CN1606978A - Hollow capsule of natural plant gum and its preparing process - Google Patents
Hollow capsule of natural plant gum and its preparing process Download PDFInfo
- Publication number
- CN1606978A CN1606978A CN 200310108012 CN200310108012A CN1606978A CN 1606978 A CN1606978 A CN 1606978A CN 200310108012 CN200310108012 CN 200310108012 CN 200310108012 A CN200310108012 A CN 200310108012A CN 1606978 A CN1606978 A CN 1606978A
- Authority
- CN
- China
- Prior art keywords
- plant gum
- glue
- chitosan
- carboxymethyl starch
- hydroxypropyl cellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
Said invention relates to formula and preparation of plant hollow capsule for packaging powdered preparation, which is composed of 16-25 % of vegetable gelatin, 2.0-5.0 % of intensifier, 0.02-0.026 % of surface active agent, 0.15-0.20 % of moistening agent, the others is water. The said vegetable gelatin is one of or both of pectin and carrageenin, said intensifier is one kind or more than one kind of chitosan, carboxymethyl starch and hydroxyporpyl cellulose. Said surface active agent is sodium dodecyl sulfate. Said moistening agent is glycerol. Said plant hollow capsule has good stability, stored for long time and also can be produced by utilizing the equipment used in producing capsule from geltin.
Description
[technical field]
The present invention relates to field of medicine preparations, specifically a kind of Capsules and production technology thereof that is used to pack powderous preparations.
[background technology]
At present, the hollow and hard capsule is very general as the application of pharmaceutical carrier, and the hollow and hard capsule generally is to be raw material with gelatin, adds water and makes, and can add antiseptic and food coloring according to producing season and user's needs.Its production technology is as follows: gelatin is soaked, is expanded, in reaction pot, stir, dissolve, the reaction pot temperature remains on 60 ℃-75 ℃, dissolving after-filtration glue, regulate gelatin concentration, store insulation, peeling removes bubble, is dipping in automatically on the glue production line through dipping in glue, oven dry, cooling, the demoulding, cutting, fit, check, packing.
Because gelatin is a kind of material that derives from animal, the capsule that gelatin is made is just placed restrictions on for the people of faith Islam, kosher, can't take, and they can only take tablet or use injection drug; In addition, gelatine capsule is responsive for temperature and humidity, and under or the situation that humidity is bigger higher in temperature, gelatine capsule can be assembled, be out of shape; Under drying condition, the easy embrittlement of capsule.
[summary of the invention]
The purpose of this invention is to provide and a kind ofly have good stability and store for a long time, be applicable to each ethnic population's plant gum Capsules and production technology thereof.
The present invention is realized by following scheme: it is primary raw material that the plant hollow capsule product adopts plant gum, is equipped with an amount of reinforcing agent, activating agent, utilizes the capsular production equipment manufacturing of gelatin hollow and hard.
A kind of plant gum Capsules, the proportioning that it is characterized in that its glue is as follows: plant gum 16%-25%, reinforcing agent 2.0%-5.0%, surfactant 0.02%-0.026%, wetting agent 0.15%-0.20%, surplus are water, described plant gum is a kind of in pectin, the carrageenan or two kinds, described reinforcing agent is one or more in chitosan, carboxymethyl starch, the hydroxypropyl cellulose, described surfactant is a sodium lauryl sulphate, and described wetting agent is a glycerol.
The plant gum Capsules, the proportioning of its glue is as follows: pectin 16%-23%, chitosan 1.0%-4.0%, carboxymethyl starch 0.5%-1.5%, hydroxypropyl cellulose 0.5%-1.5%, sodium lauryl sulphate 0.025%-0.026%, glycerol 0.169%-0.191%, and making chitosan, carboxymethyl starch, hydroxypropyl cellulose three content sum in the 2-5% scope, surplus is a water.
The plant gum Capsules, the proportioning of its glue is as follows: pectin 18%-23%, chitosan 0.5%-3.5%, carboxymethyl starch 0.5%-2.0%, hydroxypropyl cellulose 0.5%-2.0%, sodium lauryl sulphate 0.025%-0.026%, glycerol 0.169%-0.191%, and making chitosan, carboxymethyl starch, hydroxypropyl cellulose three content sum in the 2-5% scope, surplus is a water.
