CN1625982A - Method for preparing super fines of sea cucumber - Google Patents
Method for preparing super fines of sea cucumber Download PDFInfo
- Publication number
- CN1625982A CN1625982A CNA2003101053008A CN200310105300A CN1625982A CN 1625982 A CN1625982 A CN 1625982A CN A2003101053008 A CNA2003101053008 A CN A2003101053008A CN 200310105300 A CN200310105300 A CN 200310105300A CN 1625982 A CN1625982 A CN 1625982A
- Authority
- CN
- China
- Prior art keywords
- sea cucumber
- superfine powder
- temperature
- preparation
- vacuum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
A process for preparing the superfine powder of sea cucumber includes washing fresh sea cucumber, removing impurities, cutting, freeze vacuum drying, breaking, and superfine pulverizing by fluidized-bed airflow. Its advantages are no pollution and easy absorption.
Description
Technical field
The present invention relates to a kind of superfine powder process technology that can be used as the biomaterial of nutrient and healthcare products, specifically a kind of preparation method of sea cucumber superfine powder.
Background technology
Sea cucumber belongs to Echinodermata (Echinodermata) Holothuroidea (Holothridea), and the sea cucumber of broad sense comprises the kind that Holothuroidea is all, finger lintel hand order (Aspidocchirota) animal of narrow sense.Sea cucumber is important oceanic invertebrate, and according to rough Statistics, the whole world has 900～1,100 kinds of all kinds of sea cucumbers, and wherein there is kind more than 140 in China marine site.Can kind more than 40 be arranged edible sea cucumber in the world, there is kind more than 20 in China, but the big only kind surplus in the of 10 of commodity value.Sea cucumber nutrient is abundant, protein content contains 20 several amino acids up to 10～20g in every 100g water logging stichopus japonicus, comprising the necessary amino acid of human bodies such as threonine, lysine, isoleucine, also contain multiple compositions such as fat, vitamin, trace element simultaneously, but do not contain cholesterol.As a kind of nutrient health, Ancient Times in China " new compilation of materia medica " is called it " tonifying kidney and benefiting sperm; impotence is treated in establishing-Yang ", and Qing Dynasty's Zhao Xuemin is compiled the example that supplementary Amplifications of the Compendium of Materia Medica has been recorded and narrated the treatment hemorrhagic disease, and the medical value that " medicine mirror " and " property of medicine is examined " are gone up sea cucumber has carried out more detailed description.Last years of a century in 20th century, people further find, the contained acid mucopolysaccharide of sea cucumber has multiple pharmacological effect (Nie Wei such as antitumor, hypotensive and anticoagulation, Wang Shixian, pharmacological action of sea cucumber and clinical progress, Tianjin pharmacy, 2002,14 (1): 12-15), chondroitin sulfate then has significant curative effect (Collin, Peter Donald.Tissue fractions of sea cucumberfor the treatment of inflammation to arthritis; U.S. Patent No. 5,770,205, approval day: on June 23rd, 1998).This shows that along with development of modern science and technology and people's health care consciousness enhancing, nutritive value of sea cucumber and health care are worth the favor that more and more is subjected to people, the bioavilability with nutrition receives much attention especially.
At present, domestic except that the product of sea cucumber extract, the processing technology of sea cucumber powder is much more extensive, connective tissue (main part that sea cucumber the is edible) cell liquid that its drying program or freeze drying program might cause sea cucumber to be made of collagenous fibres runs off or cell rupture the active ingredient of loss sea cucumber; Or its goods fineness only reaches 70～90 orders (report that 100～500 order sea cucumber powder products are also arranged), fails to make the nutritive value of sea cucumber to obtain more effective absorbing.
