CN1701792A - Preparation for external use on skin - Google Patents
Preparation for external use on skin Download PDFInfo
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- CN1701792A CN1701792A CN 200510074305 CN200510074305A CN1701792A CN 1701792 A CN1701792 A CN 1701792A CN 200510074305 CN200510074305 CN 200510074305 CN 200510074305 A CN200510074305 A CN 200510074305A CN 1701792 A CN1701792 A CN 1701792A
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- ascorbic acid
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- skin
- skin preparations
- extenal use
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Abstract
This skin lotion containing at least one kind selected from the ascorbic acid or its derivatives uses diglycerol and a low molecular weight betaine simultaneously for improving the percutaneous absorption amount of the ascorbic acid or its derivatives, exhibiting the improving effects for blotches and somberness sufficiently and also having an excellent moisturizing effect.
Description
Technical field
The present invention relates to the skin preparations for extenal use that percutaneous absorbability is good and moisture retention is high of a kind of ascorbic acid or ascorbic acid derivates.
Background technology
As everyone knows, ascorbic acid is brought into play so-called anti-inflammatory effect, acne and is improved the synthetic cell-stimulating effects of biotic component such as effect, whitening effect, antiageing effect, antioxidant effect, promotion collagen, suppresses the cell injury of keratinization of epidermis cell under action of ultraviolet radiation or the various effects of the effect of DNA damage, wishes these effects and is widely used in skin preparations for extenal use.In order to give full play to the effect of this preparation, the Transdermal absorption amount of need give a piece of bad advice hematic acid or bad hematic acid derivant increases, promotes the effectively device of absorption.
On the other hand, with the trimethyl glycine is the low molecule betaine of representative, be widely used in skin preparations for extenal use as wetting agent, for example by share carbamide and low molecule betaine, can obtain very excellent pachylosis and improve effect (the patent documentation spy opens flat 9-48720 communique), by cooperating whitening composition, low molecule betaine, silicone oil, improve the percutaneous absorbability (spy opens the 2001-89321 communique) of whitening agent etc.
Summary of the invention
Problem of the present invention is to provide a kind of skin preparations for extenal use that contains ascorbic acid or ascorbic acid derivates, the Transdermal absorption amount height of its ascorbic acid or ascorbic acid derivates, have the effect of improving of sufficient brown patch, skin dimness, also have good moistening effect simultaneously.
The inventor etc. have carried out research with keen determination in order to solve above-mentioned problem, found that in containing one or more the skin preparations for extenal use that is selected from ascorbic acid or the ascorbic acid derivates, if share diglycerol and low molecule betaine, then can improve the percutaneous absorbability of ascorbic acid or ascorbic acid derivates, bring into play the effect of improving for brown patch, skin dimness that these materials have fully, moistening effect is good simultaneously.
Be that the present invention is following invention.
1. skin preparations for extenal use contains (A) and is selected from one or more material, (B) diglycerol and (C) low molecule betaine in ascorbic acid or the ascorbic acid derivates.
2. according to above-mentioned 1 described skin preparations for extenal use, wherein low molecule betaine is a trimethyl glycine.
3. according to above-mentioned 1 or 2 described skin preparations for extenal use, be to be used for anti-wrinkle, the anti-skin preparations for extenal use that relaxes and/or preserve moisture.
4. according to each described skin preparations for extenal use in above-mentioned 1～3, contain the diglycerol of the ascorbic acid of (A) 0.1～30 weight % or ascorbic acid derivates, (B) 1～95 weight % and (C) trimethyl glycine of 0.5～9 weight %.
5. according to each described skin preparations for extenal use in above-mentioned 1～4, contain the diglycerol of the ascorbic acid of (A) 5～20 weight % or ascorbic acid derivates, (B) 1～10 weight % and (C) trimethyl glycine of 1～8 weight %.
In addition, in this manual if do not have particular determination, % to be meant weight %.
