CN1546176A - 伤口隐形防水喷贴 - Google Patents
伤口隐形防水喷贴 Download PDFInfo
- Publication number
- CN1546176A CN1546176A CNA2003101227495A CN200310122749A CN1546176A CN 1546176 A CN1546176 A CN 1546176A CN A2003101227495 A CNA2003101227495 A CN A2003101227495A CN 200310122749 A CN200310122749 A CN 200310122749A CN 1546176 A CN1546176 A CN 1546176A
- Authority
- CN
- China
- Prior art keywords
- pasted
- wound
- wound according
- film forming
- waterproof spray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007921 spray Substances 0.000 title claims abstract description 19
- 239000000443 aerosol Substances 0.000 claims abstract description 15
- 239000003960 organic solvent Substances 0.000 claims abstract description 15
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 8
- 239000001569 carbon dioxide Substances 0.000 claims abstract description 5
- 229910002092 carbon dioxide Inorganic materials 0.000 claims abstract description 5
- VSKJLJHPAFKHBX-UHFFFAOYSA-N 2-methylbuta-1,3-diene;styrene Chemical compound CC(=C)C=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 VSKJLJHPAFKHBX-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000003292 glue Substances 0.000 claims description 14
- 229920001935 styrene-ethylene-butadiene-styrene Polymers 0.000 claims description 12
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 5
- 239000013538 functional additive Substances 0.000 claims description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 4
- 229920002725 thermoplastic elastomer Polymers 0.000 claims description 4
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 3
- 238000004945 emulsification Methods 0.000 claims description 3
- 241000411851 herbal medicine Species 0.000 claims description 3
- 229910052786 argon Inorganic materials 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 229920000578 graft copolymer Polymers 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229910052757 nitrogen Inorganic materials 0.000 claims description 2
- 229910052756 noble gas Inorganic materials 0.000 claims description 2
- 150000002835 noble gases Chemical class 0.000 claims description 2
- 239000003507 refrigerant Substances 0.000 claims description 2
- 238000000638 solvent extraction Methods 0.000 claims description 2
- 230000008450 motivation Effects 0.000 abstract 2
- 229920006465 Styrenic thermoplastic elastomer Polymers 0.000 abstract 1
- FACXGONDLDSNOE-UHFFFAOYSA-N buta-1,3-diene;styrene Chemical compound C=CC=C.C=CC1=CC=CC=C1.C=CC1=CC=CC=C1 FACXGONDLDSNOE-UHFFFAOYSA-N 0.000 abstract 1
- 239000011261 inert gas Substances 0.000 abstract 1
- 239000011505 plaster Substances 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 15
