JP6920116B2 - Hair restorer composition - Google Patents

Description

The present invention relates to a hair restorer composition.

In recent years, consumers have become more aware of skin care, and therefore, a scalp moisturizing effect is required even in a formulation used for the scalp such as a hair restorer. In addition, examples of the part of the scalp where the hair restorer is used include the frontal region and the crown, and it is known that the crown is a part of the scalp that has a small amount of water and is easily dried. ..

Therefore, in order to improve the moisturizing effect of the scalp, for example, a hair restorer containing hyaluronic acid or a salt thereof has been proposed (see, for example, Patent Documents 1 to 4). In addition, hair growth agents currently on the market contain a large amount of ethanol in order to dissolve the hair growth active ingredient (see, for example, Patent Document 5). In this hair restorer having a high ethanol content, hyaluronic acid aggregates due to ethanol and an sediment (precipitate) is generated. Therefore, hyaluronic acid cannot be contained enough to impart a moisturizing effect to the scalp. It is necessary to reduce the ethanol content in order to contain.

However, if the content of ethanol is reduced to contain hyaluronic acid, the amount of hair growth active ingredient that can be contained is reduced, the fluffy feeling of the hair on the crown is impaired, the hair growth promoting effect on the crown and the moisturizing of the scalp are impaired. There was a problem that it was difficult to achieve both effects. Further, there is a problem that the hair-growth active ingredient becomes supersaturated at a low temperature and precipitates in the hair-growth agent composition over time.
In addition, the lack of stickiness has not been sufficiently examined.

Therefore, it is desired to provide a hair restorer composition having good low temperature stability, excellent hair loss suppressing effect, hair growth promoting effect, non-stickiness, fluffy feeling of hair on the crown, and moisturizing effect of scalp.

Japanese Unexamined Patent Publication No. 2010-163418 Japanese Unexamined Patent Publication No. 2015-40173 Japanese Unexamined Patent Publication No. 2001-131031 Japanese Unexamined Patent Publication No. 2008-247752 Japanese Unexamined Patent Publication No. 2011-153122

An object of the present invention is to solve the above-mentioned problems in the past and to achieve the following object. That is, the present invention provides a hair restorer composition having good low temperature stability, excellent hair loss suppressing effect, hair growth promoting effect, non-stickiness, fluffy feeling of hair on the crown, and moisturizing effect of scalp. With the goal.

As a result of diligent studies by the present inventor in order to solve the above problems, (A) hair growth active ingredient, (B) ethanol, (C) sodium hyaluronate, and (D) polyethylene glycol are contained, and (C) ) The mass ratio (D / C) of the content (mass%) of the component (%) and the content (mass%) of the component (D) is 2,000 to 400,000, and thus the synergistic effect of each of these components. As a result, it was found that a hair restorer composition having good low-temperature stability, hair loss suppressing effect, hair growth promoting effect, non-stickiness, fluffy feeling of hair on the crown, and moisturizing effect of scalp can be obtained.

The present invention is based on the above-mentioned findings by the present inventor, and the means for solving the above-mentioned problems are as follows. That is,
<1> (A) 0.1% by mass to 5% by mass of at least one active ingredient for hair growth selected from 6-benzylaminopurine, pentadecanoic acid glyceride, and minoxidil.
(B) Ethanol 55% by mass to 85% by mass,
(C) Sodium hyaluronate with a viscosity average molecular weight of 800,000 to 2,700,000, 0.00001% by mass to 0.001% by mass,
(D) Contains 1% by mass to 5% by mass of polyethylene glycol having an average molecular weight of 190 to 420.
The mass ratio (D / C) of the content (mass%) of the component (C) to the content (mass%) of the component (D) is 2,000 to 400,000. It is a hair restorer composition.
<2> The hair restorer composition according to <1>, which further contains (E) Coleus barbatus extract.

According to the present invention, the above-mentioned problems in the prior art can be solved, the above-mentioned object can be achieved, the low temperature stability is good, the hair loss suppressing effect, the hair growth promoting effect, the non-stickiness, and the fluffy hair on the crown are fluffy. It is possible to provide a hair restorer composition having an excellent feeling and a moisturizing effect on the scalp.

(Hair growth agent composition)
The hair restorer composition of the present invention comprises (A) a hair restorer active ingredient, (B) ethanol, (C) sodium hyaluronate, and (D) polyethylene glycol, and if necessary, (E) Coleus barbatus. Contains coli extract and other ingredients.