The plant gum Capsules, when plant gum adopted carrageenan, pectin simultaneously in its glue, both ratio was 1: 1-1: 10, preferred 1: 2-1: 6.
The production technology of above-mentioned plant gum Capsules, may further comprise the steps: the percentage by weight by each component is got the raw materials ready, earlier plant gum is soaked, expanded, putting into reaction pot stirs, dissolves, add reinforcing agent, activating agent and wetting agent during this time, and in the reaction pot interlayer, feed 50 ℃-85 ℃ recirculated water, treat that fully glue is filtered with 100-120 order filter bag in the dissolving back, be stored in the heat-preserving container, regulate gelatin concentration, peeling during use except that bubble, dipping in automatically on the glue production line through dipping in glue, oven dry, cooling, the demoulding, cutting, fit, check, packing.
Plant gum stirs in reaction pot, the dissolved time is 2.5-3.5 hour.
The beneficial effect that the present invention has is: 1) product is suitable for each ethnic population; 2) good stability, indeformable under high temperature or high humidity environment, embrittlement not is convenient to permanent storage.3) with regard to plant gum prepares Capsules, this production technology is simple, and can adopt original capsule manufacture device fabrication, reduced investment.
[specific embodiment]
Below the present invention is described in further detail, and provide the specific embodiment.
The proportioning of the glue of embodiment 1, plant hollow capsule is as follows: pectin 16%-23%, chitosan 2.5%, carboxymethyl starch 0.6%, hydroxypropyl cellulose 0.6%, sodium lauryl sulphate 0.025%-0.026%, glycerol 0.169%-0.191%, surplus are water.
Its production equipment is identical with former useful manufacturing of gelatin Capsules.Pectin is soaked earlier, is expanded, be placed in the reaction pot and stir, dissolve, add chitosan, carboxymethyl starch, hydroxypropyl cellulose, sodium lauryl sulphate, feed 85 ℃ recirculated water during this time in the reaction pot interlayer, dissolving was filtered glue with 120 order filter bags after 2.5 hours in reaction pot, glue is stored in the heat-preserving container, regulate gelatin concentration, peeling removes bubble, forms the plant gum Capsules dipping in automatically on the glue production line through dipping in glue, oven dry, cooling, the demoulding, cutting, fit, check, packing.Owing to added reinforcing agent and activating agent, the gained capsule is indeformable under high temperature or high humidity environment, is convenient to permanent storage.
Can add an amount of antiseptic or practical pigment as required, production method is the same.Because add wetting agent glycerol, the water retentivity of capsule self is better, it is the moisture in the absorbing environmental neither, also can not inhaled branchs that anhydrate by the medicine in the capsule, can remain on the scope of 12.5-17.5%, meets pharmacopeia and stipulate.
Embodiment 2, pectin 18%; Carrageenan 6%; Chitosan 2.0%; Carboxymethyl starch 0.8%; Hydroxypropyl cellulose 0.8%; Sodium lauryl sulphate 0.025%, glycerol 0.18%, surplus is a water.Production method is with embodiment 1.
Embodiment 3, carrageenan 22%; Chitosan 1.5%; Carboxymethyl starch 1.0%; Sodium lauryl sulphate 0.025%, glycerol 0.16%, surplus is a water.Its production method is with embodiment 1.
Claims (6)
1, a kind of plant gum Capsules, the proportioning that it is characterized in that its glue is as follows: plant gum 16%-25%, reinforcing agent 2.0%-5.0%, surfactant 0.02%-0.026%, wetting agent 0.15%-0.20%, surplus are water, described plant gum is a kind of in pectin, the carrageenan or two kinds, described reinforcing agent is one or more in chitosan, carboxymethyl starch, the hydroxypropyl cellulose, described surfactant is a sodium lauryl sulphate, and described wetting agent is a glycerol.
