GB2274650A - Composition for skin barrier - Google Patents

Composition for skin barrier Download PDF

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Publication number
GB2274650A
GB2274650A GB9326077A GB9326077A GB2274650A GB 2274650 A GB2274650 A GB 2274650A GB 9326077 A GB9326077 A GB 9326077A GB 9326077 A GB9326077 A GB 9326077A GB 2274650 A GB2274650 A GB 2274650A
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Prior art keywords
gum
parts
composition according
skin barrier
composition
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GB9326077A
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GB2274650B (en
GB9326077D0 (en
Inventor
Satoru Numata
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Alcare Co Ltd
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Alcare Co Ltd
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Priority to JP03606293A priority Critical patent/JP3310371B2/en
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Publication of GB9326077D0 publication Critical patent/GB9326077D0/en
Publication of GB2274650A publication Critical patent/GB2274650A/en
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Publication of GB2274650B publication Critical patent/GB2274650B/en
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    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L21/00Compositions of unspecified rubbers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005Ingredients of undetermined constitution or reaction products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0031Hydrogels or hydrocolloids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/18Homopolymers or copolymers of hydrocarbons having four or more carbon atoms
    • C08L23/20Homopolymers or copolymers of hydrocarbons having four or more carbon atoms having four to nine carbon atoms
    • C08L23/22Copolymers of isobutene; Butyl rubber ; Homo- or copolymers of other iso-olefins
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L9/00Compositions of homopolymers or copolymers of conjugated diene hydrocarbons
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09DCOATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D123/00Coating compositions based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Coating compositions based on derivatives of such polymers
    • C09D123/02Coating compositions based on homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Coating compositions based on derivatives of such polymers not modified by chemical after-treatment
    • C09D123/18Homopolymers or copolymers of hydrocarbons having four or more carbon atoms
    • C09D123/20Homopolymers or copolymers of hydrocarbons having four or more carbon atoms having four to nine carbon atoms
    • C09D123/22Copolymers of isobutene; Butyl rubber Homo- or copolymers of other iso-olefines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/14Adhesives for ostomy devices
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08Cellulose derivatives
    • C08L1/26Cellulose ethers
    • C08L1/28Alkyl ethers
    • C08L1/286Alkyl ethers substituted with acid radicals, e.g. carboxymethyl cellulose [CMC]
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L3/00Compositions of starch, amylose or amylopectin or of their derivatives or degradation products
    • C08L3/04Starch derivatives, e.g. crosslinked derivatives
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L93/00Compositions of natural resins; Compositions of derivatives thereof
    • C08L93/04Rosin

Description

2274650 Composition for Skin Barrier The Present invention relates to a

composition for a medical skin barrier and, more Particularly. a composition for a skin barrier which is used as the maferial of tapes or the like for fixing medical treating means onto areas of a human body where a relatively large amount of water-containing exudate is exuded. such as for instance an artificial anus. artificial bladder, various fistulas. etc. or for Protecting such areas.

In general. by "skin barrier", a covering material having a skin Protecing function (the function of maintaining the normal -I- physiological condition of skin) is meant, but the skin barrier to which the present invention is applied is, particularly. of the type which has such a water-absorbing function as to absorb sweat and exudate fluids to thereby keep the skin at a suitable humidity.

As this type of skin barriers which are relatively popularly commercialized. there are pointed out products for the protection of artificial anuses, artificial bladders, various fistulas and products for protecting or healing wounds and injuries. For instance, in the case of a product for the protection of artificial anuses. artificial bladders and various fistulas. a skin barrier is used for bonding. onto the skin around the excretion opening. a pouch for stocking therein the feces or excrement, urine or other body liquids excreted from said excretion opening. The skin barrier for bonding or attaching such a pouch is used with the aim of ensuring that the bonding or adhesive force thereof is not deteriorated due to the water contained in the excrement and the sweat oozed out from the skin and that the excrements can be infallibly stocked over a long period of time. Or. in the case where a skin barrier is used for protection or healing of a wound or injury, the skin barrier is required to ensure that the skin barrier can perfectly cover the wound. contact the wound closely to a suitable degree, and absorb the excessive exudate fluids to thereby keep the wounded area in a suitably moist state, and help to heal the wound without sticking fast to the wound it se If.