Vacuum freezedrying claims drying bu sublimation again, its principle be with the quick-frozen of material elder generation to below the eutectic point of contained solution, under vacuum condition, make ice crystal be converted into water vapour (being called distillation) then and remove, thus the acquisition dried product.The goods of vacuum freezedrying have the advantage that many other methods can not be reached: as keep biological activity, be suitable for the processing of temperature-sensitive article and readily oxidizable substance product (Wang Yiqiang etc., vacuum freeze drying is to the influence of food quality, the Laiyang Agricultural College journal, 2003,20 (2): 149-153); Product volume is constant, has avoided material to concentrate and makes goods rotten; Form the structure of porosity and looseness, goods have extremely strong rehydration; Dehydration thoroughly, can be under sealing or normal temperature long preservation, (Jia Mingsheng, Freeze Drying Technique is in Application in Food Processing, food research and development, 1996,17 (2): 51-54) and the nutritive value loss is few.Therefore, the application of Lyophilisation technique for making in biological medicine and food service industry more and more widely, the feasibility of goods processing and economy depend on that then working process parameter selects and the produce market orientation.
To the powder body material between the nanometer, ultra-fine powder technology comprises preparation, separation, drying, conveying, mixing and the homogenizing technology of superfine powder to the space scale that superfine powder is meant object particle at micron, and process for modifying surface detects and application technology etc.Superfine powder is because its fine size, narrow diameter distribution, quality are even, thereby has specific area is big, surface-active is high, chemical reaction velocity is fast, fusing speed is fast, sintered body intensity is big and unique electricity, magnetic, optical characteristics etc.At present, superfine powder is widely used in many high-technology fields, as material, chemical industry, electronics, castoff regenerative and biological medicine etc., especially the application of superfine powder in traditional Chinese medicine and health food, expanded human medical-care health food source, make nutritious or effective in cure but discharge slow, moving of absorption difference, plant product has become high-grade trophism health food, feed as superfine pumpkin powder and to raise the artificial diabetes rabbit fruit that promptly takes effect after 9 days, (that opens is good etc. and common pumpkin powder needs just to see more than 15 days curative effect, superfine pumpkin powder is to the research of rabbit experiment diabetes effect, China's grain and oil journal, 1998,13 (2): 52-56).The dissolution rate and the utilization rate of active ingredient have been improved greatly through the Chinese medicine of ultra-fine grinding, their taking conveniences, avoided numerous and diverse decoction, Gastrodin dissolution rate as the rhizoma Gastrodiae micro powder granule has improved surplus in the of 20% than gastrodia tuber dispensing granule, and in 5 minutes Gastrodin stripping (World Science technology-Chinese medicine is integrated for Zhang Xiaojuan etc., Chinese medicine superfine powder and the application in Chinese medicine western language particle thereof more than 70%, 2002,4 (1): 47-49).
In using the numerous ultra-fine Chinese medicine of above-mentioned technology processing, health food source, the preparation of sea cucumber superfine powder yet there are no relevant report at home.
Summary of the invention
The object of the present invention is to provide the efficiently stripping of a kind of its nutritional labeling, release, thereby improve the preparation method of the sea cucumber superfine powder of bioavilability.
