CN105327400A - Medical dental implant with surface biomimetic function and manufacturing method thereof - Google Patents
Medical dental implant with surface biomimetic function and manufacturing method thereof Download PDFInfo
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- CN105327400A CN105327400A CN201510887204.6A CN201510887204A CN105327400A CN 105327400 A CN105327400 A CN 105327400A CN 201510887204 A CN201510887204 A CN 201510887204A CN 105327400 A CN105327400 A CN 105327400A
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Abstract
The invention relates to a medical dental implant with the surface biomimetic function and a manufacturing method thereof. The medical dental implant is characterized in that the medical dental implant comprises an implant body and further comprises an outer layer of a bionic artificial bone structure, the outer layer is integrally combined with the outer surface of the implant body and capable of simulating the alveolar cavity bone tissue structure around the tooth root portion of a missing tooth of a patient. According to the medical dental implant and the manufacturing method thereof, the outer layer of the bionic bone structure, which is formed in a 3D printing mode and of a massive structure, serves as the outer layer of the tooth implant body, and therefore an ideal embodiment used for simulating the artificial bone surface structure is provided. More importantly, a good activity surface layer structure foundation beneficial to bone marrow stem cell and bone-formation related cell adhesion, proliferation and growth and capable of playing the final bone-formation function is provided, the surface of the foundation is loaded with chemical components such as calcium and phosphate and bioactive molecules such as collagens, hence, a bone-formation promotion microenvironment is created, bone cell generation is induced, and fast and firm bone combination can be achieved at the early stage.
Description
Technical field
The invention belongs to a kind of bio-medical tooth implant, particularly relate to and a kind of there is bionical medical tooth implantation body of surface biological and preparation method thereof.
Background technology
Along with increase and the aged tendency of population of vehicle accident, the absence of tooth that in crowd, a variety of causes causes increases year by year.Along with the raising of living standards of the people, people require day by day to increase to the reparation of absence of tooth and replacement.Due to the develop rapidly of current planting technology, dentistry implant has been widely used in the reparation of defect of dentition and dentition defect.In order to realize enough intensity, the position implanted metal of needs at absence of tooth or the tooth of alloy type implantation body and then replacement disappearance, recover attractive in appearance and function usually.In department of stomatology etc., pure titanium metal (or alloy) is because of its good biocompatibility, and mechanical property and corrosion resistance, be used widely in tooth-planting field.But Problems existing is: these metals or alloy itself are biologically inert, are difficult to be formed with osseous tissue quick, good synostosis, thus cause the healing cycle after planting to extend, bond strength is low, even plants failed problem.Particularly for the patient having general disease, the such as patient such as diabetes, osteoporosis, further increase the difficulty that plantation is repaired, if it is improper that plantation indication is selected, carry out implant operation reluctantly usually to cause planting unsuccessfully, increase economic loss and the misery of patient, and bury the seed of conflict between doctors and patients, affect the further genralrlization application of implant denture technology simultaneously.In addition, existing implantation body mostly is import, because expense is too high, also constrains the popularization that it is clinical, is difficult to benefit vast agomphosis patient.Numerous researcher adopts various method to realize the surface modification of implantation body to reach the bond strength of early stage Integrated implant and Geng Gao, mainly comprise 3 kinds of strategies: implant surface physical modification, chemical modification, biochemistry modification thus strengthen its surface activity, promote synosteosis.Specific as follows:
First physical modification
Physical modification mainly refers to the Ultrastructural change of implant surface, and comprise sandblasting, acid etching, sandblasting adds acid etching, and titanium slurry sprays, laser treatment etc.
1. blasting treatment
Sandblasting is by Al
2o
3, TiO
2or the granule such as hydroxyapatite, spray implantation body's material surface by high pressure draught, thus make surface coarsening.Blasting treatment can increase implant surface roughness preferably, but its shortcoming easily pollutes implant surface, and the implant surface after process is residual shot blasting particles often, and still have after ultrasonic waves for cleaning, sour passivation and sterilizing residual.After implantation body implants, these microgranules can be discharged in surrounding tissue the Integrated implant affecting implantation body.In addition, the matte surface finish that sandblasting is formed is often irregular, surface stress skewness, and can only form I and II hole, can not form three-dimensional hole.
The problem of blasting treatment is:
The sand grains of A sandblasting directly causes the pollution of implantation body's finished product.