2, plant gum Capsules according to claim 1, the proportioning that it is characterized in that its glue is as follows: pectin 16%-23%, chitosan 1.0%-4.0%, carboxymethyl starch 0.5%-1.5%, hydroxypropyl cellulose 0.5%-1.5%, sodium lauryl sulphate 0.025%-0.026%, glycerol 0.169%-0.191%, and making chitosan, carboxymethyl starch, hydroxypropyl cellulose three content sum in the 2-5% scope, surplus is a water.
3, plant gum Capsules according to claim 1, the proportioning that it is characterized in that its glue is as follows: pectin 18%-23%, chitosan 0.5%-3.5%, carboxymethyl starch 0.5%-2.0%, hydroxypropyl cellulose 0.5%-2.0%, sodium lauryl sulphate 0.025%-0.026%, glycerol 0.169%-0.191%, and making chitosan, carboxymethyl starch, hydroxypropyl cellulose three content sum in the 2-5% scope, surplus is a water.
4, plant gum Capsules according to claim 1 is characterized in that the ratio of carrageenan and pectin is 1 in the described plant gum: 1-1: 10, preferred 1: 2-1: 6.
5, production technology according to the described plant gum Capsules of claim 1-4, it is characterized in that may further comprise the steps: the percentage by weight by each component is got the raw materials ready, earlier plant gum is soaked, expand, putting into reaction pot stirs, dissolving, add reinforcing agent during this time, surfactant and wetting agent, and in the reaction pot interlayer, feed 50 ℃-85 ℃ recirculated water, treat that fully glue is filtered with 100-120 order filter bag in the dissolving back, be stored in the heat-preserving container, regulate gelatin concentration during use, peeling removes bubble, is dipping in automatically on the glue production line through dipping in glue, oven dry, cooling, the demoulding, cutting, fit, check, packing.
6, the production technology of plant gum Capsules according to claim 5 is characterized in that plant gum stirs, the dissolved time is 2.5-3.5 hour in reaction pot.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310108012 CN1606978A (en) | 2003-10-15 | 2003-10-15 | Hollow capsule of natural plant gum and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310108012 CN1606978A (en) | 2003-10-15 | 2003-10-15 | Hollow capsule of natural plant gum and its preparing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1606978A true CN1606978A (en) | 2005-04-20 |
Family
ID=34758437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310108012 Pending CN1606978A (en) | 2003-10-15 | 2003-10-15 | Hollow capsule of natural plant gum and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1606978A (en) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007003113A1 (en) * | 2005-07-01 | 2007-01-11 | Liande Tang | A composition of raw materials for a plant polyose-containing hollow capsule and the properation method of such capsure |
| CN100358510C (en) * | 2005-04-27 | 2008-01-02 | 中国科学院海洋研究所 | Preparation of floridean polysaccharide vegetable prandial fiber medicinal hard capsule |
| CN101953816A (en) * | 2010-09-08 | 2011-01-26 | 浙江昂利康胶囊有限公司 | Medicinal hollow capsules and preparation method and manufacturing equipment thereof |
| CN101708171B (en) * | 2009-12-17 | 2011-12-07 | 安徽黄山胶囊有限公司 | Enteric plant hollow capsule |
| CN102525995A (en) * | 2011-12-23 | 2012-07-04 | 湖北人福康华药用辅料有限公司 | Plant officinal hollow capsule and preparation method thereof |
| CN103937037A (en) * | 2014-04-28 | 2014-07-23 | 中国科学院化学研究所 | Modified starch adhesive for preparing hollow capsule and starch-base hollow capsule thereof |
| CN104013597A (en) * | 2014-06-18 | 2014-09-03 | 青海回医药研究会 | Preparation method of Muslim gelatin hollow capsule |
| CN104055750A (en) * | 2014-07-03 | 2014-09-24 | 王荣辉 | Empty targeting capsule and preparation method thereof |
| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
-
2003
- 2003-10-15 CN CN 200310108012 patent/CN1606978A/en active Pending
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100358510C (en) * | 2005-04-27 | 2008-01-02 | 中国科学院海洋研究所 | Preparation of floridean polysaccharide vegetable prandial fiber medicinal hard capsule |