As compositions which can constitute such a skin barrier, there can be pointed out those such as a composition which comprises a hydrophilic Polymer alone. a composition which comprises a hydrophilic Polymer and a polyhydric alcohol for treating said hydrophilic Polymer into a paste or gel, a composition which is formed in such a manner that, to a hydrophilic Polymer and a hydrophobic Polymer used as base materials. modifiers such as a tackifier, a thickening agent, a moisture maintaining agent. a shape retaining agent, a dispersing agent. etc. are added and rendered into the form of granules, a paste. a gel. or a sheet.

As for the paste composition of the above-mentioned compositions. it is disclosed in Japanese Unexamined Patent Application Publication No. Sho 56-68457 that a small amount of colloidal silica (S10a), prefereably a fumed silica. is mixed into a skin protection bonding paste comprising a mixture of a hydrocollold gum and a film forming resin solution. whereby the paste used is sufficiently improved in respect of its durability, stability and shelf life against intestinal fluids or urine. In Japanese Unexamined Patent Application Publication No. Sho 56-89252. it is disclosed that a small amount of colloidal silica (preferably. fumed silica) is mixed into a mixture consisting of hydrocollold gum and polyhydroxyl alcohol, whereby the resulting paste exhibits a dry adhesion (dry tack) and a wet tack having a high adhesion even if it is contacted with liquid (wet tack) liquid. As for the gel composition, Japanese Unexamined Utility Model Application Publication No. Sho 53-89096 discloses a karaya gum gel product formed in such a manner that a gel composed mainly of karaya gum is embraced by the upper and lower surfaces of a non-woven fabric, a woven fabric, a knitted fabric or other suitable fiber material to thereby enhance the shape retention of said product in its gel s t a t e As for skin barriers composed of a hydrophilic polymer and a hydrophobic polymer as main or base materials, the belowstated products are disclosed in Japanese Unexamined-Patent Application Publications No. Sho 54-3847. No. Sho 57-169414, and No. Sho 54-4491: An adhesive material for ostomy which compirses a mixture consisting of gua gum, carob gum or a mixture thereof. pectin, karaya gum or a mixture thereof, and a mixture consisting of a pressure-sensitive adhesive component and an bonding force increasing agent or a finely powdered cellulose, dextrin, sodium carboxyImethylcellulose or acrylonitrile graft copolymer: a skin barrier composed in such a manner that, to an adherent rubbery cementing agent component and a hydrocolloid as main components, a flow improving agent is added: a medical cementing agent which comprises a mixture consisting of a Pressure-sensitive adhesive component, a mineral oil and a hydrocollid or an adhesive force increasing agent. or a mixture consisting of hydrocollold and an adhesive force increasing agent.

However. among such conventional skin barriers. there is none which is well balanced in respect of the Possession of all the following excellent properties or characteristics: An excellent preservation stability to ensure that the skin barrier can be free from deformation even if it is Preserved for a long time. an excellent flexibility to ensure that the skin barrier can get to fit the irregular skin surface. and an excellent durability to ensure that the skin barrier is free from deformation or collapse while in use.

It is the object of the Present invention to Provide a composition for skin barrier which is well balanced in all the phases of Preservation stability, flexibility. and durability.

In order to achieve the above-mentioned object, according to the present invention. a Part or the whole of the hydrocollold component of a composition which is composed mainly of an adherent rubbery cementing material component and a hydrocolloid component is composed of Psyllium seed gum.

It is advantageous if at least more than 5 parts and less than 150 parts of psyllium seed gum with reference to 100 parts of the adherent rubbery cementing material component is contained as a part of the hydrocolloid component of said composition.

