CN1618412A - Technique for making restitution skull and jawbone by using biological artificial bone material combined with CAD/CAM technology - Google Patents
Technique for making restitution skull and jawbone by using biological artificial bone material combined with CAD/CAM technology Download PDFInfo
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- CN1618412A CN1618412A CNA2004100539738A CN200410053973A CN1618412A CN 1618412 A CN1618412 A CN 1618412A CN A2004100539738 A CNA2004100539738 A CN A2004100539738A CN 200410053973 A CN200410053973 A CN 200410053973A CN 1618412 A CN1618412 A CN 1618412A
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Abstract
A technology for reconstituting the craniojaw with artificial bone material by CAD/CAM technique includes acquiring aranial data by CT, computer aided 3D reconstitution, fast shaping to restore the damaged bone model, reconstituting the 3D structure, copying the artificial bone, and clinical application. Its advantages are high bioactivity and biocompatibility, and tight adhesion to bone tissue.
Description
[technical field]
The present invention relates to technical field of biomedical materials, specifically the bio-artificial bone material is rebuild cranium jawbone processing technology in conjunction with the CAD/CAM technology.
[background technology]
World wide is used for also having following different materials than the material of large tracts of land cranium jaw defect reparation except hydroxyapatite class bioactive ceramics at present: titanium mesh, high density polyethylene (HDPE) and silicone rubber etc.Domestic and international existing technology is to adopt the titanium metal material three-dimensional reconstruction to make cranium jawbone customization body, and titanium has the following disadvantages: the one, and bio-inert material, material and human body bone are widely different, can not form synostosis with osseous tissue; The 2nd, the metal material heat conductivity is big, and there is potential zest in cerebral tissue; The 3rd, titanium metal material is shaped and processes relatively difficulty, and the process-cycle is long and processing cost is high.Hydroxyapatite class bioceramic fragility is bigger, and is difficult moulding.Though and the different materials clinical manipulation is easy to use in addition, but be bio-inert material, behind the implant into body between the long-term and osseous tissue interface clear, can not produce synostosis with osseous tissue, and these material products are prefabricated component, lacking individuality design usually influences aesthetic effect when especially using at the position that geometric shapes such as patient's frontal temporal part are had relatively high expectations.Consider that from biocompatibility and bone amalgamation angle it is indubitable that bone impairment renovation material is selected the bioactive materials close with human body bone physicochemical property.
The EH cmposite artificial bone is made up of hydroxyapatite and EAM medical resin plastotype agent two parts.The EH cmposite artificial bone solidifies the back stable chemical performance, and is water insoluble, is the good insulator of heat, and comprcssive strength, tensile strength are between cortical bone and spongy bone, and density is equivalent to body bone tissue, does not influence CT, MRT imaging.The EH cmposite artificial bone has still kept the good synosteosis that hydroxyapatite had aspect biocompatibility, have moulding easy characteristics simultaneously, therefore adopts the method for preceding prefabricated hone lamella of operation or osteocomma to carry out the reparation of cranium jaw defect in the past.Though method is simple, because the simulation of the damaged geometric shape of bone is mainly depended on X-ray photograph and to the touch at the damaged appearance of patient's bone place, therefore all has many shortcoming aspect anastomose property, circular arc degree and the maintenance pattern.
[summary of the invention]
The objective of the invention is to use computerized three-dimensional reconstruction and rapid shaping technique, directly turn over fast and make, be easy to perform the operation maintenance consistent with the defective bone geometric shape according to the CT scan data at patient's cranium jaw defect position, with healthy side symmetry, meet and repair aesthetic effect and agree that good synosteosis characteristic is arranged, be beneficial to the artificial cranium jawbone customization body of early stage knitting, a kind of specifically biologically active artificial bone material is rebuild cranium jawbone processing technology in conjunction with the CAD/CAM technology.
