CN1628836A

CN1628836A - Chinese patent drug for treating leucoderma

Info

Publication number: CN1628836A
Application number: CN 200410075351
Authority: CN
Inventors: 王俊伟
Original assignee: Individual
Current assignee: Individual
Priority date: 2004-08-23
Filing date: 2004-08-23
Publication date: 2005-06-22

Abstract

The invention provides a Chinese patent drug for treating leucoderma and the method for preparing the medicament comprises, using fourteen Chinese medicinal herbs including Vernonia amygdalina Del., puncturevine, white moss bark as raw material, carrying out low-temperature disintegrating, solvent extracting, concentration preliminary treatment, ripening and sterilizing. The medicament is made into the dosage form of powder, pill and capsule.

Description

The leukodermic Chinese patent medicine of a kind of treatment

The leukodermic Chinese patent medicine of a kind of treatment of the present invention relates to pharmaceutical field, it specifically is raw material with the Chinese herbal medicine, particularly with Caulis Vernoniae andersonii, Fructus Tribuli be that main warp is pulverized, solvent extracts, concentrate, vitiligo combination drug that technical matters such as sterilization is prepared from, effect is obvious.The invention still further relates to the preparation method of this combination drug.

Vitiligo is a kind of chronic non-infectious depigmentation common skin diseases, good sending out in each age group, because the cause of disease is not fully aware of, also there is not at present a kind of lasting specific treatment medicine, but the medical science sages of the past have utilized difficult disease such as Chinese medicine combination of inner and outside treatment vitiligo, obtain better curative effect.Though non-life threatening of vitiligo dailyly causes greatly with psychological pressure mentally to the patient, having a strong impact on work, study and social communication.According to statistics, China's vitiligo sickness rate accounts for dermopathic 0.54%-1.03%; External report shows: U.S.'s vitiligo prevalence accounts for 1%, and Denmark accounts for 0.46%, and the India Surat accounts for 1.13%, and Calcutta accounts for 0.46%, and the French West Indies is reported as about 0.5%-1%.Fructus Pruni woods elite tackling key problem is hand in hand appealed by international community, breaks through the difficult disease treatment that comprises vitiligo early.

Medical circle generally acknowledges that the leukodermic cause of disease is because the hypofunction or the forfeiture of the interior tryrosinase system of the melanocyte of skin and hair follicle cause.Onset state is with area, ethnic group and difference, and the dark more sickness rate of general colour is then high more.The leukodermic factors such as heredity, spirit nerve, chemistry, autoimmune, endocrine, low copper, infection that betide also have close ties.It is considered herein that immunologic derangement and endocrine disturbance are the key factors that vitiligo takes place, under normal circumstances, the skin melanocyte is present in skin and the intrafollicular melanocyte, tyrosine in the melanocyte is oxidized to DOPA under the effect of tryrosinase, through a series of biochemical metabolism process, generating melanocyte needs for body again.Anyly cause the organism metabolism functional disorder or influence the synthetic factor of melanocyte, can cause all that melanin generates reduces or disappears, and skin depigmentation occurs, and its result will show as leukoderma, i.e. vitiligo.

Medicine of the present invention belongs to the traditional medicine category.Motherland's medical science is that international community generally acknowledges to the therapeutic effect of chronic disease, and " acute disease sees a doctor trained in western medicine, slow disease is registered the department of Chinese medicine " become idea sanctified by usage of hospitalier.Because Chinese medicine contains multiple active ingredient, can tackle a plurality of curative drug action target spots, solve the insoluble problem of doctor trained in Western medicine, multiple components is passed through reparation, replacement or the intervention to gene, and breakthrough treatment endocrine regulation disease is satisfactory for result, Chinese medicinal ingredients is active strong, the curative effect height, toxic and side effects is little, is beneficial to the persistence medication after treatment of chronic disease.

The present invention treats Caulis Vernoniae andersonii in the leukodermic Chinese patent medicine prescription, wind dispelling, dampness are arranged, relax through, invigorate blood circulation, effect such as blood stasis dispelling, compatibility Flos Carthami, Radix Salviae Miltiorrhizae etc. can improve local microcirculation, improve photosensitization; Add QI invigorating such as Fructus Psoraleae, the Radix Polygoni Multiflori, Semen Sesami Nigrum, the Radix Astragali and keep fit two accent immunologic functions, trace element supplement; After all medicines are comprehensive, make its synergism of bringing into play each medicine, strengthen the activity of tryrosinase, promote the synthetic of dermal melanin cell, correct the tricarboxylic acid cycle system of biochemical metabolism, thus effective to the skin depigmentation disease.

