CN1572312A - Chinese patent medicine for treating cardiac function failure and its preparation method - Google Patents
Chinese patent medicine for treating cardiac function failure and its preparation method Download PDFInfo
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Abstract
The present invention relates to a Chinese patent medicine for treating cardiac function failure and its preparation method, especially a Chinese traditional medicine preparation for curing congestive heart failure (heart failure in short) and its preparation method. The preparation is prepared by drugs such as panax, aconitum carmichaeli debx, cassia twig, red sage root, red drug, motherwort, rhizoma alismatis, polyporus umbellatus, plantain seed, and Chinese date. Compared with the existing technology, the invention has the function of warming yang and benefiting qi, activating blood and removing stasis and induce diuresis and alleviate edema, and can reduce or eliminate the threat of the heart failure for human health, the product preparation has not toxic and side effects, the preparation technics is simple, the product quality can be controlled easily, and the preparation can be directly used for guiding production.
Description
Technical field: the present invention relates to a kind of Chinese patent medicine that is used for the treatment of heart failure and preparation method thereof,, belong to the field of traditional Chinese medicine technology especially for the Chinese medicine preparation of treatment congestive heart failure (abbreviation heart failure) and its preparation method.
Background technology: congestive heart failure in case how formation shows effect repeatedly increases the weight of gradually, is difficult for treatment, often becomes cardiovascular diseases's underlying cause of death, its 5 years survival rate less thaies 50%.In treatment, Folium Digitalis Purpureae, diuretic are a line medicine of treatment heart failure for many years always, but because of its toxic and side effects, limited its clinical practice as the short arrhythmia of digitalism, electrolyte disturbance etc., vasodilation again because of reducing of hypotension syndrome patient's quality of life, and these chemical drugss also have certain defective aspect the outbreak repeatedly improving patient's Abwehrkraft des Koepers, prevention heart failure.Chinese medicine effective in cure consolidation aspect the control heart failure, integrally-regulated, be difficult for advantages such as drug resistance, side effect are little, but the Chinese medicine preparation that does not still have treatment congestive heart failure determined curative effect so far, the applicant has submitted to a name to be called on May 30th, 2003 to Patent Office of the People's Republic of China: a kind of Chinese patent medicine, application number that is used for the treatment of heart failure is: 031342124 patent application, and this medicine is mainly used in the treatment to congestive heart failure; Reasonable effect is arranged, but because prevailing condition is limit, this invention is not finished fully, can not directly instruct suitability for industrialized production, provide more definite therapeutic preparation to doctor and patient.
Summary of the invention: the objective of the invention is to: be provided for Chinese patent medicine for the treatment of heart failure and preparation method thereof, especially for the Chinese medicine preparation of treatment congestive heart failure (abbreviation heart failure) and its preparation method, this Chinese patent medicine has obtained the more specific pharmaceutical preparation and the preparation method of this preparation in the present invention; With they can reasonable treatment congestive heart failure (abbreviation heart failure) this disease; The preparation that provides simultaneously relatively meets the instructions for use of suffering from this class disease patient.The Chinese patent medicine prescription that provides of the present invention is such: calculate according to components by weight percent: it mainly is prepared from by Radix Ginseng 100-250 part, Radix Aconiti Lateralis Preparata 150-400 part, Ramulus Cinnamomi 200-480 part, Radix Salviae Miltiorrhizae 500-1200 part, Radix Polygoni Ciliinerve 250-600 part, Herba Leonuri 500-1200 part, Rhizoma Alismatis 250-600 part, Polyporus 250-600 part, Semen Plantaginis 250-600 part, Fructus Jujubae 200-480 part, Semen Lepidii (Semen Descurainiae) 250-600 part, Fructus Amomi 150-400 part, Pericarpium Arecae 250-600 part.Specifically: it is prepared from by 167 parts of Radix Ginsengs, 278 parts of Radix Aconiti Lateralis Preparatas, 333 parts of Ramulus Cinnamomi, 833 parts of Radix Salviae Miltiorrhizaes, 417 parts of Radix Polygoni Ciliinerve, 833 parts of Herba Leonuris, 417 parts of Rhizoma Alismatis, 417 parts of Polyporus, 417 parts of Semen Plantaginiss, 333 parts in Fructus Jujubae, 417 parts of Semen Lepidii (Semen Descurainiae)s, 278 parts of Fructus Amomis, 417 parts of Pericarpium Arecae and appropriate amount of auxiliary materials, described adjuvant uses different adjuvants according to the difference of preparation preparation dosage form, comprising using lactose etc.