Configuration of surface after B process is irregular, not easily realizes homogeneous, controlled, conforming surface treatment effect.
C has harm (suck and have damage to respiratory system, processing method not environmentally) for the health of processing staff.
2. acid etching acid etching implant surface avoids some shortcomings of sandblasting, the surface cleaning free from admixture formed, and form is homogeneous, and surface area is also relatively large.Implant surface acid etch technique be adopt strong acid as: hydrochloric acid, sulphuric acid, phosphoric acid or their mixed liquor etc. are by a kind of surface treatment method of implant surface roughening.Acid etching can clean the impurity of implant surface to a certain extent, forms secondary roughness, can stimulated osteoblastic proliferation and differentiation, is conducive to forming synosteosis.Acid etching is easy to operate, but its surface roughness that can reach is limited.
The problem of acid etching is:
A process solvent hydrochloric acid has harm for processing staff's health.
Personnel endanger: contact its steam or smog, can cause acute poisoning, occur eye conjunctivitis, nose and oral mucosa have burn feeling, epistaxis, gingiva bleeding gingival hemorrhage, tracheitis etc.Wrongly take and can cause that digestive tract is burnt, ulcer, likely cause gastric perforation, peritonitis etc.Eye and contact skin can cause burns.Chronic Effect: Long Term Contact, causes chronic rhinitis, chronic bronchitis, dental erosion and skin lesion.
Environmental hazard: have harm to environment, can pollute water body and soil.
Fire danger: this product is not fired, tool severe corrosive, strong and stimulating, human body can be caused and burn.
Toxicological information and environmental behaviour: acute toxicity: LD50900mg/kg (rabbit per os); LC503124ppm, 1 hour (rat suction)
Hazard property: can react with some active metal powder, releasing hydrogen gas.Meet the hydrogen cyanide gas that cyanide can produce severe toxicity.Close in occurring with alkali and react, and release a large amount of heat.There is severe corrosive.
The clean halfway reagent of the finished product after B processing is residual can affect planting effect.
C cannot realize the environment protection method of clean preparation.
3. sandblasting adds acid etching surface texture technology
Commercial blast is combined with specific acid etching processing method, is integrated with the advantage of sandblasting and acid etching, overcome again the shortcoming of the two.Advantage is that method is simple to operate, and cost is low, avoids the deficiency of simple blasting treatment, reduces or avoids surface contamination, optimizes the ultrastructure of implant surface, and the machinery improved between osseous tissue and implant surface is sealed.In recent years, sandblasting acid etching is used for carrying out implant surface modification by domestic and international many scholars.
The problem that sandblasting adds acid etching is: the problem that there is reagent contamination and unclean environmental protection in acid etching process.
4. titanium slurry sprays
Be sprayed on smooth implant surface at a high speed with the liquid titanium alloy of melting, forming through cooling fast, is the implantation body obtaining clinical success.Main advantage is whole implantation body is that a kind of material is prepared from, the residual stress of interface can be reduced, increase surface area simultaneously, micro-coarse structured fixedly the playing an important role in early days for osseous tissue formed, but operating procedure is complicated, peri-implant is with titanium granule to be existed, and the stability of coating is under suspicion.
Titanium is starched the problem sprayed and is:
A operating procedure is complicated
B peri-implant is with titanium particle contamination
The stability of C coating is under suspicion
5. laser method
Laser treatment implant surface is a kind of new method of Recent study, and existing test confirms to produce desirable roughness, and in processing procedure, material does not need to contact implant surface, pollutes so can not produce implant surface.But, the object of personalized simulated patient nature bone morphosis cannot be realized.
The problem of laser method is:
Simple laser treatment can only form the structures such as specific groove, texture in implant surface, cannot realize the object of personalized simulated patient nature bone morphosis.
Second chemical modification
The good biocompatibility that chemical modification has mainly through this important bone biomimetic material of hydroxyapatite and bone guided effect and promote early stage Integrated implant.The preparation technology of hydroxyapatite coating layer mainly comprises plasma spraying method, sol-gel process, ion beam assisted deposition, electrochemical deposition method, laser method, biomimetic method etc.
