CN105878208A - Forming agent for starch-based hard medicinal vegetable capsule and application of forming agent - Google Patents
Forming agent for starch-based hard medicinal vegetable capsule and application of forming agent Download PDFInfo
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- CN105878208A CN105878208A CN201610230404.9A CN201610230404A CN105878208A CN 105878208 A CN105878208 A CN 105878208A CN 201610230404 A CN201610230404 A CN 201610230404A CN 105878208 A CN105878208 A CN 105878208A
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- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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Abstract
The invention relates to production of packaging auxiliary materials for medicines and healthy food, in particular to a forming agent for starch-based hard medicinal vegetable capsule and an application of the forming agent. The forming agent comprises 40%-80% by mass of a film-forming property and stickiness modifier, 10%-30% by mass of a tightness modifier and 10%-30% by mass of a brittleness modifier. The forming agent can be taken as an auxiliary material to be compatible with starch for preparation and production of the capsule, a gel body with the starch as the main material can have good forming property with use of the forming agent, and the produced capsule has good brittleness (2 of detected 50 capsules are brittle), good tightness (medicine leakage is not seen for the detected 50 capsules), short disintegration time (4 minutes) and long shelf life (the shelf life is longer than 1 year when the capsules are sealed in a heart-shaped specimen bottle and stored at normal temperature and normal humidity).
Description
Technical field
The present invention relates to the production of the packaging axiliary materials of medicine and health food, specifically a kind of starch
Base plant medicinal hard capsule forming agent and application thereof.
Background technology
Medicine and health food use edibility packaging material----hard capsule case is a kind of special auxiliary material,
It enters digestion together along with preparation, is absorbed by human body, and almost everyone every year can
Take in a certain amount of hard capsule preparation, so its quality and safety are directly connected to medicine finished product and guarantor
The quality of health food and safety, also directly and people healthy and safe closely bound up.The hardest
The medicine of capsule preparations and health food, the raw material overwhelming majority that its capsule shells is used is pig or ox
The animal protein colloid gelatin that skin, bone are made.The own characteristic that gelatin production raw material mixes, determines
The problem of its congenital potential safety hazard, after CCTV's exposure on April 15th, 2012 toxic capsule event,
Finding tens of family of heavy metals exceeding standard capsule pharmaceutical manufacturer, the common concern and the China that cause the whole society are whole
The earthquake of individual pharmaceuticals industry.Removing heavy metals exceeds standard outside safety problem, and zoogenous hard shell capsules is in use
There is also many other problems: first, its water content requires there is certain scope (12.5%-17.5%),
As less than this scope, then the friability of capsule increases, and is unfavorable for the filling of medicine.For some moisture absorption
Property composition, the moisture of capsule is easily filled with thing and sucks, and medicine that filling is good and health food are in the phase of storage
Capsule easily splits, if containing composition unstable after moisture absorption, also affecting effective storage phase of product.
Second, gelatin easily reacts with the composition containing aldehyde radical, produces insoluble substance, when making capsule be disintegrated
Between extend, and make capsule color change.3rd, gelatin capsule formulation to have certain constant temperature permanent
Wet environment stores, and temperature is too high, the easy softening transform of capsule, the too low capsule of temperature easy friability again.Separately
Outward, according to the national customs of domestic and international Moslem, can not eat with animality glue for capsule raw material.
This makes when Islam and area provide medicine and food, the basic nothing of gelatin hard-shell capsule preparation
Method enters these countries and regions.The most frequent appearance of rabid ox disease, more promoted people
Power goes research to find new hard shell capsules raw material.The country of worldwide production capsule for medicine is concentrated mainly on
China, the U.S., Canada and India, the wherein U.S., Canada's automatization level height, the medicine of production
Being entirely mechanism capsule with capsule, primary raw material is extracted by animal (ox, pig) osteoderm
Gelatine, hide glue.Under international green foods development main trend, current medicine sector is accelerating research and development
The substitute plant capsule of animal capsule.
The plant capsule listed at present on the market mainly has hypromellose cellulose capsule, seaweed plants glue
Capsule and three kinds of products of pulullan polysaccharide capsule, and with Hydroxypropyl methylcellulose (HPMC) capsule as main product.