<(A) Hair growth active ingredient>
The hair growth active ingredient of the component (A) is contained in order to improve the hair loss suppressing effect, the hair growth promoting effect, the non-stickiness, the fluffy feeling of the hair on the crown, and the low temperature stability.

The hair-growth active ingredient of the component (A) contains at least one selected from 6-benzylaminopurine, pentadecanoic acid glyceride, and minoxidil. The hair-growth agent composition of the present invention may further contain a hair-growth active ingredient other than the above-mentioned component (A), if necessary.
Among these, 6-benzylaminopurine, pentadecanoic acid glyceride, and minoxidil are preferable, and 6-benzyl is preferable from the viewpoints of hair loss suppressing effect, hair growth promoting effect, non-stickiness, fluffy feeling of hair on the crown, and low temperature stability. Aminopurine is more preferred.

Here, the 6-benzylaminopurine is a white crystalline powder having a molecular weight of 225.26 represented by the following structural formula, and is also known as 6-benzyladenine.

The 6-benzylaminopurine is a hair restorer (see JP-A-5-320028 and JP-A-7-23307) for the purpose of preventing skin aging and activating cells by external application to the scalp, and skin makeup. It is used as a material (see Skin Vol. 40, No. 4, P407-413, August 1998, Yutaka Mishima et al.).
As the 6-benzylaminopurine, those synthesized as appropriate may be used, or commercially available products may be used.
The synthesis method is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a method of synthesizing according to Japanese Patent Application Laid-Open No. 2005-35903, a method of purifying from a natural product, and the like.

The method for obtaining the component (A) is not particularly limited and may be appropriately selected depending on the intended purpose. A synthesized product may be used, or a commercially available product may be used. Examples of the commercially available product include 6-benzylaminopurine (manufactured by Sansho Seiyaku Co., Ltd.), pentadecanoic acid monoglyceride (manufactured by Lion Chemical Co., Ltd.), and minoxidil (manufactured by Sigma-Aldrich Japan Co., Ltd.).

The content of the hair-growth active ingredient of the component (A) includes the hair-growth agent composition from the viewpoints of hair loss suppressing effect, hair growth promoting effect, non-stickiness, fluffy feeling of hair on the crown, and low temperature stability. It is 0.1% by mass to 5% by mass, preferably 0.5% by mass to 3% by mass, based on the total amount. If the content is less than 0.1% by mass, the hair loss suppressing effect and the hair growth promoting effect are insufficient, and if it exceeds 5% by mass, the hair is not sticky, the hair on the crown is fluffy, and the temperature is low. Stability is reduced.

<(B) Ethanol>
The ethanol of the component (B) is contained to improve the non-stickiness, the fluffy feeling of the hair on the crown, the moisturizing effect of the scalp, and the low temperature stability.

Examples of the ethanol of the component (B) include absolute ethanol and 95% by volume ethanol (standard value 95% by volume to 95.5% by volume).

The ethanol content of the component (B) is anhydrous with respect to the total amount of the hair restorer composition from the viewpoints of non-stickiness, fluffy feeling of hair on the crown, moisturizing effect of scalp, and low temperature stability. In terms of ethanol, it is 55% by mass to 85% by mass, preferably 65% by mass to 80% by mass. If the content is less than 55% by mass, the non-stickiness and the fluffy feeling of the hair on the crown are lowered, and if it exceeds 85% by mass, the moisturizing effect of the scalp and the low temperature stability are lowered.

Here, the content of the component (B) is the total content of absolute ethanol including ethanol brought in from these components when a plant extract or the like is blended as other components.
The content (mass%) converted to absolute ethanol when 95% by volume ethanol is used can be calculated by the following formula 1 (Document 038-1309.pdf sent by Pharmaceuticals and Medical Devices Agency) and formula 2. can.
-Mass% of ethanol = volume% x 0.79422 (100% by volume specific gravity at 15 ° C.) / d (specific gravity at 15 ° C.) ... Equation 1
= (95 × 0.79422) /0.81639
= 92.420
-Absolute ethanol content (mass%) = 95% by volume ethanol content (mass%) x 92.420 / 100 ... Equation 2
When 95.3% by volume ethanol is used, the content (mass%) converted to absolute ethanol can be obtained by the following formulas 3 and 4.
-Mass% of ethanol = 95.3 x 0.79422 / 0.81639
= 92.712 ... Equation 3
-Absolute ethanol content (mass%) = 95.3% by volume Ethanol content (mass%) x 92.712 / 100 ... Equation 4

<(C) Sodium hyaluronate>
The sodium hyaluronate component (C) is contained to improve the non-stickiness, the fluffy feeling of the hair on the crown, the moisturizing effect of the scalp, and the low temperature stability.