1. plasma spraying method
Plasma spraying refers to and utilizes plasma gun to produce direct current arc, is heated by coating material, is formed the technology of coating after dissolving by high velocity jet in metal surface.Plasma spraying, ferroalloy or pure titanium implant surface can be made greatly to increase with the contact area of bone, thus the mechanical bonding force strengthening implantation body and bone also can reduce the stress of implantation body and bone interface, and stress is disperseed more.
The problem of plasma spraying method is:
A causes the uneven of rough base face coat and cannot carry out the face coat of complex shaped substrate due to linear spraying coating process.
Treatment temperature in B preparation process too high (10000 DEG C), and the thermal coefficient of expansion of HA and the thermal coefficient of expansion of alloy phase differ greatly, make to produce residual interfacial stress between cooling procedure floating coat and substrate, coating is even made to crack or when after coating material implantable bioartificial body, because long-term existence makes coating loosen or peel off in fluid environment.
Pyroprocess in C spraying easily makes HA decompose, and produces the dephasigns such as amorphous HA in the coating, thus affects the biological property of coating
The density of D coating structure is lower, and after implant into body, biofluid easily penetrates into substrate interface along interconnected pore, causes interfacial corrosion, causes disbonding
2. sol-gel process
The colloidal solution prepared by suitable calcium phosphorus ration is coated in implant surface, then by heating, forms one deck and combine firmly hydroxyapatite films, significantly improve the synosteosis ability of implantation body.But in sol-gal process, gel has larger contraction in sintering process, and coating is easy to crack.
The problem of sol-gel process is: coating easily ftractures
3. laser method
Substrate material surface applies a certain proportion of CaHPO in advance
42H
2o and CaCO
3mixed-powder, then carries out cladding process with laser instrument, and synthesis is completed with coating hydroxyapatite coating layer one step.Well, hardness, intensity are higher, have certain toughness for obtained coating and the combination of substrate, but the uniformity of coating and the more difficult control of stability.
The problem of laser method is: coating uniformity and the more difficult control of stability, not easily produces in batches.
4. biomimetic method
Biomimetic method has imitated the mineralising mechanism of nature physiology apatite, its feature is that bionic coating (osteoid apatite coating) is that natural sediment is out in the aqueous solution being similar to human body environment's condition, its composition, closer to the inanimate matter of human bone, is expected to have higher biocompatibility and synosteosis ability.This method is that the surface treatment of titanium implant opens new approaches.But owing to there is complex disposal process, the time is long, is difficult to the problems such as volume production.
The problem of biomimetic method is:
The A processing time is long
B complex process
C is difficult to volume production
The defect of hydroxyapatite (HA) coating
HA and titanium physicochemical property differ greatly, and simultaneously preparation technology of coating is perfect not enough, and causing HA coating in vivo can not stable for extended periods of time, and easily occur dissolving, coming off, this problem does not also solve at present well.
Residual interfacial stress is there is, the risk of cause coating cracking, stripping off between A coating and substrate
B coating uniformity and the more difficult control of stability
The C processing time is long, and complex process is not easily produced in batches
3rd biochemistry modification
Biochemistry modification is by specific albumen, enzyme or peptide are fixed on implant surface, carrys out inducing osteoblast proliferation and differentiation, more directly effectively promotes Integrated implant.Conventional bioactive molecule comprises three major types: protide, somatomedin, bioactive peptide.The main method of biochemistry modification has absorption method, electrochemical process, composite coating method etc.Absorption method is all difficult to control to the state of bioactive molecule and its quantity in titanium surface adsorption, position, distribution and intensity, and individual variation is larger.Biochemical modified to improving the biological activity on implantation body's titanium surface and promoting that the effect of Integrated implant is obvious, but wherein major part is all also in the experimentation stage, such as bone morphogenetic protein (BMP) absorbs soon in vivo, the problems such as cost is higher, interaction mechanism between the poor specificity of compound adhesion peptide arginine-glycine-aspartic acid (RGD) sequence, cytokine, all await further solution.