- 208000027418 Wounds and injury Diseases 0.000 description 15
- 239000010408 film Substances 0.000 description 8
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 7
- 239000000853 adhesive Substances 0.000 description 7
- 230000001070 adhesive effect Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 229920001971 elastomer Polymers 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 239000005060 rubber Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 229920001661 Chitosan Polymers 0.000 description 4
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 244000000010 microbial pathogen Species 0.000 description 4
- 239000003380 propellant Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 238000009835 boiling Methods 0.000 description 3
- 229920005549 butyl rubber Polymers 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000023597 hemostasis Effects 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 239000003208 petroleum Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
- 229920002943 EPDM rubber Polymers 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 239000001273 butane Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical class CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- IJVRPNIWWODHHA-UHFFFAOYSA-N 2-cyanoprop-2-enoic acid Chemical compound OC(=O)C(=C)C#N IJVRPNIWWODHHA-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- MTAZNLWOLGHBHU-UHFFFAOYSA-N butadiene-styrene rubber Chemical compound C=CC=C.C=CC1=CC=CC=C1 MTAZNLWOLGHBHU-UHFFFAOYSA-N 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000001289 litsea cubeba fruit oil Substances 0.000 description 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- FATBGEAMYMYZAF-KTKRTIGZSA-N oleamide Chemical compound CCCCCCCC\C=C/CCCCCCCC(N)=O FATBGEAMYMYZAF-KTKRTIGZSA-N 0.000 description 1
- FATBGEAMYMYZAF-UHFFFAOYSA-N oleicacidamide-heptaglycolether Natural products CCCCCCCCC=CCCCCCCCC(N)=O FATBGEAMYMYZAF-UHFFFAOYSA-N 0.000 description 1
- 229920000620 organic polymer Polymers 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920001432 poly(L-lactide) Polymers 0.000 description 1
- -1 poly-gamma-hydroxybutyric acid ester Chemical class 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种伤口隐形防水喷贴，由成膜物质、有机溶剂及气雾推动剂组成(或不加入气雾推动剂)。选用以苯乙烯－异戊二烯－苯乙烯，苯乙烯－丁二烯－苯乙烯，氢化苯乙烯－丁二烯－苯乙烯热塑性弹性体及其接枝共聚物作为成膜物质。本发明所述的成膜物质的浓度为1％～20％，有机溶剂为C5～C9的饱和烷烃。气雾推动剂为二氧化碳气体或惰性气体。本发明中还可配入具有消炎、止痛、清凉等功能的中草药植物的有机溶剂萃取物。本发明制成的新型敷料用于人体浅表创伤处理，所有材料均无毒、无致敏性，喷涂于创面能快速成膜起到封闭伤口的作用。膜的弹性好，具有透气性，又能起到防水、阻隔包括病毒在内的致病微生物、快速封闭伤口、消炎、止血、抗菌、促进创面愈合的功能。
Description
技术领域
本发明涉及一种伤口隐形防水喷贴。
背景技术