To achieve these goals, the technical solution adopted in the present invention is:
1. select for use the fresh sea cucumber of pure natural of place of production region conforms pollution-free food home environment quality technology standard to make raw material;
2. cleaning removal of impurities: sea cucumber carries out surface clean in flowing water, removes silt, ight soil in the sea cucumber body, draws out sea cucumber internal organ and enteron aisle simultaneously and abandons it;
3. the sea cucumber body wall is cut into the segment that thickness is 1～3cm (or block), to improve the freeze drying vacuum efficiency;
4. precooling stage: make the material quick-frozen to the material eutectic point, be specially: above-mentioned material tiles into dish, opening compressor freezes in advance to hothouse, behind Wen Da-13 ℃～-17 ℃ of about 10～15 minutes hothouse shelf plates, the glove charging tray is in frozen vacuum dryer, cryogenic temperature-40 ℃～-30 ℃ is set again, and cooling time reaches-25 ℃～-20 ℃ with temperature of charge and is as the criterion, general 1.5-2 hour;
5. vacuum drying: making the moisture in the material is gaseous state from solid-state direct distillation, specifically: material freezing fully after, opening vavuum pump vacuumizes water vessel earlier, again hothouse is vacuumized, energising heating shelf replenishes the required heat of water sublimed in the material then, and the plate temperature is linear to be promoted, per hour improve 6～10 ℃ approximately, the limiting temperature that the shelf heating is set is 40 ℃; Keep dry the vacuum of chamber at 15～17Pa, and water vessel vacuum is at 10～12Pa; Keep the water vessel temperature between-50 ℃～-45 ℃; After 6～20 hours, distillation is finished; Treat to stop when temperature of charge is stabilized in 35 ℃～37 ℃ desorption process; At this moment, material water ratio is 2%～5%;
6. the sealing of sea cucumber dry product is preserved, and prevents moisture absorption;
7. meal processing: earlier the sea cucumber dry product is crushed to 0.5～2.0mm size particles with general pulverizer;
8. ultra-fine grinding: sea cucumber meal impouring fluidized bed counter jet mill pulverizing chamber, with the high velocity air is power, material is by intergranular bump itself, and air-flow makes material pulverizing, breakage of particles refinement, machined parameters: air consumption 3～20m to effects such as the impact of material, shearing, frictions
3/ min, air pressure 0.5～1.0mPa, air velocity 350～500m/s; Material drops into grader through feeder, under the effect of classification vortex power, the thickness powder separates, the classified wheel of fine powder of satisfying granularity requirements enters the fine powder trapping system, and meal and reunion shape fine powder are reduced to the secondary air place, by the centrifugal ascending air of spiral material are washed strongly, the thickness powder is separated once more, grading wheel rotating speed 4,000～18,000r/min; The granularity of sea cucumber superfine powder finished product is 1,000～3,000 order, and the finished product moisture content is 6%～8%.
9. the collection manufactured goods must granularity be 1,000～3,000 purpose sea cucumber superfine powder.
Advantage of the present invention is:
1. guaranteed that the biochemical activity of nutriment is not damaged in the sea cucumber.Because the present invention has adopted this new and high technology of vacuum freeze drying, realized keeping in processing procedure product structure constant, nutritive value is constant, and especially thermo-responsive and biologically active readily oxidizable substance is not damaged, the processing technology favorable reproducibility, viable economically.
2. sea cucumber nutrient composition dissolving eduction rate obviously increases.Be example with three kinds of nutritional labelings only, the superfine powder protein content of the present invention's preparation is 5.4 times of former whole sea cucumber protein content up to more than 75%, and calcium content is 17 times of former whole sea cucumber content, and phosphorus content is 2.1 times of former whole sea cucumber content.
3. meet sanitary standard, have the environmental protection characteristics.Each processing link does not have any chemical treating process, and owing to through cleaning, removal of impurities, particularly remove internal organ, the content of harmful substance vanadium (V) in the sea cucumber superfine powder that makes is reduced to＜0.001%.
4. product has good cost performance.The product fineness that the present invention makes through vacuum freezedrying is 1,000～3, between 000 order, take the back and better bioavilability is arranged than sea cucumber individuality or meal product, thereby provide condition for reducing consumption, provide possibility for reducing use cost, injected new vitality for simultaneously the application and development of related medical health products.
5. the present invention adopts high velocity air mill comminuting method, and is easy and simple to handle, operation is few, process time is short, do not have other side reaction, sea cucumber powder purity height, pollution-free, can produce in batches.
The specific embodiment
Below in conjunction with specific embodiment in detail the present invention is described in detail.