The problem of biochemistry modification is:
The state of A bioactive molecule and stability are difficult to control
B bioactive molecule absorbs fast, poor specificity, and the mechanism of action is failed to understand
C prior art cost is high, and production efficiency is low
The defect of prior art: although prior art is all intended to (increase calcium phosphorus content) by implant surface process from physical arrangement (surface topography is coarse) and chemical composition, add the structure of bioactive molecule (increasing the bioactive ingredients such as collagen) angle simulation natural bone tissue, thus the biocompatibility of implant surface is improved by bionical means, but eventually there is larger difference with the structure of natural bone tissue, thus the bone structure of three-dimensional porous network shape cannot be obtained, therefore effective interpolation of chemistry and bioactive molecule cannot also be realized.The major defect that prior art all exists is exactly the surface layer of shortage one carrier structure bionical with natural bone tissue to greatest extent as implantation body, thus make that chemistry and bioactive ingredients can be effective be anchored to implant surface, final obtain desirable early stage fast with firmly synosteosis.Prior art surface-treated titanium implant not only has the shortcomings such as implant early stage difficulty and organization formation chemical bond, synosteosis are formed slowly, healing stage is longer, but also it is random strong to there is the course of processing, surface-treated result heterogeneity, poor stability, unmanageable problem; Can not stable for extended periods of time after coating preparation, easily occur dissolving, come off, the problem of course of processing pollution; Bioactive molecule state labile, poor specificity, the problem that production efficiency is low.In addition, also there is processing reagent has severe corrosive, contaminated environment, has the problems such as harmful effect to personnel health and environmental conservation.
Summary of the invention
The present invention for solve in known technology the technical problem that exists and provide a kind of can be bionical with natural bone tissue to greatest extent carrier structure as implantation body surface layer there is bionical medical tooth implantation body of surface biological and preparation method thereof.
The present invention for solving in known technology the technical problem that exists for having the technical scheme that the bionical medical tooth implantation body of surface biological takes is: it includes implantation body's body, also includes the skin of the biomimetic prosthetic bone structure of the imitative patient's missing tooth root of the tooth position surrounding socket bone organizational structure be combined as a whole with described implantation body body outer surface.
The present invention can also adopt following technical scheme:
Described implantation body's body is the implantation body's body of front root shape of having tooth pulled out based on the recovery patient of medical image.
The outer field thickness of the biomimetic prosthetic bone structure of described imitative patient's missing tooth root of the tooth position surrounding socket bone is 0.2-1.5 millimeter.
The present invention for solving in known technology the technical problem that exists for having one of technical scheme that the bionical medical tooth implantation body of surface biological takes is: described tooth implant body and described skin are an overall structure, and it includes following steps:
Obtain the medical image of the biomimetic artificial bone structural outside layers of imitative patient's missing tooth root of the tooth position surrounding socket bone bone structure; Extract from the medical image of above-mentioned acquisition and required be attached to described implantation body body surrounding socket bone bone structure data, add implantation body's body construction data; Set up described implantation body body and be attached to the three-dimensional digital model of the bionical implanting body of artificial tooth of described implantation body body surface surrounding socket bone bone structure individuation; The bionical implanting body of artificial tooth three-dimensional digital model of effects on surface individuation carries out format conversion; The bionical implanting body of artificial tooth mathematical model software of surperficial individuation that has after described format conversion is inputted the 3D solid manufacture that print system carries out the bionical implanting body of artificial tooth of surperficial individuation.
The present invention for solving in known technology the technical problem existed for two with the technical scheme that the bionical medical tooth implantation body of surface biological takes is: described tooth implant body and described skin are an overall structure, and it includes following steps:
Obtain and to have tooth pulled out the medical image of implantation body's body of front root shape and the medical image of the biomimetic artificial bone structural outside layers of imitative patient's missing tooth root of the tooth position surrounding socket bone bone structure based on the recovery patient of medical image; Extract from the medical image of described acquisition the required recovery patient based on medical image have tooth pulled out front root shape implantation body's body and be attached to described implantation body body surrounding socket bone bone structure data; Set up based on the recovery patient of medical image have tooth pulled out front root shape implantation body's body and be attached to the three-dimensional digital model of the bionical implanting body of artificial tooth of the individuation of described implantation body body surrounding socket bone bone structure; The implanting body of artificial tooth three-dimensional digital model bionical to described individuation carries out format conversion; Implanting body of artificial tooth mathematical model software bionical for individuation after described format conversion input print system is carried out the 3D solid manufacture of the bionical implanting body of artificial tooth of individuation.