In the present invention, by share one or more material, diglycerol and the low molecule betaine that is selected from ascorbic acid or the ascorbic acid derivates (below be also referred to as the ascorbic acid class), can significantly improve the Transdermal absorption amount of ascorbic acid or ascorbic acid derivates.Therefore, can provide the action effect of ascorbic acid or ascorbic acid derivates to be given full play to, brown patch and skin dimness etc. improve the good skin preparations for extenal use of effect.In addition, in skin preparations for extenal use of the present invention, can prevent the xerosis cutis effect and protect skin, can also keep very high skin moisture-keeping power simultaneously based on ascorbic acid or ascorbic acid derivates are distinctive.Therefore, if use skin preparations for extenal use of the present invention, the power of preserving moisture of skin improves, and brown patch, the dimness of skin improve, and elasticity, the elastic force of skin significantly improve.Like this, can provide good skin preparations for extenal use according to the present invention with anti-wrinkle effect, anti-relexation, moisture-keeping function etc.
The specific embodiment
Ascorbic acid that uses among the present invention or ascorbic acid derivates, can use in the goods or cosmetic field outside medicine, medicine, as the composition of skin preparations for extenal use and commercially available ascorbic acid or ascorbic acid derivates, they typically refer to the goods of L body.
In addition, ascorbic acid or ascorbic acid derivates can use the salt that allows as pharmaceutically, for example can enumerate with the salt of organic base (for example, the salt of front three amine salt, triethylamine salt, monoethanolamine salt, triethanolamine salt, pyridiniujm etc. and tertiary amine, alkaline ammonium salt such as arginine etc.) and salt (for example, the ammonium salt of inorganic base, alkali metal salt such as sodium salt, potassium salt, alkali salt such as calcium salt, magnesium salt, aluminum salt etc.) etc., particularly preferred salt is sodium salt, potassium salt.Specifically, can be exemplified as sodium ascorbate, potassium ascorbate etc.
In the present invention, can be used in combination ascorbic acid or ascorbic acid derivates more than a kind or 2 kinds.
Above-mentioned ascorbic acid of the present invention, preferred material in the ascorbic acid derivates is an ascorbic acid, the phosphate derivative of ascorbic acid, the sulfate derivative of ascorbic acid, the cetylate derivant of ascorbic acid, the ether derivant of ascorbic acid, the ascorbic acid phosplate of more specifically saying so, the ascorbic acid bisphosphate, the ascorbic acid triguaiacyl phosphate, ascorbic acid-2-Monosulfate, ascorbic acid-2-di-sulfate, ascorbic acid-2-three sulfuric esters, the ascorbic acid monopalmitate, Vitamin C dipalmitate, the ascorbic acid tripalmitate, ascorbic acid-2-glucoside and their salt.From safe and action effect for skin or mucosa, preferred especially ascorbic acid, ascorbic acid phosplate or their salt, ascorbic palmitate, ascorbic acid-2-glucoside.
In the present invention, can use in d body, l body and the dl body of ascorbic acid class any one.In external agent of the present invention, because the percutaneous absorbability of ascorbic acid or derivatives thereof significantly improves, therefore also can preferably use water miscible ascorbic acid or the water solublity ascorbic acid derivates (for example ester derivant of ascorbic acid or ether derivant etc.) that is considered to the Transdermal absorption difficulty usually.If enumerate the object lesson of described water solublity ascorbic acid derivates, can list the phosphate derivative of the L-ascorbic acid of L-ascorbic acid phosplate, L-ascorbic acid bisphosphate or L-ascorbic acid triguaiacyl phosphate etc. as ester derivant; Sulfuric ester as ascorbic acid can be enumerated the L-Ascorbic acid 2-sulfate.In addition, as ether derivant, can enumerate L-ascorbic acid-2-glucoside etc.Wherein, preferred L-ascorbic acid, the phosphate derivative of L-ascorbic acid, L-Ascorbic acid 2-sulfate, L-ascorbic acid-2-glucoside, from safe and action effect for skin or mucosa, preferred especially L-ascorbic acid, L-ascorbic acid phosplate, L-ascorbic acid-2-glucoside.
The ascorbic acid in the skin preparations for extenal use of the present invention or the use level of ascorbic acid derivates, with respect to the skin preparations for extenal use total weight, preferred 0.1～30 weight %.In this scope, can suit to select use level according to the various effects of needed ascorbic acid or ascorbic acid derivates or the purposes of skin preparations for extenal use.In view of effect of the present invention, further preferred 3～25 weight %, the scope of preferred especially 5～20 weight %.
