CN1557370A - Antihyperglycemic and oxidation resistant health products and preparing process thereof - Google Patents
Antihyperglycemic and oxidation resistant health products and preparing process thereof Download PDFInfo
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- CN1557370A CN1557370A CNA2004100121182A CN200410012118A CN1557370A CN 1557370 A CN1557370 A CN 1557370A CN A2004100121182 A CNA2004100121182 A CN A2004100121182A CN 200410012118 A CN200410012118 A CN 200410012118A CN 1557370 A CN1557370 A CN 1557370A
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- ginkgetin
- blood fat
- health product
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- fat reducing
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Abstract
The present invention is one kind of health article for lowering blood fat and resisting oxidation and belongs to the field of medicine technology. The health article has red rice 19-76 wt%, protoxyanidin 5-20 wt% and ginkgetin 0.7-2.5 wt% as well as starch the rest, and is prepared into powder capsule. The present invention has the synergistic effect of the components, and can prevent and eliminate various garbage in blood and delay senility. It is one ideal blood fat reducing and oxidation resisting health article.
Description
Technical field
The present invention relates to a kind of cholesterol reducing, blood fat and oxidation-resisting health-care product, is the health product of raw material with grain, plant material extract specifically, belongs to the medical products technical field.
Background technology
Bad life habits, as smoke, excessive drinking, often edible three-hypers food (higher fatty acid, high protein, high heat) lacks motion etc., indexs such as the cholesterol in the blood, sweet fat three oil, low density lipoprotein, LDL, free radical are increased, cause multiple disease and acceleration agings such as cardiovascular and cerebrovascular vessel.Studies show that free radical in the blood can be attacked normal cell in non-selectivity ground, cause in the blood fat granule too much, quicken arteriosclerosis; Simultaneously, the nucleic acid molecule of free radical in also can attack cells becomes a very important factor of bringing out cancer.In addition, the aging of cell and even human body is quickened in the over oxidation effect of free-radical generating.Remove free radical in the human vas and excessive cholesterol, sweet fat three oil, low density lipoprotein, LDL, purify the blood, prophylactic treatment cardiovascular and cerebrovascular disease, slow down aging be the significant medical research topic that the mankind face.
Medical research for many years confirms; antioxidant activity, enzyme inhibition activity, vascular protection activity, antiinflammatory and anti-tumor activity that the procyanidin that extraction separation comes out from plants such as Semen Vitis viniferae (general name of polyphenolic substance) is had, but the atherosis and thrombosis of prevention of arterial and help slow down aging.Procyanidin can be by stimulating the activity rising nitric oxide level of nitric oxide (NO) synzyme in the vascular endothelial cell, nitric oxide and epinephrine interact to produce and suppress vasoconstrictive effect, vasodilator, anti-platelet aggregation adheres to, and suppresses low density lipoprotein, LDL and cholesterol oxidation.People are used for medicine, health product and cosmetics with procyanidin, have obtained certain effect.
No. 02131251.6, Chinese patent " a kind of Chinese medicine health-care medicine " discloses the prescription that a kind of procyanidin and Radix Panacis Quinquefolii or Radix Ginseng make up, and is used for radioprotective, mediator's body immunity function; Other has Chinese patent No. 00107488.1 " effervescent anti-senility health food and preparation method thereof " to disclose a kind of composition of prescription by Folium hydrangeae strigosae, procyanidin, gynostemma pentaphyllum and fruit oligose, is used for that diseases prevention is healthy and strong, the health preserving life-prolonging anti-senility.But these two inventions there is no remarkable improvement to causing the important blood fat and the cholesterol index of person in middle and old age's aging.
On the other hand, in the Semen Ginkgo of state-owned nearly 600 years medication history be rich in natural components such as ginkgetin and terpenoid lactone, mainly be injection used as clinically but people utilize ginkgetin, be used for some treatment of diseases.In recent years, along with ginkgetin to the body health progress of research, people are used for health product with ginkgetin gradually, but be to be used to prepare health beverage or medicated wine mostly, relatively typically as No. 99113767, Chinese patent, it is primary raw material with the ginkgetin, be equipped with cosolvent, Mel agar, sodium alginate, tart flavour element, potassium sorbate, sodium benzoate etc. and make beverage, this ginkgo beverage has medicinal and health care, can improve blood circulation, vessel softening is eliminated interior free yl, defying age, life lengthening.But this beverage is difficult to be received, and this is because the uncomfortable this form of receiving of person in middle and old age colony that needs ginkgetin to be used to keep healthy.