Chinese patent medicine of the present invention is prepared into granule and can prepares like this: the Radix Ginseng alcohol reflux, reclaim ethanol, and medicinal liquid concentrates standby; Fructus Amomi (smashing), Ramulus Cinnamomi water distillating extracting oil are also used beta-cyclodextrin inclusion compound, and its medicinal residues and medicine residues of Radix Ginseng and other medicines water decoct, and filter, add ethanol after filtrate concentrates and leave standstill, filter filtrate recycling ethanol, concentrate the back thin up, filter, medicinal liquid concentrates.With Radix Ginseng medicinal liquid mixing, drying, pulverize, add volatile oil clathrate compound and an amount of lactose, mixing is granulated, packing, promptly.
Chinese patent medicine of the present invention is prepared into capsule and can prepares like this: Radix Ginseng, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Semen Lepidii (Semen Descurainiae), Radix Paeoniae Rubra, Herba Leonuri, Radix Aconiti Lateralis Preparata add alcohol reflux, reclaim ethanol, are condensed into clear paste, and drying under reduced pressure is pulverized, and fine powder is standby; Six-elements such as Ramulus Cinnamomi decoct with water, and filter, and filtrate is condensed into clear paste, add ethanol and leave standstill, and the leaching supernatant reclaims ethanol, and concentrating under reduced pressure becomes clear paste, and spray drying gets fine powder, with above-mentioned fine powder mixing, and dry granulation, coating, encapsulated, promptly.
Chinese patent medicine of the present invention is prepared into tablet and can prepares like this: Radix Ginseng, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Semen Lepidii (Semen Descurainiae), Radix Paeoniae Rubra, Herba Leonuri, Radix Aconiti Lateralis Preparata add alcohol reflux, reclaim ethanol, are condensed into clear paste, and drying under reduced pressure is pulverized, and fine powder is standby; Six-elements such as Ramulus Cinnamomi decoct with water, and filter, and filtrate is condensed into clear paste, add ethanol and leave standstill, and the leaching supernatant reclaims ethanol, the concentrating under reduced pressure clear paste, and spray drying gets fine powder, with above-mentioned fine powder mixing, dry granulation, tabletting, the bag film-coat, promptly.
Compared with prior art, the present invention has warming YANG and invigorating QI, blood circulation promoting and blood stasis dispelling, the effect of inducing diuresis to remove edema can significantly reduce or eliminate the threat of heart failure to human health, product formulation does not have toxic and side effects, and preparation technology is easy, and product quality is convenient to control, has solved the problem that exists in the original application documents of applicant, can be directly used in to instruct and produce, reach the purpose of invention.