In addition, the diglycerol that uses among the present invention is the known compound that is used for skin preparations for extenal use etc. more.
If the use level of the diglycerol of Shi Yonging is proved effective the present invention in the present invention, then be not particularly limited, can consider the usability of skin or effect and suitable the selection used.Usually with respect to whole skin preparations for extenal use, can be 1～95 weight %, preferred 1～50 weight %, more preferably 1～20 weight %, preferred especially 1～10 weight %.
Low molecule betaine among the present invention be meant molecular weight below 200 and intramolecularly form zwitterionic chemical compound, specifically, can be exemplified as quaternary ammonium base, quaternary phosphonium hydroxide, uncle's sulfonium base etc., they show the character as surfactant hardly.Wherein preferably use the N of following formula (1) expression, N, N-trialkyl aminoacid.
(in the formula, R
1, R
2And R
3Represent the alkyl of carbon number 1～6 independently of each other, n represents 1～6.)
As R
1～R
3, can be extensive use of the straight or branched alkyl of carbon number 1～6.Promptly, can distinguish illustration methyl, ethyl, propyl group, isopropyl, butyl, isobutyl group, sec-butyl, the tert-butyl group, amyl group, isopentyl, neopentyl, tertiary pentyl, hexyl, isohesyl, 3-methyl amyl, 2,2-dimethylbutyl or 2,3-dimethylbutyl etc.Wherein, R
1～R
3Can be identical, also can be different.
Specifically, can be exemplified as trimethyl glycine, triethyl group glycine, tripropyl glycine, the triisopropyl glycine of n=1, trimethyl-Beta-alanine of n=2, trimethyl-γ-An Jidingsuan of n=3 etc., preferred trimethyl glycine.
In addition, can replace these low molecule betaines, specifically, can be exemplified as the N of n=1, N, N-trimethylalanine, N, N, N-triethyl group alanine, N, N, N-triisopropyl alanine, N, N, N-trimethyl methylalanine, carnitine, acetylcarnitine etc., preferred carnitine.
In skin preparations for extenal use of the present invention, the use level of low molecule betaine, with respect to the skin preparations for extenal use gross weight, preferred 0.5～10 weight %, the various effects of ascorbic acid or derivatives thereof as required or the purposes of skin preparations for extenal use can suit to select in this scope.In view of effect of the present invention, further preferred 0.5～9 weight %, the scope of preferred especially 1～8 weight %.Sometimes then can not bring into play effect less than 0.1 weight %, in addition, if surpass 10 weight %, usability variation sometimes.
In skin preparations for extenal use of the present invention, match ratio in the combination of diglycerol and betaine, can suit to select, but from effect of the present invention, preferably with respect to diglycerol 1 weight portion, low molecule betaine is 0.01～10 weight portion, 0.1～7 weight portion more preferably, preferred especially 0.1～5 weight portion.
In skin preparations for extenal use of the present invention, except above-mentioned ascorbic acid or derivatives thereof, for the various effects that strengthen or additional ascorbic acid or derivatives thereof is had, in addition, can also make up whitening composition, the anti-inflammatory composition, antimicrobial component, the cell-stimulating composition, astringent component, antioxidant content, acne is improved composition, the aging resistance composition, the synthetic promotion composition of biotic components such as collagen, blood circulation promotes composition, the composition of preserving moisture, aging resistance become the various compositions that grade more than a kind or 2 kinds and cooperate, with to additional other the useful effects of skin preparations for extenal use.The composition more than a kind or 2 kinds in whitening composition, anti-inflammatory composition, antioxidant content, aging resistance composition or the composition of preserving moisture preferably.As the combination of these compositions, particularly preferably be combination, ascorbic acid or derivatives thereof and the whitening composition of combination, ascorbic acid or derivatives thereof and aging resistance composition of combination, ascorbic acid or derivatives thereof and antioxidant content of combination, ascorbic acid or derivatives thereof and whitening composition and the antioxidant content that can enumerate ascorbic acid or derivatives thereof and whitening composition and the combination of aging resistance composition.As these each compositions, the composition as goods outside medicine, the medicine or the skin preparations for extenal use in the cosmetic field can use all the time, and in addition, if the composition that uses future then is not particularly limited, any composition can suit to select to use.
