CN104749026A - In-vitro bone defect model as well as detection device and detection method for shape resilience - Google Patents
In-vitro bone defect model as well as detection device and detection method for shape resilience Download PDFInfo
- Publication number
- CN104749026A CN104749026A CN201510187081.5A CN201510187081A CN104749026A CN 104749026 A CN104749026 A CN 104749026A CN 201510187081 A CN201510187081 A CN 201510187081A CN 104749026 A CN104749026 A CN 104749026A
- Authority
- CN
- China
- Prior art keywords
- sample carrier
- girder
- semi
- bone
- defect model
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Prostheses (AREA)
Abstract
The invention discloses an in-vitro bone defect model as well as a detection device and a detection method for shape resilience, and belongs to the technical field of bone repair. The model disclosed by the invention comprises a sample stage and a cantilever beam arranged on the sample stage, wherein the sample stage comprises a base as well as an upper sample holder and a lower sample holder which are arranged in a vertical direction at an interval; a support pad with an adjustable area is arranged on the upper end part of the upper sample holder and another support pad with an adjustable area is arranged on the lower end part of the lower sample holder; the upper sample holder is slidably arranged on the cantilever beam; the lower sample holder is slidably arranged on the base. The detection device disclosed by the invention comprises a linear differential displacement sensor, a signal conditioner, a data acquisition card and a computer. The measurement method disclosed by the invention comprises the step of randomly presetting the action sites of the cantilever beam so as to represent the elastic coefficients of different autogenous bones. According to the model, the detection device and the detection method disclosed by the invention, quantitative detection for the shape resilience of a shape memory artificial bone material can be carried out according to the cantilever beam structure and the detection device, and a positive practical significance is achieved for the clinical applications of using shape memory artificial bones for solving defect bones.
Description
Technical field
The invention belongs to Bone Defect Repari technical field, be specifically related to a kind of external Cranial defect model and recovery of shape force checking device and detection method thereof.
Background technology
Bone nonunion is fractured and complication common in bone defect healing, and it typically refers to fracture or Cranial defect position does not form bone connection in repair process, and normal knitting process stops.Form the reason of bone nonunion and comprise that fracture gap or artificial bone and autologous spatium interosseum are too large, stress shielding, fixing instability and blood supply insufficiency etc.For bone nonunion problem, great majority research be all concentrate on bone nonunion formed after methods for the treatment of and therapeutic scheme research on, but the Retreatment after bone nonunion is formed, while causing suffering to patient's body and mind, also can produce not even lower than the expense of seance.Inventor herein develops a kind of shape memory artificial bone of Shape-based interpolation memory polymer, when there is recovery of shape in this artificial bone near body temperature, artificial bone and autologous spatium interosseum can be filled completely, produce recovery of shape power can partial-compensation stress shielding produce understressing, by zoopery preliminary proof, this artificial bone can be formed by preventing bone nonunion in advance.
But the physicochemical property of people's bone and age, sex, position are relevant, and also relevant with the health status, physiological period etc. of people, the physical dimension (mainly length and diameter) of different its Cranial defect of patient is also not quite similar.This causes the requirement of its length to artificial bone, diameter, recovery stress etc. also different.And at present, owing to also there is no quantitative device for detecting mechanical property for Bone Defect Repari artificial bone, thus the personnel that can't direct study carry out mechanical property design to artificial bone, also namely can not get suitable artificial bone size, to a certain extent, have impact on the result for the treatment of adopting shape memory artificial bone to carry out Bone Defect Repari method.
Summary of the invention
In view of this, the invention provides a kind of external Cranial defect model and recovery of shape force checking device and detection method thereof, utilize this artificial bone defect model can adjust arbitrarily Cranial defect length and diameter, and the elasticity coefficient of autologous bone can be simulated, the deflection of the autologous bone of quantitative detection, overcomes prior art and cannot obtain the problem that suitable artificial bone size existence affects result for the treatment of.
