CN1543421A - Water soluble packaging - Google Patents

Abstract

The invention is concerned with controlled release packaging comprising packaging material which is at least partially or substantially completely dispersible or dissolvable in an effective amount of a water-containing substance and which is adapted to comprise, contain or enclose one or more substances wherein the packaging is adapted for release of comprised, contained or enclosed substances in response to a predetermined stimulus in predetermined manner to a desired locus with substantially simultaneous or subsequent partial or complete dispersal or dissolving thereof.

Description

Water soluble package

The present invention relates to a kind of can be to small part or fully be dissolved in basically in the water, in order to the improved packing of h substance controllably, be used to the method that adopts this packing controllably to discharge, be used to make its method, discharge the purposes and the novel product that comprises this packing of extensive material.

Water soluble package arranged in that the document that is used for dispensable materials is known, this water soluble package partially or completely dissolves, and only stays seldom or does not have remnants.Such packing independently as in the stand alone type packing, perhaps are used for being used in combination with the non-solubility distributing box.These packing discharge the material that held, for example dangerous substance, fungicide etc., by the stain remover etc. for example of dissolving enrichedmaterial in water.

The advantage of this packing is, owing to reduced the splash in dilution of dangerous substance and the risk of overflowing, the danger of before dissolving, holding dangerous powdered rubber and preventing to suck, avoid adopting the needs of the safe handling of the packing that are used for dangerous substance etc., provide the quantitative of metering in advance as individual packages with the amount of stipulating, be convenient to carrying, the loss of material dregs, packing processing etc. minimized, so the advantage of this packing is tangible.

Although in some applications can not be satisfactory, in some applications, has the abundant residues thing, for example surface film is an acceptable.

Along with big quantity of material is released, there is the danger of breakage of packing failure.(Rhone Poulenc Agric Limited) discloses this packing in EP-A-763479, and wherein, the liquid substance that needs to discharge comprises a kind of additive in order to strengthen its viscosity.Yet this solution for problem can not be entirely satisfactory, and therefore needs sufficient restorability so that can hold a kind of water soluble package of material reliably till the moment that needs distribute.

Adopting the encapsulation technique of water-soluble glue capsule material is known in pharmaceuticals industry, be used for by adopt gel, cellulose and derivant as capsule material by with oral delivery of drug substances, vitamin, the enriching substance etc. of being used for.Gel, cellulose and derivant etc. are to be dissolved in fully basically in the water, and make the approved capsule material that is used for food and medicine purposes.These capsule materials are used in vivo in dissolving in the scope in a whole period under the different condition.

Known in the literature solubilized gel pockets, be used for holding and storing Powdered flavoring, pigment and other in fact dry composition of food at a jar, as the part of prepackaged food, the noodles that dewater for example, in described jar, add hot water, so that preparation is used for food consumed.The fault of these pouches or break and to cause the loss of content.

All the time there are the needs that improve packing and structure, so that expand the useful applications and the purposes of a large amount of water soluble package materials potentially.

An object of the present invention is to provide a kind of packing, this is packaged to small part or can disperses substantially fully and maybe can be dissolved in the hydrous matter, so that discharge the different solids and the flowing material of wide scope controllably with the various ways that extensively is, thereby this packing is a general-duty, and is easy to desired substance is operated or used in required mode.

Now, we surprisingly find, according to the present invention, can adopt that comprise can be to small part or be dissolved in the packing of the material in the hydrous substance substantially fully so that with satisfy before this mode of the target of definition provide be suitable for discharging held or the prescription of osed top material and the new combination of structure.

In the wideest scheme, according to the invention provides a kind of controlled release packing, this packing is included in can be to small part or the packing that disperse or dissolve fully basically in the hydrous matter of effective dose, it is suitable for comprising, comprises or is equipped with one or more materials, wherein, this packing be suitable for responding predetermined stimulation, in a predetermined manner, along with its basically simultaneously or subsequent section or disperse or dissolve fully, with included, comprise or the material that is equipped with is released into the desired position.

This material is discharged by the mode with solid or liquid, and preferably selects from powder, particle, crystallization, microcapsules, monolithic, suspension, dispersion, enrichedmaterial, gel, thixotrope, non-aqueous solution etc. and composition thereof.Solid matter can be in required grade or rate range.For specific application, be desirable to provide meticulous material and the process form that is used for lasting effect.An advantage of the invention is that indivedual dosage of material comprise the required scope of solid grade, and be not subjected to the adverse effect of " precipitation ", and this is to cause owing to the transportation of material and storage content or with combining of the material with variable grain grade.

D/d material can disperse with water or the solubilized packing form an integral body, and described water can disperse or the solubilized packing can and/or wherein comprise or hollow block, container or shell be housed for the shell of solid or hollow block, a hollow container or a separation container.

This packing is characterised in that, the selection of the feature of packaging structure and/or structure, packing prescription etc. or the combination of feature are to be the selection that new characteristic is provided or the combination of characteristic.More particularly, this packing is characterised in that with the new selection or the combination of transporting and storing relevant feature, for example by the packaged preparation form structure or the structure that comprise sealing and reinforcement, opposing causes the influence of release too early; The characteristic of the material that comprises, comprises or be equipped with, but described material can be viscosity or inviscid fluid, the flowing powder of non-densification and being difficult for and the material of operating or controlling of other form; The feature and/or the time that discharge, for example for simultaneously or follow-up mode discharge the combination of a kind of material or material, perhaps be used for the mode h substance that contacts with other material with in required place, so that the in-use performance or the quality of raising material; The characteristic of predetermined release of irritants etc., for example originally as hydrous matter, physics or chemical stimulation or their combination in required place.Described feature or characteristic can be disperseed or resolvability packing prescription, the additional materials or the material that constitute or construct from water dissolvable or dispersibility packing and/or by water, perhaps, and also can select according to its purposes from the structure or the structure of packing.

