capsule, technology is simple, cost is low; Soft capsule, liquid-filling capsule can fully disperse non-water-soluble extract with fat-soluble medium, accelerate to absorb, and help improving oral administration biaavailability; Speed disintegrating tablet, drop pill quicken disintegrate or molten loosing, and help absorbing, and help improving oral administration biaavailability.
The various preparations that the present invention is made, the 1-2 flavor medicine in employing high performance liquid chromatography the other side medicine carries out the assay of active ingredient or index components, and all the other flavour of a drug adopt the stronger thin layer chromatography of specificities to carry out qualitative identification.This method of quality control is than advanced, with international medical market be approaching to the quality control requirement of compound plant medicine preparation; Also can adopt the flavor of 6 in high performance liquid chromatography the other side medicine medicine to carry out the assay of active ingredient or index components, this method of quality control is state-of-the-art, integrate with fully with the quality control requirement of international medical market, provide condition for this medicine enters international medical market to compound plant medicine preparation.
Test of pesticide effectiveness result of the present invention shows:
After the administration 10 days, (n is a number of animals):
Compare with the normal control group:
△ △P＜0.01
Compare with model control group:
*P＜0.05,
*P＜0.01
Administration is described after 10 days, we have tangible hypoglycemic lipid-lowering effect, low dosage and JINQI JIANGTANG PIAN there was no significant difference, and high dose and metformin there was no significant difference, but be better than JINQI JIANGTANG PIAN.
After the administration 20 days, (n is a number of animals):
Compare with the normal control group:
△ △P＜0.01
Compare with model control group:
*P＜0.05,
*P＜0.01
Illustrate that we have tangible blood sugar lowering, the effect of T-CHOL and triglyceride, compare with model control group, p＜0.01, and JINQI JIANGTANG PIAN is because chemistry causes model, can not adhere to all death in 20 days, our effect is obviously owing to JINQI JIANGTANG PIAN, and we compare its blood sugar lowering with metformin, the effect there was no significant difference of triglyceride reducing, but the effect of hypercholesterolemia reducing obviously is better than metformin.
Acute toxicity test shows that the oral maximum tolerated dose of mice is 40.4g crude drug/kg; Long term toxicity test, successive administration 6 months, the no abnormal reaction of rat illustrates that this product is safe.
The specific embodiment:
Embodiment 1: the preparation of extract
Prescription: 9 parts of Cortex Lycii
0.6 part of Rhizoma Coptidis
3 parts of Herba Epimedii
3 parts of Cortex Cinnamomis
6 parts of Radix Puerariaes
3 parts in Rhizoma Curcumae Longae
Operation: the above-mentioned five tastes, get Cortex Lycii, Rhizoma Curcumae Longae, Cortex Cinnamomi and add 6 times of amount alcohol reflux 2 times, each 2 hours, extracting solution merged, and filtered, and decompression recycling ethanol is to there not being the alcohol flavor, and is standby; Rhizoma Coptidis powder became the coarse powder of 8 mesh sieves, spent the night with 1% soak with sulphuric acid, with 1% sulphuric acid percolation, percolation speed is 25ml/min, percolation is collected preceding 5 times of percolates to the inanimate object alkali reaction, and all the other percolates are standby as following batch percolation, transfer PH6-7 with lime cream, place about 0 ℃ and filter, sucking filtration, precipitation is abandoned it, filtrate is transferred PH1-2 with hydrochloric acid, place about 0 ℃ and spend the night, sucking filtration, precipitation cold water washing, drain, vacuum drying below 70 ℃ gets the orange colour powder, contains total alkaloids more than 80%, hydrochloric berberine is not less than 50%, and is standby; Herba Epimedii, Radix Puerariae are measured 50% alcohol reflux 3 times with 6 times, and each 2 hours, extracting solution merged, filter, decompression recycling ethanol is concentrated into 0.5g crude drug/ml to there not being the alcohol flavor, put cold, last polyamide column, water flushing post, with 20% alcohol flushing post, use 70% alcohol desorption, the stripping liquid decompression recycling ethanol concentrates and said extracted thing mixing, vacuum drying below 70 ℃ contains crude drug 29.3g/g to doing.