The sodium hyaluronate of the component (C) has a viscosity average molecular weight of 800,000 to 2,700,000 in terms of non-stickiness, fluffy hair on the crown, moisturizing effect of the scalp, and low temperature stability. It is preferably 1,000,000 to 2,000,000, more preferably 1,300,000 to 2,000,000.
If the viscosity average molecular weight is less than 800,000, the moisturizing effect of the scalp is insufficient, and if it exceeds 2,700,000, it becomes difficult to obtain it.

Here, the viscosity average molecular weight of the sodium hyaluronate can be measured by, for example, the following method (see Laurent, TC et al, Biophys Acta, 42,476 (1960)).
Precisely weigh 0.04 g of the sample, add 0.2 mol / L sodium chloride TS to dissolve it, and make 100 mL to prepare the sample solution. Take this solution 8mL exactly Ubbelohde viscometer (kinematic viscosity range ^{1mm 2 / s~5mm 2 / s)} , measuring the flow time at 25 ℃ ± 0.1 ℃. Further, exactly 2 mL of 0.2 mol / L sodium chloride TS is added and mixed, and then the flow time is measured. Further, this operation is repeated twice, and the sample solutions having four concentrations are measured. The specific viscosity and the reduced viscosity for each concentration are calculated by the following formulas 5 and 6. Next, a graph is created with the reduced viscosity on the vertical axis and the concentration (g / L) converted to the corresponding dried product on the horizontal axis, and the ultimate viscosity is obtained from the extension of the straight line connecting each point and the intersection of the vertical axis. From the obtained ultimate viscosity, the viscosity average molecular weight is calculated using the following Laurent's formula.
<Laurent's formula>
"Ultimate viscosity" (cm ³ / g) x 100 = 0.036 x ^{M 0.78} (where M represents the viscosity average molecular weight)

The sodium hyaluronate is not particularly limited, and may be a fermented product or a natural product extracted from chicken comb and purified.
The sodium hyaluronate having a viscosity average molecular weight of the component (C) of 800,000 to 2,700,000 is not particularly limited and may be appropriately selected depending on the intended purpose. For example, the viscosity average molecular weight is 800,000. ~ 1,170,000 sodium biohyaluronate HA9N (manufactured by Shiseido Co., Ltd.), hyaluronic acid FCH-120 (manufactured by Kikkoman Biochemifa Co., Ltd.) with a viscosity average molecular weight of 1,000,000 to 1,400,000, viscosity average Sodium biohyaluronate HA12N with a molecular weight of 1,100,000 to 1,600,000 (manufactured by Shiseido Co., Ltd.), 1% aqueous solution of sodium biohyaluronate with a viscosity average molecular weight of 1,370,000 to 1,530,000 (PE) N (manufactured by Shiseido Co., Ltd.), hyaluronic acid FCH-150 (manufactured by Kikkoman Biochemifa Co., Ltd.) with a viscosity average molecular weight of 1,400,000 to 1,800,000, viscosity average molecular weight of 1,800,000 to 2,200, Examples thereof include 000 hyaluronic acid FCH-200 (manufactured by Kikkoman Biochemifa Co., Ltd.) and sodium biohyaluronate HA20N (manufactured by Shiseido Co., Ltd.) having a viscosity average molecular weight of 1,900,000 to 2,700,000. These may be used alone or in combination of two or more.
Among these, sodium biohyaluronate HA9N (manufactured by Shiseido Co., Ltd.) having a viscosity average molecular weight of 800,000 to 1,170,000 and hyaluronic acid FCH-120 having a viscosity average molecular weight of 1,000,000 to 1,400,000 (manufactured by Shiseido Co., Ltd.) Kikkoman Biochemifa Co., Ltd.), sodium biohyaluronate HA20N (manufactured by Shiseido Co., Ltd.) having a viscosity average molecular weight of 1,900,000 to 2,700,000 is preferable.