This packing can be disperseed or their combination of solubilized packing or definition before this constitutes by water basically, perhaps as the front is defined, can comprise additional material, and these additional materials to small part can disperse maybe can dissolve.Preferably, as previously described, this packing can be dissolved basically fully.

Here the hydrous matter of mentioning is meant any solid-state, semisolid, liquid state or gaseous state (steam) fluid, and they comprise the effectively water of the amount of dispersing or dissolving.Water can perhaps can freely be obtained, and can collect from material or gather or be easy to and taken away by material immediately by chemistry or physically combination releasedly.Preferably, as previously described, hydrous matter comprises the water of liquid or gas form, perhaps its water or solution or vapour mixture, and for example alcohol etc. perhaps comprises having solid combination or obtainable water or semisolid.Water can disperse or the solubilized packing are accumulated by water, described water can disperse or the solubilized packing disperse or dissolve at least in part, so that the material that will comprise, comprise or be equipped with is discharged in the water of accumulation, and according to the purposes or the other factors that use, these packing that disperse or dissolve can be retained in this place or loose from this punishment.

Here the pre-determined stimulus of indication be cause comprise or any stimulation that the osed top material discharges.This stimulation can comprise be used to dissolve or disperse, by the transformation of separating out or metamorphosis takes place, break, rupture or other causes packing or its part can be permeated chemistry or physical stimulation comprise or the osed top material so that discharge institute.

This stimulation can be identical or different with the hydrous matter that is used to disperse or dissolve.Packing can disperse or dissolve in heat or cold hydrous matter, and/or can be by dissolving or other physics or chemical mode h substance, described chemical mode for example for be exposed in heat, acid or alkali, solvent and the solvent mixture, in the oxidizing condition, the emittance that comprises UV, microwave etc. or biodegrade.

Here alleged place be meant wish to be released material enters or the place Anywhere, zone etc.This place can with wish that the place that material plays a role is identical or different, but should with this ground spot correlation that plays a role.

Preferably, this is packaged on structure, structure or the prescription and comprises first and second parts, be suitable for substance dissolves and be released into required place, and control discharges stimulation or external action that element is subjected to, so that discharge with regularly predetermined and predetermined way.

This packing can comprise any suitable material, and this material can form packing, and can disperse or dissolve in hydrous matter, so that only stay its part as resistates, does not perhaps stay resistates basically.

Preferably, this water can disperse or the solubilized packing comprise natural or synthesized polymer body or its compound of selecting from below:

Polyvinyl alcohol (PVA), polyethylene oxide, chemically modified fibre element or cellulose ether and other cellulose derivative, converted starch, polyvinyl pyrrolidone, polyacrylamide or gelatin or its derivant.Chemically modified fibre element and cellulose ether are included in alkyl and/or hydroxyalkyl instead of cellulose or the cellulose ether that has 1 to 4 carbon atom on the alkyl chain, be preferably, methylcellulose (ether), hydroxyethylcellulose, HEMC, the rare ethyl cellulose of hydroxyl second, hydroxypropyl cellulose (chemical name is a HPC), hydroxypropyl methylcellulose (HPMC, chemical name are cellulose hydroxypropyl methyl ether), hydroxy butyl methyl cellulose etc.Converted starch comprises destructurized starch, crosslinked granular starch, comprises the chemically modified starch of the alkyl of substituted starch, amino starch and oxidized starch, dextrin and maltodextrin.

According to independently mechanical characteristic or their combination (" soft " or " firmly " and/or self-supporting or non-self-supporting, resilience and break too early or other characteristic) and/or independently chemical nature and their combination (slowly or soon, dissolving wholly or in part, response that required release is stimulated etc.), avirulent needs (for environment, the human or animal is healthy or the application relevant with food), can select suitably or change that water can disperse or the solubilized packing.For example, by changing or selecting aqueous ingredients, pH, water holding capacity, expanded feature, gel strength, gel point, viscosity, concentration, substituted in reaction group (crosslinked) and, water can be disperseed or the different formulations of solubilized packing and the combination that combination has desirable characteristics to emittance such as a large amount of external excitations, for example temperature, pH, solvent, solvent mixture, oxidizing condition, for example UV or microwaves, by the biodegradable sensitieness that mould and bacterium etc. carries out.For example resemble Capsules at Hard, ed.Ridgeway, it is disclosed among the WO98/27151 (Warner Lambert) that prescription and formula technique are known like that, the content of this application is in this combination as a reference.

Preferred packing comprise basically can be water-soluble fully gel, starch or cellulose or their derivant and compound.We find natural or synthesized gel rubber and HPMC have useful especially characteristic.