Congestive heart failure is meant that heart disease is developed to certain order of severity, and myocardial contraction weakens, and cardiac output reduces, thereby can not satisfy the needs of body tissue cellular metabolism; Simultaneously, venous return is obstructed, the Venous system blood stasis, thus a series of sings and symptoms appears.As: dyspnea, cough is coughed up phlegm, fatigue and weakness, die Blausucht, inappetence, nausea and vomiting, hypourocrinia, increased heart rate, distension of jugular vein, liver enlargement pain, the hepatojugular reflux positive, edema of lower limbs or the like.Though do not have this name of disease in motherland's medical science,, belong to the category of the traditional Chinese medical science obstruction of heart-QI, palpitation with fear, palpitation with a distress feeling, the syndrome of dyspnea, edema, phlegm retention, blood stasis, the diseases such as taking off of fainting according to its clinical manifestation.Disease is seen: cardiopalmus, asthma, coldness of the body with chills, distension and fullness in the abdomen, lower limbs edema, oliguria, the complexion stasis of blood are dark, mass in the abdomen, pale tongue or the stasis of blood is dark, Tai Bai or white greasy, deep-thready pulse or knot generation or disease number are at random etc. under the die Blausucht, distension of jugular vein, the side of body.According to the clinical manifestation of congestive heart failure and tcm syndrome correspondingly, study carefully its pathogenesis, surely belong to due to the yang deficiency deficiency of vital energy, the blood stasis water resistance.Its sick position is at the heart, and is relevant with lung, spleen, kidney.Lid " element is asked the flaccidity opinion " day: " the heart controlling the blood vessels of the whole body." " element ask normal person meteorological opinion " again day: " the heart gives motive force to blood circulation is also ".Song's Yang Shiying " Renzhai Zhi Zhi Fang, Effective Recipes from Renzhai House opinion blood Ying Qi is defended opinion " day: " the gas person, the general of blood also.The capable then blood of gas is capable, and gas ends then that blood ends." this shows that the motive is to promote blood operation, keeps sanguimotor power.The motive is abundant, just can keep normal mental and physical efforts, heart rate, the rhythm of the heart, blood and could move in arteries and veins, circumfluence whole body, the flourish extremity bones of the body collectively of supporting.If deficiency of heart-QI, handsome blood is unable, then sees cardiopalmus, asthma, moving then very disease still; Insufficiency of heart-QI and the uneven person who comes, then pulse condition in knot, generation, arranged, urge, puckery time.The heart matches fire, fire are the symbols of yang-energy, and further developing of insufficiency of heart-QI then is deficiency of heart-YANG, and this is that gas undermines sun also, thus there are extremity not warm again, the disease of coldness of the body and aversion to cold.Lid " heart person, the big master of the vital organs of the human body also, shake of the heart leading to shakes of all ZANG FU-organs." so with the passing of time the motive loses void, involve in lung, deficiency of the lung ascending, descending, exiting and entering is seen cough and asthma etc. unusually; Heart-fire is not given birth to spleen soil, dysfunction of the spleen in transportation and see distension and fullness in the abdomen; The heart-fire kidney yang of can not helping down, yang deficiency is then seen coldness of the body with chills, yang deficiency is can not Wen Huashui wet then sees oliguria, lower limbs edema." element is asked the regulating menstruation opinion " day: " vim and vigour person, happiness temperature and aversion to cold, cold then weep not fluence." the modern yang deficiency deficiency of vital energy, the deficiency of vital energy can not be handsome the blood operation, yang deficiency is given birth to endogenous cold, blood condenses for it, arteries and veins is obstructed for it, causes blood-vessel obstructive, so cyanotic lips is arranged, the neck arteries and veins is angry to be opened, mass in the abdomen under the side of body, purplish tongue or petechia is arranged, the disease of hesitant pulse.Lid " the capable then water of gas is capable ", the deficiency of vital energy then water transport is not normal, and yang deficiency can not be changed water, so that pathogenic water is for suffering from.Pathogenic water overflows and forms edema in skin; The heart attacked by pathogenic water and cause uneasiness aroused in interest; Not evil stop breast abdomen and cause hydrothorax, ascites.In sum, the pathogenesis of primary disease is the yang deficiency deficiency of vital energy, and the blood stasis water resistance causes the generation of above-mentioned various symptoms.Therefore, its treatment is worked as with warming YANG and invigorating QI, and blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema are method.Abundant in order to do the motive, yang-energy must be answered, the stasis of blood row that anhydrates, and all diseases are from removing.
