CN1589772A - Cosmetics - Google Patents
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- CN1589772A CN1589772A CN 200310113769 CN200310113769A CN1589772A CN 1589772 A CN1589772 A CN 1589772A CN 200310113769 CN200310113769 CN 200310113769 CN 200310113769 A CN200310113769 A CN 200310113769A CN 1589772 A CN1589772 A CN 1589772A
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Abstract
The present invention provides a cosmetic which comprises low molecular weight collagen hydrolyzed by enzyme, a vitamin-C derivative, a methacryloylphosophorylcholine copolymer and an Akebia stem extract, the cosmetic includes a plurality of cosmetic base agents which have moisture keeping effect to the skin and a high penetrability collagen, the cosmetic also has an excellent restraining effect to wrinkle generating.
Description
Technical field
The present invention relates to a kind of containing has the multiple cosmetics base of moistening effect and high osmosis collagen protein and wrinkle is generated the cosmetics with good inhibition effect skin.
Background technology
When people judge the other side's age according to appearance, generally with comprise around its canthus, the corners of the mouth and the cervical region be present on the health wrinkle what as main criterion.Especially after on the skin wrinkle being arranged, just judge that naturally this people is getting in years, therefore from keeping the angle of youthful appearance, it is very important suppressing the wrinkle generation.For this reason, all the time, people are the research of purpose being devoted to exploitation wrinkle of skin to be formed with the cosmetics that suppress effect.
People fully do not understand the mechanism that wrinkle occurs so far yet, but known ultraviolet, drying, age to increase etc. all be important reasons.Can think,, when collagen protein attenuates or reduce, keep the function of skin elasticity to reduce because the influence of these factors reduces intradermal collagen protein synthesis ability.As a result, the epidermal area that has lost flexibility and retractility is out of shape in a certain direction and subsides, thereby forms wrinkle.
, generate if will suppress wrinkle, important part is, need give the ability of skin moisture-keeping, provides collagen protein to skin for this reason.Therefore, people have the cosmetics of the power of preserving moisture in making to skin all the time, and the cosmetics that contain collagen protein.
Up to the present, for making the cosmetics that skin had the good power of preserving moisture, people have proposed various wetting agents, for example, now general the most frequently used wetting agent is water-soluble polyol such as glycerol, propylene glycol and carbamide etc., but problem is that water-soluble polyol easily produces tangible viscous sense on sense organ, and when under low humidity, using these water-soluble polyols,, the moisture in the skin make skin become dry because of being absorbed by wetting agent; And urea stability is poor, easily decompose and specific stimulation is arranged, and therefore also is difficult to use in the cosmetics that directly spread upon on the skin.
So for the wetting agent that is used for cosmetics, people are still constantly putting forward various plans.For example also has following several motion.
Promptly, open in the flat 10-7581 communique the spy, having disclosed with contained akala (Akebi) extract is preserve moisture material and the excellent results of giving skin lubrication sense and glossiness aspect of the arginase accelerative activator of effective ingredient to the moisture in the generation maintenance skin in the Skin Cell.
In addition, open in the flat 5-70321 communique the spy, having disclosed with methacryloyl ethyl oxide Phosphorylcholine is that the copolymer of construction unit is keeping function, skin is had effect aspect the especially good U.S. flesh effect based on the high-moisture of moisture absorption, moisture-keeping function.
On the other hand, collagen protein is to keep cyto-architectural a kind of protein, has the form of keeping organ, the function that keeps ICW.Especially the collagen content in the skin is all more than other organ, is 70% of gross weight, as mentioned above, is playing a very important role aspect the generation of inhibition wrinkle of skin.For this reason, it is a lot of to contain the cosmetics of collagen protein.But, because collagen protein itself is very large protein, and have insoluble, so, add directly that to use in the cosmetics be very difficult to.Therefore, general most is to act on collagen protein by enzyme to make it to become soluble modified collagen (atherocollagen), again it is used for cosmetics as the cosmetics base.
For example, as an example, can enumerate the spy and open the cosmetics for skin material that discloses in the 2001-139447 communique, it contains water solublity type i collagen albumen, alkaline pH is adjusted agent and vitamin C derivatives, can improve the wettability to skin, is a kind of quality material.
