CN1626237A - 一个蛋白质家族的抗菌用途 - Google Patents
一个蛋白质家族的抗菌用途 Download PDFInfo
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- CN1626237A CN1626237A CNA2003101173546A CN200310117354A CN1626237A CN 1626237 A CN1626237 A CN 1626237A CN A2003101173546 A CNA2003101173546 A CN A2003101173546A CN 200310117354 A CN200310117354 A CN 200310117354A CN 1626237 A CN1626237 A CN 1626237A
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
序号 | 物种 | 来源 | GenBankTM注册号 |
1 | 人 | Homo sapiens | CAC11117 |
2 | 小鼠 | Mus musculus | AAK18748 |
3 | 斑马鱼 | Danio rerio | AAH59661 |
4 | 按蚊 | Anopheles gambiae | XP_320383 |
5 | 果蝇 | Drosophila melanogas | NP_648757 |
6 | 线虫 | Caenorhabditis elegans | NP_496804 |
7 | 线虫 | Caenorhabditis elegans | B88349 |
8 | 芽殖酵母 | Schizosaccharomycespombe | CAB89006 |
9 | 酿酒酵母 | Saccharomycescerevisiae | AAB68201 |
10 | 拟南芥 | Arabidopsis thaliana | NP_566324 |
11 | 疟原虫 | Plasmodium falciparum3D7 | NP_705421 |
12 | 疟原虫 | Plasmodium yoeliiyoelii | EAA17587 |
13 | 稻瘟病菌 | Magnaporthe grisea | EAA47634 |
14 | 脉孢菌 | Neurospora crassa | EAA34843 |
项目 | 内容 |
分子量 | 8181.9 |
多肽长度(aa) | 79 |
等电点 | 9.36 |
电荷数(pH7.0) | 4.79 |
Gly含量(%) | 21.52 |
物种属名 | 多肽长度(aa) | 等电点 | 电荷数(pH7.0) | 甘氨基酸含量(%) |
Homo sapiens | 79 | 9.36 | 4.79 | 21.52 |
Mus musculus | 79 | 9.36 | 4.79 | 21.52 |
Danio rerio | 80 | 9.81 | 4.82 | 21.2 |
Anopheles gambiae | 128 | 9.73 | 10.08 | 14.1 |
Drosophila melanogaster | 79 | 9.66 | 4.82 | 20.3 |
Caenorhabditis elegans | 145 | 10.79 | 12.01 | 14.48 |
Schizosaccharomyces pombe | 107 | 10.04 | 4.05 | 13.08 |
Saccharomyces cerevisiae | 112 | 9.74 | 5.04 | 13.27 |
Plasmodium falciparum 3D7 | 168 | 9.66 | 5.15 | 15.94 |
Plasmodium Yoelii Yoelii | 167 | 9.16 | 4.15 | 15.28 |
Magnapor the grisea | 107 | 11.75 | 8.24 | 13.08 |
Arabidopsis thaliana | 74 | 9.84 | 6.18 | 14.86 |
菌株名称 | 最小抑菌浓度(ug/ml) | |
革兰氏阴性菌 | 大肠杆菌DH5α | 0.2 |
革兰氏阳性菌 | 枯草杆菌DB430 | 3 |
最初的残基 | 代表性的取代 | 优选的取代 |
Ala(A) | Val;Leu;Ile | Val |
Arg(R) | Lys;Gln;Asn | Lys |
Asn(N) | Gln;His;Lys;Arg | Gln |
Asp(D) | Glu | Glu |
Cys(C) | Ser | Ser |
Gln(Q) | Asn | Asn |
Glu(E) | Asp | Asp |
Gly(G) | Pro;Ala | Ala |
His(H) | Asn;Gln;Lys;Arg | Arg |
Ile(I) | Leu;Val;Met;Ala:Phe | Leu |
Leu(L) | Ile;Val;Met;Ala;Phe | Ile |
Lys(K) | Arg;Gln;Asn | Arg |
Met(M) | Leu;Phe;Ile | Leu |
Phe(F) | Leu;Val;Ile;Ala;Tyr | Leu |
Pro(P) | Ala | Ala |
Ser(S) | Thr | Thr |
Thr(T) | Ser | Ser |
Trp(W) | Tyr;Phe | Tyr |
Tyr(Y) | Trp;Phe;Thr;Ser | Phe |
Val(V) | Ile;Leu;Met;Phe;Ala | Leu |
Claims (9)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2003101173546A CN100484568C (zh) | 2003-12-11 | 2003-12-11 | 一个蛋白质家族的抗菌用途 |
EP04802449A EP1693381A4 (en) | 2003-12-11 | 2004-12-10 | GLYCINOUS PROTEINS, THEIR CODING SEQUENCES AND APPLICATIONS |
PCT/CN2004/001435 WO2005056591A1 (fr) | 2003-12-11 | 2004-12-10 | Proteines riches en glycine, leurs sequences codantes et leurs applications |