Prescription of the present invention is to be the yang deficiency deficiency of vital energy, and the congestive heart failure due to the blood stasis water resistance is developed, and with warming YANG and invigorating QI, blood circulation promoting and blood stasis dispelling, inducing diuresis to remove edema is a method.Be monarch drug with Radix Ginseng, Radix Aconiti Lateralis Preparata in the side; Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Herba Leonuri are ministerial drug; With Fructus Amomi, Pericarpium Arecae, Rhizoma Alismatis, Polyporus, Semen Lepidii (Semen Descurainiae) is adjuvant drug; With the Fructus Jujubae is messenger drug.
Radix Ginseng, sweet little hardship, flat, strongly invigorating primordial QI is kindly controlled all kinds of deficiency of vital energy disease, but and QI invigorating with supporing yang; Radix Aconiti Lateralis Preparata, hot, warming and activating heart-YANG, activating the spleen sun, kidney-replenishing.Join attached phase 5, warming YANG and invigorating QI brings out the best in each other, but goes up the reinforcing the heart lung and help heart-yang; But in the spleen reinforcing sun; Under can support kidney yang, with rescuing, agitate effectively in order to do gas sun, make the blood vessels tonneau, then blood stasis goes, water is wet to disappear, all diseases can be removed, this is the method for effecting a permanent cure.So monarch drug in the two medicine sides of being.
Ramulus Cinnamomi, Xin Ganwen, warming and activating heart-YANG again can the warming YANG activating QI and diuretic is wet; Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, blood circulation promoting and blood stasis dispelling; Herba Leonuri, but blood circulation promoting and blood stasis dispelling and diuretic.Four medicines share, and warming and activating heart-YANG is arranged, and the merit that blood circulation promoting and blood stasis dispelling, diuretic dry to strengthen the effect of monarch drug, is to think ministerial drug.
Fructus Amomi, arduous temperature, the stomach function regulating of being amusing, promoting the circulation of QI to alleviate the stagnation in middle-JIAO; Semen Lepidii (Semen Descurainiae), bitter cold, eliminating pathogen from the lung for relieving asthma is by the drink diuretic; Pericarpium Arecae, Xin Wen, circulation of qi promoting intestinal stasis relieving, inducing diuresis to remove edema; Rhizoma Alismatis, Polyporus, sweet light, promoting diuresis to eliminate damp pathogen; Add Semen Plantaginis again, to strengthen the merit of inducing diuresis to remove edema.Above Six-element share, and each medicine of assistant the monarch and his subjects is the adjuvant drug in the side altogether to strengthen therapeutical effect.
Fructus Jujubae, Gan Wen, the QI invigorating invigorating middle warmer, coordinating the actions of various ingredients in a prescription is to think to make.
More than all medicines share, can play warming YANG and invigorating QI altogether, blood circulation promoting and blood stasis dispelling, the merit of inducing diuresis to remove edema.Clinical trial observation and curative effect
One, include the case standard in:
1, meeting the congestive heart failure diagnostic criteria, to belong to Chinese medical discrimination be deficiency of vital energy yang deficiency, blood stasis water resistance person;
2, the sick kind left heart failure and the person that do not decline whole-heartedly;
3, the protopathy of formation heart failure is ischemic heart desease (angina pectoris belongs to the person of stablizing) or rheumatic heart patient;
4, cardiac functional grading belongs to II, III level person.Meet above condition person and can include the test case in.
Two, test method:
The test case is 400 examples, is divided into treatment group and matched group at random, and wherein 300 examples (more than ischemic heart desease 100 examples, more than rheumatic heart disease 100 examples), matched group 100 examples are organized in treatment.Oral medicine granule of treatment group, one time 1 bag, 3 times on the one, 20 days is a course of treatment.
Three, observation index and method
1, safety observation index:
(1). general health check-up project
(2). blood, urine, stool routine examination chemical examination
(3). liver, kidney function test
(4). electrolyte
(5). electrocardiogram
2, health giving quality observation index:
(1). ordinary circumstance: pulse, breathing, blood pressure, body temperature, discrepancy amount, body weight.