Realize above-mentioned purpose, design a kind of biologically active artificial bone material and rebuild cranium jawbone processing technology in conjunction with the CAD/CAM technology.It is characterized in that: comprise following processing step: patient's head CT data are picked; Computerized three-dimensional reconstruction; Rapidform machine restores the defective bone model; The reconstruction of three dimensional structure design; Biologically active artificial bone turns over the type of making, recovery; Clinical practice.Patient's head CT data pick into: it is unenhanced by the capable full head of spiral CT machine need to implement the patient that the cranium jawbone repairs, and requires scanning bed thickness≤8mm, contains symmetrical side; The transverse section data are rebuild bed thickness≤1.5mm, and it is identical with the reconstruction spacing to require to rebuild bed thickness; Location piece of writing in the data reconstruction must be packed respectively with a flat piece of writing, has different files; Data are recorded as CD with standard DICOM file format.The three-dimensional reconstruction of computer is: handling CT image digitization information translation by three-dimensional software is the three-dimensional reconstruction image data.Rapidform machine restores the defective bone model: change rapidform machine over to after the CT data process computer CAD software three-dimensional reconstruction imaging processing and carry out the entity manufacturing, restore the skeletal structure of defect and rebuild bone model.Three dimensional structure designs, is redeveloped into: combine with the CAD/CAM technology by spiral CT, make and rebuild bone and healthy side symmetry, be identical with the defect geometric shape.Biologically active artificial bone turns over the type of making, restores: turn over by the reconstruction bone model and make the Gypsum Fibrosum former, in the Gypsum Fibrosum former, insert the biologically active artificial bone material then, treat to make the needed cranium jawbone customization of patient's cranium jawbone repairing treatment body after material cured, the demoulding.Clinical practice is: after cranium jawbone customization body was made conventional high pressure steam sterilization, the use suture silk fixes and the supporting compound bone cement of EH is clogged fixing to bone interface.Biologically active artificial bone is made of powder and the two component systems of liquor.Powder and liquor mediation mass ratio are 3～7: 7～3.The powder Main Ingredients and Appearance is that bioglass material or biological activity class pottery comprise hydroxyapatite, tricalcium phosphate, carbonyldioxy apatite, saamite, fluor-apatite etc.; The liquor Main Ingredients and Appearance comprises Bis-GMA series, amido formate double methyl methacrylate and derivant or analog for the methacrylic organic resin.
The present invention compares with prior art, started the precedent that the biologically active artificial bone material is combined with computerized three-dimensional reconstruction cranium jawbone technology, biological activity height not only, the physical property of material, chemical property and osseous tissue are close, the biocompatibility degree is good, form synostosis closely with osseous tissue, and be processed to form easyly, quick, be worthy to be popularized.
[description of drawings]
Fig. 1 is the working envelope figure of the invention.
Referring to Fig. 1,1 picks for patient's head CT data; 2 is computer reconstruction; 3 restore the defective bone model for rapidform machine; 4 design, rebuild for three dimensional structure; 5 turn over the type of making, recovery for biologically active artificial bone; 6 are clinical practice.
[specific embodiment]
The present invention is further illustrated below in conjunction with accompanying drawing, and the present invention is still more clearly concerning those skilled in the art.
It is unenhanced by the capable full head of spiral CT machine that example 1. will be implemented the patient that the cranium jawbone repairs earlier, requires scanning bed thickness≤8mm, contains symmetrical side; The transverse section data are rebuild bed thickness≤1.5mm, and it is identical with the reconstruction spacing to require to rebuild bed thickness; Location piece of writing in the data reconstruction must be packed respectively with a flat piece of writing, exists different files again data to be recorded as CD with standard DICOM file format.Be the three-dimensional reconstruction image data by the Computerized three-dimensional software processes with CT image digitization information translation then, promptly get the CT data, carry out the entity manufacturing with changing the ZIPPY-1 rapidform machine over to after the CT data process computer CAD software three-dimensional reconstruction imaging processing, restore the skeletal structure of defect and rebuild bone model, combine with the CAD/CAM technology by spiral CT again, make and rebuild bone model and healthy side symmetry, be identical with the defect geometric shape, turn over by this reconstruction bone model then and make the Gypsum Fibrosum former, inserting by weight ratio again in the Gypsum Fibrosum former is the biologically active artificial bone material that the liquor of the powder of 30%-70% and 70%-30% is formed, and wherein the percentage composition of powder is hydroxy apatite particle: 20-47.5%; Tricalcium phosphate: 20-47.5%; Organic filler: 2-30%; Inorganic filler: 3-30%; The liquor Main Ingredients and Appearance comprises Bis-GMA series, amido formate double methyl methacrylate and derivant or analog for the methacrylic organic resin.At room temperature, solidified 20 minutes, treat to make the needed cranium jawbone customization of patient's cranium jawbone repairing treatment body after material cured, the demoulding.After at last skull customization body being made conventional high pressure steam sterilization, the use suture silk fixes and the supporting compound bone cement of EH is clogged fixing to bone interface.