An object of the present invention is achieved through the following technical solutions:
A kind of external Cranial defect model, comprise the cantilever beam structure that can be characterized the mould property coefficient of different autologous bone by the elasticity coefficient of different action site, described cantilever beam structure comprises sample stage and semi-girder placed on it, described sample stage comprises base and sample carrier and lower sample carrier on vertical direction is spaced, the upper end of described upper sample carrier and the bottom of lower sample carrier are provided with the adjustable supporting pad of area, described upper sample carrier is slidably arranged on a cantilever beam, and described lower sample carrier is slidably arranged on base.
Further, described upper sample carrier is provided with semi-girder chute, described base is provided with lower sample carrier chute.
Further, described upper sample carrier is provided with the lock-screw upper sample carrier can fixed on a cantilever beam.
Further, the upper end of described lower sample carrier is provided with the screw of adjustment up and down of adjustment and upper sample carrier distance.
Further, described semi-girder is provided with the scale I that accurately can measure sample carrier horizontal level, described base is provided with the scale II corresponding with scale I, described upper sample carrier is provided with the aligning groove I for aiming at scale I, described lower sample carrier is provided with the aligning groove II for aiming at scale II.
Further, described upper sample carrier has view window at semi-girder chute place, and described aligning groove I is provided with top or the bottom of view window.
Further, the temperature-controlled chamber being arranged on and between sample carrier and lower sample carrier, artificial bone being heated also is comprised.
Two of object of the present invention is achieved through the following technical solutions:
A kind of pick-up unit of the recovery of shape power based on above-mentioned a kind of external Cranial defect model, comprise external Cranial defect model, also comprise linear differential displacement transducer, signal conditioner, data collecting card and computing machine, described linear differential displacement transducer is made up of linear differential displacement sensor probe and the sleeve that cell winding is housed, be fixed on base by sleeve below it, be fixed on the free end of semi-girder by diamagnetism bar above it, described linear differential displacement sensor probe is connected with computing machine with signal conditioner, data collecting card.
Three of object of the present invention is achieved through the following technical solutions:
Adopt the detection method of above-mentioned a kind of recovery of shape force checking device, its concrete grammar is:
1) any predetermined semi-girder action site, to characterize the mould property coefficient of different autologous bone;
2) Area of bearing of upper and lower sample carrier supporting pad is made a reservation for arbitrarily;
3) distance arbitrarily between predetermined upper and lower sample carrier supporting pad;
4) arrange with 2), 3) artificial bone that matches, and be placed in temperature-controlled chamber;
5) after artificial bone temperature reaches memory temperature and is fully out of shape, the amount of deflection δ of semi-girder free end is measured
0;
6) according to semi-girder principle, restoring force F is calculated by following formula:
Wherein, a is the distance between semi-girder fulcrum O and upper sample carrier, and L, b, h are respectively the length and width of semi-girder and thick, and E is the elastic modulus of semi-girder.
7) the amount of deflection δ of artificial bone contact point semi-girder is calculated by following formula
a:
8) repeat 1), 5), 6), 7) or 2), 4), 5), 6), 7) or 3), 4), 5), 6), 7), until complete test.
Further, the different action site a of semi-girder from the pass of the mould property coefficient K of different autologous bone is:
The invention has the beneficial effects as follows:
The present invention realizes the elasticity coefficient at any autologous Cranial defect place of simulation according to cantilever beam structure and principle by the correlation parameter of adjustment semi-girder, and the temperature environment of shape memory artificial bone at autologous Cranial defect place can be built completely really by temperature-controlled chamber, simultaneously, the deflection of the artificial bone that the restoring force of shape memory artificial bone and this restoring force cause also quantitatively is detected by this pick-up unit, obtain the strain of defective bone further, and judge whether accordingly to meet human body actual needs, the need of size and the size of adjustment artificial bone, to reaching the stress level meeting human bone growth needs, owing to being operation in vitro, have easy to operate, be easy to realize, efficiency is high, the advantage that cost is low, to the regeneration research of defective bone, there is extremely strong theory support, to the clinical practice of using shape memory artificial bone to solve defective bone, there is positive realistic meaning.