External HPMC plant capsule production technology is mainly monopolized by Pfizer Inc., produces with cotton for raw material
HPMC be Main Ingredients and Appearance, the capsule technique with pulullan polysaccharide as principal component by France Capsugel glue
Capsule company monopolizing.Domestic in China, by associating emperor island, institute of oceanography of the Chinese Academy of Sciences limited public affairs of plant capsule
National inventing patent new high-tech product-the seaweed polysaccharide plant with independent intellectual property right of department's research and development
Hollow hard-shell capsule, has been obtained for " the state of State Food and Drug Administration's approval in March, 2005
Medicine quasi-word F20050001 " and " traditional Chinese medicines quasi-word F20050002 " two authentication codes, and in city
Face is sold.
But, compared with gelatine capsule, all plant capsules the most on the market all exist relatively costly
Problem, applicant attempted use originate starch the most extensive, that cost is lower be that raw material produces
Capsule, but it is unable to reach shaping film forming and the production of long term guarantee quality simply by starch conversion at all
Index request.The most domestic also have relevant patent (application number 201310435939.6,
201310091716.2) plant capsule with starch as principal component was once reported, but due to starch very
Easy aging dehydration, causes it frangible, it is impossible to ensureing its shelf-life, simple oligomict forming agent is often
It is it cannot be guaranteed that colloid viscosity conveniently and film forming, and can ensure often and just produced
Capsule can have good elasticity and friability, but after placing more than week age, due to starch
Problem of aging, then it can be caused extremely fragile.But, so that the compatibility composition of starch shaping has
Tens of kinds, the most universal these compositions are sorted out for plasticizer of researcher, do not formed for
The detailed-oriented classification of starch forming agent and understanding, therefore this most just directly results in practitioner and is formed without
The medicine compatibility method of the regulation starch property indices of system.But, the composition of compatibility glue and proportioning
Trickle change can directly affect every production and the quality index etc. of capsule, selects suitable compatibility glue,
Act on played in colloid according to compatibility glue, and carry out compatibility according to a certain percentage, become guarantee and form sediment
The key that powder capsule produces.The compositing formula of compatibility glue not only need technical staff for the characteristic of colloid,
And the compatibility of colloid and starch has enough knowledge, and need substantial amounts of grope experiment can
Obtain the forming agent being suitable for starch.Grope experiment through the most substantial amounts of, tie in conjunction with starch molecule
Structure feature, and different forming agent compatibility situation each other, this patent obtains a kind of performance
Preparation stable, with low cost, safe and reliable, conveniently starch base medicinal hard capsule forming agent
Method.
Summary of the invention
It is an object of the invention to provide a kind of with low cost, stable performance, safe and reliable starch base
Plant medicinal hard capsule forming agent and application thereof.
For achieving the above object, the present invention uses the technical scheme to be:
A kind of starch base plant medicinal hard capsule forming agent, forming agent by mass percentage, 40%-80%
Film forming, viscosity modifier, 10%-30% elasticity conditioning agent and 10-30% friability conditioning agent.
Described film forming, viscosity modifier be carragheen, gellan gum, pulullan polysaccharide, konjac glucomannan,
One or more in locust bean gum, Hydroxypropyl methylcellulose, carboxymethylcellulose calcium；
Wherein, film forming viscosity modifier accounts for the 40%-80% of forming agent weight, and its concrete composition is for by weight
Amount number meter,
Carragheen 1 part, gellan gum 0-5 part, pulullan polysaccharide 0-100 part, konjac glucomannan 0-5 part,
Locust bean gum 0-5 part, Hydroxypropyl methylcellulose 0-50 part, carboxymethylcellulose calcium 0-50 part；
Gellan gum 1 part, carragheen 0-50 part, pulullan polysaccharide 0-100 part, konjac glucomannan 0-5 part,
Locust bean gum 0-5 part, Hydroxypropyl methylcellulose 0-50 part, carboxymethylcellulose calcium 0-50 part；
Pulullan polysaccharide 1 part, carragheen 0-50 part, gellan gum 0-5 part, konjac glucomannan 0-5 part, Chinese scholartree
Bean gum 0-5 part, Hydroxypropyl methylcellulose 0-50 part, carboxymethylcellulose calcium 0-50 part；
Konjac glucomannan 1 part, carragheen 0-50 part, pulullan polysaccharide 0-100 part, gellan gum 0-5 part,
Locust bean gum 0-5 part, Hydroxypropyl methylcellulose 0-50 part, carboxymethylcellulose calcium 0-50 part；
Locust bean gum 1 part, carragheen 0-50 part, pulullan polysaccharide 0-100 part, konjac glucomannan 0-5 part,
Gellan gum 0-5 part, Hydroxypropyl methylcellulose 0-50 part, carboxymethylcellulose calcium 0-50 part；
Hydroxypropyl methylcellulose 1 part, carragheen 0-50 part, pulullan polysaccharide 0-100 part, konjac glucomannan 0-5
Part, locust bean gum 0-5 part, gellan gum 0-5 part, carboxymethylcellulose calcium 0-50 part；
Or, carboxymethylcellulose calcium 1 part, carragheen 0-50 part, pulullan polysaccharide 0-100 part, konjaku
Glue 0-5 part, locust bean gum 0-5 part, Hydroxypropyl methylcellulose 0-50 part, gellan gum 0-5 part；
It is preferably in carragheen, pulullan polysaccharide, Hydroxypropyl methylcellulose, konjac glucomannan and gellan gum
Plant or multiple.