Claims (10)
1. a biologically active artificial bone material is rebuild cranium jawbone processing technology in conjunction with the CAD/CAM technology, and it is characterized in that: comprise following processing step: (1) patient's head CT data are picked; (2) computerized three-dimensional reconstruction; (3) rapidform machine restores the defective bone model; (4) three dimensional structure design, reconstruction; (5) biologically active artificial bone turns over the type of making, recovery; (6) clinical practice.
2. a kind of biologically active artificial bone material as claimed in claim 1 is rebuild cranium jawbone processing technology in conjunction with the CAD/CAM technology, it is characterized in that: patient's head CT data pick into: it is unenhanced by the capable full head of spiral CT machine need to implement the patient that the cranium jawbone repairs, require scanning bed thickness≤8mm, contain symmetrical side; The transverse section data are rebuild bed thickness≤1.5mm, and it is identical with the reconstruction spacing to require to rebuild bed thickness; Location piece of writing in the data reconstruction must be packed respectively with a flat piece of writing, has different files; Data are recorded as CD with standard DICOM file format.
3. a kind of biologically active artificial bone material as claimed in claim 1 is rebuild cranium jawbone processing technology in conjunction with the CAD/CAM technology, it is characterized in that: the three-dimensional reconstruction of computer is: handling CT image digitization information translation by three-dimensional software is the three-dimensional reconstruction image data, obtains the CT data.
4. a kind of biologically active artificial bone material as claimed in claim 1 is rebuild cranium jawbone processing technology in conjunction with the CAD/CAM technology, it is characterized in that: rapidform machine restores the defective bone model and is: change rapidform machine over to after the CT data process computer CAD software three-dimensional reconstruction imaging processing and carry out the entity manufacturing, restore the skeletal structure of defect and rebuild bone model.
5. a kind of biologically active artificial bone material as claimed in claim 1 is rebuild cranium jawbone processing technology in conjunction with the CAD/CAM technology, it is characterized in that: three dimensional structure designs, is redeveloped into: combine with the CAD/CAM technology by spiral CT, make and rebuild bone and healthy side symmetry, be identical with the defect geometric shape.
6. a kind of biologically active artificial bone material as claimed in claim 1 is rebuild cranium jawbone processing technology in conjunction with the CAD/CAM technology, it is characterized in that: biologically active artificial bone turns over the type of making, restores and is: turn over by the reconstruction bone model and make the Gypsum Fibrosum former, in the Gypsum Fibrosum former, insert the biologically active artificial bone material then, treat to make the needed cranium jawbone customization of patient's cranium jawbone repairing treatment body after material cured, the demoulding.
7. rebuild cranium jawbone processing technology as the described a kind of biologically active artificial bone material of above-mentioned claim 1 in conjunction with the CAD/CAM technology, it is characterized in that: clinical practice is: after cranium jawbone customization body was made conventional high pressure steam sterilization, the use suture silk fixes and the supporting compound bone cement of EH is clogged fixing to bone interface.
8. a kind of biologically active artificial bone material as claimed in claim 1 is rebuild cranium jawbone processing technology in conjunction with the CAD/CAM technology, it is characterized in that: biologically active artificial bone is made of powder and the two component systems of liquor.