As previously described, packing of the present invention can be for being suitable for comprising or being equipped with any desired structure and the structure of solid-state or flowing material.Preferably, this packing comprises various forms of packing: solid-state or hollow block, hollow container or closed shape, for example capsule, sack, folder bag or pouch, sphere, taper, elongated shape, annular or cone-shaped bag etc. or closure, for example diaphragm, dividing plate, cover, lid etc.This structure or structure can according to control needs, storage needs (can pile up or can effectively to utilize the space, to be that cubical mode is stored), purposes (be suitable for being configured to being arranged in an environment supporting mechanism or with this supporting mechanism to getting in touch), adjustable property (can be releasably connected on a partition line, hook, the frame etc., so that touch) etc. selects.

Packing as previously described can provide the keystone configuration or the zone of packing, in order to strengthen, reinforcement, in dispose procedure, keep the globality of packing or be used for other purpose, for example skeleton, framework workpiece, fiber, sieve aperture, ribbing, knot, sealing etc., perhaps form one or link to each other to small part with second structure that is the continuous substantially packing of desired structure.

Selectively or additionally, this packing can comprise that the master of a sheath form comprises or encapsulating housing or layer, tablet etc., it comprises or is packaged with second of packing and comprises or encapsulated layer.

Selectively or additionally, this packing can comprise the master package material with the secondary point that weakens, the form of described secondary point is easy to rapidly or easily dissolve or break for the packing at this place have, perhaps cracking or introduce the characteristic of water, its form for example forms press back or embossing, tear-open strip line etc. for the form that does not penetrate.

Foregoing main and secondary structure and layer and weakness can comprise aforementioned identical or different packing and their combination, have identical or different characteristic, for example thickness etc.The Different Package material comprises at least a packing, and these packing are that water can disperse or the solubilized packing, and it can be the identical or different at least a packing that are suitable for discharging as previously described.

Selectively or additionally, this packing can comprise the measure that is used for being located at or being positioned at described place, in described place, the material that is comprised is released to be fixed in order to the mode on the optimum position of storage or to discharge the mode that stimulates with timing or activation, for example be used for the operation that is dissolved in the water in the place that discharges element, perhaps this packing is remained on the described position, so that in processes such as processing and storage, resist for example influence of impulsive force.

As previously described, this registration device can comprise the packing that are suitable for a suitable strut member cooperation, for example can comprise abundant elasticity of having of an elongation or flexible part, be suitable in holding the environment of this packing being or being hooked on the suitable projection or being positioned at around it, perhaps be received in the groove of an effective support part, the projection that perhaps can comprise the elastically deformable that extends in the opposite direction from the packing that comprise or encapsulate as previously described, and be suitable for being deformed into the relative maintaining body of effective bracing or strutting arrangement, position between the surface etc., and kept by elasticity.

Selectively or additionally, this packing comprises that one is suitable for absorbing or disperses that packing may be subjected to and can cause concrete structure, structure or the form of external action of the too early release of the material that institute comprises or encapsulate.For example, this packing can have the protection shape to the flowing material that comprises or encapsulate, so as to make store and carry in turbulent flow minimize, and can comprise the packing of the thickness that is suitable for bearing external action, intensity, elasticity, elasticity etc.

Aforementioned packing can be a self-supporting.

Selectively or additionally, aforementioned packing comprises the device that helps the material that rapid release comprised or encapsulated.In this case, this packing comprises that the form that is used for utilizing the combination or be included in the supplementary element of packing strengthens it to discharging the mechanism of the response that stimulates.Preferred corresponding enhancing mechanism is suitable for by contacting with hydrous matter, expand and cause discharging, for example comprise expanded or expanding agent (cornstarch), effervescent agent (sodium bicarbonate and citric acid), disintegrant (ExplotabTM that can obtain from Penwest Pharmaceuticals or the PrimojelTM that obtains from Avebe), dispersing agent (sodium starch glycollate, mosanom, carboxy methyl cellulose sodium salt etc.), perhaps contain gas, for example has the air of positive overvoltage etc., the boost inductor agent, for example be suitable for variation along with pH (in the degree of acid or alkali condition, change, or between bronsted lowry acids and bases bronsted lowry, change), variation of temperature, be subjected to microwave, UV, solvent or solvent mixture etc. and cause release.Response strengthens mechanism can form one with the packing of packing, perhaps be included in the many unlimited or blind bore wherein, so that the aforementioned surfaces zone and the weakness of increase are provided, be used for for example discharging by the dissolution that contacts with water, and provide that the air that is comprised varies with temperature, effervescent agent contacts with water, the contacting and the expansion that produces of microwave, UV, solvent and solvent mixture etc.

In another scheme of the present invention, a kind of method that is used to produce aforementioned packing is provided, comprise forming aforementioned packing, and introduce one or more aforementioned materials that will discharge, so that it is comprised, comprises or is encapsulated in wherein.According to the shape of purposes, the material that will discharge and packing, this manufacturing can be carried out with a kind of shirtsleeve operation or required order.This production method can be suitable for obtaining any aforementioned forms, structure, structure etc.

This packing can form by aforementioned any known device that is used to form packing.Proper device comprises any device that is used to form thermoplastic material, described thermoplastic material comprises does not have remaining one or more seal strips, by heat, for example water equal solvent, vacuum, pressure, extruding, moulding, for example make one or more sheet materials distortion by dipping or the effect that sprays on a former, foundry goods, the embossing etc. by dissolving or fusion.