The advantage that the present invention has and good effect are: the present invention is print the skin of formation one integrally-built Bionics Bone structure with 3D thus provide a kind of embodiment of desirable biomimetic artificial bone surface texture owing to have employed at the skin of tooth implant body.Of paramount importance there is provided a kind ofly be conducive to that bone marrow stem cell and skeletonization relevant cell adhere to, propagation and grow and play good active surface's architecture basics of final osteogenesis function, by at bioactive molecules such as chemical composition and collagen such as its area load calcium phosphorus, thus build the microenvironment that promotes skeletonization, induction osteocyte generates, and realizes early stage fast and firmly synosteosis.
This technology carries out implantation body's processing owing to adopting 3D printing technique, mainly contains following advantage:
1. process overall process to carry out in confined space, completely avoid aforesaid sandblasting, acid etching process for the infringement of the health of processor and environmental pollution.
2. the complete software according to pre-designed STL form of processing and program are carried out, so the course of processing that traditional surface treatment mode can be avoided completely to bring is random strong, and surface-treated result heterogeneity, poor stability, unmanageable problem; Can not stable for extended periods of time after coating preparation, easily occur dissolving, come off, the problem of technical sophistication.
3. processing mode is by clear light source laser direct irradiation mode successively high-temperature fusion titanium or titanium alloy metal dust, multi-shell curing is carried out for tooth implant body and outer Bionics Bone structure entirety thereof, tooth implant body and outer Bionics Bone structure sealing-off between layers thereof therefore can be avoided to affect the problem of intensity and cast the problem of defect and the course of processing pollution caused.
4. owing to adopting the implantation body's compactness extent designing expectation in advance, the eburnation degree of the density of its implantation body and individual patients can be realized to reach farthest approach, avoid causing not merging and tardy synosteosis between body osseous tissue in the implantation body that the elastic modelling quantity that sufferers of osteoporosis face et al. Ke is too hard is excessive, even plant failure.
5. for diabetes and sufferers of osteoporosis face, can also by having the medicine thus the Osseointegrated implants promoting individual patients targetedly stage by stage for the treatment of diabetes and osteoporosis effect and anti-inflammatory at biomimetic artificial bone area load of the present invention.Such as diabetics, load Remedies for diabetes at implantation body's biomimetic prosthetic bone surface, prevent diabetes the plantation failure caused, and improves plantation success rate.
6. the most important advantage of the surface topography that obtains relative to traditional machinery or chemical surface treatment mode of the present invention and component modification is, the surface that traditional approach obtains only can obtain comparatively simple single groove, shallow hole or tubular structure, or several simple structure is cumulative, but, the present invention can realize 3 D stereo network structure, the structure composition of maximum simulation nature bone, thus not only realize ideal in physical arrangement and micromorphology bionical, and for the follow-up chemical composition of adding nature bone is on this basis (as calcium phosphorus, hydroxyapatite etc.) and interpolation have bioactive molecule (such as collagen protein etc.) even the medicative medicine of tool (such as treat diabetes, osteoporosis and anti-inflammatory drug etc.) establish firmly architecture basics.Be recognized that porous three-dimensional stereochemical structure is compared with traditional simple single groove, shallow hole or tubular structure, surface area enlarges markedly, and loose structure is advantageously climbed in osteoblast, adhere to, embed, and then firmly connect and promote that the mode of new bone formation is the more desirable direct skeletonization of implant surface.Moreover, the medicative medicine of tool (such as treating diabetes, osteoporosis and anti-inflammatory drug etc.) at porous three-dimensional three-dimensional surface compared with traditional simple single groove, shallow hole or tubular structure, also be more prone to realize slow release, thus overcome the patient with above-mentioned corresponding general disease and plant failed problem, be expected to the indication expanding implant prostheses, original relative contraindication is made to be transformed into indication, for these patients bring glad tidings.
Accompanying drawing explanation
Fig. 1 is one of tooth implant structural representation of the present invention;
Fig. 2 is tooth implant structural representation two of the present invention;
Fig. 3 is tooth implant structural representation three of the present invention;
Fig. 4 is tooth implant structural representation four of the present invention;
Fig. 5 is tooth implant structural representation five of the present invention;
Fig. 6 is tooth implant structural representation six of the present invention;
Fig. 7 is tooth implant structural representation seven of the present invention.