For example,, can be exemplified as arbutin, ellagic acid, phytic acid, lucinol, Ka Momila ET, vitaminss such as vitamin A or derivatives thereof, vitamin E or derivatives thereof, pantothenic acid or derivatives thereof as whitening composition.Wherein, as preferred composition, can list pantothenic acid or derivatives thereof, ellagic acid, phytic acid, vitamin A or derivatives thereof, vitamin E or derivatives thereof.These whitening compositions can use more than a kind or 2 kinds.
When using above-mentioned whitening composition, be coupled to preferred 0.0003～10 weight % of ratio of skin preparations for extenal use of the present invention, more preferably 0.01～5 weight %.In addition, whitening composition is with respect to ascorbic acid or derivatives thereof 100 weight portions that contain in the skin preparations for extenal use of the present invention, wishes with 0.001～1000 weight portion, preferred 0.005～500 weight portion, more preferably the ratio of 0.01～100 weight portion cooperates.
As the anti-inflammatory composition, can list allantoin, Calamina, enoxolone or derivatives thereof, zinc oxide, Kessazulen, tocopherol acetas, pyridoxine hydrochloride, menthol, Camphora, Oleum Terebinthinae, indometacin, salicylic acid or derivatives thereof etc.Preferably allantoin, enoxolone or derivatives thereof, enoxolone or derivatives thereof, Kessazulen, menthol.
When using above-mentioned anti-inflammatory composition, be coupled to preferred 0.0003～10 weight % of ratio of skin preparations for extenal use of the present invention, more preferably 0.01～5 weight %.In addition, the anti-inflammatory composition is with respect to ascorbic acid or derivatives thereof 100 weight portions that contain in the skin preparations for extenal use of the present invention, wishes with 0.001～1000 weight portion, preferred 0.005～500 weight portion, more preferably the ratio of 0.01～100 weight portion cooperates.
As antioxidant content, can list tocopherol and derivant thereof, Butylated hydroxyanisole, dibenzylatiooluene, sodium sulfite, arabo-ascorbic acid and salt thereof, flavonoid, glutathion, glutathion peroxidase, glutathione-S-transferase, catalase, superoxide dismutase, sulfur oxidation protein, taurine, sulfenyl taurine, hypotaurine etc.Preferably tocopherol and derivant thereof, sulfenyl taurine, hypotaurine, sulfur oxidation protein, flavonoid.
When using antioxidant content, the ratio that is coupled to skin preparations for extenal use of the present invention is generally 0.00001～10 weight %, preferred 0.0001～5 weight %, more preferably 0.001～5 weight %.In addition, with respect to ascorbic acid or derivatives thereof 100 weight portions that contain in the skin preparations for extenal use of the present invention, wish with 0.001～1000 weight portion, preferred 0.005～500 weight portion, more preferably the ratio of 0.01～100 weight portion cooperates.
As the aging resistance composition, can be exemplified as biostearin (vitamin A, retinoic acid, axerophthal etc.), VITAMIN B15, kinetins, maloic acid, zingiberaceous plant Rhizoma Curcumae Longae extract, sphingol derivant, silicon, silicic acid, N-methyl-L-serine, methyl dihydroxy pentanone etc.Preferably biostearin (vitamin A, retinoic acid, axerophthal etc.), kinetins.
When using above-mentioned aging resistance composition, be coupled to preferred 0.0003～10 weight % of ratio of skin preparations for extenal use of the present invention, more preferably 0.01～5 weight %.In addition, the aging resistance composition is with respect to ascorbic acid or derivatives thereof 100 weight portions that contain in the skin preparations for extenal use of the present invention, wishes with 0.001～1000 weight portion, preferred 0.005～500 weight portion, more preferably the ratio of 0.01～100 weight portion cooperates.