But the molecular weight of modified collagen is about 300,000, and is still bigger.High molecular weight protein will become antigen in immunoreation.For this reason, modified collagen might become the reason that causes allergic reaction.Also promptly, it has allergia.In addition, though modified collagen has solubility, in water, be difficult for dissolving.Because molecule itself is big, also existing does not have infiltrative problem to skin.
Because these problems are arranged, therefore, as the collagen protein that is used for cosmetics, also proposed to use the method for hydrolytic collagen, the collagen protein that obtains after promptly using natural collagen protein by acid or alkali and enzyme reduction molecular weight, but its molecular weight still has 2,000～12,000, the problem of relevant allergic effect is not talkative to be solved fully, therefore the aminoacid sequence of collagen protein is cut off at random, also causes stench and painted and so on problem, and also bad to the permeability of skin.
Inventor of the present invention is for addressing these problems, study for the cosmetics that can give skin moisture-keeping power, can supply with collagen protein, find: use the raw material that contains collagen protein composition or gelatin composition, by carry out N-terminal aminoacid that specific decomposition obtains with the collagen hydrolysising protease is that glycine, molecular weight are about 280 tripeptides and can be used as the supply source of collagen protein, and becomes good cosmetics base material.And the cosmetics that are made into this tripeptides, antigenicity and allergia are very low, and have percutaneous permeability, and be as easy as rolling off a log soluble in water, and do not have abnormal flavour and peculiar taste, so at first it is proposed (opening flat 2002-68962 communique with reference to the spy) as a motion.
Inventors use above-mentioned tripeptides, and for solving the shortcoming that existing cosmetics exist, the cosmetics that permeability height, moisture-keeping function might as well, be formed with higher inhibition effect to wrinkle have carried out the developmental research that should do.
Inventors have the cosmetics that higher inhibition wrinkle forms effect for obtaining, find by further investigation: if will contain above-mentioned collagen protein and be hydrolyzed by enzyme after low-molecular-weight collagen that obtains and the specific compounds that contains wetting agent use, compound effectiveness can take place in the moisture-keeping function of wetting agent, and can more effectively supply with collagen protein to Skin Cell, thereby the wrinkle that is inhibited forms the very high cosmetics of effect, finishes the present invention thus.
Summary of the invention
The present invention relates to a kind of cosmetics, it is characterized in that, contain the extract of low-molecular-weight collagen protein, vitamin C derivatives, methacrylyl phosphocholine copolymer and akala stem that useful enzyme hydrolysis obtains with above-mentioned characteristic.
In addition, the present invention relates to the following cosmetics that consist of feature, the content of its above-mentioned various compositions is:
Low-molecular-weight collagen protein: 0.05～0.50 quality %
Vitamin C derivatives: 0.01～0.30 quality %
Methacrylyl phosphocholine copolymer: 0.025～0.050 quality %
The extract of akala stem: 0.0025～0.025 quality %
In addition, cosmetics involved in the present invention is characterized in that, in above-mentioned cosmetics, also contain hyaluronate.
In addition, cosmetics involved in the present invention is characterized in that, in above-mentioned cosmetics, the hyaluronate that is contained is a hyaluronate sodium.
In addition, cosmetics involved in the present invention is characterized in that, in above-mentioned cosmetics, the content of hyaluronate is 0.0001～0.01 quality %.
In addition, cosmetics involved in the present invention is characterized in that, in above-mentioned cosmetics, the low-molecular-weight collagen protein is collagen protein or gelatin composition are carried out specific decomposition and to get with the collagen hydrolysising protease, and it is that N-terminal aminoacid is that glycine, molecular weight are about 280 tripeptides.
In addition, cosmetics involved in the present invention is characterized in that, in above-mentioned cosmetics, vitamin C derivatives is an Ascorbic acid 2-phosphate magnesium.
In addition, cosmetics involved in the present invention is characterized in that, in above-mentioned cosmetics, methacrylyl phosphocholine copolymer is and the synthetic copolymer of hydrophobic monomer.
In addition, cosmetics involved in the present invention is characterized in that, in above-mentioned cosmetics, hydrophobic monomer is a butyl methacrylate.