More preferably carragheen；Carragheen, pulullan polysaccharide, Hydroxypropyl methylcellulose and konjac glucomannan；
Or carragheen and gellan gum.
More preferably count by weight, carragheen 0.5-2 part, pulullan polysaccharide 0.1-2 part, hydroxyl
Third methylcellulose 0.5-2 part and konjac glucomannan 0.005-0.5 part；Or carragheen 1-2 part and gellan gum 0.1-1
Part.
Elasticity conditioning agent is in potassium chloride, potassium citrate, phosphate, lauryl sodium sulfate
Plant or multiple；
Elasticity conditioning agent accounts for the 10%-30% of forming agent weight, its concrete composition for count by weight,
1 part of potassium chloride, potassium citrate 0-5 part, phosphate 0-5 part, lauryl sodium sulfate 0-5 part；
Potassium citrate 1 part, potassium chloride 0-5 part, phosphate 0-5 part, lauryl sodium sulfate 0-5
Part.
Sodium potassium phosphate 1 part, potassium citrate 0-5 part, potassium chloride 0-5 part, lauryl sodium sulfate
0-5 part.
Or, lauryl sodium sulfate 1 part, potassium citrate 0-5 part, phosphate 0-5 part, potassium chloride
0-5 part.
It is preferably: one or more in potassium chloride, sodium dihydrogen phosphate and potassium citrate.
Further it is preferably: potassium chloride；Potassium chloride and sodium dihydrogen phosphate；Or potassium chloride and citric acid
Potassium.
More preferably count by weight, potassium chloride 0.01-0.5 part and sodium dihydrogen phosphate 0.01-0.5
Part；Or potassium chloride 0.01-0.5 part and potassium citrate 0.01-0.5 part.
Friability conditioning agent is mannitol, glycerine, sorbierite, maltitol, polyethylene glycol, poly-dimension
Ketone, polyglyceryl fatty acid ester, diacetyl tartarate list double glyceride, citric acid fatty glyceride,
One or more in lactic acid fatty glyceride.
Friability and shelf-life conditioning agent account for the 10%-30% of forming agent weight, and its concrete composition is by weight
Number meter, 1 part of mannitol, glycerine 0-50 part, sorbierite 0-50 part, maltitol 0-50 part,
Polyethylene glycol 0-5 part, PVP 0-5 part, polyglyceryl fatty acid ester 0-5 part, diacetyl tartarate
Single double glyceride 0-5 part, citric acid fatty glyceride 0-5 part, lactic acid fatty glyceride 0-5
Part；
Glycerine 1 part, mannitol 0-50 part, sorbierite 0-50 part, maltitol 0-50 part, poly-second
Glycol 0-5 part, PVP 0-5 part, polyglyceryl fatty acid ester 0-5 part, diacetyl tartarate Dan Shuan
Glyceride 0-5 part, citric acid fatty glyceride 0-5 part, lactic acid fatty glyceride 0-5 part；
Sorbierite 1 part, glycerine 0-50 part, mannitol 0-50 part, maltitol 0-50 part, poly-second
Glycol 0-5 part, PVP 0-5 part, polyglyceryl fatty acid ester 0-5 part, diacetyl tartarate Dan Shuan
Glyceride 0-5 part, citric acid fatty glyceride 0-5 part, lactic acid fatty glyceride 0-5 part；
Maltitol 0.1 part, glycerine 0-50 part, sorbierite 0-50 part, mannitol 0-50 part, poly-
Ethylene glycol 0-5 part, PVP 0-5 part, polyglyceryl fatty acid ester 0-5 part, diacetyl tartarate list
Double glyceride 0-5 part, citric acid fatty glyceride 0-5 part, lactic acid fatty glyceride 0-5 part；
Polyethylene glycol 0.1 part, glycerine 0-50 part, sorbierite 0-50 part, maltitol 0-50 part,
Mannitol 0-50 part, PVP 0-5 part, polyglyceryl fatty acid ester 0-5 part, diacetyl tartarate list
Double glyceride 0-5 part, citric acid fatty glyceride 0-5 part, lactic acid fatty glyceride 0-5 part；
PVP 0.1 part, glycerine 0-50 part, sorbierite 0-50 part, maltitol 0-50 part, poly-
Ethylene glycol 0-5 part, mannitol 0-50 part, polyglyceryl fatty acid ester 0-5 part, diacetyl tartarate list
Double glyceride 0-5 part, citric acid fatty glyceride 0-5 part, lactic acid fatty glyceride 0-5 part.