As the composition of preserving moisture, except being exemplified as aminoacid and derivants thereof such as alanine, serine, leucine, isoleucine, threonine, glycine, proline, hydroxyproline, glycosamine, theanine, peptides such as collagen, collagen peptide, gelatin, glycerol, 1, polyhydric alcohol such as 3-butanediol, propylene glycol, Polyethylene Glycol, sugar alcohols such as Sorbitol, phospholipid such as lecithin, hydrolecithin, mucopolysaccharides such as hyaluronic acid, heparin, chrondroitin, outside the compositions from NMF such as lactic acid, pyrrolidone sodium carboxylate, carbamide, can also be exemplified as polyglutamic acid etc.Preferably alanine, serine, glycine, proline, hydroxyproline, glycosamine, theanine, collagen, collagen peptide, glycerol, 1,3 butylene glycol, hydrolecithin, hyaluronic acid, heparin, chrondroitin, lactic acid, pyrrolidone sodium carboxylate, polyglutamic acid.
When composition is preserved moisture in use,, can enumerate being generally 0.1～10 weight %, preferred 0.5～5 weight %, more preferably 0.5～5 weight % as the ratio that is coupled in the skin preparations for extenal use of the present invention.
Skin preparations for extenal use of the present invention can also further cooperate stabilization agent, surfactant, solvable branch, oils, saccharide or the Transdermal absorption of changing into to promote composition except cooperating above-mentioned each composition.Particularly, can further improve stability, effectiveness, the usability of the ascorbic acid or derivatives thereof in the aqueous solvent by cooperating stabilization agent, surfactant, solvable branch or the oils of changing into.
In skin preparations for extenal use of the present invention; do not damage qualities such as appearance stability or viscosity; in addition; in the scope of the amount of not damaging effect of the present invention and matter; in case of necessity in the goods or cosmetic field outside medicine, medicine; can cooperate as external agent composition and normally used various composition, as aminoacid, stimulate palliative, viscosifier, antiseptic, ultraviolet protective agent, coloring agent, dispersant, pH regulator agent, spice etc.Wherein, these compositions can cooperate independent a kind arbitrarily, also can cooperate arbitrarily more than 2 kinds.
Skin preparations for extenal use of the present invention, mix as required and cooperate above-mentioned various compositions, and then the substrate by cooperating other solvents or normally used external agent etc. in case of necessity, can be modulated into the form of pasty state, cystose, gel, liquid, emulsion state, butyrous, lamellar (the base material load is held), aerosol shape, various needs such as vaporific.They can be by this area method manufacturing commonly used.
Skin preparations for extenal use of the present invention can possess the fluidity of common pH1～8, but, wish that at preferred pH be 2～7, more preferably pH is 2～6 acidic region from the stability of ascorbic acid or derivatives thereof, to the viewpoint of the benefit of the low irritant of skin or mucosa and skin usability.
Skin preparations for extenal use of the present invention can be as cosmetics such as foundation cream, lipstick, mascara, eye shadow, eyeliner, brow and manicure materials; Foundation make up materials such as emulsion, vanishing cream, astringent, oil and facial film, detergents such as wash one's face material or cleaning agent, body detergent; Anti-Deodorant, tinea pedis therapeutic agent, pruritus, wound healing agent, wiping agent, detergent, anti-inflammatory analgesic, acne therapeutic agent, hemorrhoid, disinfection sanitizer, whitening agent, ultraviolet protective agent etc. belong to the goods outside medicine, the medicine or the various topical compositions of cosmetic field.According to the action effect to skin, the preparation that preferred the present invention is applied to skin preparations for extenal use crusts such as (crust preparations) uses.
(embodiment)
Below, further describe the present invention according to embodiment and test example, but the present invention is not limited to these embodiment etc.
(test example 1)
The skin of back of hairless mouse is clamped on the Transdermal absorption pond, be full of with normal saline by the side.Be full of with the reagent shown in the table 1 in the donor side, in two ponds, stir the limit with stirring rubber limit and under 37 ℃, be incubated.After 24 hours, measure being subjected to the ascorbic acid concentrations in the liquid of side by high-speed liquid chromatography.Measurement result is illustrated in the table 1.The result be with the ascorbic acid transit dose in the comparative example 1 (the pure solution of ascorbic acid) as 1, with its compare the expression.