Other advantages of the present invention, target and feature will be set forth to a certain extent in the following description, and to a certain extent, based on will be apparent to those skilled in the art to investigating hereafter, or can be instructed from the practice of the present invention.Target of the present invention and other advantages can be realized by instructions below and obtain.
Accompanying drawing explanation
In order to make the object, technical solutions and advantages of the present invention clearly, below in conjunction with accompanying drawing, the present invention is described in further detail, wherein:
Fig. 1 is the structural representation of a kind of external Cranial defect model of the present invention;
Fig. 2 is the structural representation of a kind of pick-up unit based on external Cranial defect mould shapes restoring force of the present invention;
Fig. 3 is the schematic diagram of shape memory artificial bone repairing bone defect;
Fig. 4 is semi-girder system sketch.
Reference numeral: 1-semi-girder; 2-base; 3-temperature-controlled chamber; Sample carrier under 4-; 5-securing member; The upper sample carrier of 6-; 7-diamagnetism bar; 8-sensor probe; 9-sleeve; 10-signal conditioner; 11-data collecting card; 12-computing machine; 13-scale I; 14-supporting pad; 15-aims at groove I; 16-view window; 17-scale II; 18-aims at groove II.
Embodiment
Hereinafter with reference to accompanying drawing, the preferred embodiments of the present invention are described in detail.Should be appreciated that preferred embodiment only in order to the present invention is described, instead of in order to limit the scope of the invention.
An object of the present invention:
As shown in Figure 1, a kind of external Cranial defect model of the present embodiment, comprise the cantilever beam structure that can be characterized the elasticity coefficient of different autologous bone by the elasticity coefficient of different action site, namely the elasticity coefficient of different autologous bone is represented on a cantilever beam by the elasticity coefficient of different action sites, described cantilever beam structure comprises the sample stage of adjustable Cranial defect size and semi-girder 1 placed on it, described sample stage comprises base 2 and sample carrier 6 and lower sample carrier 7 on vertical direction is spaced, make sample carrier 6 and lower sample carrier 7 at vertical direction in distributing one on the other, and distance is between the two consistent with the length of Cranial defect, the upper end of described upper sample carrier 6 and the bottom of lower sample carrier 7 are provided with the adjustable supporting pad of area 14, during use, upper sample carrier is adjusted to consistent with Cranial defect area with the area of the supporting pad 14 of lower sample carrier simultaneously, can simulate really like this human bone be subject to the effect of artificial bone restoring force under force and deformation situation, described upper sample carrier 6 is slidably arranged on semi-girder 1, described lower sample carrier 7 is slidably arranged on base 2, described upper sample carrier 6 is provided with semi-girder chute, described base 2 is provided with lower sample carrier chute, different action sites is adjusted by semi-girder chute, namely different human bone elasticity coefficient, and by lower sample carrier chute move left and right ensure to keep vertical with upper sample carrier 6, guarantee there is identical contact area with artificial bone, thus ensure the accuracy of experiment.
As the improvement of embodiment, described upper sample carrier 6 is provided with the lock-screw that upper sample carrier 6 can be fixed on semi-girder 1, regulated by the degree of tightness of lock-screw, the intercropping relative movement of sample carrier 6 and semi-girder 1 can be made, thus the position of adjustment check point, the upper end of described lower sample carrier 7 is provided with and adjusts screw up and down, can regulate the distance between upper and lower sample carrier and the autologous Cranial defect state consistency of reality.
As the improvement of embodiment, also comprise and being arranged between sample carrier 6 and lower sample carrier 7 temperature-controlled chamber 3 that artificial bone heats.In order to simulate the shape memory temperature of artificial bone, the invention provides a temperature-controlled chamber 3, temperature range is within room temperature-100 DEG C, and optimally, temperature range controls within room temperature-50 DEG C, and temperature-controlled chamber has the effect of temperature adjustment and temperature control, temperature control is accurate, and temperature adjustment is rapid, and the temperature-controlled chamber 3 of the present embodiment adopts organic glass to make, be convenient to observe and operation, adapt to the heat insulation of short time and insulation demand.