US10/582,420 US20070054356A1 (en) | 2003-12-11 | 2004-12-10 | Glycine-rich proteins, their coding genes and applications |
JP2006543349A JP2008504003A (ja) | 2003-12-11 | 2004-12-10 | グリシンリッチタンパク質およびそれをコードする遺伝子ならびに使用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2003101173546A CN100484568C (zh) | 2003-12-11 | 2003-12-11 | 一个蛋白质家族的抗菌用途 |
Publications (2)
Publication Number | Publication Date |
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CN1626237A true CN1626237A (zh) | 2005-06-15 |
CN100484568C CN100484568C (zh) | 2009-05-06 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CNB2003101173546A Expired - Fee Related CN100484568C (zh) | 2003-12-11 | 2003-12-11 | 一个蛋白质家族的抗菌用途 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20070054356A1 (zh) |
EP (1) | EP1693381A4 (zh) |
JP (1) | JP2008504003A (zh) |
CN (1) | CN100484568C (zh) |
WO (1) | WO2005056591A1 (zh) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050272067A1 (en) * | 2004-03-10 | 2005-12-08 | Macina Roberto A | Compositions, splice variants and methods relating to cancer specific genes and proteins |
BRPI0605658B8 (pt) | 2006-12-29 | 2021-05-25 | Embrapa Pesquisa Agropecuaria | peptídeo antibiótico rico em glicina derivado de planta |
KR102544364B1 (ko) | 2019-06-17 | 2023-06-19 | 주식회사 안단테에프엠 | Romo1 유래 항균 펩타이드 및 그 변이체 |
CN113373169A (zh) * | 2021-05-21 | 2021-09-10 | 浙江大学 | 一种制备斑马鱼蛋白激酶Aα催化亚基蛋白的基因工程菌及方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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US5221732A (en) * | 1988-12-06 | 1993-06-22 | The United States Of America As Represented By The Department Of Health And Human Services | Antimicrobial magainin modified peptides |
WO1999043802A2 (en) * | 1998-02-27 | 1999-09-02 | Sagami Chemical Research Center | HUMAN PROTEINS HAVING TRANSMEMBRANE DOMAINS AND DNAs ENCODING THESE PROTEINS |
US7060479B2 (en) * | 1999-12-08 | 2006-06-13 | Serono Genetics Institute, S.A. | Full-length human cDNAs encoding potentially secreted proteins |
WO2001060860A2 (en) * | 2000-02-17 | 2001-08-23 | Millennium Predictive Medicine, Inc. | Genes differentially expressed in human prostate cancer and their use |
AU2002220079A1 (en) * | 2000-11-15 | 2002-05-27 | Emory University | Acylated antimicrobial peptides |
-
2003
- 2003-12-11 CN CNB2003101173546A patent/CN100484568C/zh not_active Expired - Fee Related
-
2004
- 2004-12-10 JP JP2006543349A patent/JP2008504003A/ja active Pending
- 2004-12-10 US US10/582,420 patent/US20070054356A1/en not_active Abandoned
- 2004-12-10 WO PCT/CN2004/001435 patent/WO2005056591A1/zh active Application Filing
- 2004-12-10 EP EP04802449A patent/EP1693381A4/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
WO2005056591A1 (fr) | 2005-06-23 |
EP1693381A1 (en) | 2006-08-23 |
US20070054356A1 (en) | 2007-03-08 |
CN100484568C (zh) | 2009-05-06 |
JP2008504003A (ja) | 2008-02-14 |
EP1693381A4 (en) | 2007-10-24 |
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