Embodiment 1
1) select for use the fresh sea cucumber of pure natural of place of production region conforms pollution-free food home environment quality technology standard to make raw material;
2) clean removal of impurities: sea cucumber carries out surface clean in flowing water, removes silt, ight soil in the sea cucumber body, draws out sea cucumber internal organ and enteron aisle simultaneously and abandons it;
3) the sea cucumber body wall is cut into 2cm segment (or block);
4) precooling material: above-mentioned material tiles into dish, opens compressor to hothouse shelf refrigeration, and 15 minutes after plate Wen Da-15 ℃, the glove charging tray is in frozen vacuum dryer, cryogenic temperature-40 ℃ is set again, and cooling time reaches-25 ℃ with temperature of charge and is as the criterion, and present embodiment is 1.5 hours;
5) vacuum drying: concrete operations be treat material freezing fully after, open vavuum pump and earlier water vessel vacuumized, again hothouse is vacuumized, switch on then to the shelf heating, plate temperature (environment temperature) is linear to be promoted, and per hour improves about 10 ℃; The limiting temperature that the shelf heating is set is 40 ℃; Keep dry the vacuum of chamber at 15Pa, and water vessel vacuum is at 12Pa; Keep the water vessel temperature and be-45 ℃; After 6 hours, distillation is finished, and treats in the resolving to stop when temperature of charge is stabilized in 35 ℃; Dried material water ratio is 5%;
6) sealing of sea cucumber dry product is preserved, and prevents moisture absorption;
7) meal processing: earlier the sea cucumber dry product is crushed to the 2.0mm size particles with general pulverizer;
8) ultra-fine grinding: sea cucumber meal impouring fluidized bed counter jet mill pulverizing chamber is a power with the high velocity air under the normal temperature, and material is by intergranular bump itself, and air-flow makes material pulverizing, breakage of particles refinement to effects such as the impact of material, shearing, frictions.Concrete machined parameters: air consumption 20m
3/ min, air pressure 1.0mPa, air velocity 500m/s; Material drops into grader through feeder, under the effect of classification vortex power, the thickness powder separates, the classified wheel of fine powder of satisfying granularity requirements enters the fine powder trapping system, meal and reunion shape fine powder are reduced to the secondary air place, by the centrifugal ascending air of spiral material are washed strongly, and the thickness powder is separated once more, grading wheel rotating speed 14,000r/min.
9) collect manufactured goods, getting granularity is 2,000～3,000 purpose sea cucumber superfine powder (the finished product moisture content is 7%); Dress up capsule by every 250mg, take every day 1 time, one time 2.
Below with the pharmacological action of active material of sea cucumber and take the effect that embodiment illustrates that the sea cucumber superfine powder by the inventive method preparation is produced.
From the sea cucumber body wall, extract multiple bioactivator, sea cucumber acid mucopolysaccharide (Stichopus japonicus acidic mucopolysaccharides wherein, following Sjamp slightly), fucosylated chondroitin sulfate powder (Fucosylated chondroitin sulfate, below slightly FCS), glycoprotein and sea cucumber saponin (Holothurin) several bioactivators such as (being holothurin) have following tangible pharmacology clinical effect.
1) blood coagulation resisting function
The medical science man shows that to the effect of fibrinolytic system it can obviously suppress the gathering of fibrin monomer through discovering acid mucopolysaccharide (Sjamp) in many ways, increase the sensitiveness of fibrin clot to fibrinolysin, the fortifying fibre enzymatic activity, thereby accelerate fibrin gel and promoted fibrinolytic, play antithrombotic effect by the speed that fibrinolysin dissolves; And FCS has anticoagulant active, and under certain dosage its anti-freezing render a service stronger than heparin, but the researcher thinks the change of FCS induction of vascular endothelial cell membrane glycosaminoglycan activity, thereby change the blood plasma anticoagulating active.
2) reducing blood lipid, the effect of reduction blood viscosity
Clinical research shows that Sjamp can significantly reduce the concentration of T-CHOL (TC) and serum levels of triglyceride (TG), rising aPoA
1(ApoA
1) and reduce the concentration of apolipoprotein B (ApoB), and be dependence with the dosage of acid mucopolysaccharide, and acid mucopolysaccharide is the main cause that reduces plasma viscosity to the reduction of serum lipid concentrations and the adjusting of apolipoprotein composition.Because increasing with the generation of thrombotic diseases of blood fat, blood viscosity is closely related, so in thrombotic diseases was prevented and treated, the application of acid mucopolysaccharide and FCS was significant, because itself and heparin relatively have the effect of better treatment arterial thrombus and ISR.