As the improvement of embodiment, described semi-girder is provided with the scale I 13 that accurately can measure sample carrier horizontal level, described base is provided with the scale II 17 corresponding with scale I 13.Make adjustment more accurate by scale I 13, efficiency is higher, and the scale II 17 arranged by correspondence easily makes lower sample carrier 7 and supporting pad 14 complete matching of upper sample carrier 6, avoids dislocation, affects measuring accuracy,
As the improvement of embodiment, described upper sample carrier 6 is provided with the aligning groove I 15 for aiming at scale I 13, described lower sample carrier 7 is provided with the aligning groove II 18 for aiming at scale II 17.The aligning groove II 18 be arranged on the aligning groove I 15 of upper sample carrier 6 and lower sample carrier 7 is aimed at a certain scale value simultaneously, is not then equivalent to person and is in same level position, improve the precision of this model further.
As the improvement of embodiment, described upper sample carrier 6 has view window 16 at semi-girder chute place, and described aligning groove 15 is provided with top or the bottom of view window 16, is beneficial to observation, and measurement result can be made more accurate.
The principle of the present embodiment:
As shown in Figure 3, when after shape memory artificial bone (A) implantable bone defect (B), by the shape generation change of shape preset under uniform temperature stimulates, axial expansion, fills the gap between artificial bone and autologous bone (C), and applies restoring force F to autologous bone, certain distortion (ε) is there is in autologous bone under the effect of F, and give the cell in autologous bone by this strain transfer, make cell experience the stimulation of power, weaken stress shielding.
Meet relation between F and autologous ostealleosis amount (w): F=K.w, wherein K is the elasticity coefficient of bone, and K represents the deformability of autologous bone, relevant with modulus with the sectional area of bone, length, K=E.A/L
0, and modulus is relevant with the age, sex, bone density etc. of people; To specific bone tissue, K is constant.Thus, set up a kind of K value that can adjust arbitrarily to simulate the device of various bone-shaped state, and a kind of device that quantitatively can detect F.
The present embodiment utilizes semi-girder to represent autologous bone-shaped state, and provide a kind of based on cantilever beam system to adjust the defect model of K value.As shown in Figure 4, the action site (i.e. the length of a) of the adjustment modulus (E) of semi-girder, sectional area (wide × height=b × d) and artificial bone and semi-girder, just be equivalent to the state adjusting autologous bone, finally show as the distortion w difference that autologous bone renitency produces, in semi-girder system, use δ
acharacterize.
The present embodiment can by the adjustment modulus (E) of semi-girder or cross sectional moment of inertia (thick × high cube=b × h
3) adjust autologous ostealleosis ability; Optimally, regulating and controlling autologous ostealleosis by adjustment artificial bone at the action site (a) of semi-girder is most convenient.
Object two of the present invention:
A kind of pick-up unit of the recovery of shape power based on a kind of external Cranial defect model described above, as shown in Figure 2, except comprising external Cranial defect model, also comprise linear differential displacement transducer, signal conditioner 10, data collecting card 11 and computing machine 12, described linear differential displacement transducer is made up of with the sleeve 9 that cell winding is housed linear differential displacement sensor probe 8, below be fixed on base, top is fixed on the free end of semi-girder 1 by diamagnetism bar 7, described linear differential displacement sensor probe 8 and signal conditioner 10, data collecting card 11 is connected with computing machine 12.Axial expansion is there is in artificial bone under thermostimulation, after contacting with upper sample carrier 6, the recovery of shape power F produced makes semi-girder that flexion distortion occur centered by fulcrum O, and is moved up by the diamagnetism bar 7 of rigidity and linear differential displacement sensor probe 8, the amount of deflection δ of semi-girder free end
0be the maximum displacement that linear differential displacement sensor probe 8 detects, its signal is delivered to computing machine 12 by signal conditioner 10, data collecting card 11 and carries out processing the concrete numerical value obtaining recovery of shape power F.