As the adherent rubbery cementing agent. there is used an elastomer component such as natural rubber. Polylsobutylene. polybutadiene. polyisoprene. styrene-isoprene-styrene, polyurethane, polyacrylic ester. polyacrylic alkyl ester. polyvinyl alkyl ether. or polysiloxane. etc. alone or a mixture thereof. Further. it is also possible to add. as required. polyterpene resin, gum rosin. rosin ester, a rosin derivative. oil-soluble phenol resin. cumarone indene resin, or a petroleum hydrocarbon resin as a tackifier and also a mineral oil, a liquid or a low molecular weight elastomer component such as liquid polybutene or liquid polyacrylate as a softener: and it is also possible to further add an antioxidant or the like. Preferable materials for the adherent rubbery cementing agent are polyisobutylene, SIS, polyacrylic alkyl ester, and polyurethane which are all less stimulative to the skin.

As the hydrocollold, either a natural or semisynthetic or synthetic material can be used: in this connection. it is pointed out by way of example that there are natural polysaccharide such as karaya gum, guar gum. tragacanth gum.

locust bean gum. acacia gum (gum arabic), kisantan gum, karaginan. psyllium seed gum, starch. sodium alginate, pectin, gelatin. collagen. semisynthetic or synthetic polymers such as EC, HEC, pullulan, dialdehyde starch. PVP, sodium polyacrylate. polyethylene oxide. hydrophilic polymer synthesized from acrylic acid and starch.

Of the hydrocollold components. the Psyllium seed gum which should particularly be added is the natural vegetable gum collected from the seeds of Plantago ovata Forskal. etc. belonging to the Plantago species (a kind of broad-leaved plantain) cultivated mainly in the Mediterranean region of Europe and India. This psyllium seed gum has long been used as an antifebrile, medical treatment agent pertaining to dysentery, and as a medicament for intestinal sore. dry cough. hoarse or husky voice, burn. skin grazing, etc.; and further, said psyllium seed gum is used as a hairsetting lotion which is an article of cosmetics. as a stabilizer for foodstuffs. as a viscosity increasing/stabilizing agent, etc. As for the properties of the psyllium seed gum. the color of the Psyllium seed gum sold in the market is white and its particle size is 20 to 300 mesh.

In the present invention, it is desirable to use 5 to 150 parts and. more preferably 10 to 80 parts - based on 100 parts of the adherent rubbery cementing agent component - of a psyllium seed gum of 50 to 150 mesh. From the viewpoint of the purpose of the present invention to obtain a skin barrier having a high preservation stability. a sufficient flexibility. such a high shape retention that the skin barrier is not collapsed when it has absorbed water, and a sufficient durability, it is not desirable to use less than 5 parts of psyllium seed gum since. in such a case, the preservation stability of the skin barrier is so poor that. if it is left to stand at a high temperature for a long time. said skin barrier is liable to flow so that it readily gets out of shape. and. when the skin barrier has absorbed water, it is apt to collapse, thus failing to ensure that the skin barrier has a high durability. On the other hand. if more than 150 parts of psyllium seed gum is used, the preservation stability of the skin barrier becomes very high, and its durability against the water absorption thereof also becomes very high, but the flexbility of the skin barrier is spoiled, so that the skin barrier does not well get to fit the skin. and its water absorption is deteriorated: thus. the resulting skin barrier turns out to be unsuitable as such.

The skin barrier according to the Present invention is composed in such a manner that fine particles of the psyllium seed gum which is a part of the hydrocolloid component are dispersed in an adherent rubbery cementing material component. so that said fine particles become cores. which are connected together by the adherent rubbery cementing component. whereby the skin barrier retains its shape; thus. the skin barrier is provided with the advantageous characteristic that the phenomenon can be prevented that. when the other hydrocollold component absorbs water. the skin barrier would be swollen, the adherent rubbery cementing material component would be thinned, and thus the skin barrier would become apt to get out of shape. In the skin barrier according to the Present invention. the flexibility thereof is not lost at normal temperature even if said hydrocollold component (psyllium seed gum) is added in a large amount. unlike in the case of the conventonally used flow improving agent (silica. zinc oxide. talc, or the like).