Summary of the invention
The present invention is used to overcome the defective of above-mentioned health product and the blood fat reducing anti-oxidation health product that a kind of good health care effect are provided and are convenient to take.
Another object of the present invention provides the preparation method of this product.
Problem of the present invention realizes with following technical proposals:
A kind of blood fat reducing anti-oxidation health product, by weight the unit meter it comprise following raw materials according:
Monas cuspurpureus Went (containing lovastatin 0.8%) 19～76;
Procyanidin 5～20;
Ginkgetin (purity 24%) 0.7～2.5.
Surplus supplies 100 with starch.
Above-mentioned blood fat reducing anti-oxidation health product, described health product are made powder capsule.
Processing method of the present invention is as follows:
A. above-mentioned raw materials is weighed by prescription;
B. each raw material powder is broken into 100 purpose fine powders;
C. the powder after will pulverizing adds blender, stirs 15～30 minutes;
D. the compound filled capsules after will stirring;
E. the capsule after filling is through 3.5～4 hours sterilizations of cobalt 60 irradiations, and exposure dose is 6KGY;
F. pack.
Except that procyanidin, contained flavone compound is strong free radical scavenger among the present invention, can protect cell tissue to avoid effect of free-radical generating over oxidation and then prolongation aging, is prevention person in middle and old age dementia, antidotal choice drug.Ginkgetin and terpenoid lactone also have vessel softening, prevent arteriosclerosis, remove functions such as blood fat rubbish, inhibition platelet aggregation, so also be used to the prevention and the treatment of cardio-cerebrovascular diseases.
Monas cuspurpureus Went is raw material substrate, forms through fermentation with rice etc., its contained lovastatin be cholesterol synthetic in the strong inhibition agent of key enzyme hydroxyl pentanedioyl acyl coenzyme reductase, therefore, it is in the present invention as the active ingredient of cholesterol reducing.
The present invention through the scientific experimentation screening, makes each raw material give full play to its advantage on the basis that each raw material is fully studied, Synergistic can effectively prevent, remove various rubbish in the blood, slow down aging, and taking convenience, the ideal health care product of a kind of blood fat reducing antioxidation of can yet be regarded as.
Be the result of the test of the present invention below in multinomial pharmacological verifications such as clinical efficacy, stability, toxic and side effects.
1. anti-senescence function:
The present invention claims that according to the survey report of certain food function inspection center per os gives aged mouse various dose this product 36 days, compares with the blank group, and middle dosage group serum third diphenol content reduction by 11%, serum activity of SOD improve 11%; High dose group cardiac muscle lipofuscin content reduction by 32%, serum activity of SOD improve 12%;
Compare with blank group (being tried substrate concentration 0%) contrast:
The female fruit bat average life that is tried substrate concentration 0.06% prolongs 4% (P＜0.05), maximum life span prolongs 4% (P＜0.001), the half death time prolongs 4 days, and male fruit bat average life prolongs 4% (P＜0.05), and maximum life span prolongs 1% (P＜0.001);
The female fruit bat maximum life span that is tried substrate concentration 0.18% prolongs 2% (P＜0.01), and the female fruit bat maximum life span that is tried substrate concentration 0.18% prolongs 2% (P＜0.01), and male fruit bat maximum life span prolongs 2% (P＜0.001);
The male fruit bat average life that is tried substrate concentration 0.54% prolongs 4% (P＜0.05), and maximum life span prolongs 1% (P＜0.01);
2. blood lipid regulation function:
Adopt preventative hyperlipidemia model test method, per os gives this product of rat various dose after 4 weeks, compares low 8% (P＜0.05) of high metering (0.450g/kg.bw) group serum total cholesterol with high fat matched group, serum triglycerides hangs down 13% (P＜0.05), and each organizes body weight does not all have significant difference.
3. malicious secondary ill effect:
Making the toxicity survey report according to certain province health inspection center claims, through acute toxicity test, Salmonella reversion test, PCEMNR micronucleus test, mouse sperm deformity test, the rat multinomial detection of feeding trial in 30 days, the maximum tolerated dose of the large and small Mus of two kinds of sexes is all greater than 20000mg/kg.bw, illustrate that this product has no side effect, mutagenicity test result is negative, and it is all no abnormal that rat was fed the every index in back in 30 days.
