CN1541655A - Nano-scale pearl powder preparation method - Google Patents
Nano-scale pearl powder preparation method Download PDFInfo
- Publication number
- CN1541655A CN1541655A CNA03122900XA CN03122900A CN1541655A CN 1541655 A CN1541655 A CN 1541655A CN A03122900X A CNA03122900X A CN A03122900XA CN 03122900 A CN03122900 A CN 03122900A CN 1541655 A CN1541655 A CN 1541655A
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- Prior art keywords
- pearl
- margarita
- powder
- pearl powder
- nanometer
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- 239000000843 powder Substances 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 15
- 239000000084 colloidal system Substances 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 9
- 238000001035 drying Methods 0.000 claims abstract description 8
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims abstract description 7
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000000174 gluconic acid Substances 0.000 claims abstract description 5
- 235000012208 gluconic acid Nutrition 0.000 claims abstract description 5
- 235000005956 Cosmos caudatus Nutrition 0.000 claims description 33
- 244000293323 Cosmos caudatus Species 0.000 claims description 33
- 239000002245 particle Substances 0.000 claims description 16
- 239000000243 solution Substances 0.000 claims description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- 238000005453 pelletization Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 150000001669 calcium Chemical class 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
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- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to pearl powder preparation, and is especially the preparation of nano level pearl powder. The preparation process includes crushing pearl in high pressure homogenizing machine into grains of 2-5 micron size; dissolving pearl grains with citric acid or gluconic acid aqua to obtain pearl solution of 3-20 wt% concentration; regulating the pH value of pearl solution to neutrality; letting stand at room temperature to obtain pearl colloid; drying, solidifying and pelletizing to obtain pearl powder of 50-90 nm size. The said process has short time and high yield.
Description
Technical field
The invention belongs to the Margarita powder manufacture field, particularly the preparation method of nanometer pearl powder.
Background technology
Owing to contain the trace element, protein of 20 several amino acids and needed by human body and a large amount of calcium etc. in the Margarita, be a kind of famous and precious Chinese crude drug and nutrient and healthcare products.For the material that makes the contained needed by human body of Margarita can fully obtain utilizing, people are processed into beverage or tonic etc. for body-care with Margarita.But, when the processing Margarita,, be processed into quite difficulty of powder because Margarita has hard concentric laminated construction.Traditional diamond-making technique to Margarita for example has: earlier Margarita is boiled in water many times softening up to it, and then levigate in water; Or directly Margarita is added water with general Roughpulverizer fragmentation after, the reuse ball mill is pulverized the back and is dried adding under the water state; Or as the disclosed lactic acid Hydrolyze method of using of publication number CN1351869A.Traditional processing method is because Margarita is boiled bubble for a long time in water, make the nutritional labeling in the Margarita, be damaged or dissolve as albumen, aminoacid etc., the product mean diameter is mostly more than 15 microns simultaneously, be unfavorable for using, as make health care, the cosmetics effect is undesirable; In order to obtain the littler Margarita powder of particle diameter, people begin to adopt superfine techniques such as airflow milling, colloid mill, vibromill, ultrasonic grinding mill to prepare Margarita ultrafine powder.But the mean diameter of these Margarita ultrafine powders still is a micron order, generally about 3～8 μ m.And when adopting the lactic acid Hydrolyze method, owing to be subjected to the restriction of lactic acid concn and pearl particles particle diameter, the concentration of the Margarita powder that obtains is low, thereby makes the Margarita dry powder that obtains also low relatively, and production cost is high relatively.
Summary of the invention
The preparation method that the purpose of this invention is to provide nanometer pearl powder obtains higher Margarita powder volume of production under low preparation cost.
The preparation method of nanometer pearl powder of the present invention comprises the steps:
(1). adopting high pressure homogenizer that crushing pearl is become particle diameter is 2～5 microns granule;
(2). with concentration is the citric acid of 30～50wt% or the pearl particles of gluconic acid aqueous solution dissolving step (1), and obtaining concentration is the pearl powder solution of 20～30wt%;
(3). with sodium bicarbonate the pH value of step (2) hydrolyzed pearl powder solution is adjusted to neutrality, at room temperature leaves standstill, obtain the Margarita powder colloid, make the grain size of Margarita powder reach nanoscale;
(4). with the nanometer pearl powder colloid drying of step (3), solidify pelletize, getting particle diameter is 50～90 nanometer Margarita powders.