Examples of the present invention will now be described together with comparative examples.

First. the following four examples of the present invention were produced:

EXAMPLE 1 parts of Polyisobutylene having an average molecular weight of 40.000 ("Polyisobutylene 4W' by Nippon 011 Co.. Ltd.). 40 parts of sodium carboxymethylcellulose ('TMC DAICEL 1190,' by Daicel Chemical Industries Co.), 40 parts of psyllium seed gum having a particle size of 60 mesh, and 5 parts of silica (---Aerosil 300- by Japan Aerosil Co.) were fed into a pressure kneader and subjected to a kneading for 5 minutes to obtain a sheet composition for skin barrier.

EXAMPLE 2 parts of polylsobutylene having an average molecular weight of 40.000 ("Polyisobutylene 4W' by Nippon 011 Co.. Ltd.). 20 parts of sodium carboxymethylcel lulose ('TMC, DAICEL 119V by Daicel Chemical Industries Co.). 80 parts of Psyl 1 lum seed gum of 60 mesh. and 5 parts of silica ("Aerosil 300" by Japan Aerosil Co.) were fed into a pressure kneader and subjected to a kneading for 5 minutes to obtain a sheet composition for skin bar r i er.

EXAMPLE 3 parts of a liquid isoprene rubber having an average molecular weight of 27,000 and a viscosity of 740 poise at 40C (---Kuraprene LIR-W' by Kuraray Co.). 20 parts of sodium carboxymethylcellulose (CMC DAICEL 1190" by Daicel Chemical Industries Co.), and 40 parts of Psyllium seed gum of 60 mesh were fed into a universal mixer and subjected to a mixing for 5 minutes to obtain a paste composition for skin barrier.

EXAMPLE 4 parts of a liquid isoprene rubber having an average mocular weight of 29. 000 and a viscosity of 740 poise at 40t ("Kuraprene LIR-W' by Kuraray Co. ), 10 parts of sodium carboxymethylcellulose ('CMC DAICEL 1190 by Daicel Chemical Industries Co.), and 80 parts of psyllium seed gum of 60 mesh were fed into a universal mixer and subjected to a mixing for 5 minutes to obtain a paste composition for skin barrier.

Next, the following 6 examples - some of which were composed with no content of psyllium seed gum. others were composed with too low a content of psyllium seed gum. and still others were composed with an excessively high content of said psyllium seed gum - were produced as comparative examples:

COMPARATIVE EXAMPLE 1 100 parts of polylsobutylene having an average molecular -g- weight of 40.000 U'Polyisoburylene 4W' by Nippon 011 Co., Ltd.), 80 parts of sodium carboxymethylcellulose (---CMC DAICEL 1190" BY Daicel Chemical Industries Co.), and 5 parts of silica ("Aerosil 30W' by Japan Aerosil Co. ) were fed into a Pressure kneader and subjected to a kneading for 5 minutes to obtain a sheet composition for skin barrier.

COMPARATIVE EXAMPLE 2 parts of a liquid isoprene rubber having an average molecular weight of 29,000 and a viscosity of 740 poise at 401C (---Kuraprene LIR-W' by Kuraray Co.). and 60 parts of sodium carboxymethylcellulose ("CMC DAICEL 1190- by Daicel Chemical Industries Co.) were fed into a universal mixter and subjected to mixing for 5 minutes to obtain a past composition for skin bar r l er.

COMPARATIVE EXAMPLE 3 parts of polylsobutylene having an average molecular weight of 40.000 (--- Polyisobutylene 4W' by Nippon 011 Co., Ltd.), 56 parts of sodium carboxymethylcellulose ("CMC DAICEL 1190 Daicel Chemical Industries Co.), 4 parts of psyllium seed gum of 60 mesh. and 5 parts of silica ("Aerosil 300" by Japan Aerosil Co.) were fed into a pressure kneader and subjected to a kneading for 5 minutes to obtain a sheet composition for skin barr!er.