The content of sodium hyaluronate of the component (C) is based on the total amount of the hair restorer composition from the viewpoints of non-stickiness, fluffy feeling of hair on the crown, moisturizing effect of scalp, and low temperature stability. , 0.00001% by mass to 0.001% by mass, preferably 0.0001% by mass to 0.0008% by mass. If the content is less than 0.00001% by mass, the moisturizing effect of the scalp is lowered, and if it exceeds 0.001% by mass, the low temperature stability, the non-stickiness, and the fluffy feeling of the hair on the crown are lowered. do.

<(D) Polyethylene glycol>
The polyethylene glycol of the component (D) is contained to improve the non-stickiness, the fluffy feeling of the hair on the crown, the moisturizing effect of the scalp, and the low temperature stability.

The polyethylene glycol as the component (D) has an average molecular weight of 190 to 420 from the viewpoints of non-stickiness, fluffy hair on the crown, moisturizing effect of the scalp, and low temperature stability.

The average molecular weight of polyethylene glycol as the component (D) can be measured according to an average molecular weight test of polyethylene glycol 200 or the like listed in the Quasi-drug Raw Material Standard 2006 (Yakuji Nippo Co., Ltd.).
First, about 0.8 g of polyethylene glycol is precisely weighed using a precision balance, placed in a pressure-resistant stopper bottle of about 200 mL, about 25 mL of pyridine is added, heated to dissolve, and then allowed to cool. Accurately weigh 300 mL of freshly distilled pyridine into 42 g of phthalic anhydride, add to a light-shielded bottle with a capacity of 1 L, shake vigorously to dissolve, and leave to stand for 16 hours or more. Accurately weigh 25 mL of this solution, add it to the pressure-resistant stopper bottle, seal it tightly, wrap the pressure-resistant stopper bottle with a strong cloth, and put the liquid in the bottle in a water bath preheated to 98 ° C ± 2 ° C. Soak in the liquid. After heating at 98 ° C. ± 2 ° C. for 30 minutes, remove the bottle from the water bath and allow it to cool to room temperature (1 ° C. to 30 ° C., the same applies hereinafter). Next, exactly 50 mL of 0.5 mol / L sodium hydroxide solution is added and the solution is titrated with 0.5 mol / L sodium hydroxide solution. At this time, 5 drops of a phenolphthalein / pyridine solution (1 → 100) is used as an indicator. However, the end point of the titration is when the liquid continuously exhibits a pale red color for 15 seconds. Perform a blank test in the same way.
The obtained value is applied to the following formula 7 to calculate the average molecular weight.
[Average molecular weight]
-Average molecular weight = [sample amount (g) x 4,000] / (ab) ... Equation 7
a: Consumption (mL) of 0.5 mol / L sodium hydroxide solution in the blank test
b: Consumption (mL) of 0.5 mol / L sodium hydroxide solution in the sample test
In the case of polyethylene glycol having an average molecular weight of 280 to 420, the weighed amount is about 1.5 g, and other than that, it is the same as the test method for polyethylene glycol having an average molecular weight of 190 to 210.

Examples of polyethylene glycol having an average molecular weight of the component (D) of 190 to 420 include polyethylene glycol 200 (trade name: PEG 200, manufactured by Aoki Yushi Kogyo Co., Ltd.) having an average molecular weight of 190 to 210, and an average molecular weight of 280 to 320. Polyethylene glycol 300 (trade name: PEG 300, manufactured by Aoki Oil & Fat Industry Co., Ltd.), polyethylene glycol 400 (trade name: PEG 400, manufactured by Aoki Oil & Fat Industry Co., Ltd.) having an average molecular weight of 380 to 420, and the like. These may be used alone or in combination of two or more. Among these, polyethylene glycol 300 having an average molecular weight of 280 to 320 is preferable from the viewpoints of non-stickiness, softness of hair on the crown, moisturizing effect of scalp, and improvement of low temperature stability.

The content of polyethylene glycol as the component (D) is based on the total amount of the hair restorer composition from the viewpoints of non-stickiness, fluffy hair on the crown, scalp moisturizing effect, and low temperature stability. It is 1% by mass to 5% by mass, preferably 2% by mass to 4% by mass. If the content is less than 1% by mass, the moisturizing effect of the scalp and the low temperature stability are lowered, and if it exceeds 5% by mass, the non-stickiness and the fluffy feeling of the hair on the crown are lowered.