Cosmetics of the present invention, be by containing low molecular collagen, particularly containing the raw material of collagen composition or gelatin composition, obtaining N-terminal aminoacid with the collagen hydrolysising protease by specific decomposition is that glycine, molecular weight are about 280 tripeptides, and, utilize their compound action to reach the effect that good inhibition wrinkle forms with a plurality of specific chemical compounds.
The specific embodiment
Below the specific embodiment of the present invention is elaborated.
Cosmetics of the present invention are low-molecular-weight collagen protein, vitamin C derivatives, methacrylyl phosphocholine copolymer and the akala stem extract that contains through enzyme hydrolysis.
Low-molecular-weight collagen after enzyme hydrolysis is compared with common collagen protein, and is good to the dissolubility of water, to the permeability height of skin, arrives the deep layer of skin easily.Particularly as the low-molecular-weight collagen protein, be by obtain containing the raw material of collagen composition or gelatin composition by specific decomposition with the collagen hydrolysising protease, when using this N-terminal aminoacid to be about 280 tripeptides as glycine, molecular weight, because molecular weight is low, so be difficult for taking place antibody response.In addition, because antigenicity and allergia are very low, and very easily water-soluble, not only the modulation of cosmetics is easy to implement, and does not have abnormal flavour or peculiar taste, so can be used as good cosmetics base.
Utilizing enzyme to carry out collagen hydrolysate can adopt known method to carry out.When using the collagen hydrolysising protease to modulate above-mentioned N-terminal aminoacid to be about 280 tripeptides, can open the method shown in the flat 7-82299 communique according to the spy and carry out as glycine, molecular weight.In addition, also can use commercial articles, for example city wall chemical industry Co., Ltd. system " collagen tripeptide M " etc.
As mentioned above, vitamin C derivatives is widely used in the cosmetics, known, it except that have suppress melanin generate, effectively coloured melanin be reduced into colourless melanin and safe good whitening function, by organized enzyme suppress the aging resistance effect that the damage of DNA forms and utilize suppress sebum and lipid peroxide generation produced prevents also have the collagen protein synthesis facilitation the effect that acne form.When the low-molecular-weight collagen of vitamin C derivatives and high osmosis share, because both effects, the supply of the collagen skin corium that can go directly, and can collagen be absorbed by cell, be formed with tensile skin, play effects such as the vestige that makes acne is not obvious, simultaneously, also can bring into play and suppress the effect that the rugula stricture of vagina generates.
Vitamin C derivatives can be enumerated the oligosaccharide glycocide, two ascorbic palmitate, ascorbic palmitate, four-2-caproic acid capric acid acid ascorbyl ester, ascorbyl stearate, ascorbyl stearate of glucosan derivative, the ascorbic acid of for example sodium ascorbate, ascorbic acid sulfuric ester disodium, Ascorbic acid 2-phosphate magnesium, Ascorbic acid 2-phosphate sodium, ascorbic acid etc., can use in the middle of these derivants more than a kind or 2 kinds.
As said vitamin C derivant, preferred in the present invention stable phosphate type, especially Ascorbic acid 2-phosphate magnesium, these derivants not only can enter in the cell efficiently, and can be after by skin absorbs, reaction by enzyme becomes vitamin C, directly acts on cell, more effectively brings into play various effects.
Methacrylyl phosphocholine copolymer is obtained by combined polymerization according to conventional method by 2-methacryloyl ethyl oxide phosphocholine and polymerizable monomer.
As polymerizable monomer, can enumerate the hydrophobic monomer such as Arrcostab, hydroxy alkyl ester, styrene, vinyl chloride, acrylonitrile of acrylic or methacrylic acid.
As Arrcostab, hydroxy alkyl ester, can enumerate methyl ester, ethyl ester, n-butyl ester, 2-ethyl hexyl ester, 2-hydroxyethyl ester, 2-hydroxypropyl ester etc.
Be preferably acrylic acid Arrcostab in the present invention, particularly acrylic acid butyl ester.
These copolymers all have commercially available product, and known have Lipidure (NOF Corp's system) HM, a PMB etc., also used these commercially available products in the present invention.