Described material can comprise, comprise or be encapsulated in the packing by any known machinery or chemical method, described machinery or chemical method for example comprise by fusion, stir or be mixed in a kind of fusion packing or its solvent and form this material or material jointly, perhaps for example by water or a kind ofly respond to the softening packing of agent and oneself and be bonded to softening or be similar on the softening packing, adopt or do not adopt heat and pressure ground to bond or welding, and make packing seal described material with solvent, gel etc.Preferably, described sealing is to be undertaken by disclosed technology in the patent announcement of signature Capsugel, particularly, be by making packing the edge with one low-melting fluid-encapsulated, for example organic solvent contacts and apply heat energy or cause that dissolving carries out, described low-melting fluid-encapsulated for example be organic solvent, replace C as alkyl _1-5The solution of the proteolytic enzyme of alcohol, water, polymer solution or emulsion, production protein solution or emulsion, for example as the sealing of disclosed relevant capsule in EP0152517, EP0180543, EP0116744 and EP0116743, the content of these documents is combined as reference at this.

Aforementioned point of weakness can be arranged on by known measure in the packing, and described measure comprises by embossing or molding in the shape of packing such as necking down, by laser explosure or by molecular orientation in the chemical constitution of predetermined packing or order.

Aforementioned packing can be suitable for holding the solid-state or fluent of any required quality or volume.Suitably, the form of packing and structure are partly to select with reference to the volume required and characteristic of the material that will comprise or encapsulate.Preferably, this packing is suitable for comprising the material of the volume that reaches 10 liters, for example in 0.1ml to 10 liter scope.The scope of inferior one-level that is used for contemplated application is preferably in the scope of 0.1～5ml, 5～50ml, 50～500ml, 500ml～5l and 5～10l.This packing can be suitable for having with the material volume that will hold and equate or bigger volume, for example reaches three times of the volume that will comprise.Can select the volume of this packing, with material it be filled being convenient to.Suitably, this packing is suitable for comprising or encapsulating one or more materials that will discharge of single metered amount.

Packing can be suitable for bunchy, perhaps can comprise a bunchy element.Surpass in single metering under the situation of the amount of substance that may hold or encapsulate, if perhaps metering is preferred, perhaps need by simultaneously or under the situation about discharging controllably subsequently in the selection of material, packaged material can adhere to by the oneself, bunchy annex etc. and by bunchy or polymerization.

Packing can comprise a plurality of intervals, so that before discharging material is kept apart, perhaps provides orderly release.

Aforementioned packing can comprise a recognition component, for example can print directly or indirectly, molded, for example form flexible packages by closely centering on the material that is comprised, have molded projection or embossing, laser labelling etc., so that the characteristic of instruction content thing or the place of production, use pattern or design-calculated are in conjunction with feature.Preferred utilization can be dissolved in the water fully and be suitable for printing from non-aqueous solution or from the ink of aqueous system printing, fuel etc.

Aforementioned packing can be suitable for by contacting with aforementioned hydrous matter basically moment ground h substance, perhaps in order to use immediately in the controlled time of a few minutes h substance, when hope fill this pack side by side the idle loop border in case when discharging in a quarter or half an hour h substance, be filled into the process of inconvenient or maccessiable place or corresponding stimulation when the packing that will be used for discharging in hope, h substance in several hours or several days, for example wish under natural or situation about manually discharging water, to wish h substance, for example with rain or have a mind to or discharge water consistently unintentionally, described discharging water is any chemistry, machinery, structure, the part of manufacturing or similar procedure.

This packing can have the additive that is suitable for strengthening barrier characteristics, for example obtains or strengthens impenetrability for oxygen etc.

When utilizing tradition or improved capsule technique to its weighting substance, packing can be one or many of assembling.

Packing can be any required thickness, for example in the scope of 0.01-10mm.Special benefits of the present invention is, can obtain the minimum thickness in 0.01～1.0mm scope for example and prevent the elasticity of cracking, and can obtain the maximum ga(u)ge in 2～10mm scope for example and reach required precision drop away time, by selecting the performance and the characteristic of packing, structure that packing are solid-state or structure, for example aforementioned packing of the present invention structure and weaken a little.

Be to be understood that, aforementioned packing can be suitable for keeping the integraty of packing before h substance, and can or disperse with release dissolving simultaneously, perhaps in the period of a prolongation, disperse subsequently or release, in the process that this material has effectively been discharged or afterwards simultaneously, also remain on desired location that hydrous matter contacts on.

If keep its surface not contaminated extremely important, then packing can also be arranged in the additional film or container.

The packing material that maybe will hold can comprise additional indicator element, and for example one when the part of dissolving when finishing or indicating when material reaches its required effect.In case solvent carries out fully with h substance, then the colorant in the material can be detected in moisture place.Colorant can be relevant with this material, thereby in case in use material be consumed, then color disappears.

In further scheme of the present invention, provide a kind of be used for controlling from aforementioned water can disperse or the solubilized packing discharge the method for aforementioned substances, comprise this packing is positioned a place that is used to discharge and be subjected to discharging stimulation, for example contact actv. period with aforementioned hydrous matter with the actv. amount of dispersing or dissolving, so that activate aforementioned release, and material is discharged in this place, wherein, this packing is basically simultaneously or subsequently to small part or be dissolved in the hydrous matter substantially fully.This packing can comprise any aforementioned structure, structure or form feature.

The advantage of this method is, reduce the danger that objectionable impurities spills or overflows in dilution, before dissolving, hold harmful powdered rubber, and prevent the danger that sucks, avoid needing being used for the safe handling of the packing of dangerous substance etc.,, provide the metering of measurement in advance with the amount of appointment as individual packages, be convenient to carry, the waste of material dregs, packing processing etc. is minimized.