| WO2007003113A1 (en) * | 2005-07-01 | 2007-01-11 | Liande Tang | A composition of raw materials for a plant polyose-containing hollow capsule and the properation method of such capsure |
| CN101708171B (en) * | 2009-12-17 | 2011-12-07 | 安徽黄山胶囊有限公司 | Enteric plant hollow capsule |
| CN101953816A (en) * | 2010-09-08 | 2011-01-26 | 浙江昂利康胶囊有限公司 | Medicinal hollow capsules and preparation method and manufacturing equipment thereof |
| CN102525995A (en) * | 2011-12-23 | 2012-07-04 | 湖北人福康华药用辅料有限公司 | Plant officinal hollow capsule and preparation method thereof |
| CN102525995B (en) * | 2011-12-23 | 2013-10-30 | 湖北人福康华药用辅料有限公司 | Plant officinal hollow capsule and preparation method thereof |
| CN103937037A (en) * | 2014-04-28 | 2014-07-23 | 中国科学院化学研究所 | Modified starch adhesive for preparing hollow capsule and starch-base hollow capsule thereof |
| CN103937037B (en) * | 2014-04-28 | 2016-09-21 | 北京崇尚科技开发有限公司 | For preparing modified starch glue and the starch matrix Capsules thereof of Capsules |
| CN104013597A (en) * | 2014-06-18 | 2014-09-03 | 青海回医药研究会 | Preparation method of Muslim gelatin hollow capsule |
| CN104055750A (en) * | 2014-07-03 | 2014-09-24 | 王荣辉 | Empty targeting capsule and preparation method thereof |
| CN104055750B (en) * | 2014-07-03 | 2016-09-21 | 王荣辉 | There is Capsules and the preparation method of target function |
| CN107233329A (en) * | 2017-05-12 | 2017-10-10 | 安徽黄山胶囊股份有限公司 | A kind of instant Capsules and preparation method thereof |
| CN107233329B (en) * | 2017-05-12 | 2020-04-21 | 安徽黄山胶囊股份有限公司 | Instant hollow capsule and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7008639B2 (en) | Fish gelatin compositions containing a hydrocolloid setting system | |
| US7045184B2 (en) | Polyvinyl alcohol compositions | |
| CN101579326B (en) | Pulullan polysaccharide empty hard capsule and preparation method thereof | |
| CN1792179A (en) | Antistaling agent for fruits or vegetable, and its prepn. method | |
| CN1606978A (en) | Hollow capsule of natural plant gum and its preparing process | |
| CN106166143B (en) | Plant hard hollow capsule shell and preparation method thereof | |
| CN111454490B (en) | Composition for preparing edible plant plasma membrane and application thereof | |
| CN105395513B (en) | A kind of method that modified starch prepares hard shell capsules | |
| CN101513383A (en) | Face pack and preparation method thereof | |
| CN100392009C (en) | Food wrap film of collagen and preparation method | |
| CN107348304A (en) | Effervescent tablet containing Tea Polyphenols and curcumin and preparation method thereof | |
| CN103877067B (en) | A kind of Capsules controlling disintegration and preparation method thereof | |
| CN108669542A (en) | A kind of stem of noble dendrobium ferment microcapsules and preparation method thereof | |
| CN105878208A (en) | Forming agent for starch-based hard medicinal vegetable capsule and application of forming agent | |
| CN103784418A (en) | Fish skin gelatin hollow capsules and preparation method thereof | |
| CN110215406A (en) | A kind of preparation method of water solubility cannabidiol facial mask | |
| CN110150304A (en) | The plant growth regulator of chloride containing ferroheme | |
| CN109276555A (en) | A kind of labile starch base Capsules of high-ductility | |
| CN102423289A (en) | Beautifying membrane capable of complete absorption | |
| CN107836514A (en) | A kind of winter jujube tailored version efficient fresh-keeping agent and preparation method thereof | |
| CN107362063A (en) | A kind of Water-free environment-friendlyurinal facial mask | |
| CN103734658A (en) | Natural type oil-water compatible edible essence and preparation method thereof | |
| CN102488637B (en) | Environment-friendly and carrier-free food-grade cosmetic membrane | |
| KR20220111370A (en) | Cut flowers preservation composite and producing method | |
| CN106943375B (en) | Plant capsule and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |