CN1561387A - 益生菌双歧杆菌菌株 - Google Patents
益生菌双歧杆菌菌株 Download PDFInfo
- Publication number
- CN1561387A CN1561387A CNA028185773A CN02818577A CN1561387A CN 1561387 A CN1561387 A CN 1561387A CN A028185773 A CNA028185773 A CN A028185773A CN 02818577 A CN02818577 A CN 02818577A CN 1561387 A CN1561387 A CN 1561387A
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- CN
- China
- Prior art keywords
- prescription
- bifidobacterium strains
- inflammatory
- disease
- strains
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P31/10—Antimycotics
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/533—Longum
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/02—Acetobacter
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Diabetes (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE20010711 | 2001-07-26 | ||
| IE20010713 | 2001-07-26 | ||
| IE010717 | 2001-07-26 | ||
| IE010713 | 2001-07-26 | ||
| IE20010714 | 2001-07-26 | ||
| IE20010717 | 2001-07-26 | ||
| IE010711 | 2001-07-26 | ||
| IE010714 | 2001-07-26 | ||
| IE010709 | 2001-07-26 | ||
| IE20010709 | 2001-07-26 | ||
| IE20010710 | 2001-07-26 | ||
| IE010710 | 2001-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1561387A true CN1561387A (zh) | 2005-01-05 |
Family
ID=27547373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA028185773A Pending CN1561387A (zh) | 2001-07-26 | 2002-07-26 | 益生菌双歧杆菌菌株 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20030092163A1 (enExample) |
| EP (1) | EP1409644A1 (enExample) |
| JP (1) | JP2005508617A (enExample) |
| CN (1) | CN1561387A (enExample) |
| AU (1) | AU2002329006A1 (enExample) |
| BR (1) | BR0211442A (enExample) |
| CA (1) | CA2454803A1 (enExample) |
| IL (1) | IL160048A0 (enExample) |
| IN (1) | IN2004KN00093A (enExample) |
| MX (1) | MXPA04000738A (enExample) |
| PE (1) | PE20030284A1 (enExample) |
| WO (1) | WO2003010297A1 (enExample) |
Cited By (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100480370C (zh) * | 2002-07-23 | 2009-04-22 | 雀巢技术公司 | 用于消化道神经肌肉功能的益生菌 |
| CN101909643A (zh) * | 2007-11-30 | 2010-12-08 | 巴斯德研究所 | 干酪乳杆菌菌株用于制备抑制肥大细胞活化之组合物的用途 |
| CN102899261A (zh) * | 2011-03-11 | 2013-01-30 | 光晟生物科技股份有限公司 | 可产生高免疫激活反应的长双歧杆菌长亚种分离株及可刺激免疫激活的组合物 |
| CN101983237B (zh) * | 2007-12-24 | 2013-06-12 | 康斯乔最高科学研究公司 | 改善与谷蛋白摄入相关之病症个体健康状况的微生物 |
| CN103561752A (zh) * | 2011-03-09 | 2014-02-05 | 明尼苏达大学评议会 | 用于移植结肠微生物群的组合物和方法 |
| CN103623010A (zh) * | 2007-05-18 | 2014-03-12 | 雀巢产品技术援助有限公司 | 在外科手术前和/或外科手术后环境中的益生菌 |
| CN104784694A (zh) * | 2009-06-19 | 2015-07-22 | 杜邦营养生物科学有限公司 | 治疗糖尿病及相关病症的双歧杆菌 |
| US9320763B2 (en) | 2000-07-25 | 2016-04-26 | Thomas Julius Borody | Probiotic recolonisation therapy |
| US9901603B2 (en) | 2015-05-14 | 2018-02-27 | Crestovo Holdings Llc | Compositions for fecal floral transplantation and methods for making and using them and device for delivering them |
| US9962413B2 (en) | 2010-08-04 | 2018-05-08 | Crestovo Holdings Llc | Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them |
| US10092601B2 (en) | 2016-10-11 | 2018-10-09 | Crestovo Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
| US10195235B2 (en) | 2016-08-03 | 2019-02-05 | Crestovo Holdings Llc | Methods for treating ulcerative colitis |
| CN109929773A (zh) * | 2019-01-10 | 2019-06-25 | 江苏德禧生物科技有限公司 | 一株可用于富硒培养的双歧杆菌及其活性蛋白和应用 |