Polyglyceryl fatty acid ester 0.1 part, mannitol 0-50 part, glycerine 0-50 part, sorbierite 0-50
Part, maltitol 0-50 part, polyethylene glycol 0-5 part, PVP 0-5 part, diacetyl tartarate list
Double glyceride 0-5 part, citric acid fatty glyceride 0-5 part, lactic acid fatty glyceride 0-5 part.
Diacetyl tartarate list double glyceride 0.1 part, mannitol 0-50 part, glycerine 0-50 part, mountain
Pears alcohol 0-50 part, maltitol 0-50 part, polyethylene glycol 0-5 part, PVP 0-5 part, poly-sweet
Oil and fat acid esters 0-5 part, citric acid fatty glyceride 0-5 part, lactic acid fatty glyceride 0-5
Part.
Citric acid fatty glyceride 0.1 part, mannitol 0-50 part, glycerine 0-50 part, sorbierite
0-50 part, maltitol 0-50 part, polyethylene glycol 0-5 part, PVP 0-5 part, polyglycereol fat
Acid esters 0-5 part, diacetyl tartarate list double glyceride 0-5 part, lactic acid fatty glyceride 0-5 part.
Lactic acid fatty glyceride 0.1 part, mannitol 0-50 part, glycerine 0-50 part, sorbierite 0-50
Part, maltitol 0-50 part, polyethylene glycol 0-5 part, PVP 0-5 part, polyglyceryl fatty acid ester
0-5 part, diacetyl tartarate list double glyceride 0-5 part, citric acid fatty glyceride 0-5 part.
It is preferably: glycerine, lactic acid fatty glyceride, polyglyceryl fatty acid ester, maltitol and poly-
One or more in dimension ketone.
Further preferably glycerine；Glycerine, lactic acid fatty glyceride and polyglyceryl fatty acid ester；Or
Glycerine, polyglyceryl fatty acid ester, maltitol and PVP.
More preferably count by weight, glycerine 0.01-1 part, lactic acid fatty glyceride 0.01-1
Part and polyglyceryl fatty acid ester 0.01-1 part；Or glycerine 0.01-1 part, polyglyceryl fatty acid ester 0.01-1
Part, maltitol 0.01-1 part and PVP 0.01-1 part.
The application of a kind of starch base plant medicinal hard capsule forming agent, described forming agent mixes with starch base
Form preparation starch base plant medicinal hard capsule composition.
In described composition, forming agent accounts for 10wt%-50wt%, starch fiduciary point 50wt%-90wt%.
Described starch base is common starch or modified starch；Wherein, modified starch is for common starch to be
Raw material obtains through peroxidating, acidolysis, enzymolysis, high temperature high pressure process.
Described common starch is tapioca, cornstarch, wheaten starch, farina, rice shallow lake
One or more in powder.
A kind of starch base plant medicinal hard capsule: be mixed to form preparation by above-mentioned forming agent and starch base and form sediment
Powder base plant medicinal hard capsule composition prepares gained.
The preparation of capsule:
Weigh forming agent and support glue with starch base each raw material → hot water dissolving (pure water of 80-90 DEG C) → constant temperature
(38-60 DEG C) → it is stained with glue groove bin stock → automatic dipping glue (35-45 DEG C) → shaping and drying → demoulding cutting
Fastening → finished product is put in storage.