Detailed description of the invention
For content of the present invention, Characteristic can be understood further, hereby exemplify following examples, and coordinate accompanying drawing to be described in detail as follows:
As shown in figs. 1-7, a complete implant denture forms primarily of three parts: corona 4, base station 3, implantation body's body 1.Implantation body's body 1 is the alveolar bone of the part that implant denture is combined with osseous tissue, i.e. artificial tooth root, direct patients with implantation, plays fixed support effect.Base station 3, between implantation body's body 1 and corona 4, connects implantation body's body 1 to root side, connects corona 4, play the effect of forming a connecting link to hat side.Implantation body's body 1 and base station 3 are not directly exposed to oral cavity, only have corona 4 part to be exposed in oral cavity, are the parts playing final attractive in appearance and masticatory function.The skin of tooth implant body 1 is the skin 2 printing the integrally-built Bionics Bone structure of formation one with 3D.
As the present invention can be used for a few class below:
One, about the shape of implantation body's body 1:
1. as Fig. 1,2,3, shown in 4, implantation body's body 1 is cylindric or conical outer form.
2., as Fig. 5, shown in 7, implantation body's body 1 is that the recovery patient made based on medical image data has tooth pulled out implantation body's body of front root shape, and wherein Fig. 5 is two root shape, and Fig. 7 is single root shape.
3. as shown in Figure 6, implantation body's body 1 is the shape of surface with helicitic texture.
Two, about the connected mode of implantation body's body 1 and base station 3:
4. as Fig. 1,2, shown in 5, implantation body's body 1 is with base station 3 for one-part form is connected, and namely planting body 1 body and base station 3 be overall manufacture, integrated.
5. as Fig. 3,4,6, shown in 7, implantation body's body 1 is with base station 3 for two-part is connected, and namely implantation body's body 1 and base station 3 are fixed by screw, also has minority to be that taper lock connects (unlisted).
Three, the connected mode of base station 3 and corona 4: (Fig. 3,6,7, owing to only showing implantation body's body 1 part, thus do not relate to)
6., as Fig. 1, shown in 2, the connection of base station 3 and corona 4 is for passing through Screw retained.
7., as Fig. 4, shown in 5, the connection of base station 3 and corona 4 is cemented retention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
The thickness of the skin 2 of Bionics Bone structure is 0.2 millimeter, 0.8 millimeter or 1.5 millimeters.
The factor substance of medicine or promotion osteogenesis can be contained in the skin 2 of Bionics Bone structure, as calcium phosphorus, hydroxyapatite collagen protein; Treatment diabetes, osteoporosis and anti-inflammatory drug etc.
Manufacture method one of the present invention is: it includes following steps:
Step one, obtain the medical image of the biomimetic artificial bone structural outside layers of imitative patient's missing tooth root of the tooth position surrounding socket bone bone structure with CT or CBCT;
Extract in step 2, the medical image that obtains from step one and required be attached to described implantation body body surrounding socket bone bone structure data;
Step 3, in step 2 to extract mandibular organization's data process, add implantation body body construction data, set up described implantation body body and be attached to the three-dimensional digital model of the bionical implanting body of artificial tooth of described implantation body body surface surrounding socket bone bone structure individuation;
The bionical implanting body of artificial tooth three-dimensional digital model of step 4, the effects on surface individuation utilizing 3 d modeling software step 3 to be set up carries out format conversion, implanting body of artificial tooth three-dimensional digital model bionical for surperficial individuation is changed into the formatted files such as the STL that 3D print system can identify;
Step 5, the implanting body of artificial tooth mathematical model software input print system having surperficial individuation bionical after described format conversion is carried out the 3D solid manufacture of the bionical implanting body of artificial tooth of surperficial individuation; The stl file of implanting body of artificial tooth bionical for surperficial individuation input 3D print system is carried out the 3D solid manufacture of artificial bone.
Manufacture method two of the present invention: it includes following steps:
Step one, to obtain with CT or CBCT and to have tooth pulled out the medical image of implantation body's body of front root shape and the medical image of the biomimetic artificial bone structural outside layers of imitative patient's missing tooth root of the tooth position surrounding socket bone bone structure based on the recovery patient of medical image;
Step 2, from step one obtain medical image in extract the required recovery patient based on medical image have tooth pulled out front root shape implantation body's body and be attached to described implantation body body surrounding socket bone bone structure data;
Step 3, in step 2, the mandibular organization's data extracted to be processed, set up described implantation body body and be attached to the three-dimensional digital model of the bionical implanting body of artificial tooth of described implantation body body surface surrounding socket bone bone structure individuation;
The bionical implanting body of artificial tooth three-dimensional digital model of step 4, the effects on surface individuation utilizing 3 d modeling software step 3 to be set up carries out format conversion, implanting body of artificial tooth three-dimensional digital model bionical for surperficial individuation is changed into the formatted files such as the STL that 3D print system can identify;
Step 5, the implanting body of artificial tooth mathematical model software input print system having surperficial individuation bionical after described format conversion is carried out the 3D solid manufacture of the bionical implanting body of artificial tooth of surperficial individuation; The stl file of implanting body of artificial tooth bionical for surperficial individuation input 3D print system is carried out the 3D solid manufacture of artificial bone.