[Mass ratio (D / C)]
The mass ratio (D / C) of the content (mass%) of the component (C) and the content (mass%) of the component (D) is not sticky and the hair on the crown is fluffy. , And from the viewpoint of improving the moisturizing effect of the scalp, it is 2,000 to 400,000, preferably 10,000 to 300,000. If the mass ratio is less than 2,000, the moisturizing effect of the scalp is lowered, and if it exceeds 400,000, the non-stickiness, the fluffy feeling of the hair on the crown, and the moisturizing effect of the scalp are lowered.

<(E) Coleus Forskoli Extract>
The Coleus forskoli extract of the component (E) is contained to improve the non-stickiness, the fluffy feeling of the hair on the crown, and the moisturizing effect of the scalp.

The Coleus forskoli extract of the component (E) is not particularly limited, and can be appropriately selected depending on the intended purpose, and a commercially available product can also be used. Examples of the commercially available product include Coleus extract (trade name: Coleus extract, manufactured by Toyoda Fragrance Co., Ltd., extract pure content 8.5%, 95% ethanol 91.5%) and the like.

The content of the Coleus forskoli extract of the component (E) is preferably 0.01% by mass to 5% by mass, more preferably 0.1% by mass to 3% by mass, based on the total amount of the hair restorer composition. The pure content of Coleus forskoli extract is preferably 0.00003% by mass to 0.015% by mass, more preferably 0.0003% by mass to 0.009% by mass. If the content is less than 0.01% by mass (0.00003% by mass as the pure content of Coleus forskoli extract), the moisturizing effect of the scalp may be insufficient, and 5% by mass (Coleus forskoli). If the extract pure content exceeds 0.015% by mass), the non-stickiness and the fluffy feeling of the hair on the crown may decrease.

<Other ingredients>
In addition to each of the components (A) to (E), the hair restorer composition of the present invention may contain other components as necessary without impairing the effects of the present invention. can.

The other components are not particularly limited and may be appropriately selected depending on the intended purpose. For example, hydrocarbon oils, ester oils, waxes, silicone oils, anionic surfactants, amphoteric surfactants, nonions. Sexual surfactants, semipolar surfactants, ultraviolet absorbers, water-soluble polymer compounds other than the component (C), thickeners, polyhydric alcohols other than the component (D), organic salts, sugars, lower alcohols, etc. Aqueous components, anti-solvents such as pyrocton oramine, zinc pyrithione, anti-inflammatory agents such as dipotassium glycyrrhizinate, preservatives such as parabens and cason CG, pH adjusters, pearlizing agents such as ethylene glycol difatty acid ester, emulsion Agents, refreshing agents, vitamins, beauty ingredients, fragrances, powders, and other ingredients include, for example, hydrotropes, vitamins, volatile oils, hydrophobic solvents, dilutive solvents, pigments, fragrances and the like. .. These may be used alone or in combination of two or more.

-Manufacturing method-
The method for producing the hair restorer composition of the present invention is not particularly limited and may be appropriately selected depending on the intended purpose. For example, the component (A), the component (B), the component (C), and the above. It can be produced by mixing the component (D), preferably the component (E), and if necessary, the other components.

−pH−
The pH of the hair restorer composition is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 4.0 to 8.0, more preferably 5.0 to 7.0. If the pH is less than 4.0, the retention of the hair restorer composition on the scalp and skin may deteriorate, and if it exceeds 8.0, the scalp and skin may be irritated. .. On the other hand, when the pH is within a preferable range, the hair restorer composition has good retention on the scalp and skin, and is advantageous in that it does not irritate the scalp and skin.
The pH can be measured by using the hair restorer composition with a pH meter (HM-30G, manufactured by DKK-TOA CORPORATION).
The pH of the hair restorer composition can be adjusted using, for example, a desired pH adjuster. The pH adjusting agent is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include citric acid, succinic acid, 2-amino-2-methyl-1-propanol and monoethanolamine. Be done.

-Container-
The container for filling the hair restorer composition of the present invention is not particularly limited and may be appropriately selected depending on the intended purpose. Examples thereof include a dispenser container, a squeeze container, a laminated film container, a dropper container and a bottle container. Be done. As the material of the bottle, polyethylene, polypropylene, polyethylene terephthalate, polystyrene, polyvinyl chloride, ethylene-vinyl alcohol resin, acrylonitrile / styrene resin, ABS resin, polyamide, glass and the like can be used in a single layer or in combination of two or more layers. , Particularly polyethylene is preferred.