Advantage for present invention:
Forming agent of the present invention can be exclusively used in the preparation of compatibility starch and produce the auxiliary material of capsule, uses this forming agent
Colloid with starch as major ingredient can be made to obtain good mouldability, and the capsule produced has good crisp
Broken degree (50 detections, friability is less than 2), elasticity (50 detections also have no Lou medicine), disintegration
Time (4 minutes) and shelf-life (heart bottle closure ambient temperature and moisture preserves, and guarantees the quality more than 1 year).This
Invention forming agent can ensure that capsule main material is in the case of starch (more than 50% is starch), makes glue become
Type is capsule.Reduce production cost simultaneously, due to starch price at a fairly low honest and clean (10000 yuan/ton with
Under), therefore use forming agent capsule manufacture cost of material of the present invention to control below 35000 yuan/ton,
Well below the cost of gelatine capsule raw material 60000 yuan/ton and seaweed plants capsule 80000 yuan/ton
Cost.In addition using forming agent of the present invention can stop heavy metals exceeding standard problem completely, various features is the brightest
Show and be better than existing gelatine capsule and plant capsule.Ensureing that capsule friability rate is less than 95%, disintegration time is little
In 10 minutes, more than 1 year shelf-life.
Detailed description of the invention
Below example can make those of ordinary skill in the art that the present invention be more fully understood, but not
Limit the present invention by any way.
Forming agent of the present invention can be exclusively used in the preparation of compatibility starch and produce the auxiliary material of capsule, uses this forming agent can
Make the colloid with starch as major ingredient obtain good mouldability, and the capsule produced has good friability
Degree (50 detections, friability 2), elasticity (50 detections also have no Lou medicine), disintegration time (4
Minute) and the shelf-life (heart bottle closure ambient temperature and moisture preserves, more than 1 year shelf-life).
Embodiment 1
Starch base plant edible fiber medicinal transparent capsule forming agent is carragheen 1.5 kilograms, potassium chloride
0.01 kilogram, sodium dihydrogen phosphate 0.05 kilogram, 0.2 kilogram of mannitol, sorbierite 0.2 kilogram, hydroxyl
Third methylcellulose 1 kilogram, PVP 0.01kg.
The preparation of the medicinal nontransparent capsule of starch base plant edible fiber: by above-mentioned forming agent and 20 kilograms
The modified starch of viscosity 200cp stirs and evenly mixs, and adds water 160 kilograms, is heated to 80 DEG C of dissolvings, then
Be naturally cooling to that 60 DEG C of constant temperature is quiet puts glue in a suitable place to breed, then will put into glue groove, through capsule mould automatically dip in glue,
Dry, demoulding cutting fastens, i.e. can be made into capsule.
Using this formula, capsule is colloid not film forming during dipping in glue, and the thickness having a strong impact on capsule is equal
Even.It addition, the toughness of capsule finished product is not enough, takes 50 methods specified according to Chinese Pharmacopoeia and carry out crisp
Broken experiment, 40 friability, take 50 methods specified according to Chinese Pharmacopoeia and carry out elasticity experiment, 20
Grain leakage medicine.Within the disintegration time limited using Intelligent disintegration tester test capsule is 10 minutes.
Embodiment 2
Starch base plant edible fiber medicinal transparent capsule forming agent is pulullan polysaccharide 2 kilograms, phosphoric acid
Sodium dihydrogen 0.05 kilogram, 0.2 kilogram of mannitol, sorbierite 0.2 kilogram, Hydroxypropyl methylcellulose 1,000
Gram, PVP 0.01kg, konjac glucomannan 5g.
The preparation of the medicinal nontransparent capsule of starch base plant edible fiber: by above-mentioned forming agent and 20 kilograms
Viscosity stirs and evenly mixs at the modified starch of 200cp, adds water 160 kilograms, heating for dissolving, Temperature fall
Put glue in a suitable place to breed to 60 DEG C of constant temperature of glue are quiet, then glue put into glue groove, through capsule mould automatic dipping glue,
Dry, demoulding cutting fastens, i.e. can be made into capsule.
Using this formula, capsule is colloid not film forming during dipping in glue, and the thickness having a strong impact on capsule is equal
Even.It addition, the toughness of capsule finished product is not enough, takes 50 methods specified according to Chinese Pharmacopoeia and carry out crisp
Broken experiment, 36 friability, take 50 methods specified according to Chinese Pharmacopoeia and carry out elasticity experiment, 28
Grain leakage medicine.Within the disintegration time limited using Intelligent disintegration tester test capsule is 10 minutes.