(2). symptom
(3). sign
(4). Electrocardioscopy
(5). chest X-ray
(6). by cardiac function judgement carrying out cardiac functional grading
(7). cardiac determination (ultrasonic doppler)
Four, curative effect determinate standard (formulating) with reference to " the clinical research guideline of new Chinese medicine treatment congestive heart failure "
1, cardiac functional grading curative effect determinate standard:
(1). clinical recent healing: cardiac function is corrected the level to I, and symptom, sign disappear substantially, every inspection recovers normal substantially;
(2). produce effects: the cardiac function progress is more than 2 grades, but do not reach I level cardiac function, and symptom, sign and every inspection obviously improve, and the symptom integral value descends 〉=2/3;
(3) effective: 1 grade of cardiac function progress, and do not reach II level cardiac function, and symptom, sign and every inspection make moderate progress, and the symptom integral value descends 〉=1/3 also＜2/3;
(4). invalid: cardiac function does not have significant change, or increases the weight of or death.
2, clinical symptoms curative effect determinate standard:
(1). produce effects: the symptom integral value descends 〉=2/3;
(2). effectively: the symptom integral value descends 〉=1/3 also＜2/3;
(3). invalid: symptom does not have obvious improvement, and integrated value descends＜1/3.
These test of cure group actual observation 304 examples, produce effects 108 examples wherein, effective 137 examples, invalid 59 examples, total effective rate 80.59%, viewing duration do not find that untoward reaction and safety indexes are unusual.Result of the test confirms that this medicine is the new Chinese medicine of a kind of safe and reliable chronic heart failure yang deficiency deficiency of vital energy, blood stasis water resistance disease.
Need use different production technologies and use different adjuvants for utilizing prescription provided by the invention to produce, prepare each dosage form, we have also made experimental selection for this reason, as: consider that the diabetes patient can not use sucrose, so select for use lactose as production auxiliary materials, prove that by experiment it has hygroscopicity preferably, can reduce soft material viscosity, be easy to molding.
The specific embodiment
Embodiments of the invention 1: Radix Ginseng 167g soaks with 85% ethanol, and reflux, extract, 4 times reclaims ethanol, and medicinal liquid concentrates standby; Fructus Amomi 278g (smashing), Ramulus Cinnamomi 333g water distillating extracting oil is also used beta-cyclodextrin inclusion compound, its medicinal residues and medicine residues of Radix Ginseng and Radix Aconiti Lateralis Preparata 278g, Radix Salviae Miltiorrhizae 833g, Radix Polygoni Ciliinerve 417g, Herba Leonuri 833g, Rhizoma Alismatis 417g, Polyporus 417g, Semen Plantaginis 417g, Fructus Jujubae 333g, Semen Lepidii (Semen Descurainiae) 417g, Pericarpium Arecae 417g water decocts 3 times, medicinal liquid merges, filter, be concentrated into relative density 1.15-1.25 (50 ℃), add ethanol and make and contain alcohol amount and reach 55%, filter filtrate recycling ethanol, be concentrated into relative density 1.15-1.25 (50 ℃), thin up filters, and medicinal liquid concentrates, with Radix Ginseng medicinal liquid mixing, drying is pulverized, and adds volatile oil clathrate compound and an amount of lactose, mixing, granulate, packing, promptly.Oral, 3 times on the one, one time 1 bag.