Object three of the present invention:
Adopt the detection method of above-mentioned a kind of recovery of shape force checking device, its concrete grammar is:
1) namely any predetermined semi-girder action site, to characterize the elasticity coefficient of different autologous bone, also adjust different action sites, can obtain different human bone elasticity coefficient, and the different action site a of semi-girder from the pass of the mould property coefficient K of different autologous bone is:
In formula, a is the distance between semi-girder fulcrum O and upper sample carrier 6, and L, b, h are respectively the length and width of semi-girder and thick, and E is the elastic modulus of semi-girder.
(I) derivation of formula is as follows:
According to semi-girder principle, restoring force F and semi-girder free end amount of deflection δ
0meet relational expression:
And restoring force F and artificial bone contact point cantilever beam deflection δ
ameet relational expression:
Due to the deflection (δ of artificial bone
a) equal the deflection (w) of autologous bone.According to F=K.w, and in conjunction with formula (2), can draw:
Further derivation, can draw:
Formula (4) is (I) formula that will derive, also the computation model of the elasticity coefficient of autologous bone is: K is directly proportional to the modulus E of semi-girder, be directly proportional to the wide b of semi-girder, be directly proportional to the cube of semi-girder thickness h, and the cube of the semi-girder length a of artificial bone action site is inversely proportional to.
Therefore, by adjusting correlation parameter E, b, h and a of semi-girder, with regard to the elasticity coefficient of the autologous bone of adjustable, the present embodiment preferably adopts adjustment parameter a to adjust the elasticity coefficient of autologous bone.
2) Area of bearing of upper and lower sample carrier supporting pad is made a reservation for arbitrarily;
3) distance arbitrarily between predetermined upper and lower sample carrier supporting pad;
4) arrange with 2), 3) artificial bone that matches, and be placed in temperature-controlled chamber;
5) after artificial bone temperature reaches memory temperature and is fully out of shape, the amount of deflection δ of semi-girder free end is measured
0;
6) according to semi-girder principle, restoring force F is calculated by following formula:
Wherein, a is the distance between semi-girder fulcrum O and upper sample carrier, and L, b, h are respectively the length and width of semi-girder and thick, and E is the elastic modulus of semi-girder.
7) the amount of deflection δ of artificial bone contact point semi-girder is calculated by following formula
a:
8) repeat 1), 5), 6), 7) or 2), 4), 5), 6), 7) or 3), 4), 5), 6), 7), until complete test.Repeat 1), 5), 6), 7) when can obtain semi-girder E, b, h and human bone size constancy, the amount of deflection δ of different parameters a and artificial bone contact point semi-girder
a, relation between restoring force F; Repeat 2), 4), 5), 6), 7) semi-girder E, b, h, a and artificial bone length L can be obtained
0time constant, the amount of deflection δ of artificial bone different cross section A and artificial bone contact point semi-girder
a, relation between restoring force F; Repeat 3), 4), 5), 6), 7) can obtain semi-girder E, b, h, a and artificial bone section A constant time, artificial bone different length L
0with the amount of deflection δ of artificial bone contact point semi-girder
a, relation between restoring force F.