人们在从事劳作、运动等活动时常意外地发生表皮创伤。目前用于表皮创伤处理最常用的敷料为创可贴。创可贴一般是由纱布、橡皮胶以及附着于橡皮胶上的有效药物三部分组成。纱布起到支架作用，并有吸收创口渗液的功能。橡皮胶粘附于皮肤上起到固定作用。药物起抗菌、消炎、止血的功效。创可贴防水、阻隔致病微生物的功能及透气性较差，使用时影响外观。近年来国外“TheJason group”、“BayerAG”、“Smith & Nephew medical Ltd”、“TechnicalSurgical products Ltd”等厂商为了适应患者和市场的需求，开发了有机溶剂型的喷胶创可贴，并有产品投放市场。该类创可贴与传统的纱布型创可贴相比，具有优良的防水、止血和阻隔致病微生物的功能。有机溶剂型的喷胶创可贴，一般由4种组分组成：a.高分子成膜物质，b.有机溶剂，c.功能物质，d.气雾剂。选用的所有材料应确保对人体无毒、无致敏反应。国外产品选用的高分子成膜材料有聚甲基丙烯酸(甲、乙、丁)酯、氰基丙烯酸(甲、乙、丁)酯、丙烯酸(甲、乙、丁)酯、聚乙烯吡咯烷酮、硝化纤维素、醋酸纤维素、聚L-乳酸、聚γ-羟基丁酸酯、硅橡胶、氟橡胶、乙丙橡胶、三元乙丙橡胶、丁苯橡胶、天然橡胶等。根据对上述高分子材料的溶解性能选用的有机溶剂有：乙醇、异丙醇、丁醇、异戊醇、醋酸丁酯、丙酮等。选用的功能物质有壳聚糖、脱乙酰壳聚糖、海藻酸钠或钙、抗菌消炎药物等。选用的气雾剂有：氟利昂、丁烷、二甲醚等。
丙烯酸酯及硝化纤维素作为成膜物质，仅能溶于醋酸酯及丙酮、丁酮等溶剂中，醋酸酯、丙酮对部分人群有致敏反应，且丙烯酸酯类成膜材料的韧性及强度偏低。以橡胶类高分子材料作为成膜物质，虽然能克服韧性差的缺点，但橡胶类材料一般仅能溶于苯、甲苯、二氯乙烷、二氯甲烷等溶剂中，该类溶剂的毒性大，不允许和人体直接接触，而且橡胶类成膜物质刚性偏低，剥离性能较差。
众所周知，常用的氟利昂气雾剂对环境，特别是对大气臭氧层造成破坏，属国际限制使用的致冷剂和气雾剂。丁烷属低级饱和烃，沸点及闪点低，作为气雾剂使用，其用量大，易燃易爆。二甲醚对人体有毒，仅作为杀虫杀菌喷雾推动剂使用。
发明内容
本发明的目的在于：提供一种使用携带方便，对人体安全可靠，具有快速封闭伤口、消炎、止血、促进伤口愈合、防水、阻隔致病微生物性能优良的气雾剂型或喷雾剂型伤口敷料。该敷料富有弹性，具有透明性、透气性，使用时不影响外观，不引起不舒适感，能活动自如。
本发明通过以下方案实现：由成膜物质、有机溶剂组成。选用以苯乙烯-异戊二烯-苯乙烯(SIS)，苯乙烯-丁二烯-苯乙烯(SBS)，氢化苯乙烯-丁二烯-苯乙烯(SEBS)热塑性弹性体及其接枝共聚物作为成膜物质。
本发明所述的成膜物质的浓度为1％～20％，有机溶剂为C5～C9的饱和烷烃。C5～C9的饱和烷烃包括它们的直链、支链及环状异构体，可以使用单一化合物，也可以是它们的混合物。
本发明所述的伤口隐形防水喷贴还可配以气雾推动剂。气雾推动剂为二氧化碳气体或其他惰性气体，该类气体与目前国内外普遍使用的氟利昂、丁烷气等相比，具有无毒、使用安全、用量少等优点。本发明还可将SIS、SBS、SEBS的胶液制成气雾剂，亦可采用手动泵，将SIS、SBS、SEBS的胶液制成喷雾剂型。
本发明中还可配入功能添加剂，即具有消炎、止痛、清凉等功能的中草药植物的有机溶剂萃取物，功能添加剂采用薄荷脑、薄荷油、丁香油、山苍子油等具有抗菌、消炎作用的中草药的有机溶剂萃提物。
本发明可将成膜物质、有机溶剂、功能添加剂通过乳化作用，形成均相的胶液。
本发明制成的新型敷料用于人体浅表创伤处理，所有材料均无毒、无致敏性，喷涂于创面能快速成膜起到封闭伤口的作用。膜的弹性好，孔径为20～40nm，具有透气性，又能起到防水、阻隔包括病毒在内的致病微生物的功能。该敷料携带使用方便，经初步临床应用证明：喷涂于创面形成的有机高分子薄膜具有透明性、透气性，具有快速封闭伤口消炎、止血、抗菌、促进创面愈合的功效。
具体实施方式
以下结合实施例对本发明进行详细说明。
实施例1：
将95克SIS，5克丁基橡胶置于洁净的2000mL三口玻璃瓶中，加入1000～1500mL60～90℃沸程范围的石油醚，水浴加热，搅拌使SIS和丁基橡胶完全溶解，再加入0.5克过氧化二苯甲酰，在60～80℃下接枝共聚反应4小时，冷却至25℃以下，加入2mL薄荷油、1mL丁香油，在50mL的专用耐压气雾罐中装入上述胶液30mL，采用专用罐装机压入1～3g二氧化碳气体，在气雾罐表面贴上标签即制成伤口隐形防水喷贴。
实施例2：
制备步骤同实施例1，将配方改为SEBS 95克、丁基橡胶5克、薄荷脑1mL、丁香酚1克、油酸酰胺0.5克，30～60℃沸程范围的石油醚1000～2000mL，以高纯氮气作为气雾推进剂。
实施例3：
制备步骤同实施例1，将配方改为SBS 95克、三元乙丙橡胶5克、山苍子油2mL、冰片0.5克，正己烷1000～1500mL，以氩气作为气雾推进剂。
实施例4：
配方及制备步骤同实施例1，但不加入气雾推进剂，而采用手动泵制成喷雾剂型。
实施例5：
将50克SEBS置于洁净的3000mL三口玻璃瓶中，装上电动搅拌器和回流冷凝器，加入1300mL石油醚，水浴加热至60～70℃，搅拌使其溶解，冷却至室温，制成SEBS胶液。将3～5克脱乙酰壳聚糖、50mL10％的醋酸溶液加入洁净的250mL三口玻璃瓶中，加入1～3克TX 10～30(壬基酚聚醚多元醇)、薄荷油1克、丁香油2mL，加热并搅拌使其完全溶解。将制成的脱乙酰壳聚糖醋酸溶液慢慢加入到上述SEBS胶液中，快速搅拌使其乳化，压入一定量的二氧化碳作为气雾推进剂即制成均相的伤口隐形防水喷贴。
Claims (10)
1、一种伤口隐形防水喷贴，由成膜物质、有机溶剂组成，其特征在于：选用以苯乙烯-异戊二烯-苯乙烯(SIS)，苯乙烯-丁二烯-苯乙烯(SBS)，氢化苯乙烯-丁二烯-苯乙烯(SEBS)热塑性弹性体及其接枝共聚物作为成膜物质。
2、根据权利要求1所述的伤口隐形防水喷贴，其特征在于：成膜物质的浓度为1％～20％。
3、根据权利要求1或2所述的伤口隐形防水喷贴，其特征在于：有机溶剂为C5～C9的饱和烷烃，包括它们的直链、支链及环状异构体，可以使用单一化合物，也可以是它们的混合物。
4、根据权利要求1或2所述的伤口隐形防水喷贴，其特征在于：配有气雾推动剂。
5、根据权利要求4所述的伤口隐形防水喷贴，其特征在于：以二氧化碳气体或氮气、氩气等惰性气体为气雾推动剂
6、根据权利要求1或2所述的伤口隐形防水喷贴，其特征在于：将SIS、SBS、SEBS的胶液制成气雾剂。