3) antitumor, immunoregulation effect
Mainly contain two class materials with antitumor relevant in sea cucumber extract: one is the activity with the phagocytic activity that strengthens macrophage, stronger antithrombase and the acid mucopolysaccharide of antivirus action; Two for having the sea cucumber saponin of stronger antibiotic effect, antitumor activity and anti-radiation function.It is generally acknowledged that antineoplastic immune mainly is a cellular immunity, the activate the phagocytic capacity of monokaryon-macrophage system is one of leading indicator of body's immunity, and macrophage is antineoplastic main effects cell.Experimental study shows that Sjamp can significantly suppress DNA synthetic of mouse breast cancer nuclear S180 tumour cell, and tumor-bearing mice normal liver cell DNA synthetic there is facilitation, illustrate that Sjamp helps the propagation of normal liver cell, thereby infer that Sjamp has certain selection effect to mouse tumor cell and normal liver cell.Simultaneously old just bright and Wu Pingru etc. extracts glycoprotein I and glycoprotein I I from another kind of sea cucumber picolour zhuopianshen (Mensamaria intercedens) body wall, it is that component is different with Sjamp, and showing that through pharmacology activity research glycoprotein I I obviously suppresses the growth of mouse tumor cell, glycoprotein I mainly has been an immunoregulation effect.
4) antibiotic, antivirus action
Phosphate buffered liquid extract that there are some researches show sea cucumber all has the obvious suppression effect, the antibacterial action that sea cucumber extract triterpene glucosides has broad-spectrum again to exsomatize gram-positive bacteria and Gram-negative bacteria growing; In addition, two kinds of isolated sulphation triterpene glucosides (liouvillosides A, B) have viricidal effect, especially to the I herpes simplex virus type; The sea cucumber saponin has had strong inhibitory effects to fungi, extracts the sea cucumber saponin A, the B that separate and be used for athlete's foot and tinea alba infection from stichopus japonicus (Apostichopus japonicus).
5) anti-aging effects
It is generally acknowledged that increasing of oxygen radical is the main cause that causes body aging, and erythrocuprein (SOD) plays antidotal effect by removing oxygen radical.Pharmacological research shows that Stichopus variegatus (Sempen) (Stichopus variegates) extract can significantly improve the activity of mouse red blood cell SOD, has delaying senility function.Simultaneously, sea cucumber can prolong the life-span of fruit bat, increases the weight of mouse immune organ thymus gland and spleen.
6) the sea cucumber superfine powder is to the clinical drug effect of renal failure
Sea cucumber superfine powder of the present invention shows the clinical drug effect of uremia severe patient: the serious patient of several uremias is before taking, all carry out the hemodialysis clinic treatment in blood purification section of hospital, blood truly has improvement through purifying the back state of an illness, but mostly have a delicate constitution, handicapped, after taking this powder (half or a course of treatment), clinical response is then different greatly, most of patients is walked about down voluntarily, small number of patients can downstairs be taken a walk even can be walked first more than kilometer, along with a lot of patients' of prolongation of Time of Administration physique is restored, so the sea cucumber superfine powder shows the clinical effectiveness of renal failure: have and tonify Qi of the kidney, anti-ageing effect.
Take by the prepared superfine powder of technology of the present invention and also have other aspect therapeutic efficiencies:
1) the old, the male sex, 80 years old, permanent institute, bed, be hard and dry (each about 40 minutes, face is suppressed livid purple) can only eat liquid food; Day 2 sea cucumber superfine powders of the present invention of clothes, defecation is discharged two black hard spheres after 4 days, every day, stool was unimpeded fully normal afterwards, great rejoicing, adhere to taking 36 days after, facial ruddy, can normally take food, and can go out every day to walk more than 1 kilometer.