Experimental example 2: preparation tablets
Prescription: 100 parts of embodiment 1 extracts
1 part of adjuvant pregelatinized Starch
1 part of stearic acid
0.5 part of Pulvis Talci
0.5 part of carboxymethylstach sodium
1 part in dextrin
Method for making: mixing, granulate, cross 20 sieves, tabletting.0.3g/ sheet
2 of each clothes are obeyed 3 every day
Experimental example 3: soft capsule preparation
Prescription: 100 parts of embodiment 1 extracts
98 parts of adjuvant salad oils
1 part of Petiolus Trachycarpi oil
1 part in Cera Flava
Method for making: colloid mill mixing, compacting soft capsule.0.56g/ grain is oral: 1/time, 3 times/day.
Claims (9)
1. Chinese traditional patent formulation preparation of preventing and treating metabolism syndrome, it is characterized in that: it is a compound Chinese medicinal preparation, it is Cortex Lycii, Rhizoma Coptidis, Herba Epimedii, Cortex Cinnamomi, Radix Puerariae, Rhizoma Curcumae Longae that the prescription of this compound preparation is formed.
2. a kind of prescription compatibility of medicines of preventing and treating the Chinese traditional patent formulation preparation of metabolism syndrome according to claim 1, it is characterized in that: Cortex Lycii 6-30, Rhizoma Coptidis 0.5-5, Herba Epimedii 1.5-8, Cortex Cinnamomi 1.5-8, Radix Puerariae 5-30, Rhizoma Curcumae Longae 3-15 (day dosing, unit is gram).
3. a kind of Chinese traditional patent formulation preparation of preventing and treating metabolism syndrome according to claim 1, it is characterized in that: above-mentioned prescription drugs obtains extract through extracting, it is solvent that extracting method adopts water, solvent is 3～10 times of the prescription medical material, and heating and refluxing extraction 2～5 times was extracted 1～3 hour at every turn, extracting liquid filtering, be evaporated to relative density 1.25～1.40 (60 ℃), get thick paste, standby.
4. a kind of Chinese traditional patent formulation preparation of preventing and treating metabolism syndrome according to claim 1, it is characterized in that: above-mentioned prescription drugs obtains extract through extracting, extract the following method that adopts, the prescription drugs Rhizoma Curcumae Longae, Rhizoma Coptidis, Cortex Cinnamomi is doubly measured ethanol with 3-6, and heating and refluxing extraction 2-5 time was extracted 1-3 hour at every turn, the extracting solution decompression recycling ethanol, thick paste is standby, and its medicinal residues add the Cortex Lycii of recipe quantity, Herba Epimedii, Radix Puerariae is with 3-10 times of water gaging heating and refluxing extraction 2-5 time, the each extraction 1-3 hour, extracting liquid filtering, being evaporated to relative density is 1.01-1.15 (60 ℃), after cooling, stir and add ethanol down, make to contain the alcohol amount, leave standstill, get supernatant for 40-80%, decompression recycling ethanol is to there not being the alcohol flavor, mix with above-mentioned thick paste, continue to be evaporated to relative density 1.25-1.40 (60 ℃), standby.
5. a kind of Chinese traditional patent formulation preparation of preventing and treating metabolism syndrome according to claim 1, it is characterized in that: above-mentioned prescription drugs obtains extract through extracting, extract the following method that adopts, prescription drugs Cortex Lycii, Rhizoma Curcumae Longae, Cortex Cinnamomi are doubly measured ethanol with 3-6, heating and refluxing extraction 3-5 time, the each extraction 1-3 hour, the extracting liquid filtering decompression recycling ethanol, it is standby to be condensed into thick paste I; The recipe quantity Rhizoma Coptidis powder becomes coarse powder, with soak with sulphuric acid 8-14 hour of 0.5%-3%, uses with concentration sulphuric acid percolation, percolation speed is the 10-40ml/ branch, ends to percolate inanimate object alkali reaction, collects the percolate of preceding 3～6 times of amounts, transfer PH6～7 with lime cream, placed filtration 8～14 hours in 0～8 ℃, filtrate is transferred PH1～2,0～8 ℃ placement 8～14 hours with HCl, filters, the precipitation cold water washing, filter is done, vacuum drying, get the crocus powder, standby; Cortex Lycii after recipe quantity Herba Epimedii, Radix Puerariae and the alcohol extraction, Rhizoma Curcumae Longae, Cortex Cinnamomi are with 30～80% alcohol reflux of 3～6 times of amounts 3～5 times, each 1～3 hour, extracting liquid filtering, decompression recycling ethanol, to there not being the alcohol flavor, merge with above-mentioned thick paste, continuing to be evaporated to relative density is 1.20～1.35, with above-mentioned powder mixing, standby.
