CN1620467A - 分泌性蛋白质 - Google Patents

分泌性蛋白质 Download PDF

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Publication number
CN1620467A
CN1620467A CNA028282752A CN02828275A CN1620467A CN 1620467 A CN1620467 A CN 1620467A CN A028282752 A CNA028282752 A CN A028282752A CN 02828275 A CN02828275 A CN 02828275A CN 1620467 A CN1620467 A CN 1620467A
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Prior art keywords
nucleic acid
polypeptide
disease
acid molecule
diseases
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Pending
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CNA028282752A
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Chinese (zh)
Inventor
R·J·法根
C·B·菲尔普斯
A·古特里吉
C·包尔
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Ares Trading SA
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Ares Trading SA
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Publication of CN1620467A publication Critical patent/CN1620467A/zh
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CNA028282752A 2001-12-21 2002-12-23 分泌性蛋白质 Pending CN1620467A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0130720.6A GB0130720D0 (en) 2001-12-21 2001-12-21 Proteins
GB0130720.6 2001-12-21

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CN1620467A true CN1620467A (zh) 2005-05-25

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US (3) US20040106778A1 (cg-RX-API-DMAC7.html)
EP (3) EP1468018A2 (cg-RX-API-DMAC7.html)
JP (3) JP2005532034A (cg-RX-API-DMAC7.html)
KR (1) KR20040086247A (cg-RX-API-DMAC7.html)
CN (1) CN1620467A (cg-RX-API-DMAC7.html)
AU (3) AU2002356317A1 (cg-RX-API-DMAC7.html)
BR (1) BR0215284A (cg-RX-API-DMAC7.html)
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IL (1) IL162598A0 (cg-RX-API-DMAC7.html)
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Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003298344A1 (en) * 2002-12-04 2004-06-23 Laboratoires Serono Sa Novel ifngamma-like polypeptides
GB0314456D0 (en) * 2003-06-20 2003-07-23 Ares Trading Sa Interferon gamma-like protein
CA2527091A1 (en) * 2003-06-20 2004-12-29 Ares Trading S.A. Interferon gamma-like protein
AU2004269927B2 (en) * 2003-09-08 2009-09-17 Merck Serono Sa Treatment of fibrotic disease
US8778880B2 (en) * 2004-02-02 2014-07-15 Ambrx, Inc. Human growth hormone modified at position 35
ZA200606224B (en) * 2004-02-02 2007-11-28 Ambrx Inc Modified human growth hormone polypeptides and their uses
US20050260155A1 (en) * 2004-05-18 2005-11-24 Gopala Kovvali Compositions and methods for treatment of ulcerative colitis
CA2603452A1 (en) * 2005-04-04 2006-10-12 Julius-Maximillians-Universitat Wurzburg Tripeptides that down regulate the activity of plasma membrane transporters including sodium-d-glucose cotransporter sglt1
US7943328B1 (en) 2006-03-03 2011-05-17 Prometheus Laboratories Inc. Method and system for assisting in diagnosing irritable bowel syndrome
US8432899B2 (en) 2007-02-22 2013-04-30 Aylus Networks, Inc. Systems and methods for enabling IP signaling in wireless networks
US9026117B2 (en) 2006-05-16 2015-05-05 Aylus Networks, Inc. Systems and methods for real-time cellular-to-internet video transfer
US20080085524A1 (en) * 2006-08-15 2008-04-10 Prometheus Laboratories Inc. Methods for diagnosing irritable bowel syndrome
US20100094560A1 (en) * 2006-08-15 2010-04-15 Prometheus Laboratories Inc. Methods for diagnosing irritable bowel syndrome
EP2281199B1 (en) * 2008-06-04 2017-03-01 KCI Licensing, Inc. Detecting infection in reduced pressure wound treatment
HK1201176A1 (en) * 2011-10-20 2015-08-28 Neostem Oncology, Llc Antigen presenting cancer vaccine

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245966B1 (en) * 1998-07-14 2001-06-12 University Technology Corporation Adenoviral mediated gene transfer into lymphocytes
MXPA01012384A (es) * 1999-06-01 2002-09-02 Zymogenetics Inc Proteina zsig81 con haz de cuatro helices.
AU2608201A (en) * 1999-12-30 2001-07-16 Corixa Corporation Compounds for immunotherapy and diagnosis of colon cancer and methods for their use
WO2001051510A2 (en) * 2000-01-10 2001-07-19 Maxygen Holdings Ltd G-csf conjugates
US20020048763A1 (en) * 2000-02-04 2002-04-25 Penn Sharron Gaynor Human genome-derived single exon nucleic acid probes useful for gene expression analysis
US6436703B1 (en) * 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
AU2001280889A1 (en) * 2000-07-31 2002-02-13 Gene Logic, Inc. Molecular toxicology modeling
WO2004094713A2 (en) * 2003-04-16 2004-11-04 Applied Dna Sciences, Inc. System and method for marking textiles with nucleic acids
GB0314456D0 (en) * 2003-06-20 2003-07-23 Ares Trading Sa Interferon gamma-like protein

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