9. rebuild cranium jawbone processing technology as claim 1 or 7 described a kind of biologically active artificial bone materials in conjunction with the CAD/CAM technology, it is characterized in that: powder and liquor mediation mass ratio are 3～7: 7～3.
10. rebuild cranium jawbone processing technology as claim 1 or 7 described a kind of biologically active artificial bone materials in conjunction with the CAD/CAM technology, it is characterized in that: the powder Main Ingredients and Appearance is that bioglass material or biological activity class pottery comprise hydroxyapatite, tricalcium phosphate, carbonyldioxy apatite, saamite, fluor-apatite etc.; The liquor Main Ingredients and Appearance comprises Bis-GMA series, amido formate double methyl methacrylate and derivant or analog for the methacrylic organic resin.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2004100539738A CN1618412A (en) | 2004-08-24 | 2004-08-24 | Technique for making restitution skull and jawbone by using biological artificial bone material combined with CAD/CAM technology |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2004100539738A CN1618412A (en) | 2004-08-24 | 2004-08-24 | Technique for making restitution skull and jawbone by using biological artificial bone material combined with CAD/CAM technology |
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| CN1618412A true CN1618412A (en) | 2005-05-25 |
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| CNA2004100539738A Pending CN1618412A (en) | 2004-08-24 | 2004-08-24 | Technique for making restitution skull and jawbone by using biological artificial bone material combined with CAD/CAM technology |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908358A (en) * | 2014-05-03 | 2014-07-09 | 王学建 | Method for manufacturing artificial skull restoration prosthesis |
| CN103932823A (en) * | 2014-05-03 | 2014-07-23 | 王学建 | Manufacturing method for artificial skull repair prosthesis |
| CN103978789A (en) * | 2014-05-22 | 2014-08-13 | 中国科学院苏州生物医学工程技术研究所 | Head medical model quick forming method based on 3D printing |
| CN104749026A (en) * | 2015-04-20 | 2015-07-01 | 重庆大学 | In-vitro bone defect model as well as detection device and detection method for shape resilience |
| CN104783884A (en) * | 2015-05-06 | 2015-07-22 | 高仕长 | Sacroiliac joint anterior anatomy locking steel plate and design method thereof |
| CN105167831A (en) * | 2015-07-31 | 2015-12-23 | 上海倍尔康生物医学科技有限公司 | Composite skull plate and manufacturing method thereof |
| CN105666762A (en) * | 2016-03-01 | 2016-06-15 | 贵州师范大学 | Manufacturing method of individual hip joint holder die |
-
2004
- 2004-08-24 CN CNA2004100539738A patent/CN1618412A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103908358A (en) * | 2014-05-03 | 2014-07-09 | 王学建 | Method for manufacturing artificial skull restoration prosthesis |
| CN103932823A (en) * | 2014-05-03 | 2014-07-23 | 王学建 | Manufacturing method for artificial skull repair prosthesis |
| CN103978789A (en) * | 2014-05-22 | 2014-08-13 | 中国科学院苏州生物医学工程技术研究所 | Head medical model quick forming method based on 3D printing |
| CN103978789B (en) * | 2014-05-22 | 2016-05-11 | 中国科学院苏州生物医学工程技术研究所 | The head medicine model quick molding method of printing based on 3D |
| CN104749026A (en) * | 2015-04-20 | 2015-07-01 | 重庆大学 | In-vitro bone defect model as well as detection device and detection method for shape resilience |
| CN104783884A (en) * | 2015-05-06 | 2015-07-22 | 高仕长 | Sacroiliac joint anterior anatomy locking steel plate and design method thereof |
| CN105167831A (en) * | 2015-07-31 | 2015-12-23 | 上海倍尔康生物医学科技有限公司 | Composite skull plate and manufacturing method thereof |
| CN105666762A (en) * | 2016-03-01 | 2016-06-15 | 贵州师范大学 | Manufacturing method of individual hip joint holder die |
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