6. a kind of Chinese traditional patent formulation preparation of preventing and treating metabolism syndrome according to claim 1, it is characterized in that: above-mentioned prescription drugs obtains extract through extracting, extract the following method that adopts, the extracting method of prescription drugs Cortex Lycii, Rhizoma Curcumae Longae, Cortex Cinnamomi, Rhizoma Coptidis is with this claim 5 described processing methods, and is extract obtained standby; Herba Epimedii, Radix Puerariae are pressed recipe quantity and are extracted with the method for this claim 5, and the gained extracting solution is evaporated to 0.5g crude drug/ml, carry out post and separate.Adsorbent is a kind of in silica gel, polyamide, ion exchange resin, the macroporous adsorbent resin etc., uses the 20-70% alcohol desorption, the stripping liquid decompression recycling ethanol, be concentrated into thick paste and said extracted thing mixing, standby.
7. a kind of Chinese traditional patent formulation preparation of preventing and treating metabolism syndrome according to claim 1, it is characterized in that: above-mentioned prescription drugs obtains extract through extracting, extract the following method that adopts, the Rhizoma Coptidis of recipe quantity, Herba Epimedii, Radix Puerariae are by this claim 6 described processing methods, get orange colour powder and thick paste respectively, standby; The Cortex Lycii of recipe quantity, Rhizoma Curcumae Longae, Cortex Cinnamomi powder become coarse powder, use CO
2Supercritical extraction, pressure are 10-30Mpa, and temperature is 30-50 ℃, and flow is 200-300Kg/h, and the extraction time is 1-4 hour, get extract and said extracted thing mixing, and be standby.
8. a kind of Chinese traditional patent formulation preparation of preventing and treating metabolism syndrome according to claim 1, it is characterized in that: above-mentioned prescription drugs is made tablet, capsule, soft capsule, liquid-tilled hard capsule, drop pill, oral cavity quick disintegrating slice, granule through extracting the extract that obtains.
9. a kind of Chinese traditional patent formulation preparation of preventing and treating metabolism syndrome according to claim 1, it is characterized in that: adopt high performance liquid chromatography that assay is carried out in its active ingredient or index composition the 1-2 flavor in the flavor of 6 in the various preparations Chinese medicine, and regulation reasonable limit, adopt thin layer chromatography to carry out qualitative identification to all the other flavour of a drug, can control the quality of product preferably, meet of the requirement of international medical market substantially compound plant medicine preparation quality standard.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100574044A CN101310760A (en) | 2007-05-22 | 2007-05-22 | Traditional Chinese medicine for preventing and treating metabolism syndrome |
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|---|---|---|---|
| CNA2007100574044A CN101310760A (en) | 2007-05-22 | 2007-05-22 | Traditional Chinese medicine for preventing and treating metabolism syndrome |
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| CN101310760A true CN101310760A (en) | 2008-11-26 |
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| CNA2007100574044A Pending CN101310760A (en) | 2007-05-22 | 2007-05-22 | Traditional Chinese medicine for preventing and treating metabolism syndrome |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897925A (en) * | 2009-12-16 | 2010-12-01 | 成都百康医药工业药理毒理研究院 | Medicinal composition for treating metabolic syndrome |
| CN110314213A (en) * | 2019-08-12 | 2019-10-11 | 南京依美生物科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating fibroid |
-
2007
- 2007-05-22 CN CNA2007100574044A patent/CN101310760A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897925A (en) * | 2009-12-16 | 2010-12-01 | 成都百康医药工业药理毒理研究院 | Medicinal composition for treating metabolic syndrome |
| CN101897925B (en) * | 2009-12-16 | 2015-04-29 | 成都百康医药工业药理毒理研究院 | Medicinal composition for treating metabolic syndrome |
| CN110314213A (en) * | 2019-08-12 | 2019-10-11 | 南京依美生物科技有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating fibroid |
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Open date: 20081126 |