Described drying serves as easy to adopt centrifugal spray drying; Described pH is good with 6.5～7.5.
Method of the present invention is owing to adopt high pressure homogenizer with crushing pearl Margarita earlier, under anhydrous situation of mediating, the pearl particles that obtains pulverizing has guaranteed that the active ingredient of Margarita is not run off like this, simultaneously also shorten the time that obtains nanometer pearl powder, improved specific duty.
Method of the present invention adopts citric acid or gluconic acid to be hydrolyzed, under the prerequisite of not destroying the effective nutrition of Margarita powder, the calcium carbonate of Margarita can be converted into the activated calcium that human body absorbs easily when being used for the body-care product, be absorbed by the body easily, at room temperature obtain uniform nanometer pearl powder colloid simultaneously.
The specific embodiment
Embodiment 1.
(1). adopting high pressure homogenizer that crushing pearl is become particle diameter is 2～3 microns granule;
(2). with concentration is the pearl particles of the citric acid aqueous solution dissolving step (1) of 30wt%, and obtaining concentration is the pearl powder solution of 20wt%;
(3). with pH value=7 of sodium bicarbonate, at room temperature leave standstill, obtain the Margarita powder colloid, make the grain size of Margarita powder reach nanoscale step (2) hydrolyzed pearl powder solution;
(4). the nanometer pearl powder colloid of step (3) is adopted centrifugal spray dryer drying method drying, solidify pelletize, getting particle diameter is 55 nanometer Margarita powders.
Embodiment 2.
(1). adopting high pressure homogenizer that crushing pearl is become particle diameter is 2～5 microns granule;
(2). with concentration is the pearl particles of the gluconic acid aqueous solution dissolving step (1) of 50wt%, and obtaining concentration is the pearl powder solution of 30wt%;
(3). with the pH=7.5 of sodium bicarbonate, at room temperature leave standstill, obtain the Margarita powder colloid, make the grain size of Margarita powder reach nanoscale step (2) hydrolyzed pearl powder solution;
(4). the nanometer pearl powder colloid of step (3) is adopted centrifugal spray dryer drying method drying, solidify pelletize, getting particle diameter is 80 nanometer Margarita powders.
Claims (2)
1. the preparation method of a nanometer pearl powder is characterized in that this method comprises the steps:
(1). adopting high pressure homogenizer that crushing pearl is become particle diameter is 2～5 microns granule;
(2). with concentration is the citric acid of 30～50wt% or the pearl particles of gluconic acid aqueous solution dissolving step (1), and obtaining concentration is the pearl powder solution of 20～30wt%;
(3). with sodium bicarbonate the pH value of step (2) hydrolyzed pearl powder solution is adjusted to neutrality, at room temperature leaves standstill, obtain the Margarita powder colloid, make the grain size of Margarita powder reach nanoscale;
(4). with the nanometer pearl powder colloid drying of step (3), solidify pelletize, getting particle diameter is 50～90 nanometer Margarita powders.
2. the method for claim 1 is characterized in that; Described pH=6.5～7.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03122900XA CN1251691C (en) | 2003-04-30 | 2003-04-30 | Nano-scale pearl powder preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB03122900XA CN1251691C (en) | 2003-04-30 | 2003-04-30 | Nano-scale pearl powder preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1541655A true CN1541655A (en) | 2004-11-03 |
| CN1251691C CN1251691C (en) | 2006-04-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB03122900XA Expired - Fee Related CN1251691C (en) | 2003-04-30 | 2003-04-30 | Nano-scale pearl powder preparation method |
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| CN (1) | CN1251691C (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100388981C (en) * | 2005-05-12 | 2008-05-21 | 浙江长生鸟珍珠生物科技有限公司 | Method for preparing full natural Nano pearl powder |