7、根据权利要求1或2所述的伤口隐形防水喷贴，其特征在于：采用手动泵，将SIS、SBS、SEBS的胶液制成喷雾剂型。
8、根据权利要求1或2所述的伤口隐形防水喷贴，其特征在于：配入功能添加剂，即具有消炎、止痛、清凉等功能的中草药植物的有机溶剂萃取物。
9、根据权利要求1或2所述的伤口隐形防水喷贴，其特征在于：将成膜物质、有机溶剂通过乳化作用，形成均相的胶液。
10、根据权利要求8所述的伤口隐形防水喷贴，其特征在于：将成膜物质、有机溶剂、功能添加剂通过乳化作用，形成均相的胶液。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101227495A CN1331539C (zh) | 2003-12-17 | 2003-12-17 | 伤口隐形防水喷贴 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2003101227495A CN1331539C (zh) | 2003-12-17 | 2003-12-17 | 伤口隐形防水喷贴 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1546176A true CN1546176A (zh) | 2004-11-17 |
| CN1331539C CN1331539C (zh) | 2007-08-15 |
Family
ID=34338739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2003101227495A Expired - Lifetime CN1331539C (zh) | 2003-12-17 | 2003-12-17 | 伤口隐形防水喷贴 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1331539C (zh) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771781A (zh) * | 2014-08-20 | 2015-07-15 | 江阴市柏御天谷生物医药有限公司 | 液体创面保护膜及其制备方法 |
| CN104861407A (zh) * | 2015-05-30 | 2015-08-26 | 浙江汪洋高分子材料有限公司 | 一种热塑性弹性体止血带配方 |
| CN106512081A (zh) * | 2016-12-07 | 2017-03-22 | 武汉纺织大学 | 一种喷涂型壳聚糖水剂创伤敷料 |
| CN109106976A (zh) * | 2018-07-30 | 2019-01-01 | 绍兴百立盛新材料科技有限公司 | 一种液体创可贴的制备方法 |
| CN113289048A (zh) * | 2021-05-24 | 2021-08-24 | 嫒赟（上海）生物科技股份有限公司 | 具有抑菌保健功能的卫生巾及其制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940455A (en) * | 1970-08-31 | 1976-02-24 | The United States Of America As Represented By The Secretary Of The Navy | Hydrocarbon polymers |
| SU1014876A1 (ru) * | 1981-12-31 | 1983-04-30 | Предприятие П/Я В-8952 | Способ получени липкого кле |
| JPS59193817A (ja) * | 1983-04-15 | 1984-11-02 | Nitto Electric Ind Co Ltd | 外用製剤 |
| JPH04191043A (ja) * | 1990-11-27 | 1992-07-09 | Mitsui Toatsu Chem Inc | 積層シート |
| RO109551B1 (ro) * | 1992-08-28 | 1995-03-30 | Sc Novoplast Sa | Compoziție de adeziv sensibil la presiune și procedeu de obținere a acesteia |
| JP3372971B2 (ja) * | 1992-10-20 | 2003-02-04 | 住友ベークライト株式会社 | 抗血栓性材料の製造方法 |
-
2003
- 2003-12-17 CN CNB2003101227495A patent/CN1331539C/zh not_active Expired - Lifetime
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104771781A (zh) * | 2014-08-20 | 2015-07-15 | 江阴市柏御天谷生物医药有限公司 | 液体创面保护膜及其制备方法 |
| CN104861407A (zh) * | 2015-05-30 | 2015-08-26 | 浙江汪洋高分子材料有限公司 | 一种热塑性弹性体止血带配方 |
| CN106512081A (zh) * | 2016-12-07 | 2017-03-22 | 武汉纺织大学 | 一种喷涂型壳聚糖水剂创伤敷料 |
| CN109106976A (zh) * | 2018-07-30 | 2019-01-01 | 绍兴百立盛新材料科技有限公司 | 一种液体创可贴的制备方法 |
| CN109106976B (zh) * | 2018-07-30 | 2021-06-29 | 绍兴百立盛新材料科技有限公司 | 一种液体创可贴的制备方法 |