COMPARATIVE EXAMPLE 4 parts of a liquid isoprene rubber having an average molecular weight of 29.000 and a viscosity of 740 poise at 40t C'Kuraprene LIR-W' by Kuraray Co.), 56 parts of sodium carboxymethylcellulose ('CMC DAICEL 1190" by Daicel Chemical Industries Co.), and 4 parts of Psyllium seed gum of 60 mesh were fed into a universal mixer and subjected to a mixing for 5 minutes to obtain a paste composition for skin barrier.

COMPARATIVE EXAMPLE 5 parts of polyisobutylene having an average molecular weight of 40.000 U'Polyisobutylene 4W' by Nippon 011 Co., Ltd.), and 160 parts of psyllium seed gum of 60 mesh were fed into a pressure kneader and subjected to a kneading for 5 minutes to obtain a sheet composition for skin barrier.

COMPARATIVE EXAMPLE 6 parts of a liquid isoprene rubber having an average molecular weight of 29.000 and a viscosity of 740 poise at WC (---Kuraprene LIR-W' by Kuraray Co.), and 160 parts of Psyllium seed gum of 60 mesh were fed into a universal mixer and subjected to a mixing for 5 minutes to obtain a paste composition for skin barrier.

Subsequently. the examples of the present invention and the comparative examples mentioned above were examined in respect of the tack, stability. flexibility, durability and water absorption. which are all properties required of a skin barrier. The results obtained are shown in the following table. in which the mark "0 " stands for -very good". the mark "0 " stands for---good---. and the mark "x" stands for "bad". As is apparent from this table, the examples of the present invention all alike have well-balanced excellent properties. whereas. in the case of the comparative examples. at least a part of said properties is bad in any of them: and thus. they are not adequate as skin barriers.

TABLE 1

Tack Stability Flexibity Durability Water Absorption Example 1 0 0

Example 2 0 @ 0 Example 3 0 0 0 Example 4 0 0 0 Comparative 0 X X 0 Example 1

Comparative X X 0 Example 2

Compartive 0 X X X Example 3

Comparative X X X Example 4

Comparative X 0 X 0 X Example 5

Comparative X X X 0 Example 6

According to the present invention. a suitable amount of psyllium seed gum is added as a component of skin barrier, whereby there is obtained a skin barrier which is well-balanced in respect of all such properties as tack, preservation stability, flexibility, durability and water absorption which are required of such skin barrier. The present invention thus can provide a composition for skin barrier very useful in medical use.

Claims (11)

1. A composition for a skin barrier which comprises a base component of an adhesive rubbery cementing material and a hydrocolloid component, 5 wherein at least a part or the whole of the hydrocolloid component is composed of psyllium seed gum.
2. A composition for a skin barrier according to claim 1, wherein there is present 5 to 150 parts of psyllium seed gum per 100 parts of the base component.
3. A composition according to claim 2, wherein there is present 10 to 80 parts of psyllium seed gum to 100 parts of the base component.
-
4. A composition according to claim 1, 2 or 3, wherein the psyllium seed gum has a particle size in the range 50 to 150 mesh.
5. A composition according to any preceding claim, wherein the hydrocolloid component is a natural polysaccharide, a synthetic or semisynthetic polymer or a hydrophilic polymer.
6. A composition according to claim 5, wherein the hydrocolloid component is karaya gum, guar gum, tragacanth gum, locust bean gum, acacia gum (gum arabic), kisantan gum, karaginan, psyllium seed gum, starch, sodium alginate, pectin, gelatin, collagen, carboxymethyl cellulose (CMC), ethyl cellulose (EC), hydroxyethyl cellulose (HEC), pullulan, dialdehyde starch, polyvinylpyrrolidone (PVP), sodium polyacrylate, polyethylene oxide, and hydrophilic polymer synthesized from acrylic acid and starch.
7. A composition according to any preceding claim, wherein the base component is an elastomeric k material.
8. A composition according to claim 7, wherein the base component is natural rubber, polyisobutylene, polybutadlene, polyisoprene, styrene-isoprene-styrene, polyurethane, polyacrylic ester, polyacrylic alkyl ester, polyvinyl alkyl ether, polysiloxane or mixtures thereof.
9. A composition according to claim 8, wherein a tackifier, a softener or an antioxidant is added to the base component.
10. A composition according to claim 9, wherein the base component in addition includes polyterpene resin, gum rosin, rosin ester, a rosin derivative, an oil-soluble phenol resin, cumarone indene resin, a petroleum hydrocarbon resin, a mineral oil or a liquid or low molecular weight elastomer.
11. A composition substantially as hereinbefore described with reference to and as illustrated in Examples 1, 2, 3, or 4 of the accompanying examples.
GB9326077A 1993-02-01 1993-12-21 Composition for skin barrier Expired - Fee Related GB2274650B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP03606293A JP3310371B2 (en) 1993-02-01 1993-02-01 Skin protective material composition