Embodiments of the invention 2: Radix Ginseng 100g, Radix Aconiti Lateralis Preparata 150g, Radix Salviae Miltiorrhizae 500g, Radix Polygoni Ciliinerve 250g, Herba Leonuri 500g, Rhizoma Alismatis 250g, Semen Lepidii (Semen Descurainiae) 250g add 85% alcohol reflux 2 times, merge alcohol extract, reclaim ethanol, being concentrated into relative density is the clear paste of 1.15-1.25 (60 ℃), drying under reduced pressure, pulverize, fine powder is standby; Ramulus Cinnamomi 200g, Polyporus 250g, Semen Plantaginis 250g, Fructus Jujubae 200g, Fructus Amomi 150g, Pericarpium Arecae 250g decoct with water 3 times, and collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.10-1.20 (60 ℃), and adding ethanol is 75% to containing the alcohol amount, the leaching supernatant, reclaim ethanol, being evaporated to relative density is the clear paste of 1.15-1.25 (60 ℃), and spray drying gets fine powder, with above-mentioned fine powder mixing, dry granulation, coating, encapsulated, promptly.Oral, 3 times on the one, one time 5.
Embodiments of the invention 3: Radix Ginseng 250g, Radix Aconiti Lateralis Preparata 400g, Radix Salviae Miltiorrhizae 1200g, Radix Polygoni Ciliinerve 600g, Herba Leonuri 1200g, Rhizoma Alismatis 600g, Semen Lepidii (Semen Descurainiae) 600g add 85% alcohol reflux 2 times, merge alcohol extract, reclaim ethanol, being concentrated into relative density is the clear paste of 1.15-1.25 (60 ℃), drying under reduced pressure, pulverize, fine powder is standby; Ramulus Cinnamomi 480, Polyporus 600, Semen Plantaginis 600, Fructus Jujubae 480, Fructus Amomi 400, Pericarpium Arecae 600 decoct with water 3 times, and collecting decoction filters, filtrate is concentrated into the clear paste that relative density is 1.10-1.20 (60 ℃), and adding ethanol is 75% to containing the alcohol amount, the leaching supernatant, reclaim ethanol, being evaporated to relative density is the clear paste of 1.15-1.25 (60 ℃), and spray drying gets fine powder, with above-mentioned fine powder mixing, dry granulation, tabletting, the bag film-coat, promptly.Oral, 3 times on the one, one time 5.
Other preparation formulation that provides among the present invention prepares if desired, and the applicant found through experiments: can be prepared according to prior art, not need special preparation technology and adjuvant.
Claims (6)
1, a kind of Chinese patent medicine that is used for the treatment of heart failure is characterized in that: calculate according to components by weight percent: it mainly is prepared from by Radix Ginseng 100-250 part, Radix Aconiti Lateralis Preparata 150-400 part, Ramulus Cinnamomi 200-480 part, Radix Salviae Miltiorrhizae 500-1200 part, Radix Polygoni Ciliinerve 250-600 part, Herba Leonuri 500-1200 part, Rhizoma Alismatis 250-600 part, Polyporus 250-600 part, Semen Plantaginis 250-600 part, Fructus Jujubae 200-480 part, Semen Lepidii (Semen Descurainiae) 250-600 part, Fructus Amomi 150-400 part, Pericarpium Arecae 250-600 part.
2, according to the described Chinese patent medicine that is used for the treatment of heart failure of claim 1, it is characterized in that: it is prepared from by 167 parts of Radix Ginsengs, 278 parts of Radix Aconiti Lateralis Preparatas, 333 parts of Ramulus Cinnamomi, 833 parts of Radix Salviae Miltiorrhizaes, 417 parts of Radix Polygoni Ciliinerve, 833 parts of Herba Leonuris, 417 parts of Rhizoma Alismatis, 417 parts of Polyporus, 417 parts of Semen Plantaginiss, 333 parts in Fructus Jujubae, 417 parts of Semen Lepidii (Semen Descurainiae)s, 278 parts of Fructus Amomis, 417 parts of Pericarpium Arecae and appropriate amount of auxiliary materials.
3, according to claim 1 or the 2 described Chinese patent medicines that are used for the treatment of heart failure, it is characterized in that: described preparation comprises granule, hard capsule, soft capsule, tablet, drop pill, oral liquid, slow releasing preparation, controlled release preparation.