The aforementioned method that is used for controlling release can be used for a kind of material is discharged into any required application of an environment, has aforementioned any advantage simultaneously.

This packing can be located immediately at required place, perhaps can utilize suitable mechanism to be delivered to required place, keeps not contacting with hydrous matter.

Packing of the present invention can be suitable for before discharging content, in the time of in adding a water receiver, in water, sink or floating, sink or come-up and perhaps at first subsequently through floating after the schedule time or for example sink as indication or make the liquid water content maximum before discharging etc. or minimize.

The present invention can be used to discharge the agrochemical material, comprises insect or plant growth control agent, plant disease-controlling agent, soil conditioner etc.For example the insect growth control agent comprises insecticide, acaricide, rat-bane, molluscicide, kills for example for example germ, predator and natural products of telergone etc. and biocontrol agent of slug agent, vermicide (nematicide, helminthagogue), soil fumigant, exterminator and attractant; Plant growth control agent comprise herbicide, defoliant, desiccant, shattering agent and set controlling agent, the cmpd of taking root (rootingcompounds), sprout inhibitor, growth stimulant and growth inhibitor, liver moss and lichens controlling agent and plant gene controlling agent or preparation; Plant disease-controlling agent comprises fungicide, virucide, wood preservative and bactericide; And soil conditioner comprises fertilizer, trace metal additive, bacterial action control stimulant and soil consolidation agent.

Application such as this method can by technology such as spray, dusting, drillings, be used to cultivate with industry or family expenses scale, greenhouse, gardening, forestry.

The advantage of this method comprises aforementioned advantages, and may further include following advantage: safety of operation, comprise and reduce the risk polluting or carry down, and can not contact with reactive material skin, be convenient to and be easy to use, need not measure, pour into gently or used pouch is resealed, distribute as required, so that handle the packing of polluting, accurate quantification control avoids the user to be exposed in the dust granule, be provided at the dissolubility in the cold water, provide greater flexibility aspect the metering selection, and having commercially available particle, can cause the danger of product degradation in case minimizing is opened, make particle size for the dissolving optimization, and adopt minimized packing.Further advantage comprises not and adhesion such as spray spout, does not need to adopt mixer, does not have resistates, and anti-leak guarantees packing, and the cost of unit metering area is low.

This method also is suitable for discharging environmental treatment agent, for example water scavengine agent, disinfectant, waste disposal agent etc., comprise the controlling agent that is used for aquatic virus, bacterium, the biosome of carrying disease and insect, natural and industrial pollutants, comprise aquatic plants growth controlling agent, soil losses dispersing agent, cooling and circulating water neutralizing agent etc.As described above; advantage is to be used for the agricultural application and comprises following advantage: adopt gratifying material to be used for purifying and quote water; and utilize particle or do not dissolve solid-state packing or residue provides free from contamination special quality water, and cleansing action is rapid.Material can be released in the water or in the required place with the desired concn that is suitable for required effect, for example discharge with lower amount, so that, perhaps discharge, so that produce the solution that is suitable for an object that will purify, sterilize or handle or place with higher amount to consumption safely.

This method should be noted that safe material in the time of can being used to carry use, dangerous substance for example, comprise: the cleaning substance of agent of erosion, chemical reagent, discharge etc., these materials can use with the form of dilution, although they remain undesirable under powder, anhydrous or conc forms, but be safe comparatively speaking, still, in solution, then become dangerous material.In this case, the packing of unit dose can provide safe processing, and they guarantee correct dilution, and is safe for use.Except aforementioned advantages can be provided, also have further advantage, for example,, eliminated needs with the dilute form transportation wound packages material of danger by the measure of being carried out the safety dilution by the end user is provided.

This method can be used to dilute pollutants solid-state or liquid form, that for example concentrate and their composition, comprises any known stain remover or the cleaning agent that are used to clean the family expenses or the industrial stain remover of house, object and cloth and are used for the personal hygiene purposes.Its advantage comprises the above-mentioned advantage that provides, also comprise: packing can not stayed on hand, so have aesthetic advantage, and compare with powder or tablet, the transportation aspect is more satisfactory, has high integrality structurally, to prevent material division or the danger of overflowing, the danger that has reduced in a single day master package to be opened and caused product to go bad, and prolonged Keeping life relatively, have higher potential efficient, and can effectively carry crucial component, be easier to make, prescription and use, and reduced concentrated infringement clothing, the risk of skin and other article, and present and can selectively be used for the therefrom bag or the device of h substance, the soften flux that makes aequum also had in addition, bleaching agent, brightener, dispersing agent, effervescent agent and other comprise phosphatic solubilizer.These parts usually can be along with the time is rotten; perhaps may not spread all over stain remover relatively poorly; quantitative or the order in unitary package of the multi-functional material in the single dose is quantitatively for example had in a kind of another kind of material that wraps in or be contained in the packing, envelope-bulk to weight ratio is minimized.