-Use-
The hair restorer composition of the present invention has good low temperature stability, and is excellent in hair loss suppressing effect, hair growth promoting effect, non-stickiness, fluffy feeling of hair on the crown, and moisturizing effect of scalp. Therefore, for example, hair growth. It can be suitably used as an agent, a hair restorer, a scalp cosmetic, and the like.

Hereinafter, the present invention will be described in more detail based on Examples of the present invention and Comparative Examples, but the present invention is not limited to the following Examples.

(Examples 1 to 27 and Comparative Examples 1 to 15)
Hair restorer compositions having the compositions and contents shown in Tables 1 to 11 below were prepared by a conventional method. Specifically, it was adjusted by the following method.
-Preparation of hair restorer composition-
Based on the compounding composition (mass%) shown in Tables 1 to 11, the component (A) or the component (A'), the component (D) or the component (D'), and the common component are contained in the ethanol of the component (B). (C) component or (C') was added little by little to water and stirred at room temperature (20 ° C.) to 40 ° C. using a stirrer. The hair restorer compositions of Comparative Examples 1 to 15 were prepared.
When the pH of each of the obtained hair restorer compositions was measured at 25 ° C. using a pH meter (HM-30G, manufactured by DKK-TOA CORPORATION), the pH of Examples 1 to 27 and Comparative Examples 1 to 15 was any. Was also 5.5.
As for the component (B), the ethanol content of the raw material used was 95.3% by volume, so the content as absolute ethanol was calculated using the following formula. The content of the component (B) is the total content of absolute ethanol including ethanol brought in from the common component.
-Mass% of ethanol = 95.3 x 0.79422 / 0.81639
= 92.712
-Absolute ethanol content (mass%) = 95.3% by volume Ethanol content (mass%) x 92.712 / 100
The ethanol of seaweed extract and Coleus extract was converted as 95.0% by volume. Regarding the content, the 4th digit after the decimal point was rounded off, and the 3rd digit after the decimal point was described. However, in Examples 54 and 55, the 6th digit after the decimal point was rounded off and the 5th digit was described according to the number of digits of the blending amount of the Coleus extract.
-Mass% of ethanol = 95.0 x 0.79422 / 0.81639
= 92.420
-Absolute ethanol content (mass%) = 95.0% by volume Ethanol content (mass%) x 92.420 / 100
For the components other than the component (B), the content converted into pure content is shown.

Next, for each of the obtained hair growth agent compositions, "hair loss suppressing effect", "hair growth promoting effect", "non-stickiness", "fluffy feeling of hair on the crown", and "scalp" are as follows. "Moisturizing effect" and "low temperature stability" were evaluated. The results are shown in Tables 1 to 11 below. In Comparative Example 4, since the component (B) was not contained in ethanol, the component (A) was not dissolved, so that all the evaluation items could not be evaluated.
In addition, "total (mass%) of component (B)" in the table below represents the total amount of all pure ethanol contained in the hair restorer composition.

<Hair loss suppression effect and hair growth promotion effect>
To 40 ordinary women in their 50s to 60s, 1.5 mL of the hair restorer composition of Examples 1 to 27 and Comparative Examples 1 to 15 was applied twice a day to the entire scalp once for 1 month. After continuous use for a while, the number of hair loss after use was observed compared to before continuous use, and the "hair loss suppression effect" was evaluated according to the following evaluation criteria. Similarly, the amount of hair was observed, and the "hair growth promoting effect" was evaluated according to the following evaluation criteria. If the evaluation points are 3 points or more, the "hair loss suppressing effect" and the "hair growth promoting effect" are good.
[Evaluation criteria for hair loss suppression effect]
5 points: 36 or more out of 40 responded that hair loss decreased 4 points: 28 or more and 35 or less out of 40 responded that hair loss decreased 3 points: 20 or more and 27 out of 40 The following responded that hair loss decreased 2 points: 12 to 19 out of 40 responded that hair loss decreased 1 point: 11 out of 40 responded that hair loss decreased [ Evaluation Criteria for Hair Growth Promotion Effect]
5 points: 36 or more out of 40 people answered that they had more hair 4 points: 28 or more and 35 or less out of 40 people answered that they had more hair 3 points: 40 people 20 to 27 out of 40 responded that they had increased hair 2 points: 12 to 19 out of 40 responded that they had increased hair 1 point: 11 out of 40 Less than one person answered that they felt that their hair had increased.