Table 1
| Comparative example 1 | Comparative example 2 | Comparative example 3 | Embodiment 1 | Embodiment 2 | |
| The L-ascorbic acid | ??10％ | ??10％ | ??10％ | ??10％ | ??10％ |
| Diglycerol | ??- | ??5％ | ??- | ??5％ | ??10％ |
| Trimethyl glycine | ??- | ??- | ??5％ | ??5％ | ??2％ |
| Water | ??90％ | ??85％ | ??85％ | ??80％ | ??78％ |
| The percutaneous transit dose compares | ??1.0 | ??1.2 | ??1.5 | ??2.0 | ??1.8 |
Can confirm that from result of the test the transit dose of ascorbic acid is that the Transdermal absorption amount is collaborative to be increased with diglycerol and trimethyl glycine combination the time.Contain the skin preparations for extenal use of ascorbic acid, diglycerol and trimethyl glycine for combination,, therefore can give full play to the action effect that ascorbic acid has because more ascorbic acid is reached in the skin.
(test example 2)
To 10 Testing Team actual use comparative example 1 and embodiment 2, carried out feeling evaluation for the elastic sensation of brown patch degree of improvement, skin dimness degree of improvement, muscle, the water conservation sense of muscle.Behind the makeup water conditioning skin that a day twice back that washes one's face, utilization are used at ordinary times, carry out the entire face coating.Use at first continuously after two all comparative examples 1, use two all embodiment 2 continuously and estimate.As the benchmark of estimating, estimate embodiment 2 compare with comparative example 1 better, or roughly the same, still be to differ to estimate.Answer ratio that embodiment 2 compares with comparative example 1 and be designated as ◎, 60～80% when above 80% and be designated as zero, 50～60% and be designated as △, be lower than 50% be designated as *.In addition, use comparative example 1 and comparative example 3 to carry out same test by reality.The result is illustrated in the table 2.
Table 2
| Comparative example 3 | Embodiment 2 | |
| Brown patch degree of improvement | ??△ | ??○ |
| Skin dimness degree of improvement | ??○ | ??◎ |
| The elastic sensation of skin | ??○ | ??◎ |
| The water conservation sense of skin | ??△ | ??◎ |
Can confirm from result of the test, in embodiment 2 with diglycerol and trimethyl glycine and ascorbic acid combination, the percutaneous absorbability of ascorbic acid improves, the action effect that ascorbic acid had is given full play to, skin dimness or brown patch improve, the elastic force of skin improves, and the water conservation sense of skin improves in addition, gives full play to the recovery effects of the skin with elasticity and moistening.
Below enumerate example of formulations.
(embodiment 3)
Ascorbic acid 20
Trimethyl glycine 3
Diethylene glycol monoethyl ether 52.4
Diglycerol 4
Purified Water 20
Spice 0.5
Grapefruit extract 0.1
Add up to 100%
(embodiment 4)
Ascorbic acid 15
Trimethyl glycine 3
Diethylene glycol monoethyl ether 50.9
Propylene glycol 20
Purified Water 10
Diglycerol 1
Malpighia coccigera (Acerola) extract 0.1
Add up to 100%
(embodiment 5)
Ascorbic acid 2-sulfate 10
Trimethyl glycine 1
Diethylene glycol monoethyl ether 84.7
Diglycerol 4
Spice 0.3
Add up to 100%
(embodiment 6)
Ascorbic acid phosplate 10
Trimethyl glycine 3
Diethylene glycol monoethyl ether 65.4
Propylene glycol 20
Diglycerol 1
Malpighia coccigera (Acerola) extract 0.1
Spice 0.5
Add up to 100%
(embodiment 7)
Ascorbic acid phosplate sodium 15
Trimethyl glycine 3
Diethylene glycol monoethyl ether 50.9
Propylene glycol 20
Purified Water 10
Diglycerol 1
Malpighia coccigera (Acerola) extract 0.1
Add up to 100%
(embodiment 8)
Ascorbic acid 10
Trimethyl glycine 1
Diethylene glycol monoethyl ether 84.7
Diglycerol 4
Spice 0.3
Add up to 100%
(embodiment 9)
Ascorbic acid 10
Trimethyl glycine 3
Diethylene glycol monoethyl ether 65.4
Propylene glycol 20
Diglycerol 1
Malpighia coccigera (Acerola) extract 0.1
Spice 0.5
Add up to 100%
(embodiment 10)
Ascorbic acid-2-glucoside 20
Trimethyl glycine 3
Diethylene glycol monoethyl ether 54.2
Diglycerol 4
Purified Water 20
Spice 0.5
Grapefruit extract 0.1
Add up to 100%
Claims (5)
1. skin preparations for extenal use contains (A) and is selected from one or more material, (B) diglycerol and (C) low molecule betaine in ascorbic acid or the ascorbic acid derivates.