Just as Chinese herbal medicine, its extract can effectively be used as the cosmetics base to the akala stem since ancient times.As mentioned above, it be the stem of akala or its dry thing are extracted with hydrocarbon, ester, ketone, ether, halogenated hydrocarbons or alcohol etc. and extract.
Hyaluronic acid is the Portugal's amine polysaccharide that is formed by D-glucosamine and D-glucuronic acid, belongs to a kind of of mucopolysaccharide, is to extract from the cockscomb of chicken or Corii Sus domestica.Widely sold simultaneously with its neutralized salt, they all are used for the present invention.
As everyone knows, these methacrylyl phosphocholine copolymers, akala stem and hyaluronate have following characteristic respectively, but the inventor finds first, when using these materials simultaneously, can better bring into play aforesaid characteristic.
Also promptly, because the copolymer of methacrylyl phosphocholine and hydrophobic monomer has the identical structure of polar group with the lecithin of formation cell membrane, so can form the tunicle of similar cell membrane.This tunicle is a nature moisturizing factor, Carboxymethyl Chitin, and can be used as the iuntercellular lipid and have an effect, therefore have the effect that can prevent the effusive protection moisture of moisture.
Thus, can prevent the moisture loss of skin surface, play the effect of keeping moisture in the skin.
In addition, the extract of akala stem, as its effective ingredient is stigmasterol, cupreol and glycocide thereof, and in being called as the sterols of betuline, contain saponin, tannin, potassium salt etc., therefore have the effect that promotes that carbamide produces, also promptly have the activatory effect of the arginase of making, arginase can make the L-arginine convert the L-ornithine to, and produces carbamide in this process.
Thus, can stably supply with carbamide, thereby produce moistening effect to skin.
And, the pH value of hyaluronate is near the pH value of skin, invasive to skin is low, in addition, hyaluronic acid combines with the elastin laminin that is supported between each collagen protein, has the effect of the protein structure of keeping skin, its the moisture ability of keeping is also very high, have the ability of maintenance weight, and this power of preserving moisture seldom is subjected to various such environmental effects such as temperature and humidity for 6000 times moisture of deadweight.
By with these known compounds usefulness as wetting agent, can produce moistening effect that multiply each other and significant, bring into play its very high moistening effect to skin, obtain bringing into play and suppress the cosmetics that wrinkle forms effect.
Cosmetics of the present invention, with above-mentioned 4 kinds and even 5 kinds of compositions is its necessary constituent, but as the base of cosmetics, is the function of material therefor before utilizing, also use some used materials in the past in the present invention, specifically used following chemical compound.
As the oil-soluble composition, can enumerate stearic acid PG (use amount 0.5～2.0wt%, down together), tristerin (1.0～4.0), behenyl alcohol (1.0～4.0), cetyl palmitate (0.1～1.0), stearic acid (1.0～5.0), (caprylic/capric) triglyceride (2.0～6.0), macadamia oil (0.1～1.5), olive oil (0.1～1.5), dimethyl polysiloxane (ca0.2), vitamin E (0.1～0.2), propylparaben (ca0.15), Jojoba oil (0.5～1.0), glycerol (0.5～3.0).
In addition, as water soluble ingredient, can enumerate allantoin (0.01～0.2), glycyrrhizic acid 2K (0.01～0.2), BG (1.0～10.0), hydrolecithin (0.01～0.1), phenyl phenol (ca0.05), methyl hydroxybenzoate (0.15～0.2), polyacrylate (0.1～0.3), potassium hydroxide (ca0.11), PEG-20 castor oil hydrogenated (ca0.5).
In addition, as other composition, can enumerate 1-Aloe extract (0.0005～0.0025), soybean extract (0.0002～0.002), Radix Puerariae extract (0.0003～0.003), chlorella extract (0.0001～0.001), Flos Matricariae chamomillae water (0.4745～1.898).
The modulation of cosmetics can be according to shapes such as vanishing cream, solution and is different, carries out substantially in the following order.
1) water soluble ingredient is dissolved (ceiling temperature is 85 ℃) while heating up in water purification.