<Non-stickiness and fluffy hair on the crown>
Hair restorer compositions of Examples 1-27 and Comparative Examples 1-15 after washing hair with shampoo (trade name: Botanical Story Shampoo H1, manufactured by Lion Corporation) for 30 ordinary women in their 40s and 60s. 5 mL was applied to the entire scalp. After repeating this procedure for 3 days, evaluation was performed according to the following evaluation criteria. If the evaluation score is 3 points or more, the "non-stickiness" and the "fluffy feeling of the hair on the crown" are good.
[Evaluation criteria for non-stickiness and fluffy hair on the crown]
5 points: 24 or more out of 30 people answered that they were good 4 points: 18 or more and 23 or less out of 30 people answered that they were good 3 points: 12 or more and 17 or less out of 30 people 2 points: 6 to 11 out of 30 people answered that it was good 1 point: 5 out of 30 people answered that it was good

<Moisturizing effect of the scalp>
After acclimatization of 4 subjects in a 25 ° C. and 40% RH environment, the water content of the stratum corneum of the scalp was measured (initial value). Next, 1.5 mL of the hair restorer composition of Examples 1 to 27 and Comparative Examples 1 to 15 was applied, allowed to stand for 5 minutes, and then the water content of the stratum corneum of the scalp was measured again. For each of the four subjects, the rate of increase in the amount of water (%) after application was calculated with respect to the amount of water in the stratum corneum (initial value) before application, and the average rate of increase in the amount of water (%) after application was calculated. evaluated. A stratum corneum moisture meter (device name: stratum corneum film thickness moisture system ASA-M2, manufactured by Asahi Biomed Co., Ltd.) was used for the measurement. The higher the average rate of increase, the greater the amount of water. If the evaluation score is 3 points or more, the "moisturizing effect of the scalp" is good.
[Evaluation criteria]
5 points: Average increase rate of 160% or more compared to the initial value 4 points: Average increase rate of 140% or more and less than 160% compared to the initial value 3 points: Average increase rate of 120% compared to the initial value More than 140% less than 140% 2 points: Average increase rate is 100% or more and less than 120% compared to the initial value 1 point: Average increase rate is less than 100% compared to the initial value

<Low temperature stability>
45 mL of the prepared hair restorer composition is filled in a glass vial with a capacity of 50 mL (trade name: SV-50A, manufactured by Nichiden Rika Glass Co., Ltd.), stored in a constant temperature bath at -5 ° C for 1 month, and then brought to 20 ° C. The solution was taken out, visually observed, and evaluated according to the following evaluation criteria. A passing level was given when the evaluation was Δ or higher.
[Evaluation criteria]
◯: No sediment (precipitation) is generated Δ: Residue is generated, but it redissolves when left at 20 ° C for 20 minutes ×: Residue is generated and does not redissolve

(Examples 28 to 58)
In Example 1, the hair restorer compositions of Examples 28 to 58 were prepared in the same manner as in Example 1 except that the compositions and contents shown in Tables 12 to 19 below were changed.

Next, in the same manner as in Example 1, the hair loss suppressing effect, the hair growth promoting effect, the non-stickiness, the fluffy feeling of the hair on the crown, the moisturizing effect of the scalp, and the low temperature stability were evaluated. The results are shown in Tables 12 to 19 below.

The raw materials used in the above Examples and Comparative Examples are shown in Table 20 below.

The hair restorer composition of the present invention has good low temperature stability, and is excellent in hair loss suppressing effect, hair growth promoting effect, non-stickiness, fluffy feeling of hair on the crown, and moisturizing effect of scalp. Therefore, for example, hair growth. It is preferably used as an agent, a hair restorer, a scalp cosmetic, and the like.

Claims (2)

(A) 0.1% by mass to 5% by mass of at least one active ingredient for hair growth selected from 6-benzylaminopurine, pentadecanoic acid glyceride, and minoxidil.
(B) Ethanol 55% by mass to 85% by mass,
(C) Sodium hyaluronate with a viscosity average molecular weight of 800,000 to 2,700,000, 0.00001% by mass to 0.001% by mass,
(D) Contains 1% by mass to 5% by mass of polyethylene glycol having an average molecular weight of 190 to 420.
The mass ratio (D / C) of the content (mass%) of the component (C) to the content (mass%) of the component (D) is 2,000 to 400,000. Hair restorer composition (excluding hair restorer composition containing fatty acid propylene glycol ester) . (E) The hair restorer composition according to claim 1, further comprising Coleus barbatus extract.