| CN113289048A (zh) * | 2021-05-24 | 2021-08-24 | 嫒赟（上海）生物科技股份有限公司 | 具有抑菌保健功能的卫生巾及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1331539C (zh) | 2007-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zhao et al. | Injectable antiswelling and high-strength bioactive hydrogels with a wet adhesion and rapid gelling process to promote sutureless wound closure and scar-free repair of infectious wounds | |
| CN105903068A (zh) | 含有镇痛药物的医用复合壳聚糖凝胶 | |
| CN102058900B (zh) | 一种具有防水性的创面防护用液体绷带及其制备方法 | |
| EP0679390A3 (en) | Sprayable topical pharmaceutical compositions | |
| EP2292257A2 (en) | Compositions and methods for dermatological wound healing | |
| KR20120117732A (ko) | 접착제 조성물 | |
| CN106139239A (zh) | 多功能液体敷料及其制备方法 | |
| CN1331539C (zh) | 伤口隐形防水喷贴 | |
| CN1298394C (zh) | 用于使伤口愈合并防止绷带粘连伤口的制剂 | |
| EP3040087A1 (en) | Wound dressings | |
| CA2418976A1 (en) | Skin wound healing promoters | |
| EP0409550A1 (en) | Polymeric liquid dressing for skin | |
| CN104740141B (zh) | 一种抗菌喷剂及其制备方法 | |
| AU3295400A (en) | Novel hydrocolloid adhesive mass with improved resistance to deterioration of its absorption capacity after being sterilised by radiation | |
| EP1322349B1 (en) | Protectant film for skin | |
| CN107595819B (zh) | 一种纳米金刚石改性液体创可贴及其制备方法 | |
| CN100346842C (zh) | 防止破损皮肤感染的高分子聚合物液体敷料 | |
| CN109464396A (zh) | 一种含有类肝素组合物的喷雾剂 | |
| CN200951153Y (zh) | 野战用绷带 | |
| WO2006075932A3 (en) | Remedy to accelerate healing of wound and burn | |
| CN1112024A (zh) | 一种医用生物薄膜的制备方法 | |
| RU2124357C1 (ru) | Способ обработки раневых поверхностей | |
| CN109646702A (zh) | 一种适用性强且轻便高效的敷料 | |
| CN1108783C (zh) | 伤口药物保湿敷料 | |
| GB2274650A (en) | Composition for skin barrier |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: JIANGXI RUIJI BIO-ENGINEERING TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: MIAO JIUCHANG Effective date: 20131104 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 330100 NANCHANG, JIANGXI PROVINCE TO: 330029 NANCHANG, JIANGXI PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20131104 Address after: 330029 No. 382 Fang Fang Road, Nanchang, Jiangxi Patentee after: JIANGXI RUIJI BIO-ENGINEERING TECHNOLOGY Co.,Ltd. Address before: 330100 Sumitomo Bioengineering Technology Co., Ltd., Jiangxi Academy of Sciences, 108 Fang Fang Road, Nanchang, Jiangxi Patentee before: Miao Jiuchang |
|
| C56 | Change in the name or address of the patentee | ||
| CP03 | Change of name, title or address |
Address after: 330096 Nanchang province high tech Development Zone, Jiangxi Road, No. 498 Patentee after: JIANGXI RUIJI BIOTECHNOLOGY Co.,Ltd. Address before: 330029 No. 382 Fang Fang Road, Nanchang, Jiangxi Patentee before: JIANGXI RUIJI BIO-ENGINEERING TECHNOLOGY Co.,Ltd. |
|
| CX01 | Expiry of patent term |
Granted publication date: 20070815 |
|
| CX01 | Expiry of patent term |