This method can also be used to discharge food, comprise dried or powder solid, liquid and volatility form flavoring additives and spices, texturing agent, pigment, hygroscopic agent, for example rice, corn flour, salt and packing itself, oil and fat, dry milk product and other food at the oxygen mesometamorphism, seasonings and herbal medicine etc.The method that is used to discharge food has aforementioned advantages, and have following advantage: accurate dose control provides with the standard kitchen and has measured relevant size, for example not adopting needs the packing that the user opens and component separating is opened, for example in convenience food packages, help environment, avoid unedible less important packing, but microwave cooking, the not danger of being polluted by less important package panel, clean and be easy to carrying, edible land used packing, in hot water, be not easy to residual, sealed with respect to air, can keep the fresh and pot-life, taste masking and smell till when needs for example avoid polluting other food etc., the vitamin of flavoring additives, color, the maintenance of purity etc.A special advantage is, owing to make contact separation in storage, so this packing can be used to make the rotten of material to minimize, can provide the dispersiveness of improvement simultaneously, and by with discharge the best mode that contact and locate food and contact with release.

In the further scheme of the present invention, provide a kind of novel product that comprises aforementioned packing.Suitable novel product comprises the product of the aforementioned ad hoc approach that is suitable for having associated advantages.This product can be used for loading therein the material that is used to discharge, and perhaps can hold described material.This product can comprise have aforementioned structure, the packing of structure and form feature.

Now, in the mode of indefiniteness with reference to following description of drawings the present invention.

Fig. 1 a-1i is the cross-sectional schematic according to packing of the present invention.

Fig. 2 a and 2b are the scheme drawings according to packing of the present invention, and this packing comprises main and secondary structure, and it constructs selection;

Fig. 3 a and 3b are enlarged drawing and the cross-sectional schematic that comprises the packing of registration device according to of the present invention;

Fig. 4 a-4c is the diagram according to packaging structure of the present invention and manufacture method;

Fig. 5 a and 5b are the diagrams according to bunchy element of the present invention and bunchy packing;

The packing of in Fig. 1, representing various situations with the structure that obtains by dipping from the melt of packing or solution and structural form.In Fig. 1 a to 1g, that represents shell (11) and connecting portion (12,13) form comprises that water can disperse or the capsule of solubilized multilayer and/or many parts material.

Fig. 1 a represents a capsule that has the instant packing of center individual layer and peripheral double-deck fast-slow and slow-fast dissolve wrapper material respectively, is suitable for providing aforementioned weakening to connect or weakness.As the alternative structure of Fig. 1, in Fig. 1 b, represent an outer field capsule that has center and the instant and slow molten packing of peripheral individual layer and fast-slow dissolve wrapper material respectively.It is contemplated that the modification of these structures, and can be determined according to required easily manufactured property and required release characteristics.

The capsule of Fig. 1 a can be made like this, for example a profiled member is immersed in the corresponding solution of slow and fast dissolve wrapper material or melt respectively one first degree of depth, then by in solution of instant packing or melt, immerse a bigger degree of depth, to form shell (in 11a is, 11d is outer), form part (11b) simultaneously, and finally use housing (11d is outer) to fill and the folding part (11b) that covers, form sealing member (11c) simultaneously.

The capsule of Fig. 1 b can for example be made by following manner, promptly, be formed in the 11a and housing that 11d is outer (in the 11e, 11d), then, by being entered a more shallow degree of depth in slow molten packing, inside forms housing (outside the 11e), and filling and person cover housing (11d), form sealing member (11c) simultaneously.

Fig. 1 c and 1d represent capsule shell, this shell shrinkage fit is (moulding or molded) around material, and betwixt, for example (form of the unencapsulated adjacency section of 11d0 has the secondary point that weakens of the form that is a zone that is easy to dissolve (12) on protuberance, the described zone that is easy to dissolve (12) is to be suitable for stripping to move back with two shells.

Fig. 1 e and 1f represent capsule, and this capsule has a strip of wrapping material that is easy to dissolve (13), and this band (13) connects the gap between the housing (11d).Solid or liquid component are enclosed in this capsule (11d, 11d), and discharge by dissolving fast in water via the zone that is easy to dissolve (13).

Fig. 1 g represents a capsule, and this capsule comprises the quick dissolving single layer enclosure (11f) and the less important shell in inside (11d) of an encapsulated substance, in abutting connection with or fold seals to capsule, and away from shell (11d).This capsule can be suitable for encapsulating two kinds of identical or different materials and discharge stage by stage, and (11f) discharges a kind of material by instant housing, and discharges second kind of material subsequently by capsule (11d, 11d) slow molten.

Expression is filled or a kind of form of leak free master impregnating bag or folder bag (14) in Fig. 1 h and 1i, as shown in the figure, has the cap (15) of a separation or by flanging part (16) self sealss.Crimping can provide a release characteristic selectively, its form is, main structure is as point of the intensity part that prevents to discharge too early or as weakening second point of portion, this for example can be suitable for dissolving fast in water, so that along with the content in the release bag with the dissolving of back pkt. or folder bag.

The pouch of the secondary structure packing (21) around the mesh bag of the enhanced package of the dissolving slowly material (22) that one of expression is positioned at keystone configuration in Fig. 2 a and 2b, it can merge described packing (22) or otherwise be connected on the packing (21).Packing (21) are sealed in edge.

This packing is suitable for sending the classification material, thereby packing (21) instant discharges fine particle from main structure mesh bag (22), along with the dissolving slowly of mesh bag (22) discharges bulky grain subsequently.Pouch can comprise packing (21), as flexibility or rigidity packing or their combination, for example by vacuum, they can be straight or shape is arranged.This structure also can be used in and adopt the aforementioned according in other embodiments of the invention of any required packing.