Below specific embodiments of the invention:
1, semi-girder: material is aluminium alloy, elastic modulus E=57.5GPa; Cross section is rectangle, wide b=6.48mm, thick h=6.24mm, long L=246.34mm;
2, shape memory artificial bone: material is self-control polyurethane-urea; Column, l=10mm, d=8mm;
3, after instrument has built, the calibration curve (typical curve between voltage and displacement) of device is:
w
0＝0.1338U+0.012(R
2＝0.9997)
4, the restriction of semi-girder to artificial bone can be used as is the restriction of autologous bone to artificial bone, and so on semi-girder, diverse location is just equivalent to the autologous bone of different elasticity coefficient K to the restriction of artificial bone to the restriction of artificial bone.Adjust different a values, the autologous flexible bone COEFFICIENT K of corresponding different semi-girder simulations, the recovery of shape power F of artificial bone, and the artificial bone deflection δ caused by F
a,this experiment a is respectively 20,40,60,80,100mm, measurement result and result of calculation as follows:
| a/mm | 20 | 40 | 60 | 80 | 100 |
| w 0/mm | 0.012 | 0.069 | 0.246 | 0.323 | 0.534 |
| F/N | 0.975 | 0.827 | 0.799 | 0.710 | 0.682 |
| w A/mm | 0.007 | 0.041 | 0.128 | 0.269 | 0.457 |
| K/(N/mm) | 139.28 | 20.17 | 6.24 | 2.64 | 1.49 |
In upper table, along with a increases, restoring force F reduces gradually, and elasticity coefficient K reduces gradually, demonstrates the correctness of Cranial defect model of the present invention, pick-up unit and detection method preferably, and the correctness of each parameter computation model.
The present invention realizes the elasticity coefficient at any autologous Cranial defect place of simulation according to cantilever beam structure and principle by the correlation parameter of adjustment semi-girder, and the temperature environment of shape memory artificial bone at autologous Cranial defect place can be built completely really by temperature-controlled chamber, simultaneously, the deflection of the artificial bone that the restoring force of shape memory artificial bone and this restoring force cause also quantitatively is detected by this pick-up unit, swallow obtains the strain of defective bone further, and judge whether accordingly to meet human body actual needs, the need of size and the size of adjustment artificial bone, to reaching the stress level meeting human bone growth needs, owing to being operation in vitro, have easy to operate, be easy to realize, efficiency is high, the advantage that cost is low, to the regeneration research of defective bone, there is extremely strong theory support, to the clinical practice of using shape memory artificial bone to solve defective bone, there is positive realistic meaning.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, although with reference to preferred embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that, can modify to technical scheme of the present invention or equivalent replacement, and not departing from aim and the scope of the technical program, it all should be encompassed in the middle of right of the present invention.
Claims (10)
1. an external Cranial defect model, it is characterized in that: comprise the cantilever beam structure that can be characterized the elasticity coefficient of different autologous bone by the elasticity coefficient of different action site, described cantilever beam structure comprises sample stage and semi-girder placed on it, described sample stage comprises base and sample carrier and lower sample carrier on vertical direction is spaced, the upper end of described upper sample carrier and the bottom of lower sample carrier are provided with the adjustable supporting pad of area, described upper sample carrier is slidably arranged on a cantilever beam, and described lower sample carrier is slidably arranged on base.
2. a kind of external Cranial defect model according to claim 1, is characterized in that: described upper sample carrier is provided with semi-girder chute, described base is provided with lower sample carrier chute.
3. a kind of external Cranial defect model according to claim 1, is characterized in that: described upper sample carrier is provided with the lock-screw upper sample carrier can fixed on a cantilever beam.
4. a kind of external Cranial defect model according to claim 1, is characterized in that: the upper end of described lower sample carrier is provided with the screw of adjustment up and down of adjustment and upper sample carrier distance.
5. a kind of external Cranial defect model according to claim 1, it is characterized in that: described semi-girder is provided with the scale I that accurately can measure sample carrier horizontal level, described base is provided with the scale II corresponding with scale I, described upper sample carrier is provided with the aligning groove I for aiming at scale I, described lower sample carrier is provided with the aligning groove II for aiming at scale II.
6. a kind of external Cranial defect model according to claim 5, it is characterized in that: described upper sample carrier has view window at semi-girder chute place, described aligning groove I is arranged on top or the bottom of view window.
7. a kind of external Cranial defect model according to claim 1, is characterized in that: also comprise the temperature-controlled chamber being arranged on and heating artificial bone between sample carrier and lower sample carrier.