Embodiment 3
Starch base plant edible fiber medicinal transparent capsule forming agent is carragheen 1.5 kilograms, potassium chloride
0.01 kilogram, pulullan polysaccharide 0.1 kilogram, sodium dihydrogen phosphate 0.05 kilogram, 0.2 kilogram of mannitol,
Sorbierite 0.2 kilogram, Hydroxypropyl methylcellulose 1 kilogram, PVP 0.01kg.
The preparation of the medicinal nontransparent capsule of starch base plant edible fiber:
Above-mentioned forming agent and 20 kilograms of modified starches (viscosity is at 200cp) are stirred and evenly mixed, adds water 160
Kilogram, heating for dissolving, it is naturally cooling to that 60 DEG C of constant temperature of glue are quiet puts glue in a suitable place to breed, then glue is put into glue
Groove, fastens through capsule mould automatic dipping glue, drying, demoulding cutting, i.e. can be made into capsule.
Using this formula, capsule film forming during dipping in glue is good.It addition, the toughness of capsule finished product
Deficiency, takes 50 methods specified according to Chinese Pharmacopoeia and carries out friability experiment, 39 friability, take 50
Grain carries out elasticity experiment, 20 leakage medicines according to the method that Chinese Pharmacopoeia specifies.Use Intelligent disintegration tester
Within the disintegration time limited of test capsule is 10 minutes.
Embodiment 4
Starch base plant edible fiber medicinal transparent capsule forming agent is carragheen 1.5 kilograms, potassium chloride
0.01 kilogram, pulullan polysaccharide 0.1 kilogram, sodium dihydrogen phosphate 0.05 kilogram, 0.2 kilogram of mannitol,
Glycerine 0.2 kilogram, sorbierite 0.2 kilogram, Hydroxypropyl methylcellulose 1 kilogram.
Preparation: above-mentioned forming agent and 20 kilograms of viscosity are stirred and evenly mixed at the modified starch of 200cp, adds
160 kilograms of water, heating for dissolving, it is naturally cooling to that 60 DEG C of constant temperature of glue are quiet puts glue in a suitable place to breed, then by glue
Put into glue groove, fasten through capsule mould automatic dipping glue, drying, demoulding cutting, i.e. can be made into capsule.
Using this formula, capsule film forming during dipping in glue improves.It addition, the toughness of capsule finished product
Deficiency, takes 50 methods specified according to Chinese Pharmacopoeia and carries out friability experiment, 20 friability, take 50
Grain carries out elasticity experiment, 15 leakage medicines according to the method that Chinese Pharmacopoeia specifies.Use Intelligent disintegration tester
Within the disintegration time limited of test capsule is 10 minutes.
Embodiment 5
Forming agent is carragheen 2 kilograms, 0.3 kilogram of potassium chloride, glycerine 1 kilogram.
Prepared by transparent capsule: weigh viscosity 200cp modified starch 20 kilograms, carragheen 2 kilograms,
0.3 kilogram of potassium chloride, glycerine 1 kilogram.Above-mentioned dispensing is mixed, adds water 160 kilograms, add thermosol
Solve, be naturally cooling to that 60 DEG C of constant temperature of glue are quiet puts glue in a suitable place to breed, then glue is put into glue groove, through die of capsule
Plate automatic dipping glue, drying, demoulding cutting fasten, i.e. can be made into capsule.
Using above-mentioned forming agent to obtain in micelle, capsule film forming during dipping in glue is good.Take 50
The method that grain specifies according to Chinese Pharmacopoeia carries out friability experiment, 2 friability, takes 50 according to middle traditional Chinese medicines
The method that allusion quotation specifies carries out elasticity experiment, 8 leakage medicines.Use the disintegration of Intelligent disintegration tester test capsule
Time be limited to 10 minutes within.Heart bottle closure ambient temperature and moisture preserves, 6 months shelf-lifves.
Embodiment 6
Forming agent is carragheen 2 kilograms, pulullan polysaccharide 0.1 kilogram, and 0.1 kilogram of potassium chloride is sweet
Dew alcohol 0.2 kilogram, glycerine 0.5 kilogram, sorbierite 0.3 kilogram, polyethylene glycol 5g, hydroxypropyl first is fine
Dimension element 1 kilogram, konjac glucomannan 5g, locust bean gum 5g, polyglyceryl fatty acid ester 5g, diacetyl tartarate list
Double glyceride 5g.