2) in the water purification of the water soluble ingredient that contains the process intensification, add oiliness composition, by stirring (agitator: 3000rpm) carry out emulsifying through heating up.
3) emulsion is cooled to 40 ℃ of temperature, adds the additive except that collagen, when temperature is cooled to below 35 ℃, add collagen protein, mix and make it uniform dissolving.
4) resulting product is filtered, carry out Micro biological Tests.
By the following examples the present invention is carried out specific description, this embodiment does not constitute any limitation scope of the present invention.
Embodiment 1,2
Modulate the vanishing cream and the beautifying liquid of constituent shown in following table 1 as stated above.
In addition, in the modulation of beautifying liquid, used polyacrylate, the modulation of this aqueous solution is to stir by circadian mixing earlier, various water soluble ingredients are dissolved after, carry out the adjustment of pH value again.
In addition, the remainder in proportion of composing is a water purification.
Table 1
| Embodiment 1 (vanishing cream) | Embodiment 2 (beautifying liquid) | |
| Oil-soluble composition stearic acid PG tristerin docosyl alcohol glycerine cetyl palmitate stearic acid (caproic acid/capric acid) triglycerides macadamia olive oil jojoba oil dimethyl polysiloxane vitamin E propylben | ? ????1.2 ????3.3 ????2.0 ? ????0.8 ????3.0 ????4.0 ????0.5 ????0.5 ? ????0.2 ????0.2 ????0.15 | ? ? ? ? ????1.5 ? ? ? ? ? ????0.5 ? ????0.1 |
| Water soluble ingredient Ascorbic acid 2-phosphate Mg Polyoctanium-51 BG allantoin glycyrrhizic acid 2K potassium hydroxide hydrolecithin PEG-20 rilanit special phenoxetol methyl hydroxybenzoate polyacrylate | ? ????0.15 ????0.045 ????5.03 ????0.1 ????0.05 ? ????0.05 ? ????0.049 ????0.2 ? | ? ????0.05 ????0.05 ????3.38 ? ? ????0.11 ? ????0.5 ????0.05 ????0.15 ????0.26 |
| Other composition collagen tripeptide M-30 akala stem extraction Sodium Hyaluronate 1-aloe extract extract of soybean kudzu root extract chlorella extract german chamomile water | ? ????0.15 ????0.005 ????0.001 ????0.0005 ? ? ? ? | ? ????0.15 ????0.005 ? ????0.0005 ????0.0004 ????0.003 ????0.001 ????0.949 |
Comparative example 1～5
Comparative example is modulated into vanishing cream similarly to Example 1 except that following compositions, carry out the sense test by more than 20 year old, 30～40 years old, women over fifty years old, and its result is shown in table 2 (more than 20 year old), table 3 (30～40 years old) and table 4 (over fifty years old).
In addition, the result estimates expression (5: good～1: bad) with 5 grades.
Zero akala stem extract, Polyoctanium-51 (comparative example 1)
Zero Ascorbic acid 2-phosphate magnesium, Polyoctanium-51 (comparative example 2)
Zero Ascorbic acid 2-phosphate magnesium, akala stem extract (comparative example 3)
Zero collagen tripeptide M-30, Polyoctanium-51 (comparative example 4)
Zero collagen tripeptide M-30 (comparative example 5)
Table 2
| Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 | Embodiment 1 | |
| The power of preserving moisture | ????3 | ????4 | ????4 | ????2 | ????3 | ????4 |
| Moist feeling | ????3 | ????3 | ????3 | ????1 | ????3 | ????3 |
| The infiltration sense | ????4 | ????3 | ????3 | ????1 | ????3 | ????5 |
| Wrinkle | ????3 | ????3 | ????4 | ????2 | ????4 | ????5 |
| The chloasma freckle | ????4 | ????3 | ????3 | ????3 | ????3 | ????4 |
| Vitality (morning on next day) | ? ????3 | ? ????3 | ? ????4 | ? ????2 | ? ????4 | ? ????5 |
| Use (week) continuously | ????3 | ????3 | ????4 | ????2 | ????3 | ????4 |
Table 3
| Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 | Embodiment 1 | |
| The power of preserving moisture | ????3 | ????4 | ????4 | ????2 | ????4 | ????5 |
| Moist feeling | ????2 | ????2 | ????3 | ????1 | ????3 | ????4 |
| The infiltration sense | ????4 | ????3 | ????3 | ????1 | ????2 | ????4 |
| Wrinkle | ????3 | ????3 | ????4 | ????2 | ????4 | ????5 |