Present invention achieves that dental implant surface is meticulous, environmental protection, controlled, homogeneous, bionical and there is the manufacture of the individuation artificial growth body at utmost close with individual patients sclerotin.The processing mode breaking through existing dental implant surface modification technology not environmentally, for processing staff's health damage, coating shedding, cannot realize the present situation bionical with implanting the immediate individuation of individual jaw structure.Achieve that dental implant surface is meticulous, environmental protection, controlled, homogeneous, bionical, achieve the manufacture of customized type individuation biomimetic prosthetic implantation body, meet the demand of tooth implant customized type and individuation in clinical oral plantation.And greatly reduce due to traditional dental implant surface and individual patients jawbone surface topography feature gap is excessive and the knitting that causes slow, healing cycle is long, and causes tooth implant to come off after tooth implant implantation, plant the problem such as unsuccessfully.After implanting body of artificial tooth implant into body bionical for surperficial individuation of the present invention, the jaw structure characteristic of simulated patient individuation as far as possible to greatest extent, thus realize shortening crop cycle, reach quick, stablize long-term synosteosis, better exercise the function of tooth implant.
Claims (5)
1. one kind has the bionical medical tooth implantation body of surface biological, it includes implantation body's body, it is characterized in that: the skin also including the biomimetic prosthetic bone structure of the imitative patient's missing tooth root of the tooth position surrounding socket bone organizational structure be combined as a whole with described implantation body body outer surface.
2. according to claim 1 have the bionical medical tooth implantation body of surface biological, it is characterized in that: described implantation body's body is the implantation body's body of front root shape of having tooth pulled out based on the recovery patient of medical image.
3. according to claim 1 and 2 have the bionical medical tooth implantation body of surface biological, it is characterized in that: the outer field thickness of the biomimetic prosthetic bone structure of described imitative patient's missing tooth root of the tooth position surrounding socket bone is 0.2-1.5 millimeter.
4. a manufacture method with the bionical medical tooth implantation body of surface biological according to claim 1, is characterized in that: described tooth implant body and described skin are an overall structure, and it includes following steps:
Obtain the medical image of the biomimetic artificial bone structural outside layers of imitative patient's missing tooth root of the tooth position surrounding socket bone bone structure; Extract from the medical image of above-mentioned acquisition and required be attached to described implantation body body surrounding socket bone bone structure data, add implantation body's body construction data; Set up described implantation body body and be attached to the three-dimensional digital model of the bionical implanting body of artificial tooth of described implantation body body surface surrounding socket bone bone structure individuation; The bionical implanting body of artificial tooth three-dimensional digital model of effects on surface individuation carries out format conversion; The bionical implanting body of artificial tooth mathematical model software of surperficial individuation that has after described format conversion is inputted the 3D solid manufacture that print system carries out the bionical implanting body of artificial tooth of surperficial individuation.
5. the manufacture method with the bionical medical tooth implantation body of surface biological according to claim 4, is characterized in that: described tooth implant body and described skin are an overall structure, and it includes following steps:
Obtain and to have tooth pulled out the medical image of implantation body's body of front root shape and the medical image of the biomimetic artificial bone structural outside layers of imitative patient's missing tooth root of the tooth position surrounding socket bone bone structure based on the recovery patient of medical image; Extract from the medical image of described acquisition the required recovery patient based on medical image have tooth pulled out front root shape implantation body's body and be attached to described implantation body body surrounding socket bone bone structure data; Set up based on the recovery patient of medical image have tooth pulled out front root shape implantation body's body and be attached to the three-dimensional digital model of the bionical implanting body of artificial tooth of the individuation of described implantation body body surrounding socket bone bone structure; The implanting body of artificial tooth three-dimensional digital model bionical to described individuation carries out format conversion; Implanting body of artificial tooth mathematical model software bionical for individuation after described format conversion input print system is carried out the 3D solid manufacture of the bionical implanting body of artificial tooth of individuation.