The specific embodiment
Below provide several embodiment:
Raw material embodiment 1 embodiment 2 embodiment 3 embodiment 4
Monas cuspurpureus Went 76 39 45 19
Procyanidin 65 14 20
Ginkgetin 0.7 0.8 2.0 2.5
Surplus supplies 100 with starch.Wherein, the effective content of raw material ginkgetin is 24%, and the active ingredient that Monas cuspurpureus Went contains lovastatin is 0.8%, the raw material of the purity of procyanidin optional 95%.
Above-mentioned raw materials is weighed by prescription, pulverized 100 mesh sieves, granular material is mixed send into blender stirring 15～30 minutes then, filled capsules behind the mixing, populated capsule is carried out the sterilization of cobalt 60 illumination-based disinfections, and irradiation time is 3.5～4 hours, sterilization back test package warehouse-in.
Claims (3)
1. blood fat reducing anti-oxidation health product, it contains procyanidin, it is characterized in that, adds ginkgetin and Monas cuspurpureus Went therein, and addition unit is by weight counted:
Monas cuspurpureus Went 19～76;
Procyanidin 5～20;
Ginkgetin 0.7～2.5.
Surplus supplies 100 with starch, and wherein, the active ingredient of ginkgetin is 24%, and Monas cuspurpureus Went contains lovastatin 0.8%.
2. blood fat reducing anti-oxidation health product according to claim 1 is characterized in that described health product are made powder capsule.
3. according to the preparation method of claim 1 or 2 described blood fat reducing anti-oxidation health product, it is characterized in that it carries out as follows:
A. above-mentioned raw materials is weighed by prescription;
B. each raw material powder is broken into 100 purpose fine powders;
C. the powder after will pulverizing adds blender, stirs 15～30 minutes;
D. the compound filled capsules after will stirring;
E. the capsule after filling is through 3.5～4 hours sterilizations of cobalt 60 irradiations, and exposure dose is 6KGY;
F. pack.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410012118 CN1237066C (en) | 2004-01-16 | 2004-01-16 | Antihyperglycemic and oxidation resistant health products and preparing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410012118 CN1237066C (en) | 2004-01-16 | 2004-01-16 | Antihyperglycemic and oxidation resistant health products and preparing process thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1557370A true CN1557370A (en) | 2004-12-29 |
| CN1237066C CN1237066C (en) | 2006-01-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200410012118 Expired - Fee Related CN1237066C (en) | 2004-01-16 | 2004-01-16 | Antihyperglycemic and oxidation resistant health products and preparing process thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1301665C (en) * | 2005-05-18 | 2007-02-28 | 成刚 | Blood fat-regulating liver-protecting health food |
| CN107581613A (en) * | 2017-10-26 | 2018-01-16 | 广州静道科技应用有限公司 | A kind of high protein weight reducing meal replacement powder and preparation method thereof |
| CN114532503A (en) * | 2020-11-26 | 2022-05-27 | 浙江养生堂天然药物研究所有限公司 | Red-pulp apple and cherry plum composition and application thereof in reducing blood fat |
-
2004
- 2004-01-16 CN CN 200410012118 patent/CN1237066C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1301665C (en) * | 2005-05-18 | 2007-02-28 | 成刚 | Blood fat-regulating liver-protecting health food |
| CN107581613A (en) * | 2017-10-26 | 2018-01-16 | 广州静道科技应用有限公司 | A kind of high protein weight reducing meal replacement powder and preparation method thereof |
| CN114532503A (en) * | 2020-11-26 | 2022-05-27 | 浙江养生堂天然药物研究所有限公司 | Red-pulp apple and cherry plum composition and application thereof in reducing blood fat |
| CN114532503B (en) * | 2020-11-26 | 2024-05-10 | 浙江养生堂天然药物研究所有限公司 | Red apple and cherry plum composition and application thereof in reducing blood fat |
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| Publication number | Publication date |
|---|---|
| CN1237066C (en) | 2006-01-18 |
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Owner name: HEBEI JINHANFANG BIOLOGY SCIENCE DEVELOPMENT CO., Free format text: FORMER NAME OR ADDRESS: SHIJIAZHUANG JINHANFANG BIOTECHNOLOGY DEVELOPMENT CO., LTD. |
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Address after: Hebei province Shijiazhuang city Yuhua District Donggang head No. 28 Yan Hong Kong Yiyuan A block -1-1203 Patentee after: Hebei Jinhanfang Biotechnology Development Co., Ltd. Address before: Hebei province Shijiazhuang city Yuhua District Donggang head No. 28 Yan Hong Kong Yiyuan A block -1-1203 Patentee before: Shijiazhuang Jinhanfang Bio-tech Development Co., Ltd. |
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