2. skin preparations for extenal use according to claim 1, wherein low molecule betaine is a trimethyl glycine.
3. skin preparations for extenal use according to claim 1 and 2 is to be used for anti-wrinkle, the anti-skin preparations for extenal use that relaxes and/or preserve moisture.
4. according to each described skin preparations for extenal use in the claim 1～3, contain the diglycerol of the ascorbic acid of (A) 0.1～30 weight % or ascorbic acid derivates, (B) 1～95 weight % and (C) trimethyl glycine of 0.5～9 weight %.
5. according to each described skin preparations for extenal use in the claim 1～4, contain the diglycerol of the ascorbic acid of (A) 5～20 weight % or ascorbic acid derivates, (B) 1～10 weight % and (C) trimethyl glycine of 1～8 weight %.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004160139 | 2004-05-28 | ||
| JP2004160139A JP4683861B2 (en) | 2004-05-28 | 2004-05-28 | Topical skin preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1701792A true CN1701792A (en) | 2005-11-30 |
Family
ID=35452335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510074305 Pending CN1701792A (en) | 2004-05-28 | 2005-05-25 | Preparation for external use on skin |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP4683861B2 (en) |
| CN (1) | CN1701792A (en) |
| CA (1) | CA2508093A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006290749A (en) * | 2005-04-06 | 2006-10-26 | Ichimaru Pharcos Co Ltd | Melanogenesis inhibitor |
| JP2013056866A (en) * | 2011-09-09 | 2013-03-28 | Pias Arise Kk | EXPRESSION ACTIVATING AGENT OF Bmal1 GENE AND METHOD FOR ACTIVATING EXPRESSION OF Bmal1 GENE |
| JP2015127319A (en) | 2013-11-29 | 2015-07-09 | 花王株式会社 | Skin external preparation |
| JP6605283B2 (en) * | 2015-10-02 | 2019-11-13 | 御木本製薬株式会社 | Aqueous skin preparation |
| JP7497939B2 (en) | 2020-02-18 | 2024-06-11 | ポーラ化成工業株式会社 | Anti-dull skin |
| JPWO2023002873A1 (en) * | 2021-07-21 | 2023-01-26 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63145217A (en) * | 1986-12-09 | 1988-06-17 | Taisho Pharmaceut Co Ltd | Percutaneous administration composition |
| JPH01207220A (en) * | 1988-02-10 | 1989-08-21 | Lion Corp | Composition for skin |
| JP2000063255A (en) * | 1998-08-12 | 2000-02-29 | Shiseido Co Ltd | Preparation for external use for skin |
| JP2001089321A (en) * | 1999-09-17 | 2001-04-03 | Lion Corp | Skin lotion |
| JP2005060236A (en) * | 2003-08-11 | 2005-03-10 | Nonogawa Shoji Kk | External preparation for skin |
-
2004
- 2004-05-28 JP JP2004160139A patent/JP4683861B2/en not_active Expired - Lifetime
-
2005
- 2005-05-20 CA CA 2508093 patent/CA2508093A1/en not_active Abandoned
- 2005-05-25 CN CN 200510074305 patent/CN1701792A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP4683861B2 (en) | 2011-05-18 |
| CA2508093A1 (en) | 2005-11-28 |
| JP2005336133A (en) | 2005-12-08 |
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