2) a heart disease patient, the male sex, 70 years old, coach; Take the front center stalk 3 times, did support one time, have a delicate constitution; Day is taken 2-4 grain sea cucumber superfine powder, and after 15 days, sensation is not from head to foot energetically upstairs panted, and is in high spirits, recovers regular physical training;
3) uremic patient, the women, 48 years old, haemodialysis regularly had a delicate constitution, unable, can only assist in down or the wheelchair treatment of coming at other people; Day is taken 2 sea cucumber superfine powders, and it is surplus to take first quarter moon, feels good, and physique is recovered, and can come and go in the man of strange land voluntarily.
Embodiment 2
Difference from Example 1 is:
Open compressor in the step 4) to hothouse shelf refrigeration, 20 minutes after plate Wen Da-13 ℃, the glove charging tray was provided with cryogenic temperature-30 ℃ again in frozen vacuum dryer, and cooling time reaches-23 ℃ with temperature of charge and is as the criterion, and present embodiment is 2 hours;
Step 5) keeps dry the vacuum of chamber at 17Pa, and water vessel vacuum is at 12Pa; Keep the water vessel temperature and be-50 ℃; Shelf plate temperature is linear in the process of vacuum drying promotes by per hour improving 6 ℃ of settings, and the limiting temperature of shelf heating is 40 ℃; Finish distillation after 10 hours; When being stabilized in 37 ℃, temperature of charge stops resolving; At this moment, material water ratio is 3%;
Machined parameters in the step 8) ultra-fine grinding: air consumption 5m
3/ min, air pressure 0.5mPa, air velocity 350m/s; The grading wheel rotating speed 6 of grader, 500r/min.
Step 9) is collected manufactured goods, and manufactured goods granularity 1,000～2,000 order, moisture content are 6%.
Embodiment 3
Difference from Example 1 is:
Step 3) cuts into the thin slice that thickness is 1cm with sea cucumber;
Open compressor in the step 4) to hothouse shelf refrigeration, 15 minutes after plate Wen Da-16 ℃, the glove charging tray was provided with cryogenic temperature-40 ℃ again in frozen vacuum dryer, and cooling time reaches-20 ℃ with temperature of charge and is as the criterion, and present embodiment is 1.5 hours;
Shelf plate temperature is linear in the step 5) vacuum drying promotes by per hour improving 8 ℃; Finish process of vacuum drying after 15 hours; At this moment, material water ratio is 2%;
Machined parameters in the step 8) ultra-fine grinding: air consumption 15m
3/ min, air pressure 0.8mPa, air velocity 450m/s; Grading wheel rotating speed 10,000r/min.
Step 9) is collected manufactured goods, manufactured goods granularity 1,500～2,500 orders.
Claims (6)
1. the preparation method of a sea cucumber superfine powder is characterized in that: select for use the fresh sea cucumber of pure natural to make raw material, through cleaning removal of impurities, be cut into pieces or bulk after, carry out vacuum freezedrying; Dry product is processed into meal, carries out ultra-fine grinding again.
2. according to the preparation method of the described sea cucumber superfine powder of claim 1, it is characterized in that: described cleaning, removal of impurities are meant fresh sea cucumber are cleaned up in clear water, remove silt, ight soil, sea cucumber internal organ and enteron aisle in the sea cucumber body, in order to avoid sea cucumber is festered and loses due trophism.
3. according to the preparation method of the described sea cucumber superfine powder of claim 1, it is characterized in that: described being cut into pieces or bulk is with the vertical or horizontal cutting of sea cucumber, and thickness is 1～3cm.
4. according to the preparation method of the described sea cucumber superfine powder of claim 1, it is characterized in that: described vacuum freezedrying is two stages with different parameters, the one, the precooling stage, make the material quick-frozen to the material eutectic point, be specially: the temperature that controls environment earlier is to-13～-17 ℃, put into material, cryogenic temperature-40 ℃～-30 ℃ is set again, cooling time reaches-25 ℃～-20 ℃ with temperature of charge and is as the criterion; The 2nd, the vacuum drying stage, making the moisture in the material is gaseous state from solid-state direct distillation, concrete parameter: hothouse vacuum is 15～17Pa, water vessel vacuum is 10～12Pa and freezes to-50 ℃～-45 ℃, the steam distillation time is 6～20 hours, and the heat-conduction medium linear temperature increase per hour raises 6～10 ℃, if limiting temperature is 40 ℃, when being stabilized in 35 ℃～37 ℃, ends temperature of charge.