| CN100425245C (en) * | 2006-01-17 | 2008-10-15 | 李伊为 | A method for preparing nano-grade pure pearl powder |
| CN101891989A (en) * | 2010-08-04 | 2010-11-24 | 广东三和化工科技有限公司 | Volatile organic compound (VOC)-free aqueous nano color paste for smoothing nerves |
| CN101966140A (en) * | 2010-10-28 | 2011-02-09 | 浙江欧诗漫集团德清生物科技有限公司 | Method for preparing fishy smell removed submicron pearl powder with regular geometric shape |
| CN101288679B (en) * | 2008-05-23 | 2011-04-06 | 海南京润珍珠生物技术股份有限公司 | Dissolving and reducing generation method of nano pearl powder |
| CN102744136A (en) * | 2012-07-13 | 2012-10-24 | 四川厚德医药科技有限公司 | Preparation method for nanometre pearl powder |
| CN104814909A (en) * | 2015-04-27 | 2015-08-05 | 郭中河 | Water soluble nacre powder chelation technology |
| CN105476946A (en) * | 2015-12-22 | 2016-04-13 | 浙江工业大学 | Preparation method of fishy smell removed pearl powder |
| CN105796466A (en) * | 2016-05-20 | 2016-07-27 | 中山市天图精细化工有限公司 | Pearl powder aerosol |
| CN109157544A (en) * | 2018-09-18 | 2019-01-08 | 苏州太湖美药业有限公司 | A kind of preparation method of pearl powder |
-
2003
- 2003-04-30 CN CNB03122900XA patent/CN1251691C/en not_active Expired - Fee Related
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100388981C (en) * | 2005-05-12 | 2008-05-21 | 浙江长生鸟珍珠生物科技有限公司 | Method for preparing full natural Nano pearl powder |
| CN100425245C (en) * | 2006-01-17 | 2008-10-15 | 李伊为 | A method for preparing nano-grade pure pearl powder |
| CN101288679B (en) * | 2008-05-23 | 2011-04-06 | 海南京润珍珠生物技术股份有限公司 | Dissolving and reducing generation method of nano pearl powder |
| CN101891989A (en) * | 2010-08-04 | 2010-11-24 | 广东三和化工科技有限公司 | Volatile organic compound (VOC)-free aqueous nano color paste for smoothing nerves |
| CN101966140A (en) * | 2010-10-28 | 2011-02-09 | 浙江欧诗漫集团德清生物科技有限公司 | Method for preparing fishy smell removed submicron pearl powder with regular geometric shape |
| CN102744136B (en) * | 2012-07-13 | 2014-04-30 | 四川厚德医药科技有限公司 | Preparation method for nanometre pearl powder and prepared nanometer pearl powder |
| CN102744136A (en) * | 2012-07-13 | 2012-10-24 | 四川厚德医药科技有限公司 | Preparation method for nanometre pearl powder |
| CN104814909A (en) * | 2015-04-27 | 2015-08-05 | 郭中河 | Water soluble nacre powder chelation technology |
| CN104814909B (en) * | 2015-04-27 | 2018-01-02 | 郭中河 | A kind of water soluble pearl matter powder chelating technique |
| CN105476946A (en) * | 2015-12-22 | 2016-04-13 | 浙江工业大学 | Preparation method of fishy smell removed pearl powder |
| CN105476946B (en) * | 2015-12-22 | 2018-05-08 | 浙江工业大学 | Preparation method of fishy smell removed pearl powder |
| CN105796466A (en) * | 2016-05-20 | 2016-07-27 | 中山市天图精细化工有限公司 | Pearl powder aerosol |
| CN105796466B (en) * | 2016-05-20 | 2019-02-01 | 中山市天图精细化工有限公司 | A kind of pearl powder aerosol |
| CN109157544A (en) * | 2018-09-18 | 2019-01-08 | 苏州太湖美药业有限公司 | A kind of preparation method of pearl powder |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1251691C (en) | 2006-04-19 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: AILITE CLOTHING CO., LTD., NINGBO CITY Free format text: FORMER OWNER: BEIJING ZIRAN AIKANG BIOLOGY TECHNOLOGY DEVELOPMENT CO., LTD. Effective date: 20080718 |
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Effective date of registration: 20080718 Address after: Zhejiang city of Ningbo province high tech Zone Branch Road No. 96 Patentee after: Ningbo Ailite Garment Co.,Ltd. Address before: Room 3, No. 211, Huayuan Road B, Haidian District, Beijing Patentee before: BEIJING ZIRAN AIKANG BIOTECHNO |
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| CI01 | Publication of corrected invention patent application |
Correction item: Patentee name Correct: Elite Ningbo Fashion Co., Ltd. False: Ningbo Ailite Garment Co. Ltd. Number: 35 Page: 1529 Volume: 24 |
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| ERR | Gazette correction |
Free format text: CORRECT: NAME OF PATENTEE; FROM: AILITE CLOTHING CO., LTD., NINGBO CITY TO: NINGBO ELLOIT FASHION CO., LTD. |
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Granted publication date: 20060419 Termination date: 20120430 |