Prepared by transparent capsule: weigh the viscosity modified starch 20 kilograms at 200cp, carragheen 2 kilograms,
Pulullan polysaccharide 0.1 kilogram, 0.1 kilogram of potassium chloride, 0.2 kilogram of mannitol, glycerine 0.5 kilogram,
Sorbierite 0.3 kilogram, polyethylene glycol 5g, Hydroxypropyl methylcellulose 1 kilogram, konjac glucomannan 5g, locust bean gum
5g, polyglyceryl fatty acid ester 5g, above-mentioned dispensing is mixed by diacetyl tartarate list double glyceride 5g, adds
160 kilograms of water, heating for dissolving, it is naturally cooling to that 60 DEG C of constant temperature of glue are quiet puts glue in a suitable place to breed, then by glue
Put into glue groove, fasten through capsule mould automatic dipping glue, drying, demoulding cutting, i.e. can be made into capsule.
Using above-mentioned forming agent to obtain in micelle, capsule film forming during dipping in glue is good.Take
50 methods specified according to Chinese Pharmacopoeia carry out friability experiment, 2 friability, take 50 according to China
The method of States Pharmacopoeia specifications carries out elasticity experiment, 2 leakage medicines.Use collapsing of Intelligent disintegration tester test capsule
Within being limited to 5 minutes during solution.Heart bottle closure ambient temperature and moisture preserves, ten months shelf-lifves.
Embodiment 7
Forming agent is carragheen 2 kilograms, pulullan polysaccharide 0.1 kilogram, dibastic sodium phosphate 50 grams, chlorination
0.1 kilogram of potassium, 0.2 kilogram of mannitol, glycerine 0.5 kilogram, sorbierite 0.3 kilogram, carboxymethyl
Cellulose 0.1 kilogram, lauryl sodium sulfate 8 grams, konjac glucomannan 5 grams, citric acid fatty acid glycerine
Ester 5g.Prepared by transparent capsule, weigh the viscosity modified starch 20 kilograms at 200cp, carragheen 2,000
Gram, pulullan polysaccharide 0.1 kilogram, dibastic sodium phosphate 50 grams, 0.1 kilogram of potassium chloride, mannitol 0.2
Kilogram, glycerine 0.5 kilogram, sorbierite 0.3 kilogram, carboxymethylcellulose calcium 0.1 kilogram, dodecane
8 grams of base sodium sulphate, konjac glucomannan 5 grams, citric acid fatty glyceride 5g.
Preparation: above-mentioned dispensing is mixed, adds water 160 kilograms, heating for dissolving, it is naturally cooling to glue
60 DEG C of constant temperature is quiet puts glue in a suitable place to breed, and glue is then put into glue groove, through capsule mould automatic dipping glue, drying,
Demoulding cutting fastens, i.e. can be made into capsule.
Using above-mentioned forming agent to obtain in micelle, capsule film forming during dipping in glue is good.Take
50 methods specified according to Chinese Pharmacopoeia carry out friability experiment, 2 friability, take 50 according to China
The method of States Pharmacopoeia specifications carries out elasticity experiment, 0 leakage medicine.Use collapsing of Intelligent disintegration tester test capsule
Within being limited to 5 minutes during solution.Heart bottle closure ambient temperature and moisture preserves, ten months shelf-lifves.
Embodiment 8
Forming agent is carragheen 1kg, pulullan polysaccharide 100g, Hydroxypropyl methylcellulose 0.5kg, konjac glucomannan
5g, potassium chloride 100g, potassium citrate 20g, glycerine 0.5kg, lactic acid fatty glyceride 10g is poly-sweet
Oil and fat acid esters 10g.
Prepared by transparent capsule: weigh the viscosity modified starch 20 kilograms at 200cp, carragheen 1kg,
Pulullan polysaccharide 100g, Hydroxypropyl methylcellulose 0.5kg, konjac glucomannan 5g, potassium chloride 100g, citric acid
Potassium 20g, glycerine 0.5kg, lactic acid fatty glyceride 10g, polyglyceryl fatty acid ester 10g.By above-mentioned
Dispensing mixes, and adds water 160 kilograms, and heating for dissolving is naturally cooling to that 60 DEG C of constant temperature of glue are quiet puts glue in a suitable place to breed,
Then glue is put into glue groove, through capsule mould automatic dipping glue, drying, the demoulding cutting fasten,
Make capsule.