6. according to the preparation method of the described sea cucumber superfine powder of claim 1, it is characterized in that: described meal processing is that dried sea cucumber is crushed to the particle that particle diameter is 0.5～2.0mm with general pulverizer.
7. according to the preparation method of the described sea cucumber superfine powder of claim 1, it is characterized in that: described ultra-fine grinding is to adopt fluidized bed airflow crushing technology processing sea cucumber superfine powder, its machined parameters scope: air consumption 3～20m
3/ min, air pressure 0.5～1.0mPa, air velocity 350～500m/s, grading wheel rotating speed 4,000～18,000r/min; Sea cucumber superfine powder granularity is 1,000～3,000 order.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101053008A CN1314359C (en) | 2003-12-09 | 2003-12-09 | Method for preparing super fines of sea cucumber |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101053008A CN1314359C (en) | 2003-12-09 | 2003-12-09 | Method for preparing super fines of sea cucumber |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1625982A true CN1625982A (en) | 2005-06-15 |
| CN1314359C CN1314359C (en) | 2007-05-09 |
Family
ID=34757249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003101053008A Expired - Fee Related CN1314359C (en) | 2003-12-09 | 2003-12-09 | Method for preparing super fines of sea cucumber |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1314359C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416757B (en) * | 2008-12-08 | 2012-03-07 | 大连海晏堂生物有限公司 | Preparation method of beche-de-mer capsules |
| CN102894258A (en) * | 2012-10-19 | 2013-01-30 | 山东好当家海洋发展股份有限公司 | Preparation method for sea cucumber and oat food |
| CN103653040A (en) * | 2012-09-07 | 2014-03-26 | 江苏学府生物工程有限公司 | Method for producing soluble sea cucumber powder |
| CN104432089A (en) * | 2014-11-25 | 2015-03-25 | 荣成宏业海洋科技有限公司 | Instant nutritional sea cucumber food and processing method thereof |
| CN104642843A (en) * | 2015-01-19 | 2015-05-27 | 周云川 | Royal jelly wall-breaking process |
| CN104970395A (en) * | 2015-06-12 | 2015-10-14 | 青岛野长海参科技股份有限公司 | Method for preparing sea cucumber superfine powder by using fresh sea cucumber and application of sea cucumber superfine powder prepared by method |
| CN107860784A (en) * | 2017-11-22 | 2018-03-30 | 河南省农业科学院农业质量标准与检测技术研究所 | A kind of method based on NMR metabonomic technologies parsing dioscorea opposita thumb nutritional component distributing |
| CN112473963A (en) * | 2020-11-05 | 2021-03-12 | 精晶药业股份有限公司 | Preparation method of crystalline L-carnitine ultrafine powder |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102450653A (en) * | 2010-10-22 | 2012-05-16 | 曹吉祥 | Animal spleen dry powder |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1081904C (en) * | 1998-04-07 | 2002-04-03 | 程显峰 | Full holothurian capsule and its making method |
-
2003
- 2003-12-09 CN CNB2003101053008A patent/CN1314359C/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101416757B (en) * | 2008-12-08 | 2012-03-07 | 大连海晏堂生物有限公司 | Preparation method of beche-de-mer capsules |
| CN103653040A (en) * | 2012-09-07 | 2014-03-26 | 江苏学府生物工程有限公司 | Method for producing soluble sea cucumber powder |
| CN102894258A (en) * | 2012-10-19 | 2013-01-30 | 山东好当家海洋发展股份有限公司 | Preparation method for sea cucumber and oat food |
| CN102894258B (en) * | 2012-10-19 | 2014-10-29 | 山东好当家海洋发展股份有限公司 | Preparation method for sea cucumber and oat food |
| CN104432089A (en) * | 2014-11-25 | 2015-03-25 | 荣成宏业海洋科技有限公司 | Instant nutritional sea cucumber food and processing method thereof |
| CN104642843A (en) * | 2015-01-19 | 2015-05-27 | 周云川 | Royal jelly wall-breaking process |