Expression water dissolvable capsule (31) in Fig. 3 a, its form is, remains on first capsule halves on the strut member (33) in the place (34) by the capsule shells (32) that can be out of shape with restoring.By water dissolvable capsule (31) is positioned at bracing or strutting arrangement (33), causing too early, the external action in the place (34) of release is minimized.Along with contacting with water, this housing (31) dissolving discharges content, Ding Wei housing (32) dissolving subsequently.

Capsule of expression in Fig. 3 b, this capsule can be made by the water dissolvable packing, is suitable for utilizing the wing location of elastically deformable, thereby external action is located and damaged potentially to a capsule in this place.

Expression has the structure of packaging structure of the packing (41) of solubilized sealing member or crimping (42) in Fig. 4 a～4c.Packing can constitute by comprising flowing to seal or to push so that as Fig. 4 b (i) and 4b (ii) shown in, form one and have along the having of seam portion of length and stitch or seamless tube.Expression comprises the water dissolvable packing according to the bunchy of the bunchy element of water dissolvable packing of the present invention (52) and capsule (51) form in Fig. 5 a and 5b.Along with contacting with water, the bunchy element dissolves subsequently, and the bunchy capsule dissolves rapidly so that discharge their content, the auxiliary opposing of bunchy element cause with the external action of release too early before water contact.

Claims (29)

1, a kind of controlled release packing, this packing is included in can be to small part or the packing that disperse or dissolve fully basically in the hydrous matter of effective dose, it is suitable for comprising, comprises or is equipped with one or more materials, wherein, this packing be suitable for responding predetermined stimulation, in a predetermined manner, along with its basically simultaneously or subsequent section or disperse or dissolve fully, with included, comprise or the material that is equipped with is released into the desired position.

2, packing as claimed in claim 1, wherein, this material is discharged by the mode with solid or liquid, and preferably selects from the powder of required grade or rate range, particle, crystallization, microcapsules, monolithic, suspension, dispersion, enrichedmaterial, gel, thixotrope, non-aqueous solution etc. and composition thereof.

3, packing as claimed in claim 1 or 2, it is characterized in that, the selection of the feature of packaging structure and/or structure and/or packing prescription etc. or the combination of feature are to be the selection that characteristic is provided or the combination of characteristic, wherein, described feature or characteristic are from water dissolvable or dispersibility packing and/or come additional materials or the material that free water can be disperseed or the resolvability packing are filled a prescription, constituted or construct, perhaps from the structure or the structure of packing, and described feature or characteristic also can be selected according to its purposes.

4, as any one described packing of claim 1 to 3, it is complete hydrolysis basically.

5, as any one described packing of claim 1 to 4, be in hydrous matter, can disperse or soluble, hydrous matter comprises any solid-state, semisolid, liquid state or gaseous state (steam) fluid of the water that comprises effective dispersion or decomposition amount, can be chemistry or physically releasable combination, perhaps can be freely to obtain, and can or accumulate in together from material set, perhaps be easy to and packaged immediately material is taken away.

6, as any one described packing of claim 1 to 5, be suitable for responding a kind of predetermined stimulation and discharge, described stimulation comprise any be used to dissolve or disperse, by the transformation of separating out or metamorphosis takes place, break, rupture or other causes packing or its part can be permeated chemistry or physical stimulation comprise or the osed top material so that discharge institute.

7, as any one described packing of claim 1 to 6, wherein, this stimulation is identical or different with the hydrous matter that is used to disperse or dissolve, wherein, packing are to disperse or dissolve in heat or cold hydrous matter, and can be by dissolving or other physics or chemical mode h substance, described chemical mode for example for be exposed in heat, acid or alkali, solvent and the solvent mixture, in the oxidizing condition, the emittance that comprises UV, microwave etc. or biodegrade.

8, as any one described packing of claim 1 to 7, be used for material is discharged into the three unities, this place comprise wish to be released material enters or the place Anywhere, zone etc., this place can with wish that the place that material plays a role is identical or different, but should with this ground spot correlation that plays a role.

9, as any one described packing of claim 1 to 8, this is packaged on structure, structure or the prescription and comprises first and second parts, be suitable for substance dissolves and be released into required place, and control discharges stimulation or external action that element is subjected to, so that discharge with regularly predetermined and predetermined way.

10, as any one described packing of claim 1 to 9, wherein, this water can disperse or the solubilized packing comprise natural or synthesized polymer body or its compound of selecting from below: polyvinyl alcohol (PVA), polyethylene oxide, chemically modified fibre element or cellulose ether and other cellulose derivative, converted starch, polyvinyl pyrrolidone, polyacrylamide or gelatin or its derivant.

11, as any one described packing of claim 1 to 10, its form is: solid-state or hollow block, hollow container or closed shape, for example capsule or pouch or sphere, taper, elongated shape, annular or cone-shaped bag etc. or closure, for example diaphragm, dividing plate, cover, lid etc.

12, as any one described packing of claim 1 to 11, comprise: the keystone configuration of packing or zone, in order to strengthen, reinforcement, in dispose procedure, to keep the globality of packing or be used for other purpose, for example skeleton, framework workpiece, fiber, sieve aperture, ribbing, knot, sealing etc., it forms one with second structure that is the continuous substantially packing of desired structure or links to each other to small part.

13, as any one described packing of claim 1 to 12, comprising: the master of a sheath form comprises or encapsulating housing or layer, tablet etc., and it comprises or be packaged with second of packing and comprises or encapsulated layer.