4, as the described preparation method that is used for the treatment of the Chinese patent medicine of heart failure of claim 1-3, it is characterized in that: with this Chinese patent medicine concrete be prepared into granule the time can be like this: the Radix Ginseng alcohol reflux, reclaim ethanol, medicinal liquid concentrates standby; The Fructus Amomi of smashing, Ramulus Cinnamomi water distillating extracting oil are also used beta-cyclodextrin inclusion compound, and its medicinal residues and medicine residues of Radix Ginseng and other medicines water decoct, and filter, add ethanol after filtrate concentrates and leave standstill, filter filtrate recycling ethanol, concentrate the back thin up, filter, medicinal liquid concentrates, with Radix Ginseng medicinal liquid mixing, drying, pulverize, add volatile oil clathrate compound and an amount of lactose, mixing is granulated, packing, promptly.
5, according to the described preparation method that is used for the treatment of the Chinese patent medicine of heart failure of claim 4, it is characterized in that: Chinese patent medicine is concrete can prepare when being prepared into capsule like this: Radix Ginseng, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Semen Lepidii (Semen Descurainiae), Radix Paeoniae Rubra, Herba Leonuri, Radix Aconiti Lateralis Preparata add alcohol reflux, reclaim ethanol, be condensed into clear paste, drying under reduced pressure, pulverize, fine powder is standby; Six-elements such as Ramulus Cinnamomi decoct with water, and filter, and filtrate is condensed into clear paste, add ethanol and leave standstill, and the leaching supernatant reclaims ethanol, and concentrating under reduced pressure becomes clear paste, and spray drying gets fine powder, with above-mentioned fine powder mixing, and dry granulation, coating, encapsulated, promptly.
6, according to the described preparation method that is used for the treatment of the Chinese patent medicine of heart failure of claim 4, it is characterized in that: Chinese patent medicine is concrete can prepare when being prepared into tablet like this: Radix Ginseng, Radix Salviae Miltiorrhizae, Rhizoma Alismatis, Semen Lepidii (Semen Descurainiae), Radix Paeoniae Rubra, Herba Leonuri, Radix Aconiti Lateralis Preparata add alcohol reflux, reclaim ethanol, be condensed into clear paste, drying under reduced pressure, pulverize, fine powder is standby; Six-elements such as Ramulus Cinnamomi decoct with water, and filter, and filtrate is condensed into clear paste, add ethanol and leave standstill, and the leaching supernatant reclaims ethanol, the concentrating under reduced pressure clear paste, and spray drying gets fine powder, with above-mentioned fine powder mixing, dry granulation, tabletting, the bag film-coat, promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200410045437 CN1241632C (en) | 2003-05-30 | 2004-05-20 | Chinese patent medicine for treating cardiac function failure and its preparation method |
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| CN03134212 | 2003-05-30 | ||
| CN03134212.4 | 2003-05-30 | ||
| CN 200410045437 CN1241632C (en) | 2003-05-30 | 2004-05-20 | Chinese patent medicine for treating cardiac function failure and its preparation method |
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| CN1241632C CN1241632C (en) | 2006-02-15 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199720B (en) * | 2007-12-17 | 2010-08-18 | 郝丽华 | Chinese medicine compound for oral administration for treating chronicity nephritis |
| CN101199812B (en) * | 2007-12-18 | 2010-10-27 | 山东步长制药有限公司 | Chinese medicine granules for treating heart function exhaustion, producing method and quality controlling method thereof |
-
2004
- 2004-05-20 CN CN 200410045437 patent/CN1241632C/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101199720B (en) * | 2007-12-17 | 2010-08-18 | 郝丽华 | Chinese medicine compound for oral administration for treating chronicity nephritis |
| CN101199812B (en) * | 2007-12-18 | 2010-10-27 | 山东步长制药有限公司 | Chinese medicine granules for treating heart function exhaustion, producing method and quality controlling method thereof |
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| Publication number | Publication date |
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| CN1241632C (en) | 2006-02-15 |
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