| The chloasma freckle | ????3 | ????2 | ????2 | ????2 | ????2 | ????4 |
| Vitality (morning on next day) | ????3 | ????3 | ????3 | ????2 | ????3 | ????4 |
| Use (week) continuously | ????3 | ????3 | ????3 | ????2 | ????3 | ????4 |
Table 4
| Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 | Embodiment 1 | |
| The power of preserving moisture | ????3 | ????4 | ????4 | ????2 | ????4 | ????5 |
| Moist feeling | ????2 | ????2 | ????2 | ????1 | ????2 | ????5 |
| The infiltration sense | ????4 | ????3 | ????3 | ????1 | ????2 | ????4 |
| Wrinkle | ????2 | ????2 | ????3 | ????2 | ????3 | ????4 |
| The chloasma freckle | ????3 | ????2 | ????1 | ????2 | ????2 | ????4 |
| Vitality (morning on next day) | ????3 | ????3 | ????3 | ????1 | ????3 | ????5 |
| Use (week) continuously | ????2 | ????2 | ????3 | ????1 | ????3 | ????5 |
From above result as can be known, by in collagen tripeptide M-30, adding Ascorbic acid 2-phosphate magnesium, can improve penetration, and chloasma is produced effect.
In addition, by in collagen tripeptide M-30, adding the akala stem extract, can effectively preserve moisture.
And, by in collagen tripeptide M-30, adding Polyoctanium-51, can improve the power of preserving moisture, also produce effect to crease-resistant.
In addition, if use Ascorbic acid 2-phosphate magnesium and akala stem extract separately, then can only obtain the evaluation equal with ordinary cosmetics.
In addition, if do not contain collagen tripeptide M-30, even be used other three kinds of materials, although can confirm to preserve moisture, wrinkle removing, vitality have certain effect, can not become the high-quality cosmetics aspect combination property.
Also promptly, the present invention forms according to the combination cooperation of four kinds of materials, obtains all demonstrating in the chloasma wrinkle vitality various aspects of preserving moisture for the first time the cosmetics of good result.
Can reach a conclusion from these results, infiltration just because of collagen tripeptide M-30, Ascorbic acid 2-phosphate magnesium has promoted this infiltration again, the regeneration of collagen protein is activated, and the artificial epithelium effect by Polyoctanium-51 has been sealed the collagen tripeptide M of infiltration again, and the carbamide that is produced by the akala stem extract also works simultaneously, so effectiveness is taken place in penetration, the power of preserving moisture and chloasma, wrinkle etc., and this effect is continued.
Utilizability on the industry
Cosmetics of the present invention by compound interpolation high osmosis collagen protein and collagen absorption enhancer and wetting agent, and can obtain the wrinkle of skin is formed the good material with inhibition effect, and it can be used widely in the cosmetics industry.
Claims (9)
1. cosmetics is characterized in that, contain low-molecular-weight collagen protein, vitamin C derivatives, methacrylyl phosphocholine copolymer and akala stem extract by enzyme hydrolysis.
2. cosmetics as claimed in claim 1 is characterized in that, the content of described each composition is as follows:
Low-molecular-weight collagen protein: 0.05～0.50 quality %
Vitamin C derivatives: 0.01～0.30 quality %
Methacrylyl phosphocholine copolymer: 0.025～0.050 quality %
The extract of akala stem: 0.0025～0.025 quality %
3. cosmetics as claimed in claim 1 or 2 is characterized in that, also contain hyaluronate.
4. cosmetics as claimed in claim 3 is characterized in that, hyaluronate is a hyaluronate sodium.
5. as claim 3 or 4 described cosmetics, it is characterized in that the content of hyaluronate is 0.0001～0.01 quality %.
6. as each described cosmetics of claim 1～5, it is characterized in that, the low-molecular-weight collagen protein is to utilize the collagen hydrolysising protease that collagen protein or gelatin are carried out specific decomposition and get, and it is that N-terminal aminoacid is that glycine, molecular weight are about 280 tripeptides.