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GB9326077D0 GB9326077D0 (en) 1994-02-23
GB2274650A true GB2274650A (en) 1994-08-03
GB2274650B GB2274650B (en) 1996-06-26

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000094A1 (en) * 1994-06-24 1996-01-04 Coloplast A/S An adhesive agent and use of such agent
WO2001091684A2 (en) * 2000-05-26 2001-12-06 Kimberly-Clark Wordlwide, Inc. Menses specific absorbent systems
WO2007114726A1 (en) * 2006-04-06 2007-10-11 Boris Karpovich Gavrilyuk Monolayer wound coating and a method for the production thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7651485B2 (en) * 2002-11-27 2010-01-26 Bristol-Myers Squibb Company Ostomy pouch adhesives such as polysiloxanes that are resistant to stomal effluent

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1088992A (en) * 1963-09-19 1967-10-25 Squibb & Sons Inc Protective dressings
GB1598966A (en) * 1977-06-08 1981-09-30 Squibb & Sons Inc Ostomy adhesive
GB1598968A (en) * 1977-06-08 1981-09-30 Squibb & Sons Inc Ostomy composition
US4367732A (en) * 1980-12-05 1983-01-11 Coloplast A/S Skin barrier

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154806C (en) * 1986-12-19 1989-06-26 Coloplast As Saarplejemiddel containing an active substance for the promotion of wound management and process for production thereof
US4952618A (en) * 1988-05-03 1990-08-28 Minnesota Mining And Manufacturing Company Hydrocolloid/adhesive composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1088992A (en) * 1963-09-19 1967-10-25 Squibb & Sons Inc Protective dressings
GB1598966A (en) * 1977-06-08 1981-09-30 Squibb & Sons Inc Ostomy adhesive
GB1598968A (en) * 1977-06-08 1981-09-30 Squibb & Sons Inc Ostomy composition
US4367732A (en) * 1980-12-05 1983-01-11 Coloplast A/S Skin barrier

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000094A1 (en) * 1994-06-24 1996-01-04 Coloplast A/S An adhesive agent and use of such agent
WO2001091684A2 (en) * 2000-05-26 2001-12-06 Kimberly-Clark Wordlwide, Inc. Menses specific absorbent systems
WO2001091684A3 (en) * 2000-05-26 2002-03-28 Kimberly Clark Wordlwide Inc Menses specific absorbent systems
GB2379394A (en) * 2000-05-26 2003-03-12 Kimberly Clark Co Menses specific absorbent systems
GB2379394B (en) * 2000-05-26 2004-07-21 Kimberly Clark Co Menses specific absorbent systems
US7687681B2 (en) 2000-05-26 2010-03-30 Kimberly-Clark Worldwide, Inc. Menses specific absorbent systems
WO2007114726A1 (en) * 2006-04-06 2007-10-11 Boris Karpovich Gavrilyuk Monolayer wound coating and a method for the production thereof

Also Published As

Publication number Publication date
JP3310371B2 (en) 2002-08-05
GB9326077D0 (en) 1994-02-23
JPH06225931A (en) 1994-08-16
DE4400568A1 (en) 1994-08-04
DE4400568C2 (en) 1996-02-15
GB2274650B (en) 1996-06-26

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Effective date: 20071221