Another purpose that the present invention treats the vitiligo Chinese patent medicine provides a kind of preparation method of this medicine.It is characterized in that the formula Chinese drug raw material is abided by after Gu concocts into the prepared slices of Chinese crude drugs; It is standby to choose Caulis Vernoniae andersonii, the Radix Astragali, Semen Sesami Nigrum, Fructus Fici, Radix Salviae Miltiorrhizae, the Radix Angelicae Dahuricae, Fructus Psoraleae, Flos Carthami eight flavor pulverize at low temperature to 120 mesh sieve fine powders; With Cortex Dictamni, Fructus Tribuli, the Radix Polygoni Multiflori, Herba Ecliptae, Radix Arnebiae (Radix Lithospermi), the Poria Six-element is cataclasm, water decocts secondary, 3 hours for the first time, 2 hours for the second time, filter, discard residue, collecting decoction, filtrate is condensed into thick paste; Mix with standby fine powder, drying is ground into impalpable powder, and mixing carries out ripening, sterilization treatment 20-30 minute under 100 ℃ of-110 ℃ of temperature, make powder; With the powder water pill, freeze-day with constant temperature is used the Pulvis Talci coating, and polishing makes pill; Powder is filled with the Capsules shell, and grain is picked up in polishing, makes capsule.

The present invention treats leukodermic Chinese patent medicine medicine, based on more than, in conjunction with clinical nearly hundred examples for many years the use of patients with vitiligo is observed, total effective rate reaches more than 94%, if with the topical agent associating, effect is better.So vitiligo new Chinese medicine of the present invention is the effective agent of a kind of worth exploitation, popularization, raising vitiligo cure rate really, and is significant, has a extensive future.

Claims

1, the leukodermic Chinese patent medicine of a kind of treatment is characterized in that it is the medicament of being made by following proportioning raw materials:

Caulis Vernoniae andersonii 10-30 part Fructus Tribuli 10-30 part Cortex Dictamni 10-20 part

Radix Arnebiae (Radix Lithospermi) 10-25 part Radix Polygoni Multiflori 10-20 part Fructus Psoraleae 10-20 part

Poria 10-20 part Flos Carthami 10-20 part Semen Sesami Nigrum 10-20 part

Radix Astragali 10-20 part Radix Salviae Miltiorrhizae 10-20 part Radix Angelicae Dahuricae 10-20 part

Fructus Fici 10-15 part Herba Ecliptae 10-15 part;

2, treatment vitiligo Chinese patent medicine according to claim 1 is characterized in that the weight proportion of each raw material is:

25 parts of 25 portions of Radix Arnebiae (Radix Lithospermi)s of 30 parts of Cortex Dictamnis of 30 portions of Fructus Tribulis of Caulis Vernoniae andersonii

20 parts on 20 parts of Flos Carthamis of 20 parts of Fructus Psoraleaes of 20 parts of Poria of the Radix Polygoni Multiflori

20 parts of 20 parts of Radixs Angelicae Dahuricae of 20 portions of Semen Sesami Nigrums of 20 parts of Radix Salviae Miltiorrhizaes of the Radix Astragali

10 parts of 10 portions of Herba Ecliptaes of Fructus Fici.

3, treatment vitiligo Chinese patent medicine according to claim 1 and 2 is characterized in that said medicament is powder, pill and capsule.

4, according to the preparation method of claim 1 or 2 or 3 described treatment vitiligo Chinese patent medicines, it is characterized in that earlier the formula Chinese drug raw material being abided by Gu concocts into the prepared slices of Chinese crude drugs after; Caulis Vernoniae andersonii, the Radix Astragali, Semen Sesami Nigrum, Fructus Fici, Radix Salviae Miltiorrhizae, the Radix Angelicae Dahuricae, Fructus Psoraleae, Flos Carthami eight flavor pulverize at low temperature to 120 mesh sieve fine powders are standby; With Cortex Dictamni, Fructus Tribuli, the Radix Polygoni Multiflori, Herba Ecliptae, Radix Arnebiae (Radix Lithospermi), the Poria Six-element is cataclasm, water decocts secondary, 3 hours for the first time, 2 hours for the second time, filter, discard residue, collecting decoction, filtrate is condensed into thick paste; Mix with standby fine powder, drying is ground into impalpable powder, and mixing carries out ripening, sterilization treatment 20-30 minute under 100 ℃ of-110 ℃ of temperature, make powder; With the powder water pill, freeze-day with constant temperature is used the Pulvis Talci coating, and polishing makes pill; Powder is filled with the Capsules shell, and grain is picked up in polishing, makes capsule.