7. as each described cosmetics of claim 1～6, it is characterized in that vitamin C derivatives is an Ascorbic acid 2-phosphate magnesium.
8. as each described cosmetics of claim 1～7, it is characterized in that methacrylyl phosphocholine copolymer is and the synthetic copolymer of hydrophobic monomer.
9. cosmetics as claimed in claim 8 is characterized in that, hydrophobic monomer is a butyl methacrylate.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003311202A JP2005075809A (en) | 2003-09-03 | 2003-09-03 | Cosmetic |
| JP2003311202 | 2003-09-03 |
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| Publication Number | Publication Date |
|---|---|
| CN1589772A true CN1589772A (en) | 2005-03-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310113769 Pending CN1589772A (en) | 2003-09-03 | 2003-11-21 | Cosmetics |
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|---|---|
| JP (1) | JP2005075809A (en) |
| CN (1) | CN1589772A (en) |
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| CN102415597A (en) * | 2010-09-16 | 2012-04-18 | 株式会社芳珂 | Beauty drink possessing apple extract and collagen tripeptide |
| CN107157791A (en) * | 2017-06-22 | 2017-09-15 | 芜湖福民生物药业股份有限公司 | Phosphocholine modified moisturiser and preparation method thereof |
| CN107334713A (en) * | 2017-06-22 | 2017-11-10 | 芜湖福民生物药业股份有限公司 | Phosphocholine modified acne eliminating cream and preparation method thereof |
| CN107349126A (en) * | 2017-06-22 | 2017-11-17 | 芜湖福民生物药业股份有限公司 | Phosphocholine modified anti-wrinkle frost and preparation method thereof |
| CN108451785A (en) * | 2017-06-22 | 2018-08-28 | 芜湖福民生物药业股份有限公司 | Phosphocholine modified content in freckle cream and preparation method thereof |
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| WO2007013624A1 (en) * | 2005-07-29 | 2007-02-01 | National University Corporation Tokyo Medical And Dental University | Gel and medical material composed of such gel |
| JP4846300B2 (en) * | 2005-08-18 | 2011-12-28 | フマキラー株式会社 | Pest repellent for human body |
| JP5101193B2 (en) * | 2007-07-06 | 2012-12-19 | 富士フイルム株式会社 | Cosmetic composition |
| JP6247847B2 (en) * | 2013-07-10 | 2017-12-13 | 日本メナード化粧品株式会社 | Skin wrinkle formation preventive / improving agent, hyaluronic acid production promoter, collagen production promoter and MMP inhibitor |
| JP6605794B2 (en) * | 2014-09-22 | 2019-11-13 | 株式会社ファンケル | Arginase 1 production promoter |
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| CN110478266B (en) * | 2019-09-17 | 2022-09-16 | 广东丸美生物技术股份有限公司 | Collagen tripeptide-rich cosmetic composition, skin care cosmetic, application and preparation method |
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2003
- 2003-09-03 JP JP2003311202A patent/JP2005075809A/en active Pending
- 2003-11-21 CN CN 200310113769 patent/CN1589772A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102415597A (en) * | 2010-09-16 | 2012-04-18 | 株式会社芳珂 | Beauty drink possessing apple extract and collagen tripeptide |
| CN107157791A (en) * | 2017-06-22 | 2017-09-15 | 芜湖福民生物药业股份有限公司 | Phosphocholine modified moisturiser and preparation method thereof |
| CN107334713A (en) * | 2017-06-22 | 2017-11-10 | 芜湖福民生物药业股份有限公司 | Phosphocholine modified acne eliminating cream and preparation method thereof |
| CN107349126A (en) * | 2017-06-22 | 2017-11-17 | 芜湖福民生物药业股份有限公司 | Phosphocholine modified anti-wrinkle frost and preparation method thereof |
| CN108451785A (en) * | 2017-06-22 | 2018-08-28 | 芜湖福民生物药业股份有限公司 | Phosphocholine modified content in freckle cream and preparation method thereof |
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| JP2005075809A (en) | 2005-03-24 |
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