8. the pick-up unit based on the recovery of shape power of a kind of external Cranial defect model as described in as arbitrary in claim 1-7, comprise external Cranial defect model, it is characterized in that: also comprise linear differential displacement transducer, signal conditioner, data collecting card and computing machine, described linear differential displacement transducer is made up of linear differential displacement sensor probe and the sleeve that cell winding is housed, be fixed on base by sleeve below it, be fixed on the free end of semi-girder by diamagnetism bar above it, described linear differential displacement sensor probe and signal conditioner, data collecting card is connected with computing machine.
9. adopt the detection method of a kind of recovery of shape force checking device as claimed in claim 8, its concrete grammar is:
1) any predetermined semi-girder action site, to characterize the mould property coefficient of different autologous bone;
2) Area of bearing of upper and lower sample carrier supporting pad is made a reservation for arbitrarily;
3) distance arbitrarily between predetermined upper and lower sample carrier supporting pad;
4) arrange with 2), 3) artificial bone that matches, and be placed in temperature-controlled chamber;
5) after artificial bone temperature reaches memory temperature and is fully out of shape, the amount of deflection δ of semi-girder free end is measured
0;
6) according to semi-girder principle, restoring force F is calculated by following formula:
Wherein, a is the distance between semi-girder fulcrum O and upper sample carrier, and L, b, h are respectively the length and width of semi-girder and thick, and E is the elastic modulus of semi-girder.
7) the amount of deflection δ of artificial bone contact point semi-girder is calculated by following formula
a:
8) repeat 1), 5), 6), 7) or 2), 4), 5), 6), 7) or 3), 4), 5), 6), 7), until complete test.
10. the detection method of a kind of recovery of shape force checking device according to claim 9, is characterized in that: the different action site a of semi-girder from the pass of the mould property coefficient K of different autologous bone is:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510187081.5A CN104749026A (en) | 2015-04-20 | 2015-04-20 | In-vitro bone defect model as well as detection device and detection method for shape resilience |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510187081.5A CN104749026A (en) | 2015-04-20 | 2015-04-20 | In-vitro bone defect model as well as detection device and detection method for shape resilience |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104749026A true CN104749026A (en) | 2015-07-01 |
Family
ID=53589040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510187081.5A Pending CN104749026A (en) | 2015-04-20 | 2015-04-20 | In-vitro bone defect model as well as detection device and detection method for shape resilience |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104749026A (en) |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2574147Y (en) * | 2002-09-30 | 2003-09-17 | 四川大学 | Human lower jawbone bio-mechanics model |
| CN1618412A (en) * | 2004-08-24 | 2005-05-25 | 上海倍尔康生物医学科技有限公司 | Technique for making restitution skull and jawbone by using biological artificial bone material combined with CAD/CAM technology |
| CN1699960A (en) * | 2005-05-25 | 2005-11-23 | 中国科学院上海微系统与信息技术研究所 | Improved method for testing micro-cantilever beam elasticity coefficient |
| CN101239012A (en) * | 2008-02-25 | 2008-08-13 | 中南大学 | Method for acquiring maxilla coloboma section model |
| CN102519803A (en) * | 2011-12-30 | 2012-06-27 | 华东理工大学 | Multi-head miniature test specimen creep experiment device and test method |
| CN103940679A (en) * | 2014-04-17 | 2014-07-23 | 南京航空航天大学 | Three-point externally extending bending creep parameter measurement device and operating method thereof |
| CN104020038A (en) * | 2014-06-17 | 2014-09-03 | 山东大学 | Combinatorial testing accessory of vibration testing platform and static fatigue testing method |
-
2015
