CN1582337B - 丙型肝炎病毒疫苗 - Google Patents

丙型肝炎病毒疫苗 Download PDF

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Publication number
CN1582337B
CN1582337B CN028246659A CN02824665A CN1582337B CN 1582337 B CN1582337 B CN 1582337B CN 028246659 A CN028246659 A CN 028246659A CN 02824665 A CN02824665 A CN 02824665A CN 1582337 B CN1582337 B CN 1582337B
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base pair
region
seq
nucleic acid
adenoviral
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Expired - Lifetime
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CN028246659A
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Chinese (zh)
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CN1582337A (zh
Inventor
E·A·埃米尼
D·C·卡斯罗
A·J·贝特
J·W·施弗
A·尼科西亚
A·拉姆
A·卢扎戈
R·科尔特斯
S·科罗卡
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MSD Italia SRL
Merck Sharp and Dohme BV
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Istituto di Ricerche di Biologia Molecolare P Angeletti SpA
Merck Sharp and Dohme LLC
Merck and Co Inc
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Publication of CN1582337A publication Critical patent/CN1582337A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/10—Plasmid DNA
    • C12N2800/108—Plasmid DNA episomal vectors
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    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
    • C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
    • C12N2810/6018—Adenoviridae
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
    • C12N2830/003—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor tet inducible
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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CN028246659A 2001-10-11 2002-10-10 丙型肝炎病毒疫苗 Expired - Lifetime CN1582337B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32865501P 2001-10-11 2001-10-11
US60/328,655 2001-10-11
US36377402P 2002-03-13 2002-03-13
US60/363,774 2002-03-13
PCT/US2002/032512 WO2003031588A2 (en) 2001-10-11 2002-10-10 Hepatitis c virus vaccine

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN200910251298.2A Division CN101988071B (zh) 2001-10-11 2002-10-10 丙型肝炎病毒疫苗
CN2006100778047A Division CN1880457B (zh) 2001-10-11 2002-10-10 Ad6重组核酸

Publications (2)

Publication Number Publication Date
CN1582337A CN1582337A (zh) 2005-02-16
CN1582337B true CN1582337B (zh) 2011-12-14

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CN028246659A Expired - Lifetime CN1582337B (zh) 2001-10-11 2002-10-10 丙型肝炎病毒疫苗

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US (3) US7598362B2 (enExample)
EP (1) EP1436397B1 (enExample)
JP (1) JP4475561B2 (enExample)
CN (1) CN1582337B (enExample)
AT (1) ATE467680T1 (enExample)
AU (1) AU2002337840B2 (enExample)
CA (1) CA2461380C (enExample)
DK (1) DK1436397T3 (enExample)
WO (1) WO2003031588A2 (enExample)

Cited By (1)

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CN101988071B (zh) * 2001-10-11 2016-07-06 默沙东公司 丙型肝炎病毒疫苗

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CN102645534B (zh) * 2012-04-26 2015-08-12 杭州市萧山区第一人民医院 基于量子点编码微球芯片检测丙型肝炎病毒的方法
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN101988071B (zh) * 2001-10-11 2016-07-06 默沙东公司 丙型肝炎病毒疫苗

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CN1582337A (zh) 2005-02-16
EP1436397A2 (en) 2004-07-14
WO2003031588A3 (en) 2003-10-30
JP2005505286A (ja) 2005-02-24
EP1436397A4 (en) 2005-02-16
WO2003031588A2 (en) 2003-04-17
US8142794B2 (en) 2012-03-27
CA2461380C (en) 2011-03-22
CA2461380A1 (en) 2003-04-17
US20040247615A1 (en) 2004-12-09
US8530234B2 (en) 2013-09-10
US20100129901A1 (en) 2010-05-27
EP1436397B1 (en) 2010-05-12
US20090233992A1 (en) 2009-09-17
US7598362B2 (en) 2009-10-06
AU2002337840B2 (en) 2007-08-09
JP4475561B2 (ja) 2010-06-09
ATE467680T1 (de) 2010-05-15
DK1436397T3 (da) 2010-08-09

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