Using above-mentioned forming agent to obtain in micelle, capsule film forming during dipping in glue is good.Take
50 methods specified according to Chinese Pharmacopoeia carry out friability experiment, 2 friability, take 50 according to China
The method of States Pharmacopoeia specifications carries out elasticity experiment, 0 leakage medicine.Use collapsing of Intelligent disintegration tester test capsule
Within being limited to 5 minutes during solution.Heart bottle closure ambient temperature and moisture preserves, 1 year shelf-life.
Embodiment 9
Forming agent is carragheen 1.5kg, gellan gum 150g, potassium chloride 150g, potassium citrate 30g,
Glycerine 0.75kg, polyglyceryl fatty acid ester 15g, maltitol 15g, PVP 15g.
Prepared by transparent capsule: weigh the viscosity modified starch 20 kilograms at 200cp, carragheen 1.5kg,
Gellan gum 150g, potassium chloride 150g, potassium citrate 30g, glycerine 0.75kg, polyglyceryl fatty acid ester
15g, maltitol 15g, PVP 15g.Above-mentioned dispensing is mixed, adds water 160 kilograms, heating
Dissolve, be naturally cooling to that 60 DEG C of constant temperature of glue are quiet puts glue in a suitable place to breed, then glue is put into glue groove, through capsule
Template automatic dipping glue, drying, demoulding cutting fasten, i.e. can be made into capsule.
Using above-mentioned forming agent to obtain in micelle, capsule film forming during dipping in glue is good.Take
50 methods specified according to Chinese Pharmacopoeia carry out friability experiment, 2 friability, take 50 according to China
The method of States Pharmacopoeia specifications carries out elasticity experiment, 0 leakage medicine.Use collapsing of Intelligent disintegration tester test capsule
Within being limited to 5 minutes during solution.Heart bottle closure ambient temperature and moisture preserves, 18 months shelf-lifves.
Claims (7)
1. a starch base plant medicinal hard capsule forming agent, it is characterised in that: forming agent presses quality hundred
Proportion by subtraction meter, 40%-80% film forming, viscosity modifier, 10%-30% elasticity conditioning agent and 10-30% are crisp
Broken degree conditioning agent.
2. according to starch base plant medicinal hard capsule forming agent described in claim 1, it is characterised in that:
Described film forming, viscosity modifier are carragheen, gellan gum, pulullan polysaccharide, konjac glucomannan, locust bean
One or more in glue, Hydroxypropyl methylcellulose, carboxymethylcellulose calcium；Elasticity conditioning agent is chlorination
One or more in potassium, potassium citrate, phosphate, lauryl sodium sulfate；Friability conditioning agent
For mannitol, glycerine, sorbierite, maltitol, polyethylene glycol, PVP, polyglycerol fatty acid
Ester, diacetyl tartarate list double glyceride, citric acid fatty glyceride, lactic acid fatty glyceride
In one or more.
3. an application for the starch base plant medicinal hard capsule forming agent described in claim 1, it is special
Levy and be: described forming agent and starch base are mixed to form preparation starch base plant medicinal hard capsule composition.
4. the application of the starch base plant medicinal hard capsule forming agent as described in claim 3, its feature
It is: in described composition, forming agent accounts for 10wt%-50wt%, starch fiduciary point 50wt%-90wt%.
5. the application of the starch base plant medicinal hard capsule forming agent as described in claim 6 or 7, its
It is characterised by: described starch base is common starch or modified starch；Wherein, modified starch is with commonly
Starch is that raw material obtains through peroxidating, acidolysis, enzymolysis, high temperature high pressure process.
6. its feature of application of the starch base plant medicinal hard capsule forming agent as described in claim 5 exists
In: described common starch is tapioca, cornstarch, wheaten starch, farina, rice
One or more in starch.
7. a starch base plant medicinal hard capsule, it is characterised in that: by above-mentioned forming agent and starch
Base is mixed to form preparation starch base plant medicinal hard capsule composition and prepares gained.
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| CN113018275A (en) * | 2021-03-11 | 2021-06-25 | 安徽黄山胶囊股份有限公司 | Povidone empty capsule and production process thereof |
| CN113018275B (en) * | 2021-03-11 | 2023-02-14 | 安徽黄山胶囊股份有限公司 | Povidone empty capsule and production process thereof |
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