- 2015-04-20 CN CN201510187081.5A patent/CN104749026A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2574147Y (en) * | 2002-09-30 | 2003-09-17 | 四川大学 | Human lower jawbone bio-mechanics model |
| CN1618412A (en) * | 2004-08-24 | 2005-05-25 | 上海倍尔康生物医学科技有限公司 | Technique for making restitution skull and jawbone by using biological artificial bone material combined with CAD/CAM technology |
| CN1699960A (en) * | 2005-05-25 | 2005-11-23 | 中国科学院上海微系统与信息技术研究所 | Improved method for testing micro-cantilever beam elasticity coefficient |
| CN101239012A (en) * | 2008-02-25 | 2008-08-13 | 中南大学 | Method for acquiring maxilla coloboma section model |
| CN102519803A (en) * | 2011-12-30 | 2012-06-27 | 华东理工大学 | Multi-head miniature test specimen creep experiment device and test method |
| CN103940679A (en) * | 2014-04-17 | 2014-07-23 | 南京航空航天大学 | Three-point externally extending bending creep parameter measurement device and operating method thereof |
| CN104020038A (en) * | 2014-06-17 | 2014-09-03 | 山东大学 | Combinatorial testing accessory of vibration testing platform and static fatigue testing method |
Non-Patent Citations (3)
| Title |
|---|
| H.LU ET AL.: "Probing the origins and control of shrinkage stress in dental resin-composites:I.shrinkage stress characterization technique", 《JOURNAL OF MATERIALS SCIENCE:MATERIALS IN MEDICINE》 * |
| MARTIN Y.M. CHIANG ET AL.: "Analyses of a cantilever-beam based instrument for evaluating the development of polymerization stresses", 《DENTAL MATERIALS》 * |
| 鲍海飞 等: "微悬臂梁法向弹性系数的标定方法与分析", 《测试技术学报》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Libertiaux et al. | Experimental verification of brain tissue incompressibility using digital image correlation | |
| EP3217880B1 (en) | Person bed having a sensing apparatus for body statics for imaging medical examination devices | |
| Koozekanani et al. | Possible mechanisms for observed pathophysiological variability in experimental spinal cord injury by the method of Allen | |
| US20110288586A1 (en) | Closed-Loop Automated Chiropractic Adjustment Device | |
| CN104257437B (en) | A kind of animal spinal cord damage modeling device | |
| CN103966091B (en) | Cell composite force-electricity loads the device measured | |
| CN204233259U (en) | A kind of joint of vertebral column extension table | |
| CN104287737B (en) | A kind of ankle moving angle instrument for quick measuring | |
| CN108595876A (en) | A kind of Portable tenonometer and intraocular pressure test method based on finite element analysis model | |
| CN101259021A (en) | Vertebral column trunk external measuring rule | |
| CN104749026A (en) | In-vitro bone defect model as well as detection device and detection method for shape resilience | |
| Oladapo et al. | Energy harvesting analysis of hip implantin achieving sustainable development goals | |
| CN105212951B (en) | Backbone is in body biomechanical measurement device | |
| Varady et al. | Biomechanical comparison of a novel monocortical and two common bicortical external fixation systems regarding rigidity and dynamic stability | |
| CN110037648A (en) | A kind of equipment and label localization method of measurement exophthalmos amount | |
| Gardner et al. | An instrumented spacial linkage for monitoring relative three-dimensional motion between fracture fragments | |
| CN113768595A (en) | Intelligent bone traction tool, traction system and traction method | |
| RU2468747C2 (en) | Method and device for determining value of asymmetries of length of lower extremities and pelvis misalignment | |
| Paskaleva et al. | Mathematic modeling of the muskov quadrangle for the evaluation of the muscle disorders in children and adults | |
| CN209107578U (en) | Ankle fusion operation guiding system | |
| Tamura et al. | Dynamic tensile behavior of fiber bundles freshly isolated from nerve roots | |
| RU2337619C1 (en) | Device for measurement of rachiocampsises | |
| CN211023257U (en) | Animal fracture molding device | |
| Blynskiy et al. | A system for automated distraction with electrical stimulation of osteogenesis | |
| Quaresma et al. | Development of a Mechanical Instrument to Evaluate Biomechanically the Spinal Column in Pregnant Women |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150701 |