| US11026978B2 (en) | 2016-10-11 | 2021-06-08 | Finch Therapeutics Holdings Llc | Compositions and methods for treating multiple sclerosis and related disorders |
| US11040073B2 (en) | 2017-04-05 | 2021-06-22 | Finch Therapeutics Holdings Llc | Compositions and methods for treating diverticulitis and related disorders |
| US11166990B2 (en) | 2018-07-13 | 2021-11-09 | Finch Therapeutics Holdings Llc | Methods and compositions for treating ulcerative colitis |
| US11202808B2 (en) | 2015-05-22 | 2021-12-21 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
| CN113862175A (zh) * | 2014-12-23 | 2021-12-31 | 4D制药研究有限公司 | 免疫调控 |
| US11213549B2 (en) | 2016-10-11 | 2022-01-04 | Finch Therapeutics Holdings Llc | Compositions and method for treating primary sclerosing cholangitis and related disorders |
| US11357801B2 (en) | 2016-06-15 | 2022-06-14 | Arizona Board Of Regents On Behalf Of Arizona State University | Methods for treating autism spectrum disorder and associated symptoms |
| US11433102B2 (en) | 2017-04-05 | 2022-09-06 | Finch Therapeutics Holdings Llc | Compositions and methods for treating Parkinson's disease (PD) and related disorders |
| US11542560B2 (en) | 2012-05-25 | 2023-01-03 | Board of Regents on Behalf of Arizona State University | Microbiome markers and therapies for autism spectrum disorders |
| CN116083327A (zh) * | 2023-04-07 | 2023-05-09 | 天赋能(天津)功能食品研究发展有限公司 | 长双歧杆菌婴儿亚种及在缓解便秘、抗结肠组织炎症和改善肠道菌群方面的应用 |
| CN116574659A (zh) * | 2023-06-14 | 2023-08-11 | 江南大学 | 一株可缓解类风湿性关节炎的长双歧杆菌婴儿亚种及其应用 |
| US11819523B2 (en) | 2016-07-01 | 2023-11-21 | Regents Of The University Of Minnesota | Compositions and methods for C. difficile treatment |
| US11865145B2 (en) | 2017-08-07 | 2024-01-09 | Finch Therapeutics Holdings Llc | Compositions and methods for maintaining and restoring a healthy gut barrier |
| US11890306B2 (en) | 2017-05-26 | 2024-02-06 | Finch Therapeutics Holdings Llc | Lyophilized compositions comprising fecal microbe-based therapeutic agents and methods for making and using same |
| US11911419B2 (en) | 2018-09-27 | 2024-02-27 | Finch Therapeutics Holdings Llc | Compositions and methods for treating epilepsy and related disorders |
| US12290538B2 (en) | 2019-07-19 | 2025-05-06 | Finch Therapeutics Holdings Llc | Methods and products for treatment of gastrointestinal disorders |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563522B2 (en) | 1997-07-08 | 2013-10-22 | The Iams Company | Method of maintaining and/or attenuating a decline in quality of life |
| US7182943B2 (en) * | 2002-05-15 | 2007-02-27 | UNIVERSITé LAVAL | Method and system for modulation of microbial cell characteristics |
| SE526711C2 (sv) * | 2003-01-31 | 2005-10-25 | Probi Ab | Nya stammar av Bifidobacterium med förmåga att överleva i magtarmkanalen och producera glutamin in vivo, samt kompositioner och användningar därav |
| US20040197304A1 (en) | 2003-04-01 | 2004-10-07 | The Procter & Gamble Company And Alimentary Health, Ltd. | Methods of determining efficacy of treatments of inflammatory diseases of the bowel |
| EP2280285A1 (en) * | 2003-09-15 | 2011-02-02 | Oklahoma Medical Research Foundation | Method of using cytokine assays to diagnose, treat, and evaluate inflammatory and autoimmune diseases |
| WO2005030230A1 (en) * | 2003-09-30 | 2005-04-07 | Probiomics Limited | Compositions and methods for treatment or prevention of psoriasis and related disorders |