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| CN106037965A (en) * | 2016-08-23 | 2016-10-26 | 天津医科大学口腔医院 | Individualized biomimetic dental implant and manufacture method thereof |
| CN106725938A (en) * | 2016-12-23 | 2017-05-31 | 大连三生科技发展有限公司 | A kind of implant system with Angled abutment |
| CN106725932A (en) * | 2016-12-23 | 2017-05-31 | 大连三生科技发展有限公司 | Straight base station implant system based on titanium-zirconium alloy |
| CN106725934A (en) * | 2016-12-23 | 2017-05-31 | 大连三生科技发展有限公司 | A kind of planting body with primary and secondary screw thread |
| CN107080600A (en) * | 2017-06-30 | 2017-08-22 | 深圳市倍康美医疗电子商务有限公司 | A kind of artificial tooth and forming method with retention pin |
| WO2017188832A1 (en) * | 2016-04-28 | 2017-11-02 | Af Praktyka Stomatologiczna Artur Frydrychewicz | Bionic implants and manufacturing methods thereof |
| CN106333753B (en) * | 2016-08-23 | 2019-07-02 | 天津医科大学口腔医院 | The dental implant and preparation method thereof of individuation bionic |
| CN111093557A (en) * | 2017-09-18 | 2020-05-01 | 奥齿泰有限责任公司 | Dental implant assembly and method for manufacturing same |
| CN111419443A (en) * | 2020-03-27 | 2020-07-17 | 河北医科大学第二医院 | Alveolar bone shaping device |
| CN111544139A (en) * | 2020-03-23 | 2020-08-18 | 浙江大学 | Personalized bionic implant for synchronously repairing defects of teeth and peripheral alveolar bones and forming method thereof |
| JP7292572B1 (en) * | 2022-12-15 | 2023-06-19 | 諒 大槻 | Artificial tooth manufacturing method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2017188832A1 (en) * | 2016-04-28 | 2017-11-02 | Af Praktyka Stomatologiczna Artur Frydrychewicz | Bionic implants and manufacturing methods thereof |
| CN106037965A (en) * | 2016-08-23 | 2016-10-26 | 天津医科大学口腔医院 | Individualized biomimetic dental implant and manufacture method thereof |
| CN106333753B (en) * | 2016-08-23 | 2019-07-02 | 天津医科大学口腔医院 | The dental implant and preparation method thereof of individuation bionic |
| CN106725938A (en) * | 2016-12-23 | 2017-05-31 | 大连三生科技发展有限公司 | A kind of implant system with Angled abutment |
| CN106725932A (en) * | 2016-12-23 | 2017-05-31 | 大连三生科技发展有限公司 | Straight base station implant system based on titanium-zirconium alloy |
| CN106725934A (en) * | 2016-12-23 | 2017-05-31 | 大连三生科技发展有限公司 | A kind of planting body with primary and secondary screw thread |
| CN107080600B (en) * | 2017-06-30 | 2019-01-01 | 深圳市倍康美医疗电子商务有限公司 | A kind of artificial tooth and forming method with retention pin |
| CN107080600A (en) * | 2017-06-30 | 2017-08-22 | 深圳市倍康美医疗电子商务有限公司 | A kind of artificial tooth and forming method with retention pin |
| CN111093557A (en) * | 2017-09-18 | 2020-05-01 | 奥齿泰有限责任公司 | Dental implant assembly and method for manufacturing same |
| CN111544139A (en) * | 2020-03-23 | 2020-08-18 | 浙江大学 | Personalized bionic implant for synchronously repairing defects of teeth and peripheral alveolar bones and forming method thereof |
| CN111544139B (en) * | 2020-03-23 | 2021-07-20 | 浙江大学 | Personalized bionic implant for synchronously repairing defects of teeth and peripheral alveolar bones and forming method thereof |
| CN111419443A (en) * | 2020-03-27 | 2020-07-17 | 河北医科大学第二医院 | Alveolar bone shaping device |
| JP7292572B1 (en) * | 2022-12-15 | 2023-06-19 | 諒 大槻 | Artificial tooth manufacturing method |
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