| CN104970395A (en) * | 2015-06-12 | 2015-10-14 | 青岛野长海参科技股份有限公司 | Method for preparing sea cucumber superfine powder by using fresh sea cucumber and application of sea cucumber superfine powder prepared by method |
| CN104970395B (en) * | 2015-06-12 | 2018-10-30 | 青岛野长海参科技股份有限公司 | A kind of application for the method and the sea cucumber Ultramicro-powder prepared by this method preparing sea cucumber Ultramicro-powder using fresh sea cucumber |
| CN107860784A (en) * | 2017-11-22 | 2018-03-30 | 河南省农业科学院农业质量标准与检测技术研究所 | A kind of method based on NMR metabonomic technologies parsing dioscorea opposita thumb nutritional component distributing |
| CN107860784B (en) * | 2017-11-22 | 2020-02-07 | 河南省农业科学院农业质量标准与检测技术研究所 | Method for analyzing distribution of nutritional components of dioscorea opposita based on NMR metabonomics technology |
| CN112473963A (en) * | 2020-11-05 | 2021-03-12 | 精晶药业股份有限公司 | Preparation method of crystalline L-carnitine ultrafine powder |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1314359C (en) | 2007-05-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8927523B2 (en) | Compound sea cucumber preparation and manufacturing method thereof | |
| CN1314359C (en) | Method for preparing super fines of sea cucumber | |
| CN105585639B (en) | Cordyceps militaris fruiting body heteropolysaccharide and application thereof | |
| CN101461852A (en) | Method for preparing super fine powder of rose | |
| CN101919875B (en) | Preparation method of enteromorpha mushroom polysaccharide compound | |
| CN104592412A (en) | Method for extracting chestnut polysaccharide | |
| CN106729601B (en) | Placenta lipopolysaccharide and polypeptide dual immunopotentiator and preparation method thereof | |
| CN101899120B (en) | Method for refining jujube polysaccharide | |
| CN1844160A (en) | Sulfonated changium root polysaccharides and preparing method and use thereof | |
| CN104844721B (en) | Extraction and separation method of Agrocybe aegirit polysaccharides | |
| CN1178672C (en) | Process for preparing polypeptide-nucleic acid nutritive liquid of sheep placenta | |
| CN104744601A (en) | Method for extracting and purifying fleurotus ferulae polysaccharide | |
| CN108567836A (en) | A method of combined extraction separation flavones and polysaccharide from hawthorn skin slag | |
| CN116425897B (en) | Rosa roxburghii polysaccharide, and preparation method and application thereof | |
| CN105541996A (en) | Method for extracting thymosin, medium molecular thymus protein and DNA from thymus tissue | |
| CN110141602A (en) | A kind of extracting method and application of Folium Mori alkaloid | |
| CN104403020A (en) | Semi-bionic lentinan extraction method | |
| CN101445564A (en) | Method for extracting cervus elaphus Linnaeus polysaccharide | |
| CN106366184A (en) | Preparation method of hirudin crude extract | |
| CN113088549A (en) | Method for extracting antioxidant polypeptide from human placental blood | |
| CN105962286A (en) | Plant salt containing lavandulaangustifoliamill extract and preparation method of plant salt | |
| CN101704887A (en) | Matrix protein in nacre based on secretions of mantle of pinctada and preparation method thereof | |
| KR20220076576A (en) | Method for separating water-soluble extract and fat-soluble extract containing betaglucan from mushroom | |
| CN101554473A (en) | Method for preparing compound with hypoglycemic function containing cornu cervi pantotrichum insulin-like active factors | |
| CN114717286B (en) | Preparation method of hazel mushroom antioxidant peptide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070509 Termination date: 20131209 |