| GB0323039D0 (en) * | 2003-10-01 | 2003-11-05 | Danisco | Method |
| AU2004275438B2 (en) * | 2003-10-01 | 2008-05-29 | Commonwealth Scientific & Industrial Research Organisation | Probiotic storage and delivery |
| US8871266B2 (en) | 2003-10-01 | 2014-10-28 | Commonwealth Scientific & Industrial Research Organisation | Probiotic storage and delivery |
| US20090257993A1 (en) | 2003-12-17 | 2009-10-15 | M Rabet Laura | Lactic Acid Producing Bacteria and Lung Function |
| US20050158294A1 (en) | 2003-12-19 | 2005-07-21 | The Procter & Gamble Company | Canine probiotic Bifidobacteria pseudolongum |
| US8877178B2 (en) | 2003-12-19 | 2014-11-04 | The Iams Company | Methods of use of probiotic bifidobacteria for companion animals |
| US20050152884A1 (en) | 2003-12-19 | 2005-07-14 | The Procter & Gamble Company | Canine probiotic Bifidobacteria globosum |
| US7785635B1 (en) | 2003-12-19 | 2010-08-31 | The Procter & Gamble Company | Methods of use of probiotic lactobacilli for companion animals |
| US8894991B2 (en) | 2003-12-19 | 2014-11-25 | The Iams Company | Canine probiotic Lactobacilli |
| WO2005072718A1 (ja) * | 2004-01-28 | 2005-08-11 | Kurume University | 乳清発酵物を含有する医薬組成物 |
| JP2005247780A (ja) * | 2004-03-05 | 2005-09-15 | Masakazu Maruyama | ウイルス性肝炎治療剤 |
| ES2262418B1 (es) * | 2004-12-28 | 2007-11-01 | Consejo Superior Investig. Cientificas | Extractos proteicos con amplio espectro de actividad antibacteriana y cepas del genero bifidobacterium que los producen. |
| TW200700074A (en) * | 2005-03-04 | 2007-01-01 | Calpis Co Ltd | Inducer of t cell apoptosis |
| WO2006097949A1 (en) * | 2005-03-16 | 2006-09-21 | Actial Farmacêutica, Lda. | Mixture of at least 6 species of lactic acid bacteria and/or bifidobacteria in the manufacture of sourdough |
| AU2011205121B2 (en) * | 2005-04-08 | 2012-07-05 | Alimentary Health Ltd | Method of use of orally administered probiotic bifidobacteria for human beauty benefits |
| CN101155616A (zh) | 2005-04-08 | 2008-04-02 | 宝洁公司 | 用于人类美容有益效果的口服益生菌双歧杆菌的使用方法 |
| ATE432337T1 (de) * | 2005-05-16 | 2009-06-15 | Univ Liege | Probiotische bifidobacterium arten |
| AU2006253006B8 (en) | 2005-05-31 | 2011-09-15 | Alimentary Health Ltd | Feline probiotic Lactobacilli |
| EP1885383B1 (en) * | 2005-05-31 | 2016-09-21 | IAMS Europe B.V. | Feline probiotic bifidobacteria |
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| CN109929773A (zh) * | 2019-01-10 | 2019-06-25 | 江苏德禧生物科技有限公司 | 一株可用于富硒培养的双歧杆菌及其活性蛋白和应用 |
| US12290538B2 (en) | 2019-07-19 | 2025-05-06 | Finch Therapeutics Holdings Llc | Methods and products for treatment of gastrointestinal disorders |
| CN116083327A (zh) * | 2023-04-07 | 2023-05-09 | 天赋能(天津)功能食品研究发展有限公司 | 长双歧杆菌婴儿亚种及在缓解便秘、抗结肠组织炎症和改善肠道菌群方面的应用 |
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Also Published As
| Publication number | Publication date |
|---|---|
| US20060121015A1 (en) | 2006-06-08 |
| AU2002329006A1 (en) | 2003-02-17 |
| PE20030284A1 (es) | 2003-05-01 |
| BR0211442A (pt) | 2004-11-09 |
| MXPA04000738A (es) | 2004-07-08 |
| IN2004KN00093A (enExample) | 2006-03-03 |
| US20030092163A1 (en) | 2003-05-15 |
| JP2005508617A (ja) | 2005-04-07 |
| WO2003010297A1 (en) | 2003-02-06 |
| EP1409644A1 (en) | 2004-04-21 |
| CA2454803A1 (en) | 2003-02-06 |
| IL160048A0 (en) | 2004-06-20 |
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