14, as any one described packing of claim 1 to 13, comprise: master package material with the secondary point that weakens, the form of described secondary point is easy to rapidly or easily dissolve or break for the packing at this place have, perhaps cracking or introduce the characteristic of water, its form for example forms press back or embossing, tear-open strip line etc. for the form that does not penetrate.

15, as any one described packing of claim 1 to 14, comprise: be used for being located at or being positioned at the measure in described place, in described place, the material that is comprised be fixed in order to the mode on the optimum position of storage or with regularly or the mode that activates release of irritants be released, for example be used for the operation that is dissolved in the water in the place that discharges element, perhaps this packing is remained on the described position, so that in processing and storing process, resist for example influence of impulsive force.

16, as any one described packing of claim 1 to 15, wherein, this registration device comprises abundant elasticity of having of an elongation or flexible part, be suitable in holding the environment of this packing being or being hooked on the suitable projection or being positioned at around it, perhaps be received in the groove of an effective support part, the projection that perhaps can comprise the elastically deformable that extends in the opposite direction from packing as previously described, and be suitable for being deformed into the relative maintaining body of effective bracing or strutting arrangement, position between the surface etc., and kept by elasticity.

17,, comprise that one is suitable for absorbing or disperses that packing may be subjected to and can cause structure, structure or the form of external action of the too early release of the material that institute comprises or encapsulate as any one described packing of claim 1 to 16.

18, as any one described packing of claim 1 to 17, comprise: utilize in conjunction with or be included in the form of the supplementary element in the packing and strengthen it discharging the mechanism of the response that stimulates, it can be selected from following apparatus, promptly, be suitable for by contacting with hydrous matter, expand and cause discharging, for example comprise expanded or expanding agent, effervescent agent, disintegrant, dispersing agent, perhaps contain gas, for example has the air of positive overvoltage etc., the boost inductor agent for example is suitable for the variation along with pH, variation of temperature, be subjected to microwave, UV, solvent or solvent mixture etc. and cause release.

19, a kind of production method of making as any one described packing of claim 1 to 18 comprises the material that forms packing, and introduces one or more aforementioned materials that will discharge, so that it is comprised, comprises or is encapsulated in wherein.

20, method as claimed in claim 19, wherein, the material that forms packing does not residually seal one or more sheet materials, by heating, solvent, for example water, vacuum, pressure etc., utilize by dipping or spray that profiled member, foundry goods or an embossing etc. are gone up, the effect of extruding, moulding from solvent or melt, make one or more sheet materials distortion.

21, as any one described method of claim 19 to 20, described method comprises: seal by utilizing machinery or chemical mode, with the material that will discharge, it comprises: water or a kind ofly respond to the softening packing of agent and oneself and be bonded to softening or be similar on the softening packing, adopt solvent, bonding such as gel or welding, the edge of packing contacts with a fusing point, depress fluid-encapsulated, organic solvent for example, water, polymer solution or emulsion, the solution of proteolytic enzyme produces a protein solution etc., and applies heat energy etc. so that cause fusing.

22, as any one described method of claim 19 to 21, wherein, comprise a discriminating element, for example print directly or indirectly, molded, embossing or laser labelling, so that the characteristic of instruction content thing or the place of production, use pattern or design-calculated are in conjunction with feature.

23, as the described method of claim 19 to 22, wherein, the material of packing or being received comprises additional indicator elment, for example finishes or indicates when material has been realized its required effect when dissolving for one.

24, a kind of be used for controlling from aforementioned water can disperse or the solubilized packing discharge the method for aforementioned substances, comprise this packing is positioned a place that is used to discharge and be subjected to discharging stimulation, for example contact actv. period with aforementioned hydrous matter with the actv. amount of dispersing or dissolving, so that activate aforementioned release, and material is discharged in this place, wherein, this packing simultaneously or be dissolved in the hydrous matter fully subsequently.

25, method as claimed in claim 24, be used to discharge agrochemical substances, comprise insect or plant growth control agent, plant disease-controlling agent, soil conditioner etc., utilize dust, technology such as drilling, be used for application such as the cultivating of industry or family expenses scale, greenhouse, gardening, forestry.

26, method as claimed in claim 24, be used to discharge the environmental treatment agent, described environmental treatment agent comprises: water scavengine agent, disinfectant, waste disposal agent etc., comprise the controlling agent that is used for aquatic virus, bacterium, the biosome of carrying disease and insect, natural and industrial pollutants, comprise aquatic plants growth controlling agent, soil losses dispersing agent, cooling and circulating water neutralizing agent etc.

27, method as claimed in claim 24, be used to carry and discharge and should be noted that safe material when using, dangerous substance for example, comprise: the cleaning substance of agent of erosion, chemical reagent, discharge etc., these materials can use with the form of dilution, although they remain undesirable under powder, anhydrous or conc forms, are safe comparatively speaking, but, in solution, then become dangerous material.

28, method as claimed in claim 24, be used to discharge for example concentrated solid or stain remover or other cleaning agent of liquid form, comprise the family and the industrial stain remover that are used to clear up house, object and clothing, and any known stain remover or the cleaning agent that are used for personal hygiene.

29, method as claimed in claim 24, be used to discharge food, comprise dried or powder solid, liquid and volatility form flavoring additives and spices, texturing agent, pigment, hygroscopic agent, be used for for example rice, corn flour, salt and packing itself, oil and fat, dry milk product and other food, seasonings and herbal medicine etc. at the oxygen mesometamorphism.

Images